ALKBH5 deficiency suppresses hepatocarcinogenesis in mice via mA-dependent STAT1 restoration.

RNA mA methylation, as the most prevalent modification in mRNA, is a dynamic and reversible process primarily regulated by mA methyltransferases ("writers"), mA demethylases ("erasers"), and mA recognition proteins ("readers"). It has been shown that N6-methyladenosine (mA) plays a pivotal role in hepatocellular carcinoma (HCC). In this study we investigated the contribution of the mA eraser AlkB homolog 5 (ALKBH5) to hepatocarcinogenesis, particularly during the early stages of liver cancer development.

Different Distribution of Carotenoid Content in Periderm-Phloem-Xylem of Red Carrot Taproots.

The color of carrot taproots is mainly determined by the types and contents of carotenoids and anthocyanins. Consistency in taproot color from the outside to the inside is an important indicator of carrot quality. However, most carrot cultivars exhibit inconsistency in taproot color across these tissues.

MMRNet: Ensemble deep learning models for predicting mismatch repair deficiency in endometrial cancer from histopathological images.

Combining molecular classification with clinicopathologic methods improves risk assessment and chooses therapies for endometrial cancer (EC). Detecting mismatch repair (MMR) deficiencies in EC is crucial for screening Lynch syndrome and identifying immunotherapy candidates. An affordable and accessible tool is urgently needed to determine MMR status in EC patients.

Atomically dispersed iron-zinc dual-metal sites to boost catalytic oxygen reduction activities for efficient zinc-air batteries.

Developing asymmetric heteronuclear dual-atom catalysts (DACs) through coordination microenvironment regulation and investigating their structure-activity relationship for the catalytic oxygen reduction reaction (ORR) are crucial for energy conversion and storage devices such as zinc-air batteries (ZABs). In this work, a novel catalyst with its Fe and Zn diatomic sites atomically dispersed on nitrogen-doped hierarchical porous carbon (FeZn-NC-800) was designed and synthesized under a cyanamide-assisted sintering atmosphere to stabilize Zn single atoms in the structure. Benefiting from specific synergy between the Fe and Zn atoms and the hierarchical porous carbon substrate, the obtained FeZn-NC-800 catalyst exhibits remarkable ORR performance with a positive half-wave potential of 0.

Mechanically Adaptive Materials Based on Dynamic Chemical Bonds.

Adaptiveness is an important feature for biological creatures to survive and interact with variable environments. Mechanically adaptive polymers (MAPs), which have been developed recently inspired by this adaptive nature, can regulate their mechanical properties in response to external stimuli or environmental changes. Specifically, MAPs based on dynamic chemical bonds have been synthesized and reported as an emerging material because of the intrinsic self-adaptability, outstanding mechanical properties and durable applications.

[Chemical constituents from petroleum ether fraction of Artemisia stolonifera].

The chemical constituents in the petroleum ether fraction of Artemisia stolonifera were investigated. Twenty compounds(1-20) were isolated from the petroleum ether fraction of A. stolonifera by silica gel, Sephadex LH-20, and ODS chromatography and semi-preparative HPLC.

Vapor-Deposited High-Entropy Metallic Glasses.

Physical vapor deposition (PVD) at an appropriate temperature has been shown to produce ultrastable glass by the mechanism of surface accelerated diffusion. Recently, high-entropy materials have been discovered to display slower atomic diffusion due to the multicomponent high-entropy effects. How this delayed atomic motion influences the formation and stability of PVD glass remains elusive.

Synthesis and biological evaluation of sulfonamide derivatives containing imidazole moiety as ALK5 inhibitors.

Four series of sulfonamide derivatives (13a-b, 14a-d, 15a-b, and 16a-d) were synthesized and evaluated for their activin receptor-like kinase 5 (ALK5) inhibitory activities. Of these, compounds 13b (IC = 0.130 μM) and 15a (IC = 0.

Root Endophyte-Manipulated Alteration in Rhizodeposits Stimulates in the Rhizosphere to Enhance Drought Resistance in Peanut.

Drought dramatically affects plant growth and yield. A previous study indicated that endophytic fungus can improve the drought resistance of peanuts, which is related with the root arbuscular mycorrhizal fungi (AMF) community; however, how root endophytes mediate AMF assembly to affect plant drought resistance remains unclear. Here, we explored the mechanism by which endophytic fungus recruits AMF symbiotic partners via rhizodeposits to improve host drought resistance.

Metal-organic framework derived heterostructured phosphide bifunctional electrocatalyst for efficient overall water splitting.

Developing high active and stable cost-effective bifunctional electrocatalysts for overall water splitting to produce hydrogen is of vital significance in clean and sustainable energy development. This work has prepared a novel porous unreported MOF (Ni-DPT) as a precursor to successfully synthesize a non-noble bifunctional NiCoP/NiP@NF electrocatalyst through doping strategy and interface engineering. This catalyst is constructed by layered self-supporting arrays with heterojunction interface and rich nitrogen-phosphorus doping.

Effect of tandem repeats of antimicrobial peptide CC34 on production of target proteins and activity of Pichia pastoris.

Antimicrobial peptides (AMPs) are attracting attention in the fields of medicine, food, and agriculture because of their broad-spectrum antibacterial properties, low resistance, and low-residue in the body. However, the low yield and instability of the prepared AMP drugs limit their application. In this study, we designed a tetramer of the AMP CC34, constructed and transfected two recombinant expression vectors with pGAPZαA containing a haploid CC34 and tetraploid CC34 (CC34-4js) into Pichia pastoris to explore the effect of biosynthesized peptides.

Tough, Reprocessable, and Recyclable Dynamic Covalent Polymers with Ultrastable Long-Lived Room-Temperature Phosphorescence.

Room-temperature phosphorescence (RTP) polymers, whose emission can persist for a long period after photoexcitation, are of great importance for practical applications. Herein, dynamic covalent boronic ester linkages with internal B-N coordination are incorporated into a commercial epoxy matrix. The reversible dissociation of B-N bonds upon loading provides an efficient energy dissipation pathway for the epoxy network, while the rigid epoxy matrix can inhibit the quenching of triplet excitons in boronic esters.

Erratum: Lentinan-functionalized Selenium Nanoparticles target Tumor Cell Mitochondria via TLR4/TRAF3/MFN1 pathway: Erratum.

[This corrects the article DOI: 10.7150/thno.46467.

No evidence for a causal link between infection and nonalcoholic fatty liver disease: A bidirectional Mendelian randomization study.

Although clinical studies have shown the possible relationship between () infection and the development of nonalcoholic fatty liver disease (NAFLD), their causal relationship is still unknown. This bidirectional Mendelian randomization (MR) study aimed to investigate the causal link between i infection and NAFLD. Two previously reported genetic variants SNPs rs10004195 and rs368433 were used as the instrumental variables (IVs) of infection.

Leonurus japonicus Houtt. (Motherwort): Systematic research through chemical profiling, stability under controlled conditions and pharmacokinetic analysis on screening Q-markers for quality control.

Leonurus japonicus Houtt. (Motherwort) is the fresh or dried aerial part of Leonurus japonicus Houtt. (Labiaceae), which is widely used in clinical practice and daily life, used to treat gynecological diseases.

Universal Self-Healing Poly(dimethylsiloxane) Polymer Crosslinked Predominantly by Physical Entanglements.

Harsh conditions are inevitable for long-term use of self-healing polymers. However, the majority of reported self-healing materials cannot remain stable under harsh conditions due to the presence of vulnerable dynamic crosslinking sites. Herein, a universal self-healing poly(dimethylsiloxane) (PDMS) polymer is reported.

[Main chemical constituents in aerial parts of Glycyrrhiza uralensis by UPLC-Q-Exactive Orbitrap-MS].

Chemical constituents from aerial parts of Glycyrrhiza uralensis were analyzed and identified using ultra-high performance liquid chromatography coupled with hybrid quadrupole-orbitrap mass spectrometry(UPLC-Q-Exactive Orbitrap-MS). The chromatographic column of Waters Acquity UPLC BEH-C_(18)(2.1 mm×100 mm, 1.

Lentinan-functionalized Selenium Nanoparticles target Tumor Cell Mitochondria via TLR4/TRAF3/MFN1 pathway.

Malignant ascites caused by cancer cells results in poor prognosis and short average survival time. No effective treatment is currently available for malignant ascites. In this study, the effects of lentinan (LNT)-functionalized selenium nanoparticles (Selene) on malignant ascites were evaluated.

Inhibition of lncRNA PART1 Chemosensitizes Wild Type but Not KRAS Mutant NSCLC Cells.

Background: Lung cancer has the highest incidence among solid tumors in men and is the third most common cancer in women. Despite improved understanding of genomic and mutational landscape in non-small cell lung cancer (NSCLC), the five-year survival in these patients has remained stagnant at a dismal 15%. The first line of treatment commonly adapted for NSCLC patients with somatic mutation in is tyrosine kinase inhibitor gefitinib or erlotinib.

Protopanaxadiol inhibits epithelial-mesenchymal transition of hepatocellular carcinoma by targeting STAT3 pathway.

Diol-type ginsenosides, such as protopanaxadiol (PPD), exhibit antioxidation, anti-inflammation, and antitumor effects. However, the antitumor effect of these ginsenosides and the mechanism of PPD remain unclear. In this work, the antitumor effects of several derivatives, including PPD, Rg5, Rg3, Rh2, and Rh3, were evaluated in five different cancer cell lines.