Narrow-Band Green-Emitting Magnetoplumbite-Structured CeZnAlO:Mn Phosphor for Wide Color Gamut Backlighting.

A novel magnetoplumbite-type narrow-band green-emitting phosphor, CeZnAlO:Mn, has been created by replacing the [La-Mg] pair in the prototype material LaMgAlO with the [Ce-(Zn/Mn)] pair. When excited by blue light at 450 nm, optimized CeZnAlO:Mn, featuring a high Mn doping content of 35%, emits a bright green light that peaks at 517 nm, with a full width at half maximum (fwhm) of 30 nm and internal/external quantum efficiencies of 75%/19%, respectively. Additionally, optimized CeZnAlO:0.

Assessing availability of depression severity indicators in electronic health record data: A retrospective study in two large academic health care systems in the United States.

The high prevalence of major depressive disorder (MDD) combined with low treatment response supports continued research in this area. Electronic health records (EHR) are an important real-world data source for such MDD research, yet indicators of depression severity, a key confounder, are unreliably available. We examined the availability of depression severity indicators in the EHR and identified patient characteristics associated with having a severity indicator available for patients with an MDD diagnosis.

A plasmon-electron addressable and CMOS compatible random access memory.

The rapid increase in data generation and storage poses substantial challenges, necessitating a transition from traditional charge-based devices to high-speed optical alternatives for computational tasks. Photon-assisted or plasmon-assisted memory devices emerge as promising solutions for facilitating faster read/write operations. By using surface plasmon polaritons for writing operations, we can dynamically read memory states through the measurement of tunneling currents in thin layers of HfO ferroelectric materials sandwiched between Au thin film electrodes.

Hepatolenticular Degeneration With Primary Liver Cancer:Report of One Case and Review of the Literature.

Hepatolenticular degeneration is a rare disease,and the number of cases of primary liver cancer occurring on the basis of liver cirrhosis caused by hepatolenticular degeneration is very small.This paper reports a case of hepatolenticular degeneration with primary liver cancer,and then reviews and summarizes current cases of this disease both domestically and internationally.

Machine learning for complex systems with abnormal pattern by exception maximization outlier detection.

This paper proposes a novel fast online methodology for outlier detection called the exception maximization outlier detection (EMOD) algorithm, which employs probabilistic models and statistical algorithms to detect abnormal patterns from the outputs of complex systems. The EMOD is based on a two-state Gaussian mixture model and demonstrates strong performance in probability anomaly detection working on real-time raw data rather than using special prior distribution information. We confirm this using the synthetic data from two numerical cases.

LINC02154 Promotes Esophageal Squamous Cell Carcinoma Progression via the PI3K-AKT-mTOR Signaling Pathway by Interacting With IGF2BP2.

As important types of noncoding RNAs, long noncoding RNAs (lncRNAs) have been found to be involved in the progression of various cancers. Accumulating evidence indicates that LINC02154 plays a critical role in cancer progression, but the underlying mechanisms regulating esophageal squamous cell carcinoma (ESCC) remain unclear. Here, we found that LINC02154 is significantly upregulated in ESCC cell lines and ESCC tissues.

Efficacy and safety of GLS4 with entecavir vs entecavir alone in chronic hepatitis B patients: A multicenter clinical trial.

Objectives: GLS4 is a first-in-class hepatitis B virus (HBV) capsid assembly modulator that inhibits HBV replication by interfering with assembly and disassembly of the virus nucleocapsid, this prospective, open-label, comparative, phase 2b trial evaluated the antiviral activity and safety of GLS4/ritonavir (RTV) combined with entecavir in hepatitis B e antigen-positive patients.

Methods: 250 CHB patients were enrolled, including treatment-naïve patients and those interrupted anti-HBV drugs for ≥ 6 months (Part A, n=125), and patients who had taken ETV for ≥1 year and had achieved viral suppression (Part B, n=125). Patients were randomly allocated to receive 120 mg GLS4/100 mg RTV plus 0.

Resveratrol loaded microglia-derived exosomes attenuate astrogliasis by restoring mitochondrial function to reduce spinal cord injury.

The activation of astrocytes in the injured lesion induces the progression of spinal cord injury (SCI). However, adverse side-effects during systemic administration have limited applications. Exosomes (Exos) are an emerging clinical treatment method that exerts anti-inflammatory effects by reducing pro-inflammatory factors and promoting functional recovery.

Utilization of TiN and the Texture of Bionic Pangolin Scales to Improve the Wear Resistance of Cast Steel 20Mn Metal.

This research centers around cast steel 20Mn, which is the material utilized for the ear-picking roller of a corn harvester. The study delves into methods of enhancing its hydrophobicity and wear resistance. Fiber laser-processing technology was employed to fabricate pangolin bionic micro-textures on the material surface, and PVD technology was utilized to deposit a TiN coating.

Flow Matching for Optimal Reaction Coordinates of Biomolecular Systems.

We present flow matching for reaction coordinates (FMRC), a novel deep learning algorithm designed to identify optimal reaction coordinates (RC) in biomolecular reversible dynamics. FMRC is based on the mathematical principles of lumpability and decomposability, which we reformulate into a conditional probability framework for efficient data-driven optimization using deep generative models. While FMRC does not explicitly learn the well-established transfer operator or its eigenfunctions, it can effectively encode the dynamics of leading eigenfunctions of the system transfer operator into its low-dimensional RC space.

Effect of pH on antitumor activity of Chinese cobra (Naja atra) cytotoxin-XII.

Unlabelled: Cytotoxins (CTXs), proteins found in cobra venom, selectively inhibit tumor cell proliferation. Herein, we selected CTX-XII because of its potent antitumor activity to investigate the effect of solution pH on its response. MTT assay results showed significantly higher inhibition rates for CTX-XII at pH 5.

Enhanced Sampling of Biomolecular Slow Conformational Transitions Using Adaptive Sampling and Machine Learning.

Biomolecular simulations often suffer from the "time scale problem", hindering the study of rare events occurring over extended time scales. Enhanced sampling techniques aim to alleviate this issue by accelerating conformational transitions, yet they typically necessitate well-defined collective variables (CVs), posing a significant challenge. Machine learning offers promising solutions but typically requires rich training data encompassing the entire free energy surface (FES).

GMS-YOLO: An Algorithm for Multi-Scale Object Detection in Complex Environments in Confined Compartments.

Many compartments are prone to pose safety hazards such as loose fasteners or object intrusion due to their confined space, making manual inspection challenging. To address the challenges of complex inspection environments, diverse target categories, and variable scales in confined compartments, this paper proposes a novel GMS-YOLO network, based on the improved YOLOv8 framework. In addition to the lightweight design, this network accurately detects targets by leveraging more precise high-level and low-level feature representations obtained from GhostHGNetv2, which enhances feature-extraction capabilities.

Fullerene on non-iron cluster-matrix co-catalysts promotes collaborative H and N activation for ammonia synthesis.

Developing highly effective catalysts for ammonia (NH) synthesis is a challenging task. Even the current, prevalent iron-derived catalysts used for industrial NH synthesis require harsh reaction conditions and involve massive energy consumption. Here we show that anchoring buckminsterfullerene (C) onto non-iron transition metals yields cluster-matrix co-catalysts that are highly efficient for NH synthesis.

Playing for 3D Human Recovery.

Image- and video-based 3D human recovery (i.e., pose and shape estimation) have achieved substantial progress.

H3K18 Lactylation Potentiates Immune Escape of Non-Small Cell Lung Cancer.

Recently discovered epigenetic modification lysine lactylation contributes to tumor development and progression in several types of cancer. In addition to the tumor-intrinsic effects, histone lactylation may mediate tumor microenvironment remodeling and immune evasion. In this study, we observed elevated pan-lysine lactylation and histone H3 lysine 18 lactylation (H3K18la) levels in non-small cell lung cancer (NSCLC) tissues, which was positively correlated with poor patient prognosis.

Expression mechanisms of mir-486-5p and its host gene sANK1 in porcine muscle.

Background: MiR-486-5p has been identified as a crucial regulator of the PI3K/AKT signalling pathway, which plays a significant role in skeletal muscle development. Its host gene, sANK1, is also essential for skeletal muscle development. However, the understanding of porcine miR-486-5p and sANK1 has been limited.

Production of cleavage-resistant phytase transgenic pigs by handmade cloning.

With the rapid development of intensive animal husbandry in the livestock industry, large quantities of manure waste containing phytate phosphorus are being generated. Phytase can effectively solve the problem of high phosphorus pollution in the feces of monogastric animals. Enviropig, which produces phytase in the salivary glands and secretes the enzyme in the saliva, were first generated in 1999.

Preparation of a Novel Oat -Glucan-Chromium(III) Complex and Its Hypoglycemic Effect and Mechanism.

This study synthesized a novel oat -glucan (OBG)-Cr(III) complex (OBG-Cr(III)) and explored its structure, inhibitory effects on α-amylase and α-glucosidase, and hypoglycemic activities and mechanism in vitro using an insulin-resistant HepG2 (IR-HepG2) cell model. The Cr(III) content in the complex was found to be 10.87%.

Single-atom and cluster catalysts for thermocatalytic ammonia synthesis at mild conditions.

Ammonia (NH) is closely related to the fields of food and energy that humans depend on. The exploitation of advanced catalysts for NH synthesis has been a research hotspot for more than one hundred years. Previous studies have shown that the Ru B sites (step sites on the Ru (0001) surface uniquely arranged with five Ru atoms) and Fe C sites (iron atoms with seven nearest neighbors) over nanoparticle catalysts are highly reactive for N-to-NH conversion.