Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
A magnetoelastic (ME) biosensor for wireless detection of analytes in liquid is described. The ME biosensor was tested against human IgG in the range 0-20 μg∙mL. The sensing elements, anti-human IgG produced in goat, were immobilized on the surface of the sensor by using a recently introduced photochemical immobilization technique (PIT), whereas a new amplification protocol exploiting gold coated magnetic nanoparticles (core-shell nanoparticles) is demonstrated to significantly enhance the sensitivity. The gold nanoflowers grown on the magnetic core allowed us to tether anti-human IgG to the nanoparticles to exploit the sandwich detection scheme. The experimental results show that the 6 mm × 1 mm × 30 μm ME biosensor with an amplification protocol that uses magnetic nanoparticles has a limit of detection (LOD) lower than 1 nM, works well in water, and has a rapid response time of few minutes. Therefore, the ME biosensor is very promising for real-time wireless detection of pathogens in liquids and for real life diagnostic purpose.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466411 | PMC |
| http://dx.doi.org/10.3390/nano10081526 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Magnetic nano-crosslinked lipase aggregates: Preparation and catalytic synthesis of OPO.
Int J Biol Macromol
September 2025
Department of Pharmaceutical Engineering, School of Engineering, China Pharmaceutical University, Nanjing, 211198, China; Engineering Research Center for Smart Pharmaceutical Manufacturing Technologies, Ministry of Education, China Pharmaceutical University, Nanjing, 211198, China. Electronic addres
1,3-Dioleoyl-2-palmitoylglycerol (OPO) is crucial for infant nutrition; however, conventional immobilized lipase requires high-purity enzymes, which increases costs and limits industrial scalability. Herein, Rhizomucor miehei lipase (RML) was immobilized on surface-modified magnetic nanoparticles using cross-linked enzyme aggregates (CLEAs) technology to produce FeO@SiO@TPOAC@RML CLEAs. This approach combines the separation and immobilization of enzymes, allowing for the use of lower-purity lipase, which enhances its suitability for industrial-scale processes.
View Article and Find Full Text PDFReview of engineered magnetic chitosan nanoparticles for drug delivery: Advances, challenges, and future prospects.
Int J Biol Macromol
September 2025
Centre for Research Impact & Outcome, Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, India; Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, 73000, Thailand. Electronic address:
Magnetic chitosan nanoparticles represent a promising platform in targeted drug delivery by merging the biocompatibility and mucoadhesiveness of chitosan with the superparamagnetic iron-oxide cores magnetite (Fe₃O₄) or maghemite (γ-Fe₂O₃). This synergy enables enhanced therapeutic precision through external magnetic guidance, controlled release, and stimuli-responsive behavior. MCNPs are particularly valuable in oncology, allowing site-specific drug delivery, magnetic hyperthermia, and real-time imaging via MRI.
View Article and Find Full Text PDFEnzyme-mediated nanoreactors with cascade metabolic modulation for enhanced chemo-chemodynamic combination therapy.
J Colloid Interface Sci
September 2025
School of Materials, Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, China. Electronic address:
Harnessing the significant buildup of lactic acid (LA) within the tumor microenvironment (TME) for metabolic manipulation presents a promising avenue for cancer treatment. Nevertheless, single-agent therapies often fail to address the complex and varying needs of TME heterogeneity, posing a substantial scientific hurdle in oncology. In this context, we employ asymmetric mesoporous silica nanoparticles (AMS NPs) as delivery vehicles, simultaneously loading them with zinc‑cobalt‑manganese ferrite nanoparticles (ZCMF NPs), lactate oxidase (LOX), and doxorubicin (DOX).
View Article and Find Full Text PDFTwo birds with one stone: Versatile lanthanide-doped core-shell-shell nanoparticles with enhanced red upconversion for nanothermometry and MR imaging.
J Colloid Interface Sci
September 2025
Department of Radiation Oncology, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu 610041, China. Electronic address: Zhaoy
Lanthanide-doped fluoride nanoparticles show great potential for optical thermometry and bioimaging. However, their applications are still constrained by inherent limitations in luminescence intensity and functional versatility. To overcome these challenges, we propose a core-active shell-inert shell nanostructure that integrates multifunctional capabilities within a single platform.
View Article and Find Full Text PDFFabrication of Hydrophilic Gadolinium Hydroxide Sheets via A Gadolinium-Based Precipitation Reaction.
Inorg Chem
September 2025
Division of Physical Sciences and Engineering, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia.
In this work, we report a facile strategy for synthesizing hydrophilic Gd(OH) sheets via a Gd-based interfacial precipitation reaction at the interface of organosilane-modified GdO nanoparticles and a cation exchange resin. This strategy, independent of the specific organosilane used, produces two-dimensional sheets with a distinct lamellar structure and excellent aqueous dispersibility. Characterization confirms the formation of Gd(OH) sheets with promising fluorescent and magnetic properties.
View Article and Find Full Text PDF