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Broadband light interferometry, which is a well-developed method for surface profiling, has been applied with great success in the past years. Conventional multi-wavelength interferometric surface profilers mostly utilize the light irradiance to locate the zero fringe order, but the accuracy and stability can be negatively influenced by intensity fluctuations and external light disturbance, which is a serious problem. In this paper we discuss a hybrid technique combining light intensity and spectral modulation to determine zero optical path difference in which the light instability can be effectively suppressed. Additionally, the phase evaluation at each pixel will provide a high vertical resolution to obtain the characterization of the micro structure. The hybrid-interference method will not only improve the sensitivity of the measurement system but also level up the robustness and stability. Both simulation and experiment on a micro-dome structure have been presented to verify the effectiveness. Furthermore, the proposed method may be promising to replace the previously intensity-based method, especially in a complex application environment.
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http://dx.doi.org/10.1364/AO.56.002301 | DOI Listing |
Int J Pharm X
June 2025
Medical School, Southeast University, Nanjing 210009, China.
This study aimed to create multifunctional nanoparticles (NPs), specifically AS1411@MPDA-Len-Cy5.5 (AMLC), for the purpose of developing effective strategies for treating hepatocellular carcinoma (HCC) through targeted therapy and photothermal therapy (PTT). The study involved synthesizing mesoporous polydopamine (MPDA)-NPs, loading lenvatinib (Len) and Cy5.
View Article and Find Full Text PDFRSC Adv
September 2025
Food and Drug Safety Research Center, Pharmaceutical Sciences Institute, Tabriz University of Medical Sciences Tabriz Iran.
This study focuses on developing an analytical method to efficiently extract and concentrate several adipate and phthalate plasticizers that can migrate from plastic packaging into various wound disinfectants. The study employed an approach that combined dispersive micro solid phase extraction with dispersive liquid-liquid microextraction using ZIF-4 as an adsorbent. The adsorbent was thoroughly characterized to understand its properties.
View Article and Find Full Text PDFFront Pharmacol
August 2025
Department of Genetics and Cell Biology, School of Basic Medicine, Qingdao University, Qingdao, Shandong, China.
Background: Osteoporosis (OP) is a chronic, systemic skeletal disorder characterized by progressive bone loss and microarchitectural deterioration, which increases fracture susceptibility and presents a challenging set of global healthcare problems. Current pharmacological interventions are limited by adverse effects, high costs, and insufficient long-term efficacy. Here, we identify snow crab shell-derived polypeptides (SCSP) as a potent osteoprotective agent.
View Article and Find Full Text PDFInt J Biol Macromol
September 2025
College of Food Science, Northeast Agricultural University, Harbin, 150030, China; College of Food Science and Engineering, Jilin University, Changchun, 130062, China; Heilongjiang Province China-Mongolia-Russia Joint R&D Laboratory for Bio-processing and Equipment for Agricultural Products (Interna
This study developed a novel self-assembled bigel by combining a chestnut starch (CS) hydrogel with a γ-oryzanol/β-sitosterol (γ-ORY/β-SIT) oleogel. The influence of the hydrogel to oleogel ratio on the macro and micro structures, mechanical properties and thermal stability of the bigels was examined, and its potential as a healthier solid fat substitute was further explored. The results indicated that as the proportion of hydrogel increased (10 %-50 %), all bigels maintained a consistent semi-solid structure without any phase separation.
View Article and Find Full Text PDFArterial thrombosis is a multifaceted process characterized by platelet aggregation and fibrin deposition, leading to the occlusion of blood vessels. It plays a central role in cardiovascular conditions such as myocardial infarction and ischemic stroke. Gaining insight into the mechanisms underlying arterial thrombosis is essential for developing effective treatments aimed at preventing thrombotic events and reducing associated health burdens.
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