Design and analysis of a high-precision uniform field scanning micro-motion platform for ultra-high field magnetic resonance imaging.

To meet the scanning requirements for ultra-high magnetic field strength (≥7 T) and high uniformity within Magnetic Resonance Imaging (MRI) equipment, this paper presents the design and implementation of a fully automated five-axis micro-positioning platform with a positioning accuracy of 50 μm. The platform enables full-area magnetic field measurement inside MRI devices via high-precision automatic scanning, providing data assurance for the precise current loading of the homogeneous field system. A systematic design of the motion actuator, probe fine-tuning mechanism, and probe rod of the micro-motion platform is described, utilizing 3D modeling software.

Baseline MRI habitat imaging for predicting treatment response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer.

Purpose: This study was to assess whether baseline magnetic resonance habitat imaging can predict the efficacy of neoadjuvant chemoradiotherapy (nCRT) in patients with locally advanced rectal cancer (LARC).

Methods: This retrospective study analyzed data from 181 patients with locally advanced rectal cancer, including 60 who exhibited a good treatment response. The cohort was randomly divided into a training set (127 patients, 42 with good response) and a validation set (54 patients, 18 with good response).

A Long-Lasting Rechargeable Seawater Zn-Air Battery Enabled by Vacancy-Driven CoO-MoS Bifunctional Cathodes.

The global energy crisis and unsustainable reliance on fossil fuels make it particularly urgent to develop efficient renewable energy storage solutions. Aqueous zinc-air batteries (ZABs) have become extremely promising candidates due to their low cost, abundant surface resources, inherent safety, and high theoretical energy density. This study explores the feasibility of using seawater as an electrolyte for ZABs, with the aim to reduce costs and alleviate competition for limited freshwater resources.

Dual effects of Au nanorods to enhance the electroluminescence of Si-based perovskite light-emitting devices.

Silicon-based perovskite light-emitting devices (Si-based PeLEDs) currently attract much attention because of their potential applications in optoelectronic integrations. However, up to now, the device's performance is still unsatisfactory. Here, we propose an approach to improve the electroluminescence of Si-based PeLEDs by introducing Au nanorods into the hole transport layer.

UPL3 promotes BZR1 degradation, growth arrest, and seedling survival under starvation stress in Arabidopsis.

Sugar-mediated regulation of hormone signaling is crucial for optimizing growth under normal conditions and ensuring survival during environmental stress. Previous studies have shown that sugar starvation induces the degradation of BRASSINAZOLE RESISTANT 1 (BZR1), the master transcription factor of the brassinosteroid (BR) signaling pathway, thereby inhibiting growth. However, the molecular mechanism linking sugar signaling to BZR1 degradation remains unknown.

Identification and functional analysis of terpene synthases revealing the aroma variations among different Chrysanthemum indicum var. aromaticum ploidy germplasm.

In both natural and cultivated populations of Chrysanthemum indicum var. aromaticum (CIA), diploid and tetraploid germplasms coexist, yet the comparative aroma profiles and their biosynthetic mechanisms remain poorly characterized. This study used a combination of ultra-fast gas-phase electronic nose, widely targeted flavor-omics and sensory evaluation assays, and identified 15 core aroma compounds in diploid CIA and 10 in tetraploid CIA.

Forensic analysis of minor victims from homicide cases in Shanghai, China: A 11-year retrospective study.

Homicide involving minors (under 18 years old) has always posed challenges for forensic experts. This study aims to summarize the forensic characteristics of minor victims from homicide cases in Shanghai (2010-2020), and retrospectively analyzed statistical changes over different periods. Of the 120 investigated minor victims, 66 were males and 54 were females.

Heat stress induces pathological and molecular responses in the gills of largemouth bass (Micropterus salmoides) revealed by histology, transcriptomics, and DNA methylomics.

Largemouth bass (Micropterus salmoides), an important species in both aquatic ecosystems and aquaculture, is increasingly affected by heat extremes. Heat stress poses significant challenges to fish health, particularly affecting key organs like the gills. This study investigated the effects of heat stress (37 °C) on the gills of juvenile largemouth bass, focusing on histopathology and molecular adaptations, including genome-wide gene expression and DNA methylation.

Bilateral Vocal Cord Paralysis Following a Fall: A Rare Case With a Fatal Outcome.

Bilateral vocal cord paralysis is characterized by the immobility of the vocal cord and can lead to acute respiratory distress, requiring urgent airway intervention. This article describes a rare case of bilateral vocal cord paralysis following a fall. An 87-year-old female developed dysphonia after experiencing a fall-related accident.

Prevalence, antibiotic resistance, resistance and virulence determinants of in China: A systematic review and meta-analysis.

() is recognized as a serious food contaminant that extensively results in foodborne diseases. Numerous studies have been conducted on the prevalence and antibiotic resistance of , but there is a lack of comprehensive analysis of published data. This study provides a comprehensive overview of the epidemiology, antibiotic resistance, and virulence determinants of in China through a systematic review and meta-analysis.

Embryonic temperature influences transcriptomic and methylation profiles in the liver of juvenile largemouth bass.

Understanding the impacts of environmental conditions at early life stages on phenotypes and physiological responses to thermal variability at later stages is crucial for elucidating adaptive strategies in fish species. This study investigated the lasting effects of embryonic temperature on the growth performance, transcriptomic profiles, and CpG methylation status of juvenile largemouth bass (Micropterus salmoides) under normal and heat stress (HS) conditions. Embryos were incubated at three temperatures (22 °C, 25 °C, and 28 °C), reared at a constant 25 °C for three months, and subjected to acute HS at 37 °C.

Lung cancer associated transcript 1 binds heat shock protein 90 to promote growth of hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is one of leading causes of cancer-related death and new approaches are urgently needed, given current dearth of therapies. Long non-coding RNAs (lncRNAs) have been linked to cancer formation and impact cell regulatory pathways. We have investigated molecular mechanisms of action of "lung cancer associated transcript 1" (LUCAT1, a lncRNA) in HCC and studied the potential role of targeting these.

Harmonic analysis and optimization for closed-loop superconducting shim coils of 7 T MRI magnet.

Background: High-resolution brain imaging is crucial in clinical diagnosis and neuroscience, with ultra-high field strength MRI systems ( ) offering significant advantages for imaging neuronal microstructures. However, achieving magnetic field homogeneity is challenging due to engineering faults during the installation of superconducting strip windings and the primary magnet.

Purpose: This study aims to design and optimize active superconducting shim coils for a 7 T animal MRI system, focusing on the impact of safety margin, size, and adjustability of the second-order shim coils on the MRI system's optimization.

Spontaneous Hydrogen Production Coupled with Glucose Valorization through Modulating Au-Pt Coordination on Ultrathin AuPt Twin Nanowires.

Organics electrooxidation coupled hydrogen production has attracted increasing attention due to the low operation voltage. Nevertheless, the spontaneous production of hydrogen coupled with organics valorization remains challenging. Herein, we develop ultrathin AuPt twin nanowire (NW) catalysts for both electrochemical glucose oxidation and hydrogen evolution reaction towards a spontaneous hydrogen production system.

Integrative analysis based on ATAC-seq and RNA-seq reveals a novel oncogene PRPF3 in hepatocellular carcinoma.

Background: Assay of Transposase Accessible Chromatin Sequencing (ATAC-seq) is a high-throughput sequencing technique that detects open chromatin regions across the genome. These regions are critical in facilitating transcription factor binding and subsequent gene expression. Herein, we utilized ATAC-seq to identify key molecular targets regulating the development and progression of hepatocellular carcinoma (HCC) and elucidate the underlying mechanisms.

Retinal Microvasculature Causally Affects the Brain Cortical Structure: A Mendelian Randomization Study.

Purpose: To reveal the causality between retinal vascular density (VD), fractal dimension (FD), and brain cortex structure using Mendelian randomization (MR).

Design: Cross-sectional study.

Participants: Genome-wide association studies of VD and FD involving 54 813 participants from the United Kingdom Biobank were used.

c-Jun N-terminal kinase 1/P53 signaling mediates intrinsic apoptosis of largemouth bass (Micropterus salmoides) hepatocytes under heat stress.

The increasing frequency of high-temperature extremes threatens largemouth bass Micropterus salmoides, a significant fish for freshwater ecosystems and aquaculture. Our previous studies at the transcript level suggested that heat stress induces hepatic apoptosis in largemouth bass. In the current study, we sought to validate these findings and further investigate the role of the c-Jun N-terminal kinase (JNK)/P53 signaling in hepatic apoptosis under heat stress.

Constructing Gradient Orbital Coupling to Induce Reactive Metal-Support Interaction in Pt-Carbide Electrocatalysts for Efficient Methanol Oxidation.

Reactive metal-support interaction (RMSI) is an emerging way to regulate the catalytic performance for supported metal catalysts. However, the induction of RMSI by the thermal reduction is often accompanied by the encapsulation effect on metals, which limits the mechanism research and applications of RMSI. In this work, a gradient orbital coupling construction strategy was successfully developed to induce RMSI in Pt-carbide system without a reductant, leading to the formation of L1-PtM-MC (M = Ti, Zr, Hf, V, Nb, Ta, Cr, Mo, and W) intermetallic electrocatalysts.

Biomarkers Screening and Mechanisms Analysis of the Restraint Stress-Induced Myocardial Injury in Hyperlipidemia ApoE Mice.

Objectives: To explore the biomarkers and potential mechanisms of chronic restraint stress-induced myocardial injury in hyperlipidemia ApoE mice.

Methods: The hyperlipidemia combined with the chronic stress model was established by restraining the ApoE mice. Proteomics and bioinformatics techniques were used to describe the characteristic molecular changes and related regulatory mechanisms of chronic stress-induced myocardial injury in hyperlipidemia mice and to explore potential diagnostic biomarkers.

Coenzyme Q deficiency may predispose to sudden unexplained death via an increased risk of cardiac arrhythmia.

Cardiac arrhythmia is currently considered to be the direct cause of death in a majority of sudden unexplained death (SUD) cases, yet the genetic predisposition and corresponding endophenotypes contributing to SUD remain incompletely understood. In this study, we aimed to investigate the involvement of Coenzyme Q (CoQ) deficiency in SUD. First, we re-analyzed the exome sequencing data of 45 SUD and 151 sudden infant death syndrome (SIDS) cases from our previous studies, focusing on previously overlooked genetic variants in 44 human CoQ deficiency-related genes.

Pyroptosis inhibitors MCC950 and VX-765 mitigate myocardial injury by alleviating oxidative stress, inflammation, and apoptosis in acute myocardial hypoxia.

Acute myocardial infarction (AMI) is a prevalent cardiovascular disease with high morbidity and mortality rates worldwide. Pyroptosis is an inflammatory form of programmed cell death that has been linked to various pathological conditions. However, its exact contribution to the onset and progression of heart injury in AMI has not yet fully elucidated.

Tailoring Zirconia Supported Intermetallic Platinum Alloy via Reactive Metal-Support Interactions for High-Performing Fuel Cells.

Developing efficient and anti-corrosive oxygen reduction reaction (ORR) catalysts is of great importance for the applications of proton exchange membrane fuel cells (PEMFCs). Herein, we report a novel approach to prepare metal oxides supported intermetallic Pt alloy nanoparticles (NPs) via the reactive metal-support interaction (RMSI) as ORR catalysts, using Ni-doped cubic ZrO (Ni/ZrO) supported L1-PtNi NPs as a proof of concept. Benefiting from the Ni migration during RMSI, the oxygen vacancy concentrations in the support are increased, leading to an electron enrichment of Pt.