Publications by authors named "Luke B Villareal"
Salmonellosis, caused by serovar Typhimurium, is a significant global threat. Host immunity limits bacterial replication by inducing hepcidin, which degrades ferroportin, reducing iron transfer. However, this boosts macrophage iron storage, aiding intracellular pathogens like .
View Article and Find Full Text PDFBackground/objectives: Hypoxia-inducible factor (HIF)-3α1's role in colorectal cancer (CRC) cells, especially its effects on epithelial-mesenchymal transition (EMT), zinc finger E-box binding homeobox 2 (ZEB2) gene expression, and iron metabolism, remains largely unstudied. This research sought to elucidate these relationships.
Methods: RNA-seq was conducted to investigate the impact of HIF-3α1 overexpression in CRC cells.
Inflammatory bowel disease (IBD) is a chronic and debilitating disorder characterized by inflammation of the gastrointestinal tract. Despite extensive research, the exact cause of IBD remains unknown, hampering the development of effective therapies. However, emerging evidence suggests that hypoxia, a condition resulting from inadequate oxygen supply, plays a crucial role in intestinal inflammation and tissue damage in IBD.
View Article and Find Full Text PDFArticle Synopsis
- Transferrin receptor (TFRC) is crucial for iron uptake in cells, and its expression is unexpectedly high in iron-rich cancer cells, despite the risk of toxicity.
- The study reveals that loss of the APC gene activates β-catenin, which increases TFRC levels in colorectal cancer, promoting iron accumulation that enhances β-catenin signaling.
- Disrupting TFRC leads to reduced colonic iron and activates DNA damage responses, which may be targeted for new colorectal cancer treatments using iron chelation and DNA-damaging agents.