Identification of endothelial INSR as an osteosarcoma-related biomarker and therapeutic target based on weighted gene co-expression network analysis.

Background: Osteosarcoma (OS) is the most common primary malignant bone tumor characterized by a high rate of metastasis. The clinical efficacy of current targeted drugs for OS is limited, highlighting the urgent need to identify novel therapeutic targets. The study aimed to identify potential drug targets for OS by combining weighted gene co-expression network analysis (WGCNA) with single-cell analysis.

Polyoxometalate-Based Self-Healing Photochromic Smart Windows for Excellent Solar Heat Management.

With the increasing global demand for energy efficiency solutions, smart windows capable of controlling excess solar radiation and reducing electric energy usage have emerged as promising options and are undergoing substantial development. However, the use of smart windows is constrained by limitations associated with temperature regulation capabilities and damage upon accidental scratches. To overcome these obstacles, we introduce a method for creating transparent self-healing photochromic coatings by simply alternately depositing polyethylenimine (PEI)-polyoxometalate (POM) complexes and poly(acrylic acid) (PAA) on glass substrates.

Investigation of the Impact of Hydrophobic Chains on the Corrosion Inhibition Properties of Triazine-Based Bisquaternary Ammonium Salts.

Surface activity parameters such as critical micelle concentration (CMC), saturation adsorption (Г), and limiting molecular area (A) of three triazinyl bisquaternary ammonium salts with different hydrophobic chain lengths (C-2-C, C-2-C and C-2-C) were analyzed from surface tension tests. The results showed that the CMC value of C-2-C was much lower (0.026 mmol/L) than that of C-2-C and C-2-C.

Preparation and properties study of self-healing anticorrosive coating based on MCM-41 nanocontainer and triazinyl corrosion inhibitor.

In this paper, a self-healing anticorrosive coating with pH response based on epoxy was prepared. Firstly, triazinyl corrosion inhibitor (Inh) was loaded into mesoporous molecular sieve (MCM-41) by the vacuum impregnation method. Polyethylenimine (PEI) and sodium polystyrene sulfonate (PSS) were coated on the surface through the layer-by-layer (LBL) self-assembly method.

Nanomaterials-enabled biosensing platforms for microcystin-LR detection: a review of analytical advancements.

Microcystin-LR (MC-LR), one of the most highly toxic microcystins, is widely present in aquatic ecosystems. This review first outlines the hazardous risks posed by MC-LR to the environment and human health, and then examines current detection methods and their limitations. To address these challenges, the article systematically discusses recent progress in nanomaterials-enabled biosensors for MC-LR detection.

Ruminally Protected Isoleucine, Leucine, Methionine, and Threonine Supplementation of Low-Protein Diets Improved the Performance and Nitrogen Efficiency of Dairy Cows.

This study evaluated the effects of supplementing rumen-protected methionine, threonine, isoleucine, and leucine to low-protein diets on lactating dairy cow performance. Sixty Holstein cows were assigned to one of four dietary treatments in a 9-week randomized complete block design: positive control (16% crude protein diet; 16% CP), negative control (12% CP), 12% CP plus the four essential amino acids (12% CP + EAA), and 14% CP supplemented with the four EAA (14% CP + EAA). The milk protein yield was significantly decreased in the 12% CP group compared to the 16% CP group but was restored to comparable levels with EAA supplementation of both the 12% and 14% CP diets.

Unraveling the oncogenic role of LINC00504 and its interaction with miR-545-3p and ARIHI in hepatocellular carcinoma: novel insights for molecular therapy.

Objectives: Hepatocellular carcinoma (HCC) is a serious global health threat associated with high morbidity and mortality. The importance of long non-coding RNAs (lncRNAs) in tumor progression is growing. The aim of this study was to explore the expression, functional properties and molecular mechanisms of LINC00504 in HCC.

Effects of maternal blood beta-hydroxybutyrate on brown adipose tissue functions and thermogenic and metabolic health in neonatal calves.

Maternal metabolic health, particularly during late pregnancy, plays a crucial role in fetal development and postnatal metabolic function. Elevated levels of BHB in dry cows, commonly observed in late gestation, may affect offspring development, but the effects on brown adipose tissue (BAT) and metabolic health remain unclear. In this study, 60 pregnant Holstein dairy cows were categorized into 2 groups based on serum BHB concentrations measured at 1, 3, 5, and 7 wk after dry-off: maternal low BHB (n = 30; mean ± SEM, 0.

Advances in the Study of Age-Related Macular Degeneration Based on Cell or Cell-Biomaterial Scaffolds.

Age-related macular degeneration (AMD), a progressive neurodegenerative disorder affecting the central retina, is pathologically defined by the irreversible degeneration of photoreceptors and retinal pigment epithelium (RPE), coupled with extracellular drusen deposition and choroidal neovascularization (CNV), and AMD constitutes the predominant etiological factor for irreversible vision impairment in adults aged ≥60 years. Cell-based or cell-biomaterial scaffold-based approaches have been popular in recent years as a major research direction for AMD; monotherapy with cell-based approaches typically involves subretinal injection of progenitor-derived or stem cell-derived RPE cells to restore retinal homeostasis. Meanwhile, cell-biomaterial scaffolds delivered to the lesion site by vector transplantation have been widely developed, and the implanted cell-biomaterial scaffolds can promote the reintegration of cells at the lesion site and solve the problems of translocation and discrete cellular structure produced by cell injection.

Low-loss and tight-bend waveguides via multiple scans of a femtosecond laser.

In this paper, in situ multiple scans of a femtosecond laser are employed to optimize the refractive index distribution in a glass optical waveguide. The emergence of second bright core boundary (SBCB) and the increasing density of three- and four-membered rings in silica were thoroughly investigated. They can lead to a higher refractive index in a waveguide core and enhance the light confinement capability, which can increase the spatial integration density of bent waveguide structures.

High-salt diet decreases FOLFOX efficacy via gut bacterial tryptophan metabolism in colorectal cancer.

Background: FOLFOX is the recommended chemotherapy regimen for colorectal cancer (CRC), but its response rate remains low. Our previous studies have established a close relationship between gut microbiota and the anti-CRC effect of FOLFOX, though the underlying mechanisms remain unclear. Diet has been confirmed as a key factor influencing gut microbiota, and high-salt diets, representative of western dietary habits, has been shown to affect gut microbiota, immune function, and the risk of developing CRC.

A cohort study of serum 25-hydroxyvitamin D levels and the risk of hyperlipidaemia in adults.

Objective: This study aims to investigate the potential association between serum 25(OH)D levels and the risk of hyperlipidemia in adults through a prospective cohort study conducted in Zhejiang Province.

Methods: Baseline surveys and follow-up studies were conducted to collect and analyze follow-up data over a three-year period. Vitamin D deficiency was defined as 25(OH)D < 20 ng/mL, insufficiency as 20-29 ng/mL, and sufficiency as 25(OH)D ≥ 30 ng/mL.

Effect of Thermal Reflow on Microstructural Morphology and Contact Mechanics in the Photo-Lithographic Fabrication of Biomimetic Adhesive Materials.

Bionic adhesive materials with 3D complex micro/nanostructures have several advantages of low preload, strong adhesion, switchable adhesion, etc. As the primary high-precision fabrication method for such materials, lithography is inherently limited by its 2D processing capabilities. Achieving complex 3D morphologies typically requires auxiliary processes, such as dipping and double-sided separate UV exposures, which increase both the complexity and limitations of the fabrication process.

Improving Corrosion Resistance of Zircaloy-4 via High-Current Pulsed Electron Beam Surface Irradiation.

Zircaloy-4 is extensively used in nuclear reactors as fuel element cladding and core structural material. However, the safety concerns post-Fukushima underscore the need for further enhancing its high-temperature and high-pressure water-side corrosion resistance. Therefore, this study aimed to investigate the effects of high-current pulsed electron beam (HCPEB) irradiation on the microstructures and corrosion resistance of Zircaloy-4, with the goal of improving its performance in nuclear applications.

Accumulation of microtubule-associated protein tau promotes hepatocellular carcinogenesis through inhibiting autophagosome-lysosome fusion.

Dysregulated expression of microtubule-associated protein tau (MAPT) has been reported in a variety of human cancers. However, whether and how Tau influences hepatocellular carcinogenesis remains elusive. This study was aimed to investigate the role and the underlying mechanism of Tau in the proliferation, invasion, migration and sorafenib sensitivity of hepatocellular carcinoma (HCC) cells.

Two novel triazine-based quaternary ammonium salt Gemini surfactants as potential corrosion inhibitors for carbon steel in a sulfate-reducing bacteria solution: Experimental and theoretical studies.

In this paper, two triazine ring-containing quaternary ammonium salt Gemini surfactants (C-2-C and C-2-C) were synthesized. The minimum inhibitory concentrations against sulfate-reducing bacteria (SRB) of C-2-C, C-2-C and dodecyl dimethyl benzyl ammonium chloride (1227) were determined using the double-dilution method. The performance of C-2-C and C-2-C in inhibiting carbon steel corrosion in the presence of SRB was examined, with 1227 serving as a control sample.

Multi-Mechanism Collaborative Bionic Fixation Technique Between a Wide Range of Solid Interfaces.

For rough surfaces, stable, fast, and repeatable fixation has wide applicability in transportation, fire protection, and other fields. Different rough surfaces present technical challenges for achieving convenient and reliable fixation. Based on the highly adhesive attachment structures of typical organisms, a multi-mechanism (negative pressure adsorption, mechanical locking, and chemical bonding) cooperative bionic fixation device is proposed.

Fermented Palm Kernel Cake Improves the Rumen Microbiota and Metabolome of Beef Cattle.

In this study, we utilised palm kernel cake as a substrate and fermented it with a composite of bacteria ( CGMCC No. 27203 and CGMCC No. 27202) and enzymes.

Correlation between hyperlipidemia and serum vitamin D levels in an adult Chinese cohort.

Vitamin D deficiency has emerged as a significant concern in public health due to its potential association with various metabolic disorders. This study aimed to investigate the relationship between serum vitamin D levels and the susceptibility to hyperlipidemia among adults. Using a multi-stage sampling approach, we recruited a cohort of 2072 eligible individuals aged over 18 years.

Analysis of differences in the rumen microbiome and metabolic function in prepartum dairy cows with different body condition scores.

Background: The rumen is a crucial digestive organ for dairy cows. The rumen microbiota assists in the digestion of plant feed through microbe-mediated fermentation, during which the plant feed is transformed into nutrients for the cow's use. Variations in the composition and function of the rumen microbiome affect the energy utilization efficiency of dairy cows, which is one of the reasons for the varying body condition scores (BCSs).