98%
921
2 minutes
20
Unusual DS-1-like intergenogroup reassortant rotaviruses with a bovine-like G8 genotype (DS-1-like G8P [8] rotaviruses) have emerged and rapidly spread in several countries. In this study, the nucleotide sequences of seven human rotavirus G8P [8] strains in 2017 and 2019 in Japan were determined using viral metagenomics. Its genomic constellation (VP7-VP4-VP6-VP1-VP2-VP3-NSP1-NSP2-NSP3-NSP4-NSP5 genes) was defined as G8-P [8]-I2-R2-C2-M2-A2-N2-T2-E2-H2. Our genetic analysis revealed that the Japanese G8P [8] rotavirus strains in 2017 and 2019 were classified into the same lineages G8-5 and P [8]-3, but they were phylogenetically located on separate branches and belonged to distinct clusters. Our study is the first attempt to investigate the evolution of emerging rotavirus G8P [8] in Japan.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381655 | PMC |
http://dx.doi.org/10.1007/s13337-022-00765-z | DOI Listing |
Vet Microbiol
September 2025
College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China. Electronic address:
Rotavirus (RV) is a major cause of gastroenteritis in both humans and many mammals, including livestock. However, information regarding RV in sheep remains limited, particularly in China. This study reports the first isolation and characterization of the G8-P[1]-I2-R2-C2-M2-A11-N2-T6-E2-H3 type sheep RV strain (GS13) in China.
View Article and Find Full Text PDFViruses
August 2025
Virology Center, Adolfo Lutz Institute, Sao Paulo 01246-902, Brazil.
In Brazil, molecular surveillance expanded after Rotarix™ vaccine introduction, alongside G2P[4] dominance. The G2P[6] genotype, despite sharing the same DS-1-like constellation as G2P[4] strains, remains rare. This retrospective study analyzed eight Brazilian G2P[6] strains (2012-2014) through RT-PCR and 11-segments sequencing, followed by phylogenetic analysis.
View Article and Find Full Text PDFBMC Genomics
August 2025
Chinese PLA Center for Disease Control and Prevention, Beijing, China.
Background: Rotavirus A group (RVA) is a leading cause of viral diarrhea, posing a substantial economic and public health burden. Compared to other enteric viruses, RVA possesses diverse genetic mechanisms, making it more challenging to control and prevent. Moreover, surveillance and evolutionary studies on RVA remain limited in Southern China.
View Article and Find Full Text PDFViruses
June 2025
Interdisciplinary Center for Research in Animal Health (CIISA), Faculty of Veterinary Medicine, University of Lisbon, 1300-477 Lisbon, Portugal.
(. ) remains the leading cause of pediatric diarrhea. Although Angola introduced Rotarix, the human monovalent .
View Article and Find Full Text PDFTrop Med Health
June 2025
Division of One Health, Research Center for GLOBAL and LOCAL Infectious Diseases (RCGLID), Oita University, Yufu, Oita, 879-5593, Japan.
Background: Rotavirus infections are a major cause of severe gastroenteritis in children. Human rotavirus strains with the unconventional G8P[14] genotype have sporadically been detected in diarrheic patients in different parts of the world. However, full genomes of only two human G8P[14] strains from Africa (North Africa) have been sequenced, and the origin and evolutionary patterns of African G8P[14] strains remain to be elucidated.
View Article and Find Full Text PDF