Blood pressure and vascular function response to maximal graded exercise tests in young men with masked hypertension.

Individuals with masked hypertension have out-of-office blood pressure (BP) readings in the hypertensive range, but office BP readings below the hypertensive cutoff, making masked hypertension less likely to be diagnosed. The aim of this study was to determine whether in-laboratory measurements of BP and vascular function in response to exercise can serve as indicators of masked hypertension in young adults. Thirty-three young men with office BP <130/80 mmHg, free of smoking and clinical diseases, were included in this study.

Sex-specific DNA methylation associations with circulating urate levels and BCG-induced urate changes.

Background: Urate concentration and the physiological regulation of urate homeostasis exhibit clear sex differences. DNA methylation has been shown to explain a substantial proportion of serum urate variance, mediate the genetic effect on urate concentration, and co-regulate with cardiometabolic traits. However, whether urate concentration is associated with DNA methylation in a sex-dependent manner is unknown.

Long-term DNA methylation changes mediate heterologous cytokine responses after BCG vaccination.

Background: Epigenetic reprogramming shapes immune memory in both innate (trained immunity) and adaptive immune cells following Bacillus Calmette-Guérin (BCG) vaccination. However, the role of dynamic DNA methylation changes in post-vaccination immune responses remains unclear.

Results: We established a cohort of 284 healthy Dutch individuals, profiling genome-wide DNA methylation and cytokine responses to ex vivo stimulation at baseline, 14 days, and 90 days post-BCG vaccination.

High-pressure homogenization treatment on yeast protein: Effect on structure and emulsifying properties.

Yeast protein (YP) is an innovative alternative protein with significant nutritional value, yet it has been underutilized due to structural restrictions and poor functionality. To expand its' application in food industry, we investigated how different homogenization pressures affect its physicochemical and emulsifying properties. High-pressure homogenization (HPH) greatly enhanced the emulsifying properties, especially at 60 MPa with increased emulsifying activity and stability indices by 53.

Interfacial reactions and speciation identification during arsenic treated with nanoscale zerovalent iron (nZVI) in water: A review.

This perspective briefly summarized the progress of inorganic arsenic (As) treated with nanoscale zerovalent iron (nZVI) in water over the past two decades. The intrinsic interfacial reaction between As and nZVI encompassed multiple effects, such as complexation, oxidation, reduction, and co-precipitation, ascribed to core-shell structure of nZVI and environmental behavior of As in water. Surface complexation occurred via ligand exchange of arsenate anions with Fe-OH groups on the iron oxide shell.

Study on measurement and prediction of agricultural product supply chain resilience based on improved EW-TOPSIS and GM (1,1)-Markov models under public emergencies.

The COVID-19 pandemic, African Swine Fever, and other major public health emergencies have affected the agricultural product supply chain in recent years. It appeared in various chain breakdown and blocking issues, in which the resilience was drastically reduced and food security and social stability were greatly disrupted. This dissertation adopted an improved EW-TOPSIS method to evaluate resilience and determined the significance of influence factors of the agricultural product supply chain in China, showing that adjustment capability was closely connected to resilience.

Electronic band structure engineering of π-d conjugated metal-organic framework for sodium organic batteries.

Two-dimensional conjugated metal organic frameworks (2D c-MOFs) hold significant promise as electrode materials for alkali metal ion batteries while their electrochemical properties still lack reasonable and effective regulation. Here, two representative 2D c-MOFs (M-HHTQ/M-HHTP, M=Cu or Ni) as positive electrodes are used as models to explore the basic/microscopic principles of their complex storage mechanism in sodium ion batteries (SIBs). It is demonstrated that the energy storage mechanism of 2D c-MOFs is determined by the interaction between coordination covalent bonds and organic linkers.

Association between Metabolic Syndrome Score and Subclinical Atherosclerosis.

Background: Previous studies have presented conflicting results on the correlation between metabolic syndrome (MetS) and subclinical atherosclerosis. However, the binary MetS definition cannot reflect the severity of metabolic disorders continuously and dynamically. The present study calculated the MetS score and explored the association between MetS score and subclinical atherosclerosis.

Multiplex lateral flow immunoassay for simultaneous detection and specific discrimination of Xoo and Xoc in rice plants.

Xanthomonas oryzae pv. oryzae (Xoo) and Xanthomonas oryzae pv. oryzicola (Xoc) are two important rice bacterial pathogens, causing serious losses of global rice yield every year.

Effects of at-risk alcohol use on nighttime blood pressure, urinary catecholamines, and sleep quality in midlife adults.

Background: The association between alcohol and hypertension has been predominantly based on office blood pressure (BP) measurements. However, little is known about the effect of alcohol use on nighttime BP and the underlying mechanisms. The purpose of this study was to investigate the effects of at-risk alcohol use on nighttime BP, urinary catecholamines, and sleep quality in midlife adults.

A 3D four-fold interpenetrated conductive metal-organic framework for fast and robust sodium-ion storage.

Two-dimensional conductive metal-organic frameworks (2D c-MOFs) with high electrical conductivity and tunable structures hold significant promise for applications in metal-ion batteries. However, the construction of 3D interpenetrated c-MOFs for applications in metal-ion batteries is rarely reported. Herein, a 3D four-fold interpenetrated c-MOF (Cu-DBC) constructed by conjugated and contorted dibenzo[,]chrysene-2,3,6,7,10,11,14,15-octaol (DBC) ligands is explored as an advanced cathode material for sodium-ion batteries (SIBs) for the first time.

Spin polarization induced by atomic strain of MBene promotes the ·O production for groundwater disinfection.

Superbugs in groundwater are posing severe health risks through waterborne pathways. An emerging approach for green disinfection lies at photocatalysis, which levers the locally generated superoxide radical (·O) for neutralization. However, the spin-forbidden feature of O hinders the photocatalytic generation of active ·O, and thus greatly limited the disinfection efficiency, especially for real groundwater with a low dissolved oxygen (DO) concentration.

Improving Cardiogenic Shock Team Activation Through Nurse Education and Alert Implementation.

Background: Patients with cardiogenic shock have a 25% to 50% mortality rate despite the introduction of mechanical circulatory devices and coordinated medical treatment. The use of shock teams has improved outcomes for these patients.

Local Problem: A cardiovascular hospital with a multidisciplinary shock team had inconsistency and delays in recognition and diagnosis of patients with cardiogenic shock.

Insertion of a transjugular intrahepatic portosystemic shunt leads to sustained reversal of systemic inflammation in patients with decompensated liver cirrhosis.

Background/aims: Systemic Inflammation (SI) is considered a key mechanism in disease progression and development of complications in decompensated liver cirrhosis. SI is mainly driven by portal hypertension and bacterial translocation. Transjugular intrahepatic portosystemic shunt (TIPS) insertion represents an effective treatment for portal hypertension.

PINK1-deficiency facilitates mitochondrial iron accumulation and colon tumorigenesis.

Mitophagy, the process by which cells eliminate damaged mitochondria, is mediated by PINK1 (PTEN induced kinase 1). Our recent research indicates that PINK1 functions as a tumor suppressor in colorectal cancer by regulating cellular metabolism. Interestingly, PINK1 ablation activated the NLRP3 (NLR family pyrin domain containing 3) inflammasome, releasing IL1B (interleukin 1 beta).

Urea/Thiourea Imine Linkages Provide Accessible Holes in Flexible Covalent Organic Frameworks and Dominates Self-Adaptivity and Exciton Dissociation.

Unraveling the robust self-adaptivity and minimal energy-dissipation of soft reticular materials for environmental catalysis presents a compelling yet unexplored avenue. Herein, a top-down strategy, tailoring from the unique linkage basis, flexibility degree, skeleton electronics to trace-guest adaptability, is proposed to fill the understanding gap between micro-soft covalent organic frameworks (COFs) and photocatalytic performance. The thio(urea)-basis-dominated linkage within benzotrithiophene-based COFs induce the framework contraction/swelling (intralayer micro-flexibility) in response to tetrahydrofuran or water.

Multifaceted Aquatic Environmental Differences between Nanoplastics and Microplastics: Behavior and Fate.

Microplastics and nanoplastics are emerging pollutants of concern in the aquatic environment that are causing increasing global environmental and human health problems. Although there has been extensive research on microplastics and nanoplastics, little has been said about the differences in their behavior in the aquatic environment, and many studies have considered them as the same class of hazardous materials; but in fact, microplastics and nanoplastics should be considered as two different types of environmentally hazardous materials. In this review, we propose that microplastics and nanoplastics behave in the aquatic environment in a size-dependent manner and should be distinguished.

No value of non-selective beta-blockers after TIPS-insertion.

Background And Aims: Non-selective beta-blockers (NSBB) are a well-established treatment in patients with clinically significant portal hypertension. However, their potential role after insertion of a transjugular intrahepatic portosystemic shunt (TIPS) still needs to be determined. Of note, recent studies suggested that favourable anti-inflammatory effects of NSBB might be independent from pressure reduction.

Sex-specific epigenetic signatures of circulating urate and its increase after BCG vaccination.

Background: Urate concentration and the physiological regulation of urate homeostasis exhibit clear sex differences. DNA methylation has been shown to explain a substantial proportion of serum urate variance, mediate the genetic effect on urate concentration, and co-regulate with cardiometabolic traits. However, whether urate concentration is associated with DNA methylation in a sex-dependent manner is unknown.

Association between patent foramen ovale morphology and clinical outcomes following transcatheter closure.

Background: Anatomic variations of the patent foramen ovale (PFO) are commonly observed, yet limited research has investigated their impact on clinical outcomes following transcatheter closure. We aimed to explore the association between PFO morphology and clinical outcomes.

Methods: Consecutive patients with cryptogenic stroke who underwent PFO closure were prospectively enrolled at a single center from September 2019 to April 2023.

Myeloid NCOA4 sequesters KEAP1 to reduce ferroptosis for protection against salmonellosis in mice.

Salmonellosis, caused by serovar Typhimurium, is a significant global threat. Host immunity limits bacterial replication by inducing hepcidin, which degrades ferroportin, reducing iron transfer. However, this boosts macrophage iron storage, aiding intracellular pathogens like .

Tuning Electron Delocalization of Redox-Active Porous Aromatic Framework for Low-Temperature Aqueous Zn-K Hybrid Batteries with Air Self-Chargeability.

Air self-charging aqueous batteries promise to integrate energy harvesting technology and battery systems, potentially overcoming a heavy reliance on energy and the spatiotemporal environment. However, the exploitation of multifunctional air self-charging battery systems using promising cathode materials and suitable charge carriers remains challenging. Herein, for the first time, we developed low-temperature self-charging aqueous Zn-K hybrid ion batteries (AZKHBs) using a fully conjugated hexaazanonaphthalene (HATN)-based porous aromatic framework as the cathode material, exhibiting redox chemistry using K as charge carriers, and regulating Zn-ion solvation chemistry to guide uniform Zn plating/stripping.

Association between triglyceride-glucose index and endothelial dysfunction.

Background: Triglyceride-glucose (TyG) index, a simple surrogate marker for insulin resistance (IR), has been reported as an independent predictor of arterial structural damage and future cardiovascular events. The association between TyG index and endothelial dysfunction remains uncertain.

Objective: The purpose of this study was to investigate the association between TyG index and endothelial dysfunction.