Antibacterial Activities of Prenylated Flavonoids from against pv .

The increasing resistance of phytopathogenic bacteria to chemical pesticides has underscored the urgent need for novel bactericidal agents. produces a wide range of secondary metabolites with a wide range of biological activities. Here, eight prenylated flavonoids were evaluated for the activity against phytopathogenic bacteria.

Cryptolepine Derivatives Are Insecticide Leads by Targeting Insect Chitinolytic Enzymes and Bilin-Binding Protein.

Multitarget inhibitors (MIs) against insect chitinolytic enzymes are potential pesticide candidates. However, currently known Mis suffers from low biological activity and limited possibilities for structural modification. Here, cryptolepine and its halogenated derivatives were discovered as MIs against all of four insect chitinolytic enzymes from (ChtI, ChtII, Chi-h and Hex1) with values at μM level.

Raman Fingerprints of Phase Transitions and Ferroic Couplings in van der Waals Multiferroic CuCrPS.

CuCrPS (CCPS), a type-II multiferroic material, exhibits unique phase transitions involving ferroelectric, antiferroelectric, and antiferromagnetic ordering. In this study, we conduct a comprehensive investigation on the intricate phase transitions and their multiferroic couplings in CCPS across a wide temperature range from 4 to 345 K through Raman spectroscopic measurements down to 5 cm. We first assign the observed Raman modes with the support of theoretical calculations and angle-resolved polarized Raman measurements.

Design and discovery of novel antifungal candidates with 1,3-Dicarbonyl as a promising pharmacophore.

Background: Pongamol is a flavonoid natural product containing a 1,3-dicarbonyl structure, which has various biological activities and plays an important role as the main skeleton in new drug development. 1,3-dicarbonyl compounds are not only widely used as synthetic building blocks in many organic reactions, but also commonly found in natural products and active molecules in pharmaceuticals. Sixty-one dicarbonyl derivatives were designed and synthesized using the 1,3-dicarbonyl active fragment as a structural unit and their antifungal activities against six agricultural plant pathogens were determined.

Scalable Bottom-Up Synthesis of Nanoporous Hexagonal Boron Nitride (-BN) for Large-Area Atomically Thin Ceramic Membranes.

Nanopores embedded within monolayer hexagonal boron nitride (-BN) offer possibilities of creating atomically thin ceramic membranes with unique combinations of high permeance (atomic thinness), high selectivity (via molecular sieving), increased thermal stability, and superior chemical resistance. However, fabricating size-selective nanopores in monolayer -BN via scalable top-down processes remains nontrivial due to its chemical inertness, and characterizing nanopore size distribution over a large area remains extremely challenging. Here, we demonstrate a facile and scalable approach of exploiting the chemical vapor deposition (CVD) process temperature to enable direct incorporation of subnanometer/nanoscale pores into the monolayer -BN lattice, in combination with manufacturing compatible polymer casting to fabricate centimeter-scale nanoporous atomically thin ceramic membranes.

Telecom-Wavelength Single-Photon Emitters in Multilayer InSe.

The development of robust and efficient single-photon emitters (SPEs) at telecom wavelengths is critical for advancements in quantum information science. Two-dimensional (2D) materials have recently emerged as promising sources for SPEs, owing to their high photon extraction efficiency, facile coupling to external fields, and seamless integration into photonic circuits. In this study, we demonstrate the creation of SPEs emitting in the 1000-1550 nm near-infrared range by coupling 2D indium selenide (InSe) with strain-inducing nanopillar arrays.

Protein-Enabled Size-Selective Defect-Sealing of Atomically Thin 2D Membranes for Dialysis and Nanoscale Separations.

Atomically thin 2D materials present the potential for advancing membrane separations via a combination of high selectivity (from molecular sieving) and high permeance (due to atomic thinness). However, the creation of a high density of precise nanopores (narrow-size-distribution) over large areas in 2D materials remains challenging, and nonselective leakage from nanopore heterogeneity adversely impacts performance. Here, we demonstrate protein-enabled size-selective defect sealing (PDS) for atomically thin graphene membranes over centimeter scale areas by leveraging the size and reactivity of permeating proteins to preferentially seal larger nanopores (≥4 nm) while preserving a significant amount of smaller nanopores (via steric hindrance).

Design and synthesis aldehydes-thiourea and thiazolyl hydrazine derivatives as promising antifungal agents against Monilinia fructicola.

Background: Fungal diseases present a significant threat to global agriculture, necessitating the development of new, safe, and effective fungicides. Existing fungicides face resistance and health risks, prompting the synthesis of novel compounds. Researchers have synthesized aldehyde-based thiourea and thiazolyl hydrazine derivatives, evaluating their antifungal activities to identify impactful pesticide molecules.

Antifungal Activity of Phloroglucinol Derivatives against and .

Naturally derived compounds show promise as treatments for microbial infections. Polyphenols, abundantly found in various plants, fruits, and vegetables, are noted for their physiological benefits including antimicrobial effects. This study introduced a new set of acylated phloroglucinol derivatives, synthesized and tested for their antifungal activity in vitro against seven different pathogenic fungi.

Prenylated Flavonoids Isolated from the Root of as Potent Antifungal Agents against .

, a traditional Chinese herb, produces a wide range of secondary metabolites with a broad spectrum of biological activities. In this study, we isolated six isopentenyl flavonoids from the roots of and evaluated their activities against phytopathogenic fungi. In vitro activities showed that kurarinone and sophoraflavanone G displayed broad spectrum and superior activities, among which sophoraflavanone G displayed excellent activity against tested fungi, with EC values ranging from 4.

Realization of a two-dimensional Weyl semimetal and topological Fermi strings.

A two-dimensional (2D) Weyl semimetal, akin to a spinful variant of graphene, represents a topological matter characterized by Weyl fermion-like quasiparticles in low dimensions. The spinful linear band structure in two dimensions gives rise to distinctive topological properties, accompanied by the emergence of Fermi string edge states. We report the experimental realization of a 2D Weyl semimetal, bismuthene monolayer grown on SnS(Se) substrates.

Interplay between Topological States and Rashba States as Manifested on Surface Steps at Room Temperature.

The unique spin texture of quantum states in topological materials underpins many proposed spintronic applications. However, realizations of such great potential are stymied by perturbations, such as temperature and local fields imposed by impurities and defects, that can render a promising quantum state uncontrollable. Here, we report room-temperature scanning tunneling microscopy/spectroscopy observation of interaction between Rashba states and topological surface states, which manifests local electronic structure along step edges controllable by the layer thickness of thin films.

Wavefront distortion correction in scanning tunneling microscope image.

We report an algorithm to identify and correct distorted wavefronts in atomic resolution scanning tunneling microscope images. This algorithm can be used to correct nonlinear in-plane distortions without prior knowledge of the physical scanning parameters, the characteristics of the piezoelectric actuator, or individual atom positions. The 2D image is first defined as a sum of sinusoidal plane waves, where a nonlinear distortion renders a curve for an otherwise ideal linear wavefront.

Impacts of nature reserve policy on regional ecological environment quality: A case study of Sanjiangyuan region.

Uncovering the ecological effectiveness of nature reserve policies will help protect and manage nature reserves in the future. Taking Sanjiangyuan region as an example, we examined the impacts of the spatial layout characteristics of natural reserves on the ecological environment quality by constructing the dynamic degree of land use and land cover change index, and depicted the spatial differences of the ecological effectiveness of natural reserve policies both inside and outside the natural reserves. Combined with ordinary least squares and field survey results, we explored the influencing mechanism of nature reserve policies on ecological environment quality.

Monolayer Superconductivity and Tunable Topological Electronic Structure at the Fe(Te,Se)/Bi Te Interface.

The interface between 2D topological Dirac states and an s-wave superconductor is expected to support Majorana-bound states (MBS) that can be used for quantum computing applications. Realizing these novel states of matter and their applications requires control over superconductivity and spin-orbit coupling to achieve spin-momentum-locked topological interface states (TIS) which are simultaneously superconducting. While signatures of MBS have been observed in the magnetic vortex cores of bulk FeTe Se , inhomogeneity and disorder from doping make these signatures unclear and inconsistent between vortices.

Breaking of Inversion Symmetry and Interlayer Electronic Coupling in Bilayer Graphene Heterostructure by Structural Implementation of High Electric Displacement Fields.

Controlling the interlayer coupling in two-dimensional (2D) materials generates novel electronic and topological phases. Its effective implementation is commonly done with a transverse electric field. However, phases generated by high displacement fields are elusive in this standard approach.

Antibacterial activity and action mechanism of flavonoids against phytopathogenic bacteria.

As the most difficult to control in plant disease, phytopathogenic bacteria cause huge losses to agricultural products and economy worldwide. However, the commercially available bactericides are few and enhance pathogen resistance. To alleviate this situation, 50 flavonoids were evaluated for their antibacterial activities and mechanism of action against two intractable plant bacterial pathogens.

Emergence of distinct electronic states in epitaxially-fused PbSe quantum dot superlattices.

Quantum coupling in arrayed nanostructures can produce novel mesoscale properties such as electronic minibands to improve the performance of optoelectronic devices, including ultra-efficient solar cells and infrared photodetectors. Colloidal PbSe quantum dots (QDs) that self-assemble into epitaxially-fused superlattices (epi-SLs) are predicted to exhibit such collective phenomena. Here, we show the emergence of distinct local electronic states induced by crystalline necks that connect individual PbSe QDs and modulate the bandgap energy across the epi-SL.

Kinetic Control of Angstrom-Scale Porosity in 2D Lattices for Direct Scalable Synthesis of Atomically Thin Proton Exchange Membranes.

Angstrom-scale pores introduced into atomically thin 2D materials offer transformative advances for proton exchange membranes in several energy applications. Here, we show that facile kinetic control of scalable chemical vapor deposition (CVD) can allow for direct formation of angstrom-scale proton-selective pores in monolayer graphene with significant hindrance to even small, hydrated ions (K diameter ∼6.6 Å) and gas molecules (H kinetic diameter ∼2.

Tavaborole-Induced Inhibition of the Aminoacyl-tRNA Biosynthesis Pathway against Contributes to Disease Control and Fruit Quality Preservation.

The inhibitory effect of tavaborole on the invasion of in grapes and tomatoes, as well as the potential mechanism involved, was discovered in this study. Our findings showed that tavaborole inhibited spore germination and mycelial expansion in vitro and that the control efficiency in vivo on fruit decay was dose-dependent, which was effective in reducing disease severity and maintaining the organoleptic quality of the fruit, such as reducing weight loss and retaining fruit hardness and titratable acid contents during storage. Furthermore, the precise mechanism of action was investigated further.