Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
A phytochemical investigation of the leaves of Callicarpa macrophylla led to the isolation of five new diterpenoids (1-5), macrophypenes A-E, and nine known analogues (6-14). The structures of 1-5 were established on the basis of extensive analysis of NMR spectroscopic data, X-ray diffraction data, and experimental and calculated electronic circular dichroism spectra. Compound 1 is a spiroditerpenoid with a novel skeleton, and compound 5 is a rare ent-abietane diterpenoid possessing a peroxide bridge. Compounds 1, 5-7, and 11-14 stimulate nerve growth factor mediated neurite outgrowth from PC12 cells.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.jnatprod.5b00018 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Bioactive diterpenoids from the leaves of Callicarpa formosana Rolfe.
Fitoterapia
September 2025
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. Electronic address:
Five undescribed clerodane and one labdane diterpenoids (1-6), together with six known diterpenoids (7-12), were isolated from the leaves of Callicarpa formosana Rolfe. Their structures were elucidated by HR-ESI-MS, NMR and ECD spectral data. The bioactivity screening showed (2R,5R,8S,9R,10S)-2-ethoxy-kolavic acid 15-methyl ester (4) displayed anti-inflammatory activity in vivo.
View Article and Find Full Text PDFNew Diterpenoids With Anti-Inflammatory Activity From Callicarpa rubella Collected in Vietnam.
Phytochem Anal
July 2025
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan.
Introduction: Callicarpa rubella is a notable folk medicinal plant of the genus Callicarpa. It is extensively ethnobotanically used for its traditional uses to cure rheumatism, inflammation, and pain in traditional Chinese medicinal systems.
Objectives: This study aimed to isolate unreported diterpenoids with anti-inflammatory activities.
Nutritional Importance of a Liana Species for a Population of Bornean Orangutans.
Am J Biol Anthropol
April 2025
Department of Anthropology, Rutgers, The State University of New Jersey, New Brunswick, New Jersey, USA.
Objectives: Temporal variation in food availability can pose nutritional challenges to primates. Characterizing the nutritional content of the non-preferred foods that primates switch to, termed fallback foods, is useful for identifying the nutritional challenges of lean periods, the nutritional limits of what primates can subsist on, and physiological adaptations. We explored the temporal patterning and the nutritional contribution of food items for Bornean orangutans (Pongo pygmaeus wurmbii) at Tuanan, Indonesia, with particular attention to the liana, Bowringia callicarpa.
View Article and Find Full Text PDF3,4-seco-Prenyllabdane sesterterpenoids and 3,4-seco-labdane diterpenoids with Zika virus inhibitory potential from Callicarpa nudiflora.
Phytochemistry
August 2025
Key Laboratory of Medicinal Chemistry for Natural Resource of Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Research & Development Center for Natural Products, School of Chemical Science and Technology, and School of Pharmacy, State Key Laboratory for Conservation
Two rearranged prenyllabdane sesterterpenoids nudiflorawus A-B (1-2) with a previously unreported carbon skeleton, and five undescribed 3,4-seco-labdane diterpenoids, nudiflorawus C-G (3-7), along with two known diterpenoids (8-9), were isolated from the leaves of Callicarpa nudiflora. Compounds 1-2 exhibited the first example of 3,4-seco-prenyllabdane sesterterpenoids with a unique six-membered ring in the side chain. Their structures were established via various spectroscopic methods.
View Article and Find Full Text PDFSeven novel sesquiterpenes with hemostasis activities from leaves of Callicarpa nudiflora.
Bioorg Chem
May 2025
Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address:
A pair of epimer with an unprecedented 4/7/6 tricyclic skeleton sesquiterpene (1 and 2) and five novel sesquiterpene (3-7) were isolated from Callicarpa nudiflora Hook. et Arn. Their structures were established by extensive spectroscopic analyses, single crystal X-ray diffraction, experimental electronic circular dichroism (ECD) spectra comparison and DP4+ probability analysis.
View Article and Find Full Text PDF