A Frontier Review of Semantic SLAM Technologies Applied to the Open World.

With the growing demand for autonomous robotic operations in complex and unstructured environments, traditional semantic SLAM systems-which rely on closed-set semantic vocabularies-are increasingly limited in their ability to robustly perceive and understand diverse and dynamic scenes. This paper focuses on the paradigm shift toward open-world semantic scene understanding in SLAM and provides a comprehensive review of the technological evolution from closed-world assumptions to open-world frameworks. We survey the current state of research in open-world semantic SLAM, highlighting key challenges and frontiers.

A Fault-Tolerant Localization Method for 5G/INS Based on Variational Bayesian Strong Tracking Fusion Filtering with Multilevel Fault Detection.

In this paper, for the needs of high-precision and high-continuity localization in complex environments, a modeling method based on time-varying noise and outlier noise is proposed, and variational Bayesian strong tracking filtering is used for 5G/INS fusion localization. A hierarchical progressive fault detection mechanism is proposed to detect IMU rationality faults and consistency faults in 5G observation information. The main contributions are reflected in the following two aspects: first, by innovatively introducing Pearson VII-type distribution for noise modeling, dynamically adjusting the tail thickness characteristics of the probability density function through its shape parameter, and effectively capturing the distribution law of extreme values in the observation data.

SGF-SLAM: Semantic Gaussian Filtering SLAM for Urban Road Environments.

With the growing deployment of autonomous driving and unmanned systems in road environments, efficiently and accurately performing environmental perception and map construction has become a significant challenge for SLAM systems. In this paper, we propose an innovative SLAM framework comprising a frontend tracking network called SGF-net and a backend filtering mechanism, namely Semantic Gaussian Filter. This framework effectively suppresses dynamic objects by integrating feature point detection and semantic segmentation networks, filtering out Gaussian point clouds that degrade mapping quality, thus enhancing system performance in complex outdoor scenarios.

Rapid and sensitive detection of using the RPA/Cas12f1_ge4.1 system with fluorescence and lateral flow readouts.

Unlabelled: Tuberculosis remains a major global health threat, with existing detection methods often limited by efficiency and resource demands. Our previous PAM-dependent dsDNA Target-activated Cas12f1 Reporter (PDTCTR) fluorescence sensing platform, while effective for PAM-dependent pathogen detection, was constrained by its reliance on specialized fluorescence equipment and lack of visual output, limiting its use in resource-limited settings. To overcome these limitations, we introduce an innovative RPA/CRISPR-Cas12f1_ge4.

Kinases Associated with Herpes Zoster Virus Infection Unveiled by Phosphoromics Profiling.

Introduction: Reactivation of varicella-zoster virus (VZV) causes herpes zoster (HZ) in humans and elicits a VZV-specific immune response. However, the effect of VZV on host protein post-translational modifications (PTMs) remains largely unknown.

Objective: In this study, we investigated global changes in phosphorylation levels in HZ patients with postherpetic neuralgia (PHN) compared to healthy controls.

CCL20 Expression via AKT-ERK1/2-AP1 Pathway in Infection: Implications for EMT and Cell Migration.

Purpose: , a clinically significant respiratory pathogen, primarily causes community-acquired pneumonia and contributes to asthma development, with its persistent infection frequently resulting in fibrotic pulmonary changes and structural airway abnormalities. This study investigates the signaling pathways regulating CCL20 expression in THP-1 cells following infection and its impact on cell migration and epithelial-mesenchymal transition (EMT).

Methods: THP-1 cells were infected with , and the expression of CCL20 was measured over time and at various doses.

The effects of various physical modalities on pain in patients with knee osteoarthritis: A network meta-analysis.

Objective: This study aims to evaluate the effectiveness of various physical therapy methods in reducing pain for patients with knee osteoarthritis (KOA) through a network meta-analysis.

Methods: We conducted a comprehensive search across multiple databases, including PubMed, Embase, Cochrane Library, VIP, WanFang Data, and CNKI, to identify randomized controlled trials (RCTs) on physical therapies for KOA. The search spanned from the inception of each database to October 2024.

Exploring the Relationship Between Immune Cells and Scoliosis by Mendelian Randomization, Colocalization Analysis, and SMR.

Scoliosis is a condition that can have severe consequences for millions of individuals on an annual basis. Current research in this field is increasingly focusing on the role of the immune system in the development of the disease. However, the precise relationship between immunity and scoliosis remains to be fully elucidated.

DCC-2036 inhibits osteosarcoma via targeting HCK and the PI3K/AKT-mTORC1 axis to promote autophagy.

Background: Osteosarcoma is a common bone tumor in adolescents and children, characterized by rapid progression, high malignancy, poor prognosis, and a tendency for pulmonary metastasis. Despite extensive research efforts, the specific driver gene associated with osteosarcoma remains unidentified, underscoring the urgent need for novel therapeutic targets and targeted treatment options.

Methods: In vitro studies were conducted to assess the effects of DCC-2036 on the proliferation, migration, and invasion of osteosarcoma (OS) cell lines, employing cloning and Transwell experiments.

Clinical Indicator Analysis: Unraveling the Distinct Clinical Characteristics of Kümmell's Disease Compared to Osteoporotic Vertebral Compression Fractures.

Study Design: Retrospective case-control study.

Objective: To examine the differences in various clinical indicators between Kümmell's disease (KD) and osteoporotic vertebral compression fractures (OVCF), in order to assist in the diagnosis of KD and provide a foundation for further analysis of its risk factors.

Summary Of Background Data: The mechanisms underlying the progression of OVCF to KD remain unclear, and research analyzing the indicators between the two conditions is still limited.

Multi-Source, Fault-Tolerant, and Robust Navigation Method for Tightly Coupled GNSS/5G/IMU System.

The global navigation satellite system (GNSS) struggles to deliver the precision and reliability required for positioning, navigation, and timing (PNT) services in environments with severe interference. Fifth-generation (5G) cellular networks, with their low latency, high bandwidth, and large capacity, offer a robust communication infrastructure, enabling 5G base stations (BSs) to extend coverage into regions where traditional GNSSs face significant challenges. However, frequent multi-sensor faults, including missing alarm thresholds, uncontrolled error accumulation, and delayed warnings, hinder the adaptability of navigation systems to the dynamic multi-source information of complex scenarios.

A ERA/Cas12f1_ge4.1 biosensor for rapid, sensitive, and cost-effective detection of Chlamydia psittaci via fluorescence and lateral flow assays.

Rapid and accurate detection of Chlamydia psittaci, the causative agent of psittacosis, is crucial for both human and animal health but presents significant challenges, particularly in grassroots health institutions. Our previous PDTCTR fluorescence sensing platform, which combined the engineered Cas12f1_ge4.1 system with recombinase polymerase amplification (RPA), significantly enhanced detection efficiency.

A Line of Sight/Non Line of Sight Recognition Method Based on the Dynamic Multi-Level Optimization of Comprehensive Features.

With the advent of the 5G era, high-precision localization based on mobile communication networks has become a research hotspot, playing an important role in indoor emergency rescue in shopping malls, smart factory management and tracking, as well as precision marketing. However, in complex environments, non-line-of-sight (NLOS) propagation reduces the measurement accuracy of 5G signals, causing large deviations in position solving. In order to obtain high-precision position information, it is necessary to recognize the propagation state of the signal before distance measurement or angle measurement.

Rapid and visual detection of hepatitis B virus using the ERA/Cas12f1_ge4.1-based lateral flow assay system.

Hepatitis B virus (HBV) is a major pathogen posing significant challenges to global public health, making early diagnosis critical for preventing severe liver diseases. We previously developed a fluorescent biosensor named PAM-dependent dsDNA Target-activated Cas12f1 Trans Reporter (PDTCTR). However, its reliance on specialized fluorescence equipment and lack of visual readout limited its application in resource-limited settings.

Intelligent Beam-Hopping-Based Grant-Free Random Access in Secure IoT-Oriented Satellite Networks.

This research presents an intelligent beam-hopping-based grant-free random access (GFRA) architecture designed for secure Internet of Things (IoT) communications in Low Earth Orbit (LEO) satellite networks. In light of the difficulties associated with facilitating extensive device connectivity while ensuring low latency and high reliability, we present a beam-hopping GFRA (BH-GFRA) scheme that enhances access efficiency and reduces resource collisions. Three distinct resource-hopping schemes, random hopping, group hopping, and orthogonal group hopping, are examined and utilized within the framework.

OGT mediated HDAC5 O-GlcNAcylation promotes osteogenesis by regulating the homeostasis of epigenetic modifications and proteolysis.

Background: O-GlcNAc transferase (OGT) is responsible for attaching O-linked N-acetylglucosamine (O-GlcNAc) to proteins, regulating diverse cellular processes ranging from transcription and translation to signaling and metabolism. This study focuses on the role and mechanisms of OGT in osteogenesis.

Materials And Methods: We found that OGT is downregulated in osteoporosis by bioinformatics analysis, determined its role in osteogenic differentiation by using OGT inhibitors (or OGA inhibitors) as well as conditional knockout OGT mice in and in , and explored and specific mechanisms by quantitative proteomic analysis and RNA-seq, qRT-PCR, western blotting, immunofluorescence, H&E, ALP, ARS, Masson staining, IHC, micro CT, etc.

Efficacy of pH-Responsive Surface Functionalized Titanium Screws in Treating Implant-associated S. aureus Osteomyelitis with Biofilms Formation.

Implant-associated Staphylococcus aureus (S. aureus) osteomyelitis (IASO) leads to high orthopedic implant failure rates due to the formation of Staphylococcal abscess community within the bone marrow and bacterial colonization in the osteocyte lacuno-canalicular network (OLCN). To address this, antimicrobial peptides (HHC36)-loaded titania nanotubes (NTs) are developed on titanium screws (Ti-NTs-P-A), which integrate pH-responsive polymethacrylic acid to control HHC36 release for eradicating bacteria in IASO.

A New Scene Sensing Model Based on Multi-Source Data from Smartphones.

Smartphones with integrated sensors play an important role in people's lives, and in advanced multi-sensor fusion navigation systems, the use of individual sensor information is crucial. Because of the different environments, the weights of the sensors will be different, which will also affect the method and results of multi-source fusion positioning. Based on the multi-source data from smartphone sensors, this study explores five types of information-Global Navigation Satellite System (GNSS), Inertial Measurement Units (IMUs), cellular networks, optical sensors, and Wi-Fi sensors-characterizing the temporal, spatial, and mathematical statistical features of the data, and it constructs a multi-scale, multi-window, and context-connected scene sensing model to accurately detect the environmental scene in indoor, semi-indoor, outdoor, and semi-outdoor spaces, thus providing a good basis for multi-sensor positioning in a multi-sensor navigation system.

Panaxatriol exerts anti-senescence effects and alleviates osteoarthritis and cartilage repair fibrosis by targeting UFL1.

Introduction: Osteoarthritis (OA), the most common degenerative joint disease, can eventually lead to disability. However, no safe or effective intervention is currently available. Therefore, there is an urgent need to develop effective drugs that reduce cartilage damage and treat OA.

Improving Non-Line-of-Sight Identification in Cellular Positioning Systems Using a Deep Autoencoding and Generative Adversarial Network Model.

Positioning service is a critical technology that bridges the physical world with digital information, significantly enhancing efficiency and convenience in life and work. The evolution of 5G technology has proven that positioning services are integral components of current and future cellular networks. However, positioning accuracy is hindered by non-line-of-sight (NLoS) propagation, which severely affects the measurements of angles and delays.

ERA-CRISPR/Cas12a system: a rapid, highly sensitive and specific assay for .

Introduction: , the causative agent of human tuberculosis, poses a significant threat to global public health and imposes a considerable burden on the economy. However, existing laboratory diagnostic methods for are time-consuming and have limited sensitivity levels.

Methods: The CRISPR/Cas system, commonly known as the "gene scissors", demonstrates remarkable specificity and efficient signal amplification capabilities.

Initial therapeutic evidence of a borosilicate bioactive glass (BSG) and FeO magnetic nanoparticle scaffold on implant-associated bone infection.

Implant-associated () osteomyelitis is a severe challenge in orthopedics. While antibiotic-loaded bone cement is a standardized therapeutic approach for osteomyelitis, it falls short in eradicating Staphylococcus abscess communities (SACs) and bacteria within osteocyte-lacuna canalicular network (OLCN) and repairing bone defects. To address limitations, we developed a borosilicate bioactive glass (BSG) combined with ferroferric oxide (FeO) magnetic scaffold to enhance antibacterial efficacy and bone repair capabilities.