Evaluating the operational efficiency of the compact urban medical group in Qiqihar based on the three-stage DEA and Malmquist index model.

Background: Since the establishment of medical alliances, a key issue regarding their ability to better address the imbalance in China's medical resources lies in the changes in operational efficiency before and after their formation. This study focuses on urban medical groups, a reform model of medical alliances, and systematically analyzes the changes in operational efficiency before and after the group-based reform, aiming to provide empirical evidence for improving the group-based management model.

Methods: This study employs a dual-method framework combining three-stage DEA for static efficiency evaluation and Malmquist index analysis for dynamic assessment.

Effects of Cerebellar Repetitive Transcranial Magnetic Stimulation at Different Frequencies on Working Memory: An EEG Study.

Background: The cerebellum serves as an important target for non-invasive cognitive regulation because of its involvement in diverse cognitive processes via cerebro-cerebellar circuits. However, the efficiency of repetitive transcranial magnetic stimulation (rTMS) in different cognitive behavior protocols remains elusive.

Objective: To investigate changes in working memory and behavioral performance after different cerebellar rTMS to provide objective neurobiological guidance for optimizing cerebellar TMS parameters.

Genomic Characterization and Pathogenicity of a Novel Birnavirus Strain Isolated from Mandarin Fish ().

Background: Birnaviruses infect a wide range of aquatic and terrestrial hosts, including several economically important fish species. This study aimed to isolate and characterize a novel birnavirus strain from mandarin fish (), a high-value freshwater species in Chinese aquaculture.

Methods: A novel strain, designated mandarin fish birnavirus (MFBV), was isolated from diseased fish and propagated in SCK cells.

Nucleation of biomimetic hydroxyapatite nanoparticles on the surface of human type I collagen using a hybrid all-atom and coarse-grained model.

Inorganic mineral/collagen composite materials are one of the most attractive implant materials for bone repair engineering. Mineralized collagen composites have a similar hierarchical structure and biological activity to natural bone; however, the mechanism of the mineralization process is complex, and the properties of mineralized materials are difficult to control during the preparation process. Currently, this is a significant challenge in coarse-grained organic-inorganic systems.

Resource substitutability path for China's energy storage between lithium and vanadium.

The limited availability of lithium resources is often considered as potential constraints for the wide implementation of lithium-ion battery (LIB) energy storage technology. Alternative storage solutions, such as vanadium redox flow batteries (VRBs), are thus gaining traction as viable substitutes for LIB energy storage. However, how price volatility and cost affect technology substitution and thus scale and dynamics of energy storage market remains hitherto poorly characterized.

A cross-sectional survey on the relationship between metacognitive ability and completion ability among Chinese nursing students: the mediating role of perceived campus atmosphere ability and the moderation of simulation teaching method.

Background: With the continuous development of medical technology, the demand for high-quality of nursing student training is increasing, and nursing, as an important part of health care service work, is facing new challenges. In recent years, the proportion of nursing undergraduates among registered nurses in China has been increasing year by year. Enhancing the completion ability of nursing students and improving the quality of undergraduate nursing training is a need for the development of nursing education.

Effects of Carotenoid Supplementation on Exercise-Induced Oxidative Stress: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.

Objective: This study aims to investigate the potential effects of carotenoid supplementation on mitigating exercise-induced oxidative stress and to provide guidance for future research.

Methods: We conducted a systematic review and meta-analysis using Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We searched multiple databases from inception to August 2024 for randomized clinical trials investigating the effects of carotenoid supplementation on biomarkers of oxidative stress, inflammatory markers, antioxidant levels, and metabolic parameters in the context of exercise-induced oxidative stress.

Genome-Wide Identification and Expression Analysis of mA Methyltransferase Family in Maxim.

-methyladenosine (mA) RNA modification plays important regulatory roles in plant development and adaptation to the environment. However, there has been no research regarding mA RNA methyltransferases (MT-A70) in Maxim. Here, we performed a comprehensive analysis of the MT-A70 family in (), including gene structures, phylogenetic relationships, conserved motifs, gene location, promoter analysis, GO enrichment analysis, and expression profiles.

A R2R3-MYB Transcription Factor of Regulates Seed-Coat Color and Seed Size in Arabidopsis.

The seed-coat color and seed size have an impact on both the evolutionary fitness and the grain yield of crops. Soybean is a major oil crop, and the seed-coat color and seed size exhibit natural diversity among the different soybean varieties. Here, we found an R2R3-MYB transcription factor of , which shows a significant increase in expression as the seed-coat color changes from yellow to black in different soybean varieties.

The SIK3-N783Y mutation is associated with the human natural short sleep trait.

Sleep is an essential component of our daily life. A mutation in human salt induced kinase 3 (hSIK3), which is critical for regulating sleep duration and depth in rodents, is associated with natural short sleep (NSS), a condition characterized by reduced daily sleep duration in human subjects. This NSS hSIK3-N783Y mutation results in diminished kinase activity in vitro.

Time-Dependent Regulation of Sleep-Wakefulness and Electroencephalographic Characteristics by Spontaneous Running in Male Mice.

The relationship between physical activity and sleep quality is a critical area of investigation, given the importance of both behaviours for health and disease. Despite the common use of running wheels to assess circadian rhythms and exercise, their impact on sleep has not been thoroughly explored. Here, we present a detailed analysis of how voluntary running affected sleep/wakefulness duration, architecture and electrophysiological characteristics in mice.

A novel model of central precocious puberty disease: Paternal MKRN3 gene-modified rabbit.

Background: Makorin ring finger protein 3 gene (MKRN3) gene mutation is the most common genetic cause of central precocious puberty (CPP) in children. Due to the lack of ideal MKRN3-modified animal model (MKRN3-modified mice enter puberty only 4-5 days earlier than normal mice), the related research is limited.

Methods: Therefore, the MKRN3-modified rabbit was developed using CRISPR (clustered regularly interspaced short palindromic repeats) gene editing technology.

Exercise-induced cytosolic calcium oscillations: mechanisms and modulation of T-cell function.

This study investigated time-dependent changes in intracellular Ca⁺ levels in T cells, regulatory mechanisms, and functional effects after acute exercise. Male C57BL/6 mice were assigned to control and exercise groups, with the latter sacrificed at different intervals post-exercise. Murine splenic lymphocytes were isolated, and cytosolic Ca⁺ levels were measured using Fluo-3/AM.

New insights into roles of IL-7R gene as a diagnostic biomarker for post-stroke depression.

Background: Post-stroke depression (PSD) is the most prevalent neuropsychiatric complication following a stroke. The inflammatory theory suggests that PSD may be associated with an overactive inflammatory response. However, research findings regarding inflammation-related indicators in PSD remain inconsistent and elusive.

A fatal familial insomnia patient initially misdiagnosed as Alzheimer's disease: a case report.

Background: Fatal familial insomnia (FFI) is a rare autosomal dominant inherited disease and a type of prion diseases. We report a case of fatal familial insomnia (FFI) in a 52-year-old man who was initially misdiagnosed as Alzheimer's disease.

Case Presentation: The patient presented with persistent insomnia as the initial symptom, accompanied by cognitive impairment, autonomic dysfunction, and disorders of voluntary movement.

Role of repeat transurethral resection in no-muscle-invasive bladder tumour: an umbrella review.

Background: Repeat transurethral resection of bladder tumour (reTURB) is a conventional treatment for non-muscle-invasive bladder cancer (NMIBC) to enhance prognosis. However, the necessity of reTURB in NMIBC remains controversial owing to upstaging of treatments and new evidence.

Objectives: We performed an umbrella review to determine the need for reTURB in patients with NMIBC.

Distribution and diversity of cultured endophytic fungi in Maxim. at different altitudes on the northeastern Qinghai-Tibetan Plateau.

Endophytic fungi are a crucial microbial resource that can influence plant growth and development through their interactions with host plants. Maxim. is an important traditional Tibetan herb used to treat a range of diseases in the Qinghai-Tibetan region.

Regulation of maize growth and immunity by ZmSKI3-mediated RNA decay and post-transcriptional gene silencing.

Disease resistance is often associated with compromised plant growth and yield due to defense-growth tradeoffs. However, key components and mechanisms underlying the defense-growth tradeoffs are rarely explored in maize. In this study, we find that ZmSKI3, a putative subunit of the SUPERKILLER (SKI) complex that mediates the 3'-5' degradation of RNA, regulates both plant development and disease resistance in maize.

Genome-wide analysis of the AP2/ERF gene family in Pennisetum glaucum and the negative role of PgRAV_01 in drought tolerance.

APETALA2/ethylene-responsive (AP2/ERF) plays crucial roles in resisting diverse stresses and in regulating plant growth and development. However, little is known regarding the structure and function of the AP2/ERF genes in pearl millet (Pennisetum glaucum). The AP2/ERF gene family may be involved in the development and maintenance of P.

Telemedicine-medical "snack community"-PHS ecosystem: Insights into the double-edged sword role of telemedicine in clinical practice and medical education during the COVID-19 pandemic and beyond.

Telemedicine has gained tremendous development during the COVID-19 pandemic. With deblocking and opening, telemedicine accelerates the evolvution of the medical "snack community" and undermines the perception of medical students and staff, which promotes the incidence of psychosocial-related disorders. Moreover, the inconsistent telemedicine adaptability between medical workers and patients aggravates the doctor-patient conflict due to the aging population and COVID-19 squeal.

Comprehensive analysis of B3 family genes in pearl millet () and the negative regulator role of in drought tolerance.

Introduction: Members of the plant-specific B3 transcription factor superfamily play crucial roles in various plant growth and developmental processes. Despite numerous valuable studies on B3 genes in other species, little is known about the B3 superfamily in pearl millet.

Methods And Results: Here, through comparative genomic analysis, we identified 70 B3 proteins in pearl millet and categorized them into four subfamilies based on phylogenetic affiliations: ARF, RAV, LAV, and REM.

Enhancing Lithium-Sulfur Battery Performance with MXene: Specialized Structures and Innovative Designs.

Established in 1962, lithium-sulfur (Li-S) batteries boast a longer history than commonly utilized lithium-ion batteries counterparts such as LiCoO (LCO) and LiFePO (LFP) series, yet they have been slow to achieve commercialization. This delay, significantly impacting loading capacity and cycle life, stems from the long-criticized low conductivity of the cathode and its byproducts, alongside challenges related to the shuttle effect, and volume expansion. Strategies to improve the electrochemical performance of Li-S batteries involve improving the conductivity of the sulfur cathode, employing an adamantane framework as the sulfur host, and incorporating catalysts to promote the transformation of lithium polysulfides (LiPSs).