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Summary: QTLNetwork is a software package for mapping and visualizing the genetic architecture underlying complex traits for experimental populations derived from a cross between two inbred lines. It can simultaneously map quantitative trait loci (QTL) with individual effects, epistasis and QTL-environment interaction. Currently, it is able to handle data from F(2), backcross, recombinant inbred lines and double-haploid populations, as well as populations from specific mating designs (immortalized F(2) and BC(n)F(n) populations). The Windows version of QTLNetwork was developed with a graphical user interface. Alternatively, the command-line versions have the facility to be run in other prevalent operating systems, such as Linux, Unix and MacOS.
Availability: http://ibi.zju.edu.cn/software/qtlnetwork.
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http://dx.doi.org/10.1093/bioinformatics/btm494 | DOI Listing |
Cereb Cortex
August 2025
Nencki Institute of Experimental Biology, PAS, 3 Pasteur Street, 02-093 Warsaw, Poland.
In the visual cortices, receptive fields (RFs) are arranged in a gradient from small sizes in the center of the visual field to the largest sizes at the periphery. Using functional magnetic resonance imaging (fMRI) mapping of population RFs, we investigated RF adaptation in V1, V2, and V3 in patients after long-term photoreceptor degeneration affecting the central (Stargardt disease [STGD]) and peripheral (Retinitis Pigmentosa [RP]) regions of the retina. In controls, we temporarily limited the visual field to the central 10° to model peripheral loss.
View Article and Find Full Text PDFMedicine (Baltimore)
September 2025
Nanchang Bright Eye Hospital, Nanchang, Jiangxi, China.
Introduction: This bibliometric analysis aims to explore global trends, research hotspots, and future directions in multidrug resistance of multiple myeloma (MM), providing insights for overcoming resistance mechanisms and optimizing therapeutic strategies.
Methods: We analyzed 3300 publications indexed in the Web of Science Core Collection (2015-2024) using CiteSpace and VOSviewer. Multidimensional evaluations of countries/regions, institutions, authors, journals, and keywords were conducted, supplemented by visual network mapping to elucidate research dynamics and collaborative patterns.
Food Res Int
November 2025
School of Preclinical Medicine, Chengdu University, Chengdu, Sichuan 610106, China. Electronic address:
Background: Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disease characterized by insulin resistance and progressive decline in pancreatic beta cell function. It is a public health problem of great magnitude that has been increasing globally over the last 4 decades. The latest research has found that sugar-sweetened beverages (SSBs), as an important dietary risk factor, are closely related to the occurrence and development of T2DM.
View Article and Find Full Text PDFJ Appl Gerontol
September 2025
Geriatric Research, Education, and Clinical Center (GRECC), James J. Peters VA Medical Center, Bronx, NY, USA.
Many older adults rely on a complex network of paid and unpaid care partners. Gaps in these networks can lead to unmet functional, medical, and socioemotional needs and poor health outcomes. We explored the structure, function and adequacy of older veterans' care networks using care mapping, a collaborative visual tool.
View Article and Find Full Text PDFACS Appl Mater Interfaces
September 2025
Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8568, Japan.
Chemical sensor arrays mimic the mammalian olfactory system to achieve artificial olfaction, and receptor materials resembling olfactory receptors are being actively developed. To realize practical artificial olfaction, it is essential to provide guidelines for developing effective receptor materials based on the structure-activity relationship. In this study, we demonstrated the visualization of the relationship between sensing signal features and odorant molecular features using an explainable AI (XAI) technique.
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