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Ultrasensitive pressure sensors are constructed with few-layer MoS films. As-designed Fabry-Perot (F-P) sensors exhibit nearly synchronous pressure-deflection responses with a very high sensitivity (89.3 nm Pa ), which is three orders of magnitude higher than those of conventional diaphragm materials (e.g., silica, silver films). This kind of F-P sensor may open up new avenues for 2D materials in biomedical and environmental applications.
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http://dx.doi.org/10.1002/adma.201603266 | DOI Listing |
Adv Mater
September 2025
Key Laboratory of Low Dimensional Quantum Structures and Quantum Control of Ministry of Education, School of Physics and Electronics, Hunan Normal University, Changsha, 410081, China.
The high sensitivity and wide linearity are crucial for flexible tactile sensors in adapting to diverse application scenarios with high accuracy and reliability. However, conventional optimization strategies of constructing microstructures suffer from the mutual restriction between the high sensitivity and wide linearity. Herein, a novel design of localized gradient conductivity (LGC) with partly covered low-conductivity (low-σ) carbon/Polydimethylsiloxane layer on high-conductivity (high-σ) silver nanowires film upon the micro-dome structure is proposed.
View Article and Find Full Text PDFAnal Chem
September 2025
State Key Laboratory of Chemical Safety, College of Chemistry and Chemical Engineering, China University of Petroleum (East China), Qingdao 266580, PR China.
Low-turnover osteoporosis diagnosis urgently requires sensitive detection of low-abundance osteocalcin (OC), yet conventional methods remain constrained by insufficient sensitivity, cumbersome instrumentation, and laborious operations. We devise a CRISPR-driven pressure bioassay that synergistically integrates molecular recognition, enzymatic amplification, and signal transduction for dual-amplification-enhanced OC quantification. The system features an engineered "locked-to-activated" molecular switch, where target binding liberates CRISPR-activating DNA strands, initiating Cas14a-catalyzed cleavage of ssDNA tethers on FeO-ssDNA-Pt nanoassemblies.
View Article and Find Full Text PDFSensors (Basel)
August 2025
Electronic Information School, Wuhan University, Wuhan 430072, China.
Flexible hydrogel sensors demonstrate emerging applications, such as wearable electronics, soft robots, and humidity smart devices, but their further application is limited due to their single-responsive behavior and unstable, low-sensitivity signal output. This study develops a dual-responsive starch-based conductive hydrogel via a facile "one-pot" strategy, achieving mechanically robust pressure sensing and ultra-sensitive humidity detection. The starch-Poly (2,3-dihydrothieno-1,4-dioxin)-poly (styrenesulfonate) (PEDOT:PSS)-glutaraldehyde (SPG) hydrogel integrates physical entanglement and covalent crosslinking to form a porous dual-network architecture, exhibiting high compressive fracture stress (266 kPa), and stable electromechanical sensitivity (ΔI/I, ~2.
View Article and Find Full Text PDFAdv Mater
August 2025
Institute for Advanced Study, Shenzhen University, Shenzhen, 518000, P. R. China.
Stroke is a leading cause of long-term disability worldwide, with post-stroke aphasia significantly impairing communication and social interaction. Traditional rehabilitation devices are often bulky, expensive, and impractical for daily use, particularly in speech recovery, where accessible and effective solutions remain limited. To address this challenge, this study introduces a portable and wearable sensor system for stroke-induced aphasia rehabilitation.
View Article and Find Full Text PDFJ Chromatogr A
October 2025
Key Laboratory of Cold Chain Food Processing and Safety Control (Zhengzhou University of Light Industry), Ministry of Education, Zhengzhou, China; Henan Province Engineering Research Center of Meat Precision Processing and Quality Safety Control, Zhengzhou, China. Electronic address: baiyanhong212@1
In this study, an online ultrasensitive method was established for analyzing 38 veterinary drugs in beef by integrating ultrahigh performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) with a modified QuEChERS method through a fractionized sampling and stacking (FSS) interface. Large volumes of purified solution were fractionized, stacked, separated, and analyzed by the established FSS-UPLC-MS/MS system without significantly prolonging analysis time and causing overload problems. For all drugs, good linearities with R≥0.
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