Biomechanical evaluation of various fixation strategies in oblique lumbar interbody fusion: a finite element analysis.

Background Context: Typical oblique lumbar interbody fusion (OLIF) generally employed either the single lateral screw (SLS) or dual pedicle screws (DPS) for instrumentation, each with their own limitations.

Purpose: The study aimed to investigate the biomechanical properties of two additional fixation strategies including single reverse pedicle screw (SRS) and dual overlapped screws (DOS) compared with SLS and DPS.

Study Design: A finite element (FE) analysis study.

Uniportal endoscopic decompression and debridement for infectious diseases of spine with neurological deficits: a retrospective study in China.

Study Design: A retrospective study.

Purpose: To evaluate the clinical efficacy of uniportal endoscopic decompression and debridement (UEDD) in treating infectious diseases of the spine (IDS) with neurological deficits.

Overview Of Literature: IDS patients with neurological deficits often require urgent surgical decompression.

Transcriptome and MicroRNA Analysis of in Response to Low-Temperature Stress.

Walnuts are among the globally significant woody food and oil tree species. At high latitudes, they frequently experience late-frost damage, inducing low-temperature stress, which significantly affects walnut seedlings. The aim of this study was to investigate the physiological and biochemical alterations in walnut seedlings under low-temperature (LT) stress along with its underlying molecular mechanisms.

Breast cancer image classification based on H&E staining using a causal attention graph neural network model.

Breast cancer image classification remains a challenging task due to the high-resolution nature of pathological images and their complex feature distributions. Graph neural networks (GNNs) offer promising capabilities to capture local structural information but often suffer from limited generalization and reliance on shortcut features. This study proposes a novel causal discovery attention-based graph neural network (CDA-GNN) model.

Metal Ion and Antibiotic Co-loaded Nanoparticles for Combating Methicillin-Rresistant -Induced Osteomyelitis.

Methicillin-resistant (MRSA) causes osteomyelitis (OM), which seriously threatens public health due to its antimicrobial resistance. To increase the sensitivity of antibiotics and eradicate intracellular bacteria, a Zn and vancomycin (Van) codelivered nanotherapeutic (named Man-Zn/Van NPs) was fabricated and characterized via mannose (Man) modification. Man-Zn/Van NPs exhibit significant inhibitory activity against extra- and intracellular MRSA and obviously decrease the minimum inhibitory concentration of Van.

Application of metagenomic next-generation sequencing for rapid molecular identification in spinal infection diagnosis.

Objective: This study aimed to determine the sensitivity and specificity of metagenomic next-generation sequencing (mNGS) for detecting pathogens in spinal infections and to identify the differences in the diagnostic performance between mNGS and targeted next-generation sequencing (tNGS).

Methods: A total of 76 consecutive patients with suspected spinal infections who underwent mNGS, culture, and histopathological examinations were retrospectively studied. The final diagnosis of the patient was determined by combining the clinical treatment results, pathological examinations, imaging changes and laboratory indicators.

Delayed postoperative neurological deficits from scoliosis correction: a case series and systematic review on clinical characteristics, treatment, prognosis, and recovery.

Objective: This study was designed to investigate the clinical features, treatment modalities, and risk factors influencing neurological recovery in patients who underwent scoliosis correction with delayed postoperative neurological deficit (DPND).

Methods: Three patients with DPND were identified from 2 central databases for descriptive analysis. Furthermore, all DPND cases were retrieved from the PubMed and Embase databases.

The relationship between caffeine and its metabolites and bone mineral density in postmenopausal women: a cross-sectional analysis from the NHANES database.

We aim to explore the association between caffeine and its metabolites and bone mineral density (BMD) in postmenopausal women. Data of 4286 postmenopausal women were extracted from the National Health and Nutrition Examination Survey (NHANES) database in 2009-14 in this cross-sectional study. Weighted linear regression and stepwise regression analyses were used to screen the covariates.

Genome-Wide Identification and Expression Analysis of NCED Gene Family in Pear and Its Response to Exogenous Gibberellin and Paclobutrazol.

The 9--epoxycarotenoid dioxygenase () is a key enzyme for the process of ABA synthesis that plays key roles in a variety of biological processes. In the current investigation, genome-wide identification and comprehensive analysis of the gene family in 'Kuerle Xiangli' ( Yu) were conducted using the pear genomic sequence. In total, nineteen members of genes were identified from the whole genome of pear, which are not evenly distributed over the scaffolds, and most of which were focussed in the chloroplasts.

Glucocorticoid-loaded pH/ROS dual-responsive nanoparticles alleviate joint destruction by downregulating the NF-κB signaling pathway.

Rheumatoid arthritis (RA) is an autoimmune disease causing severe symptoms that are difficult to treat. Nano-drug delivery system is recognized as a promising strategy for management of RA. However, how to thoroughly release payloads from nanoformulations and synergistic therapy of RA needs to be further investigated.

[Cloning and expression analysis of gene in walnut].

(GIGANTEA) is one of the output key genes for circadian clock in the plant. The gene was cloned and its expression in different tissues was analyzed to facilitate the functional research of . RT-PCR (reverse transcription-polymerase chain reaction) was used to clone gene in present study.

Evolution of the PEBP gene family in Juglandaceae and their regulation of flowering pathway under the synergistic effect of JrCO and JrNF-Y proteins.

Phosphatidyl ethanolamine-binding protein (PEBP) has a conserved PEBP domain and plays an important role in regulating the flowering time and growth of angiosperms. To understand the evolution of PEBP family genes in walnut family and the mechanism of regulating flowering in photoperiod pathway, 53 genes with PEBP domain were identified from 5 Juglandaceae plants. The PEBP gene family of Juglandaceae can be divided into four subgroups, FT-like, TFL-like, MFT-like and PEBP-like subgroups.

Comprehensive Identification and Analyses of the GRF Gene Family in the Whole-Genome of Four Juglandaceae Species.

The gene family plays an important role in plant growth and development as regulators involved in plant hormone signaling and metabolism. However, the Juglandaceae gene family remains to be studied. Here, we identified 15, 15, 19, and 20 genes in , , , and , respectively.

Older age and depressive state are risk factors for re-positivity with SARS-CoV-2 Omicron variant.

Background: The reinfection rate of SARS-CoV-2 Omicron variant is high; thus, exploring the risk factors for reinfection is important for the effective control of the epidemic. This study aimed to explore the effects of psychological and sleep factors on re-positivity with Omicron.

Methods: Through a prospective cohort study, 933 adult patients diagnosed with Omicron BA.

Rapid and sensitive detection of quizalofop-p-ethyl by gold nanoparticle-based lateral flow immunoassay in agriproducts and environmental samples.

Quizalofop-p-ethyl is a widely used herbicide that poses a threat to human health and environmental safety. In this study, anti-quizalofop-p-ethyl monoclonal antibodies (mAbs) were prepared and used to develop a gold nanoparticle-based lateral flow immunoassay (AuNP-LFIA) for the detection of quizalofop-p-ethyl in agriproducts and environmental samples. Four hybridoma cell lines were obtained, among which 5B6D10E11 secreted mAb with the highest sensitivity, with a 50 % inhibition concentration of 4.

Adaptive Bilateral Texture Filter for Image Smoothing.

The biggest challenge of texture filtering is to smooth the strong gradient textures while maintaining the weak structures, which is difficult to achieve with current methods. Based on this, we propose a scale-adaptive texture filtering algorithm in this paper. First, the four-directional detection with gradient information is proposed for structure measurement.

Genome-Wide Identification, Classification, Expression and Duplication Analysis of bZIP Family Genes in L.

Basic leucine zipper (bZIP), a conserved transcription factor widely found in eukaryotes, has important regulatory roles in plant growth. To understand the information related to the bZIP gene family in walnut, 88 JrbZIP genes were identified at the genome-wide level and classified into 13 subfamilies (A, B, C, D, E, F, G, H, I, J, K, M, and S) using a bioinformatic approach. The number of exons in JrbZIPs ranged from 1 to 12, the number of amino acids in JrbZIP proteins ranged from 145 to 783, and the isoelectric point ranged from 4.

The impact of lockdown on nitrogen dioxide (NO) over Central Asian countries during the COVID-19 pandemic.

Nitrogen dioxide (NO) is one of the main air pollutants, formed due to both natural and anthropogenic processes, which has a significant negative impact on human health. The COVID-19 pandemic has prompted countries to take various measures, including social distancing or stay-at-home orders. This study analyzes the impact of COVID-19 lockdown measures on nitrogen dioxide (NO) changes in Central Asian countries.

Competitive immune-nanoplatforms with positive readout for the rapid detection of imidacloprid using gold nanoparticles.

Two high-sensitivity competitive immune-nanoplatforms based on the inner filter effect (IFE-IN) and magnetic separation (MS-IN) with a positive readout were developed to rapidly detect imidacloprid (IMI) using gold nanoparticles (AuNPs). For IFE-IN, IMI competes with AuNPs-labeled IMI antigens (IMI-BSA-AuNPs) to bind with anti-IMI monoclonal antibody (mAb)-conjugated NaYF:Yb,Er upconversion nanoparticles, which changes the fluorescence signal at excitation/emission wavelength of 980/544 nm. For MS-IN, the immunocomplex of IMI-BSA-AuNPs and magnetic-nanoparticles-labeled mAb (mAb-MNPs) dissociates in the presence of IMI, and the optical density of IMI-BSA-AuNPs at 525 nm increases with the IMI concentration after magnetic separation.

Genome-Wide Characterization and Expression Analysis of the HD-ZIP Gene Family in Response to Salt Stress in Pepper.

HD-ZIP is a unique type of transcription factor in plants, which are closely linked to the regulation of plant growth and development, the response to abiotic stress, and disease resistance. However, there is little known about the HD-ZIP gene family of pepper. In this study, 40 HD-ZIP family members were analyzed in the pepper genome.

Exosomes: Multifaceted Messengers in Atherosclerosis.

Purpose Of Review: Atherosclerosis (AS) is a chronic inflammatory disease that contributes to the development of coronary artery disease, which has become a leading health burden worldwide. Though several strategies such as pharmacological treatment, exercise intervention, and surgery have been used in clinical practice, there is still no effective strategy to cure AS. Exosomes are extensively studied both as diagnostic markers as well as for therapeutic purposes due to their role in pathological processes related to AS.

Circulating Non-coding RNAs and Cardiovascular Diseases.

The discovery of noncoding RNAs (ncRNAs) including short microRNAs, long ncRNAs and circular RNAs has broaden our knowledge about mammalian genomes and transcriptomes. A growing number of evidence on aberrantly regulated ncRNAs in cardiovascular diseases has indicated that ncRNAs are critical contributors to cardiovascular pathophysiology. Moreover, multiple recent studies have reported that ncRNAs can be detected in the bloodstream that differs between health subjects and diseased patients and some of them are remarkably stable.

Author Correction: Combined use of satellite and surface observations to study aerosol optical depth in different regions of China.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Combined use of satellite and surface observations to study aerosol optical depth in different regions of China.

Aerosol optical depth (AOD) is one of essential atmosphere parameters for climate change assessment as well as for total ecological situation study. This study presents long-term data (2000-2017) on time-space distribution and trends in AOD over various ecological regions of China, received from Moderate Resolution Imaging Spectroradiometer (MODIS) (combined Dark Target and Deep Blue) and Multi-angle Imaging Spectroradiometer (MISR), based on satellite Terra. Ground-based stations Aerosol Robotic Network (AERONET) were used to validate the data obtained.