Identification of Prognostic Biomarkers in Gene Expression Profile of Neuroblastoma Via Machine Learning.

Neuroblastoma (NB) is a common pediatric solid malignancy characterized by heterogeneous clinical outcomes. The identification of predictive and interpretable prognostic biomarkers is critical for advancing precision medicine in NB. We proposed an integrative network-based machine learning method for biomarker discovery, which employed a network smoothed -statistic support vector machine to select prognostic related biomarkers, and then we performed network analysis on these biomarkers to find hub genes.

A --Chlorinated Azobenzene Molecule for Visible-Light Photon Energy Conversion and Storage.

The development of photoactive molecules for photothermal energy storage is a focus of research in solar energy utilization technology. Azobenzene photoswitch has emerged as a promising candidate for solar energy conversion and storage due to its unique photoisomerization characteristics. Nonetheless, a majority of azobenzene-based molecular photothermal systems have a significant drawback: they depend on ultraviolet light for -to- isomerization to store photon energy rather than visible light, which seriously hinders the development of azobenzene photoswitch in practical solar energy utilization applications.

Extraction and Activity Mechanism of α-Glucosidase Inhibitory Peptides From Seabuckthorn Seed Meal.

Seabuckthorn seed meal (SSM) is a by-product of the oil extraction process from seabuckthorn seeds. Despite its high protein content, SSM remains largely underutilized. This study aimed to extract seabuckthorn seed meal protein peptides (SSPPs) with hypoglycemic activity and investigate their mechanism of action.

Integrating multi-omics data reveals neuroblastoma subtypes in the tumor microenvironment.

Neuroblastoma (NB) is a severe pediatric tumor originating from the developing sympathetic nervous system, characterized by diverse clinical outcomes, including spontaneous regression and aggressive metastasis. This variability suggests the existence of different NB subtypes, necessitating accurate classification for effective targeted treatment. In this study, we employed the similarity network fusion (SNF) algorithm and identified three NB subtypes, including mesenchymal-like (MES), MYCN-like (MYCN), and neurogenic-like (Neurogenic).

Acetylation of the polysaccharide from Houttuynia cordata rhizome and their α-glucosidase inhibition mechanism.

In this study, the polysaccharide (RHCP) extracted from Houttuynia cordata rhizome was acetylated through the acetic anhydride method. The physicochemical properties of RHCP and its acetylated derivatives (Ac-RHCP) were determined by infrared spectra, scanning electron microscopy, and Congo red test. Meanwhile, the α-glucosidase inhibition mechanism of RHCP and Ac-RHCP was analyzed by inhibition kinetics, and circular dichroism and fluorescence spectroscopy.

Hypoglycemic effect of -fermented mulberry pomace extract and in .

Mulberry pomace is rich in phytochemicals, but there are few studies on its utilization as a by-product. Natural foods containing phytochemicals can alleviate the toxic effects of excessive glucose intake. In this study, we investigated the protective effect of -fermented mulberry pomace extract (FMPE) under hyperglycemic conditions.

Modulation of Gut Microbiota by Fermented Raspberry Juice In Vitro and In Vivo.

The aim of this study was to investigate the modulation of gut microbiota by fermented raspberry juice (FRJ) both in vitro and in vivo. Results showed that total phenolic content and antioxidant activities of FRJ reached the highest after fermentation for 42 h. Seventeen phenolic compounds were contained in FRJ, mainly including ellagic acid (496.

Lactobacillus casei-fermented blueberry pomace augments sIgA production in high-fat diet mice by improving intestinal microbiota.

Intestinal secretory immunoglobulin A (sIgA)-improving function of Lactobacillus casei-fermented blueberry pomace (FBP) was investigated in this study. Male C57BL/6 mice were fed with control diet (CD) or high-fat diet (HFD) with or without FBP supplementation. Expressions of sIgA-associated genes/proteins were evaluated by quantitative polymerase chain reaction (qPCR), western blot and enzyme-linked immunosorbent assay (ELISA).

Fermented blueberry pomace ameliorates intestinal barrier function through the NF-κB-MLCK signaling pathway in high-fat diet mice.

The barrier-improving functions of fermented blueberry pomace (FBP) and its potential mechanism were investigated in this study. Polyphenols and the approximate composition of FBP were evaluated according to the National Standard of the People's Republic of China and the UPLC-MS system. Male C57BL/6 mice were fed a control diet (CD) or a high-fat diet (HFD) with or without FBP supplementation.