A dual-potential self-enhancing electrochemiluminescence immunosensor for simultaneous detection of estrogenic hormones E2 and E3 in water.

17β-estradiol (E2) and estriol (E3), as natural estrogen contaminants in aquatic environments, have significant risks to ecosystems and human health by disrupting endocrine functions and inducing reproductive disorders even at trace levels. To address the urgent need for simultaneous monitoring of these structurally similar targets, we developed a dual-potential electrochemiluminescence (ECL) immunosensor for efficient parallel detection of E2 and E3. The sensor employs poly (1-naphthylamine)-molybdenum disulfide decorated with gold-silver bimetallic nanoclusters (PNA-MoS@AuAg NCs) as an ECL emitter, utilizing the self-enhancing property of AuAg NCs for intermolecular charge transfer and dual-potential-responsive properties to generate two well-resolved ECL signals (-0.

A Wideband Multimodal Flexible Sensor Integrating Vertical Graphene and Sea Urchin-Like Nanoparticles for Post-Stroke Rehabilitation.

Stroke is a leading cause of long-term disability worldwide, with post-stroke aphasia significantly impairing communication and social interaction. Traditional rehabilitation devices are often bulky, expensive, and impractical for daily use, particularly in speech recovery, where accessible and effective solutions remain limited. To address this challenge, this study introduces a portable and wearable sensor system for stroke-induced aphasia rehabilitation.

Wearable Au@Cu-MOF Carbon Nanofiber Biosensor for Monitoring Nutrients and Metabolites.

Wearable sweat biosensors engineered for continuous measurement and real-time analysis of diverse health-related biomarkers have garnered considerable interest in recent years. Their excellent sensitivity, noninvasiveness, and point-of-care monitoring capabilities make them extremely desirable. Here, we report a wearable sweat sensor patch based on a composite of gold nanoparticles (AuNPs) modified Copper MOF (Cu-MOF)-derived electrospun carbon nanofibers (CNFs) for the individual and simultaneous detection of uric acid (UA), tyrosine (Tyr), and other metabolites.

A wearable spatiotemporal controllable ultrasonic device with amyloid-β disaggregation for continuous Alzheimer's disease therapy.

The rising prevalence of Alzheimer's disease (AD) due to an aging population has made the search for effective treatments more urgent than ever. Previous studies have demonstrated that continuous ultrasound can depolymerize amyloid proteins, offering potential relief from AD. In this study, we present a portable, fully integrated wearable ultrasound system designed to promote amyloid protein depolymerization.

Fully Integrated Wearable Biosensor for Multiple Phosphorylated Tau Protein Detection.

Early diagnosis is critical for the prevention and treatment of Alzheimer's disease (AD), as it allows for timely detection and intervention. Here, we developed a fully integrated wearable electrochemical sensing patch for early screening of AD, which combines sample collection and detection within a device. This wearable patch integrates a custom-developed microneedle sampling system with a wearable multimodal electrochemical biosensor.

An Ultrasensitive Wearable Nanosensor for Minimally Invasive Self-Screening of Alzheimer's Disease.

The rising global prevalence of Alzheimer's disease (AD) has emerged as a critical public health challenge, placing strain on families, communities, and healthcare systems. Despite advances in diagnostic methods, current techniques for early AD detection remain limited, often being invasive, costly, and impractical for regular use. Here, we report a fully integrated wearable nanosensor offering an easily accessible and user-friendly strategy for AD screening.

Innovative biosensing smart masks: unveiling the future of respiratory monitoring.

Real-time monitoring of respiratory health is increasingly critical, particularly in addressing global health challenges such as Corona Virus Disease 2019 (COVID-19). Smart masks equipped with biosensing mechanisms revolutionize respiratory health monitoring by enabling real-time detection of respiratory parameters and biomarkers. In recent years, significant advancements have been achieved in the development of smart masks based on different sensor types with high sensitivity and accuracy, flexible functionality, and portability, providing new approaches for remote and real-time monitoring of respiratory parameters and biomarkers.

Microsampling and exosome-enriched optical biochip for non-invasive detection of breast cancer exosomes in clinical human tear fluid.

Tumor exosome detection is one of the most clinically relevant liquid biopsy methods for non-invasive breast cancer diagnosis. However, conventional methods are often unsuitable for routine use due to large sample requirements, low precision, and complex procedures. To overcome these challenges, we have developed a novel optical biochip that integrates tear collection, exosome enrichment, and detection into a single platform.

An Integrated Janus Bioelectronic Bandage for Unidirectional Pumping and Monitoring of Wound Exudate.

Single-functional wound dressings provide limited therapeutic benefits for chronic wound healing. Effective care for chronic wounds requires a multifunction that integrates exudate management, therapeutic treatment, and continuous monitoring. Here, we introduce an integrated Janus bioelectronic wound care bandage designed to achieve self-pumping exudate management via an electrospinning Janus dressing with opposite wettability, antibacterial properties through silver nanoparticles (AgNPs), and the monitoring of multiplex biomarkers in wounds via electrochemical sensors positioned on the drainage side.

Bletilla striata polysaccharide-based dissolving microneedle patch integrated with nanoparticles for promoting hair regrowth.

Hair loss (alopecia) has become a condition that plagues billions of people worldwide, which can occur at any age. Alopecia severely reduces the life quality and affects the self-esteem of patients, especially in adolescents. Due to the deficiency of current therapeutic formulations, such as frequent dosing, low bioavailability, significant side effects and high cost, it is urgent to develop a safe and effective strategy for the treatment of hair loss.

VG@nAu-based fluorescent biosensor for grading Alzheimer's disease by detecting P-tau181 protein in clinical samples.

Background: Alzheimer's disease (AD) is a neurodegenerative disorder with a very long duration, posing a serious threat to people's life and health. To date, no medicine that can cure or reverse the disease has been developed or reported, so early diagnosis and timely intervention are essential. The concentration of Phosphorylated tau181 (P-tau181) in blood has been approved by FDA as a standard for assisting clinical diagnosis of AD.

Enhancing biosensing of trace tau protein in clinical samples via emergence macroscopic directed aggregation.

Alzheimer's disease (AD) is an irreversible neurodegenerative disorder that poses a significant risk to human health and well-being. The high cost and invasiveness of neuroimaging and cerebrospinal fluid (CSF) analysis underscores the necessity for accessible early screening via blood samples. In this study, we developed an ultrasound-based strategy for emergent macroscopic that enhances the acoustic response enrichment of specific proteins by introducing functionalized microspheres.

Autonomous Sweating Wearable Platform for Bilirubin Sensing Based on Thermal Stimulation.

Bilirubin (BR), with diverse physiological functions and health implications, is a vital biomarker related to liver diseases such as jaundice and hepatitis. It is generally tested by blood. Sweat wearable devices provide a noninvasive way to monitor BR but face challenges in stability and selectivity, and acquiring sufficient sweat is difficult for sedentary individuals.

Janus Wettable Mask with Integrated Ratiometric Fluorescent Probe for Comfortable Exhaled HS Gas Sensing.

The exhaled HS gas is considered a promising noninvasive, rapid biomarker for diagnosing oral health and respiratory diseases. However, there is an urgent need in the healthcare industry for a sensitive, accurate, low-cost, and comfortable wearable breath sensor for HS detection. Herein, a Janus wettable mask was developed by integrating the ratiometric fluorescent probes and asymmetric wettable fabric into the interior of the mask, for the comfortable and visual detection of HS.

Integrated Ultrasound-Enrichment and Machine Learning in Colorimetric Lateral Flow Assay for Accurate and Sensitive Clinical Alzheimer's Biomarker Diagnosis.

The colloidal gold nanoparticle (AuNP)-based colorimetric lateral flow assay (LFA) is one of the most promising analytical tools for point-of-care disease diagnosis. However, the low sensitivity and insufficient accuracy still limit its clinical application. In this work, a machine learning (ML)-optimized colorimetric LFA with ultrasound enrichment is developed to achieve the sensitive and accurate detection of tau proteins for early screening of Alzheimer's disease (AD).

Machine learning-powered wearable interface for distinguishable and predictable sweat sensing.

The constrained resources on wearable devices pose a challenge in meeting the demands for comprehensive sensing information, and current wearable non-enzymatic sensors face difficulties in achieving specific detection in biofluids. To address this issue, we have developed a highly selective non-enzymatic sweat sensor that seamlessly integrates with machine learning, ensuring reliable sensing and physiological monitoring of sweat biomarkers during exercise. The sensor consists of two electrodes supported by a microsystem that incorporates signal processing and wireless communication.

Fully integrated microneedle biosensor array for wearable multiplexed fitness biomarkers monitoring.

Fitness monitoring has become increasingly important in modern lifestyles; the current fitness monitoring always relies on physical sensors, making it challenging to detect pertinent issues at a deeper level when exercising. Here, we report a fully integrated wearable microneedle sensor that simultaneously measures fitness related biomarkers (e.g.

A Fully Integrated Conformal Wearable Ultrasound Patch for Continuous Sonodynamic Therapy.

Cancer treatment is a continuous process, that the current therapy cannot meet the requirement well, including radiotherapy and chemotherapy. Wearable ultrasound device has the potential for continuous sonodynamic therapy due to its portability. However, the miniaturization of ultrasonic probe, system integration of device, and the strategy of continuous treatment are still urgent issues to be addressed.

Integrated Mini-Pillar Platform for Wireless Real-Time Cell Monitoring.

Cell culture as the cornerstone of biotechnology remains a labor-intensive process requiring continuous manual oversight and substantial time investment. In this work, we propose an integrated mini-pillar platform for in situ monitoring of multiple cellular metabolism processes, which achieves media anchoring and cell culture through an arrayed mini-pillar chip. The assembly of polyaniline (PANI)/dendritic gold-modified microelectrode biosensors exhibits high sensitivity (63.

Alterations of pathogen transmission patterns and attenuated immune stimulation might be the cause of increased adult respiratory infections cases in 2023, results from a multi-center study in mainland China.

Background: Several respiratory infections outbreaks have been observed in mainland China after reduction of non-pharmaceutical interventions. Other countries have seen increases in respiratory infections outside typical seasons post-COVID-19, warranting investigation into underlying causes.

Methods: We established monitoring networks for suspected respiratory infection in 14 tertiary hospitals nationwide.

Ultrasound-Induced Enrichment of Ultra-Trace miRNA Biosensing in Nanoliter Samples.

The rapid and accurate analysis of micro-samples is a crucial foundation for precision medicine, particularly for early screening and monitoring of cancer, where it holds significant importance. Ultrasound-based multifunctional biocompatible manipulation techniques have been extensively applied in a variety of biomedical fields, providing insights for the development of rapid, cost-effective, and accurate biomarker detection strategies. In this chapter, we combine ultrasound-based gradient pressure fields with functionalized microsphere enrichment to develop a biosensing method for ultra-trace miRNA enrichment in nanoliter samples without PCR.

Wearable Vertical Graphene-Based Microneedle Biosensor for Real-Time Ketogenic Diet Management.

Ketogenic diets have attracted substantial interest in the treatment of chronic diseases, but there are health risks with long-term regimes. Despite the advancements in diagnostic and therapeutic methods in modern medicine, there is a huge gap in personalized health management of this dietary strategy. Hence, we present a wearable microneedle biosensor for real-time ketone and glucose monitoring.

Colorimetric detection of electrolyte ions in blood based on biphasic microdroplet extraction.

Background: Timely diagnosis and prevention of diseases require rapid and sensitive detection of biomarkers from blood samples without external interference. Abnormal electrolyte ion levels in the blood are closely linked to various physiological disorders, including hypertension. Therefore, accurate, interference-free, and precise measurement of electrolyte ion concentrations in the blood is particularly important.

Smart Janus textiles for biofluid management in wearable applications.

Janus textiles with asymmetric wettability have shown great potential in wearable applications due to their ability to manage biofluids efficiently. This review summarizes recent advances in smart Janus textiles for biofluid control and monitoring, focusing on wearable technologies. We first introduce the design configurations and fabrication approaches of Janus textiles, including asymmetric generation and asymmetric decoration strategies.