Characteristics of Gut Microbiota in Patients with Polycystic Ovary Syndrome and Its Association with Metabolic Abnormalities: A Review.

Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine disorder that has garnered attention in recent years for its intricate relationship with gut microbiota, which plays a significant role in the metabolic abnormalities associated with this condition. This review focuses on the characteristics of gut microbiota in polycystic ovary syndrome (PCOS). By analyzing current literature, we will focus on the alterations in gut microbiota composition, influential factors, and the pathophysiological mechanisms linking gut microbiota and PCOS, diagnostic approaches, therapeutic strategies, as well as controversies and future directions in this field are discussed.

Robust Imidazole-Linked 2D Covalent Organic Frameworks for Efficient Electrochemical Sodium-Ion Storage.

Exploring stable and functional linkages through facile one-pot cyclocondensation reactions represents one of the frontiers in the development of covalent organic frameworks (COFs), which can enhance structural robustness and diversity while broadening their application potential. In this study, we report a facile synthetic strategy using p-toluenesulfonic acid (PTSA) as a proton mediator to construct two imidazole-linked COFs (TABQ-COF and TAPT-COF) via one-pot cyclocondensation of aromatic aldehydes with ortho-diamines. These two COFs not only possess good crystallinity but also exhibit excellent physicochemical stability and contain abundant redox-active sites, which endows them with charming advantages for electrochemical energy storage.

Donor-Acceptor Porous Aromatic Framework Cathode with Fast Redox Kinetics for Ultralow-Temperature (-70 °C) Potassium-Organic Batteries.

Low-temperature rechargeable batteries are essential for cryogenic energy storage. However, lowering the working temperature will exacerbate the disadvantages of slowed reaction kinetics and mechanical instability of inorganic electrode materials, thus causing severe capacity degradation. In this work, for the first time, we demonstrated that constructing a donor-acceptor (D-A) porous aromatic framework (PAF-310) using p-type phenazine (PZ) and n-type hexaazatrinaphthylene (HATN) as storage blocks can accelerate charge transport and thus facilitate the reaction kinetics even at low-temperature conditions.

In Situ Construction of Amide-Functionalized 2D Conjugated Metal-Organic Frameworks with Multiple Active Sites for High-Performance Potassium-Ion Batteries.

Two-dimensional conjugated metal-organic frameworks (2D -MOFs) represent a promising class of electrode materials for potassium-ion batteries (PIBs), attributed to their superior conductivity, large specific surface area, high charge carrier mobility, and tunable active sites. However, most reported 2D -MOF-based cathode materials for PIBs usually encounter challenges, such as low specific capacity and inadequate cycling stability. In this context, we herein designed and synthesized a new hexahydroxy salicylamide ligand (6OH-HBB) via a straightforward two-step synthesis with a high yield of 93%, which was subsequently utilized to construct a 2D Cu-HBB-MOF with multiple active sites through an in situ metal coordination-induced planarization strategy.

Two dimensional Conjugated Metal-Organic Frameworks with Multiple Redox-Active Sites towards High-Performance Sodium-Ion Battery.

Two dimensional (2D) conjugated metal-organic frameworks (2D c-MOFs) have emerged as promising electroactive materials for energy storage owing to their high conductivity and large charge carrier mobility. However, their broader implementation is hindered by limitations in capacity and cycling stability, primarily due to the restricted density, diversity, and stability of the redox sites. In this study, a new 2D c-MOF (Cu-TTPQ) with multiple redox-active sites that incorporated quinone and pyrazine functionalities as cathode materials for sodium-ion batteries (SIBs) is developed.

DDSSnet: a fast strain demodulation approach for OFDR-based fiber shape reconstruction.

In optical fiber shape sensing technology, enhancing sensing accuracy while simultaneously achieving real-time shape reconstruction presents a notable challenge. This work presents a fast strain demodulation algorithm for the optical frequency domain reflectometry (OFDR) shape sensing system. The fast strain demodulation algorithm comprises deviation calculation and deviation denoising for shape-sensing convolutional neural network (DDSSnet).

Integrated multi-omics analysis reveals complement component 3 as a central driver of immune dysregulation in polycystic ovary syndrome.

Background: Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine disorder with a complex pathophysiology, affecting various aspects of women's health. Despite its widespread impact, the molecular basis and immunological aspects of PCOS remain insufficiently understood, limiting effective diagnosis and treatment strategies.

Objective: This study aims to elucidate the molecular and immunological landscape of PCOS by integrating gene expression profiles from healthy and PCOS-affected ovaries using both bulk and single-cell omics data, with the goal of constructing a comprehensive bioinformatics network that identifies potential biomarkers and therapeutic targets.

A 3D four-fold interpenetrated conductive metal-organic framework for fast and robust sodium-ion storage.

Two-dimensional conductive metal-organic frameworks (2D c-MOFs) with high electrical conductivity and tunable structures hold significant promise for applications in metal-ion batteries. However, the construction of 3D interpenetrated c-MOFs for applications in metal-ion batteries is rarely reported. Herein, a 3D four-fold interpenetrated c-MOF (Cu-DBC) constructed by conjugated and contorted dibenzo[,]chrysene-2,3,6,7,10,11,14,15-octaol (DBC) ligands is explored as an advanced cathode material for sodium-ion batteries (SIBs) for the first time.

Redox-Bipolar Covalent Organic Framework Cathode for Advanced Sodium-Organic Batteries.

Redox-active covalent organic frameworks (COFs) are promising candidates for sodium-ion batteries (SIBs). However, the construction of redox-bipolar COFs with the anions and cations co-storage feature for SIBs is rarely reported. Herein, redox-bipolar COF constructed from aniline-fused quinonoid units (TPAD-COF) is developed as the cathode material in SIBs for the first time.

A tricycloquinazoline based 2D conjugated metal-organic framework for robust sodium-ion batteries with co-storage of both cations and anions.

There is growing interest in 2D conjugated metal-organic frameworks (2D -MOFs) for batteries due to their reversible redox chemistry. Nevertheless, currently reported 2D -MOFs based on n-type ligands are mostly focused on the storage of cations for batteries. Herein, we successfully synthesize nitrogen-rich and electron-deficient p-type ligand-based Ni(HATQ) assembled from 2,3,7,8,12,13-hexaaminotricycloquinazoline (HATQ), and the ion co-storage feature of cations and anions in sodium ion batteries (SIBs) is demonstrated for 2D -MOFs for the first time.

Biosynthesis of Halogenated Tryptophans for Protein Engineering Using Genetic Code Expansion.

Genetic Code Expansion technology offers significant potential in incorporating noncanonical amino acids into proteins at precise locations, allowing for the modulation of protein structures and functions. However, this technology is often limited by the need for costly and challenging-to-synthesize external noncanonical amino acid sources. In this study, we address this limitation by developing autonomous cells capable of biosynthesizing halogenated tryptophan derivatives and introducing them into proteins using Genetic Code Expansion technology.

2D Conjugated Metal-Organic Frameworks Bearing Large Pore Apertures and Multiple Active Sites for High-Performance Aqueous Dual-Ion Batteries.

2D conjugated metal-organic frameworks (2D c-MOFs) with large pore sizes and high surface areas are advantageous for adsorbing iodine species to enhance the electrochemical performance of aqueous dual-ion batteries (ADIBs). However, most of the reported 2D c-MOFs feature microporous structures, with few examples exhibiting mesoporous characteristics. Herein, we developed two mesoporous 2D c-MOFs, namely PA-TAPA-Cu-MOF and PA-PyTTA-Cu-MOF, using newly designed arylimide based multitopic catechol ligands (6OH-PA-TAPA and 8OH-PA-PyTTA).

Conjugation and Topology Engineering of 2D π-d Conjugated Metal-Organic Frameworks for Robust Potassium Organic Batteries.

The evolution of two-dimensional conjugated metal-organic frameworks (2D c-MOFs) provides a significant prospect for researching the next generation of green and advanced energy storage systems (ESSs). Especially, conjugation and topology engineering serve as an irreplaceable character in adjusting the electrochemical properties of ESSs. Herein, we proposed a novel strategy using conjugation and topology engineering to demonstrate the application of 2D c-MOFs in robust potassium-ion batteries (PIBs) for the first time.

A Rhombic 2D Conjugated Metal-Organic Framework as Cathode for High-Performance Sodium-Ion Battery.

2D conjugated metal-organic frameworks (2D c-MOFs) have garnered significant attention as promising electroactive materials for energy storage. However, their further applications are hindered by low capacity, limited cycling life, and underutilization of the active sites. Herein, Cu-TBA (TBA = octahydroxyltetrabenzoanthracene) with large conjugation units (narrow energy gap) and a unique rhombus topology is introduced as the cathode material for sodium-ion batteries (SIBs).

A bipolar organic molecule towards the anion/cation-hosting cathode compatible with polymer electrolytes for quasi-solid-state dual-ion batteries.

Ion concentration and mobility are tightly associated with the ionic conductance of polymer electrolytes in solid-state lithium batteries. However, the anions involved in the movement are irrelevant to energy generation and cause uncontrolled dendritic growth and concentration polarization. In the current study, we proposed the strategy of using a bipolar organic molecule as the anion/cation-hosting cathode to expand the active charge carriers of polymer electrolytes.

Boosting H Storage in Aqueous Zinc Ion Batteries via Integrating Redox-Active Sites into Hydrogen-Bonded Organic Frameworks with Strong π-π Stacking.

In the emerging aqueous zinc ion batteries (AZIBs), proton (H ) with the smallest molar mass and fast (de)coordination kinetics is considered as the most ideal charge carrier compared with Zn counterpart, however, searching for new hosting materials for H storage is still at its infancy. Herein, redox-active hydrogen-bonded organic frameworks (HOFs) assembled from diaminotriazine moiety decorated hexaazatrinnphthalene (HOF-HATN) are for the first time developed as the stable cathode hosting material for boosting H storage in AZIBs. The unique integration of hydrogen-bonding networks and strong π-π stacking endow it rapid Grotthuss proton conduction, stable supramolecular structure and inclined H storage.

Advancing protein therapeutics through proximity-induced chemistry.

Recent years have seen a remarkable growth in the field of protein-based medical treatments. Nevertheless, concerns have arisen regarding the cytotoxicity limitations, low affinity, potential immunogenicity, low stability, and challenges to modify these proteins. To overcome these obstacles, proximity-induced chemistry has emerged as a next-generation strategy for advancing protein therapeutics.

Anchoring π-d Conjugated Metal-Organic Frameworks with Dual-Active Centers on Carbon Nanotubes for Advanced Potassium-Ion Batteries.

Potassium-ion batteries (PIBs) are gradually gaining attention owing to their natural abundance, excellent security, and high energy density. However, developing excellent organic cathode materials for PIBs to overcome the poor cycling stability and slow kinetics caused by the large radii of K ions is challenging. This study demonstrates for the first time the application of a hexaazanonaphthalene (HATN)-based 2D π-d conjugated metal-organic framework (2D c-MOF) with dual-active centers (Cu-HATNH) and integrates Cu-HATNH with carbon nanotubes (Cu-HATNH@CNT) as the cathode material for PIBs.

Stable quasi-solid-state lithium-organic battery based on composite gel polymer electrolyte and compatible organic cathode material.

High-performance organic small-molecule electrode materials are troubled with their high solubility in liquid electrolytes. The construction of quasi-solid-state lithium organic batteries (LOBs) using gel polymer electrolytes with high mechanical properties, compromised ionic conductivity, high safety, and eco-friendly is an effective way to inhibit the dissolution of active materials. Herein, two hexaazatriphenylene (HATN)-based organic cathode materials (HATNA-6OCH and HATNA-6OH) are synthesized and then matched with polyvinylidene fluoride-hexafluoropropylene (PVDF-HFP)-based gel polymer electrolytes to construct quasi-solid-state LOBs.

Immobilizing Quinone-Fused Aza-Phenazine into π-d Conjugated Coordination Polymers with Multiple-Active Sites for Sodium-Ion Batteries.

The development of coordination polymers with π-d conjugation (CCPs) provides ide prospects for exploring the next generation of environmental-friendliness energy storage systems. Herein, the synthesis, experimental characterizations, and Na-ion storage mechanism of π-d CCPs with multiple-active sites are reported, which use quinone-fused aza-phenazine (AP) and aza-phenazin (AP) as the organic ligands coordinated with the metal center (Ni ). Among them, NiQAP as the cathode material exhibits impressive electrochemical properties applied in sodium-ion batteries (SIBs), including the high initial/stable discharge specific capacities (180.

Dynamic wavelength calibration based on synchrosqueezed wavelet transform.

With the developments of the tunable laser source (TLS), there are increasing demands for high-resolution dynamic wavelength calibration in recent years. Considering mutual constraints between wide measurement range and high calibration resolution, we propose a dynamic wavelength calibration method based on an auxiliary Mach-Zehnder interferometer (MZI) and the synchrosqueezed wavelet transform (SSWT). Our proposed method can achieve a calibration resolution of 5 fm and a tuning range of 10 nm.

Elevation of NO-N from biochar amendment facilitates mitigating paddy CH emission stably over seven years.

Biochar application into paddy is an improved strategy for addressing methane (CH) stimulation of straw biomass incorporation. Whereas, the differentiative patterns and mechanisms on CH emission of straw biomass and biochar after long years still need to be disentangled. Considering economic feasibility, a seven-year of field experiment was conducted to explore the long-term CH mitigation effect of annual low-rate biochar incorporation (RSC, 2.

Synthesis of a new Ag-decorated Prussian blue analog with high peroxidase-like activity and its application in measuring the content of the antioxidant substances in Murr.

A new Prussian blue analog (PBA) that contains three metal elements and has peroxidase-like activity was synthesized by a simple method. Then, AgNO solution was added slowly to the PBA solution under continuous stirring. We found that this synthesis method could be used to prepare other PBAs, and that the anchoring of Ag on the surface of PBA could enhance the peroxidase-like activity of the material, suggesting potential applications for the Ag-decorated Prussian blue analog (Ag-PBA) in traditional Chinese medicine.