Rapid and Sensitive Fluorometric Quantification of Black Carbon in Biological Fluids.

The increase in wildfire frequency worldwide has contributed to persistent atmospheric black carbon (BC) pollution, which was closely relative to multiple adverse health effects. Accurate quantification of BC in biological tissues and fluids is fundamental for evaluating its health effect; however, existing analytical methodologies are hindered by time-consuming protocols, low throughput, and the need for expensive instrumental infrastructure. In this study, we developed a fluorometric method for quantifying BC in various biological fluids with the advantages of simplicity, high sensitivity, and low cost.

Nanopore sequencing and hybrid assembly: unraveling the genomic landscape of dollar spot with enhanced annotation and drug resistance profiling.

The increasing multi-drug resistance observed in the turfgrass pathogen spp. has emerged as a critical issue. Understanding the mechanisms underlying fungicide resistance is crucial to address this challenge.

Social Class and Children's Third-party Intervention Tendency and Forms.

This study investigated how social class is related to children's third-party intervention (TPI) tendency and forms (compensation vs. punishment). Children from different social class backgrounds watched short animated films depicting two cartoon characters making fair or unfair decisions in resource distribution scenarios.

Prognostic Value of Ubiquitination-Related Genes in Ovarian Cancer and Their Correlation With Tumor Immunity.

Numerous studies have emphasized the importance of the ubiquitin-proteasome system (UPS) in the malignant progression of ovarian cancer (OC). However, whether ubiquitination-related genes (UbRGs) can be used to predict the prognosis of OC remains to be revealed. Patients with OC were divided into two clusters based on the expression of UbRGs, and prognosis was compared between the two clusters.

ZMIZ1 lactylation induces tamoxifen resistance in breast cancer through increasing transcriptional activity of Nanog to impact cell stemness and cholesterol uptake.

Tamoxifen is a critical drug for the treatment of oestrogen receptor (ER)-positive breast cancer (BC), which represents the majority of BC subtypes. However, many BC tumours that initially respond eventually develop acquired Tamoxifen resistance. Bioinformatics analysis was conducted on genes affected by Tamoxifen and upregulated in Tamoxifen-resistant cells to identify the biological processes associated with Tamoxifen resistance.

Mechanism of ABCD3 inhibiting colorectal cancer progression by regulating Wnt/β-catenin.

Background: Accumulating evidence highlights the critical role of dysregulated Wnt/β-catenin signaling in colorectal cancer (CRC) pathogenesis. However, the clinical translation of therapeutics targeting this pathway remains challenging. While ABCD3 is known to modulate the Wnt/β-catenin signaling pathway and influence CRC progression, its precise molecular regulatory mechanisms and prognostic significance require further elucidation.

Histone lactylation-driven YTHDF2 promotes non-small cell lung cancer cell glycolysis and stemness by recognizing m6A modification of SFRP2.

Histone lactylation is involved in non-small cell lung cancer (NSCLC) by transcriptional regulation of gene expression. YTH N6-methyladenosine RNA binding protein F2 (YTHDF2) is a N6-methyladenosine (m6A) "reader" that recognizes m6A methylation of mRNA and can be regulated by histone lactylation. This study aimed to investigate the role of histone lactylation in NSCLC and the underlying mechanism using in vitro experiments.

Enhanced Anionic Redox Reaction of Na-Layered Li-Containing Mn-Based Cathodes by Cu-Mediated Reductive Coupling Mechanism.

Na-layered Li-containing Mn-based cathodes (NaLiMnO, NLMOs) with additional Na storage ability resulting from the anionic redox reaction (ARR) hold great promise for sodium-ion batteries (NIBs). However, practical applications of NLMOs encounter challenges, such as migration of transition metal Mn, loss of lattice oxygen, and voltage decay during cycling. Here, we show that Cu plays an important role in enhancing the ARR via the reductive coupling mechanism (RCM).

Iridium(III)-Catalyzed C-H Bond Activation of Phenols to Build Up Phenothiazine-Containing 2-(2-Hydroxyphenyl)azoles: Access to Single-Molecule White-Light Materials and Room-Temperature Phosphorescence Materials.

Reported herein is the first example of iridium(III)-catalyzed C-H bond activation of phenols to construct phenothiazine-containing 2-(2-hydroxyphenyl)azole-based π-conjugated luminescent materials. The novel phenothiazine-containing 2-(2-hydroxyphenyl)azoles exhibit distinct white-light emission, which could be fabricated as low-cost and robust organic white-light-emitting diodes. Additionally, the doped system of phenothiazine-containing 2-(2-hydroxyphenyl)azole@triphenylamine displays an ultralong lifetime and afterglow, which could be further used in encryption.

Genomic mutation profile and metabolic alterations in diffuse large B-cell lymphoma with abdominal bulky mass.

Diffuse large B-cell lymphoma (DLBCL) is a tumor with significant clinical and genetic heterogeneity. DLBCL with bulky mass (≥ 7.5 cm) exhibits a negative prognostic impact.

Spatiotemporal Variations and Sources of Airborne Particulate Matter in Urban Metro Platforms and Carriages in China.

Since 2013, China has significantly improved its control over atmospheric air pollution. However, air pollution in indoor environments, particularly in urban metro systems, has been largely neglected. In this study, we comprehensively investigated the spatiotemporal variations in particulate matter (PM) pollution inside metro stations and carriages across seven Chinese cities.

Research on Leak Detection and Localization Algorithm for Oil and Gas Pipelines Using Wavelet Denoising Integrated with Long Short-Term Memory (LSTM)-Transformer Models.

Traditional leakage prediction models for long-distance pipelines have limitations in effectively synchronizing spatial and temporal features of leakage signals, leading to data processing that heavily relies on manual experience and exhibits insufficient generalization capabilities. This paper introduces a novel leakage detection and localization algorithm for oil and gas pipelines, integrating wavelet denoising with a Long Short-Term Memory (LSTM)-Transformer model. The proposed algorithm utilizes pressure sensors to collect real-time pipeline pressure data and applies wavelet denoising to eliminate noise from the pressure signals.

Population Genomics of Aspergillus sojae is Shaped by the Food Environment.

Traditional fermented foods often contain specialized microorganisms adapted to their unique environments. For example, the filamentous mold Aspergillus oryzae, used in saké fermentation, has evolved to thrive in starch-rich conditions compared to its wild ancestor, Aspergillus flavus. Similarly, Aspergillus sojae, used in soybean-based fermentations like miso and shochu, is hypothesized to have been domesticated from Aspergillus parasiticus.

Local-region treatment comparison following conversion therapy of hepatocellular carcinoma: a period and age-dependent analysis.

Background: Transarterial chemoembolization (TACE) is a potential conversion therapeutic strategy for unresectable hepatocellular carcinoma (uHCC). However, therapeutic options following conversion therapy are still controversial.

Objectives: This study aimed to compare the efficacy and safety of surgical resection (SR) and microwave ablation (MWA) after TACE conversion therapy for uHCC.

OCCMNet: Occlusion-Aware Class Characteristic Mining Network for multi-class artifacts detection in endoscopy.

Multi-class endoscope artifacts detection is crucial for eliminating interference caused by artifacts during clinical examinations and reducing the rate of misdiagnosis and missed diagnoses by physicians. However, this task remains challenging such as data imbalance, similarity, and occlusion among artifacts. To overcome these challenges, we propose an Occlusion-Aware Class Characteristic Mining Network (OCCMNet) to detect eight classes of artifacts in endoscope simultaneously.

Association of Poor Sleep Quality With Adverse Outcomes in Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.

Objectives: Inflammatory bowel disease (IBD) is a group of chronic diseases with adverse events such as disease flare, progression, drug escalation, hospitalization, and surgery. Meanwhile, patients with IBD often have sleep disorders. We performed this systematic review and meta-analysis aiming to investigate the relationship between sleep quality of patients with IBD and their prognosis.

Clinical and Multiorgan Proteomics Characteristics of the Diverse Fatal Phase in Super Elderly Patients With SARS-CoV-2 Infection: A Descriptive Study.

This study aims to identify the risk factors associated with clinical outcomes and the proteomic changes in organs related to fatal SARS-CoV-2 infection within the super-elderly population. This retrospective analysis included all elderly individuals with COVID-19 admitted to the Second Medical Center of PLA General Hospital from December 2022 to January 2023. The follow-up period ended on March 30, 2023.

Protein molecular structures of USP53, NPY2R, and DCTN1-AS1 and impact on tumors: Analysis of prognostic biomarkers for diffuse large B-cell lymphoma.

In the past few years, three protein molecules-USP53, NPY2R, and DCTN1-AS1-have garnered significant attention in scientific research due to their potential implications in tumor development. Mass spectrometry and proteomics techniques were used to analyze the three-dimensional structure of these protein molecules and predict their active sites and functional domains. The effects of USP53, NPY2R and DCTN1-AS1 on biological behavior of tumor cells were studied by constructing gene knockout and overexpression cell models.

Automatic MRI-TRUS Fusion Technique for Transperineal Biopsy Guidance: From Preoperative Planning to Intraoperative Navigation.

Background: Targeted and systematic transperineal biopsy of lesions guided by magnetic resonance imaging (MRI) and transrectal ultrasonography (TRUS) fusion technique may optimize the biopsy procedure and enhance the detection of prostate cancer. We described the transperineal biopsy guided by an automatic MRI-TRUS fusion technique, and evaluated the accuracy and feasibility of this method in a prospective single-center study.

Methods: The proposed method focuses on automating the delineation of prostate contours in both the MRI and TRUS images, the registration and fusion of MRI and TRUS images, the generation and visualiztion of the systematic biopsy cores in their corresponding locations within the 2D and the 3D views, as well as the computation and visualiztion of needle trajectories from preoperative planning to intraoperative navigation.

A High-Entropy Engineering on Sustainable Anionic Redox Mn-Based Cathode with Retardant Stress for High-Rate Sodium-Ion Batteries.

Manganese-based (Mn-based) layered oxides have emerged as competitive cathode materials for sodium-ion batteries (SIBs), primarily due to their high energy density, cost-effectiveness, and potential for mass production. However, these materials often suffer from irreversible oxygen redox reactions, significant phase transitions, and microcrack formation, which lead to considerable internal stress and degradation of electrochemical performance. This study introduces a high-entropy engineering strategy for P2-type Mn-based layered oxide cathodes (HE-NMCO), wherein a multi-ingredient cocktail effect strengthens the lattice framework by modulating the local environmental chemistry.

Coordination Regulation Enabling Deep Eutectic Electrolyte for Fast-Charging High-Voltage Lithium Metal Batteries.

The safety and cycle stability of lithium metal batteries (LMBs) under conditions of high cut-off voltage and fast charging put forward higher requirements for electrolytes. Here, a sulfonate-based deep eutectic electrolyte (DEE) resulting from the eutectic effect between solid sultone and lithium bis(trifluoromethanesulfonyl)imide without any other additives is reported. The intermolecular coordination effect triggers this eutectic phenomenon, as evidenced with nuclear magnetic resonance, and thus the electrochemical behavior of the DEE can be controlled by jointly regulating the coordination effects of F···H and Li···O intermolecular interactions.

Efficacy and Safety of Polatuzumab Vedotin Plus Rituximab, Cyclophosphamide, Doxorubicin and Prednisone for Previously Untreated Diffuse Large B-Cell Lymphoma: A Real-World, Multi-Center, Retrospective Cohort Study.

Polatuzumab vedotin plus R-CHP (Pola-R-CHP) is approved as a new standard first-line therapy for diffuse large B-cell lymphoma (DLBCL) based on the POLARIX trial. However, real-world data on its efficacy and safety in unselected patients is lacking. We conducted a retrospective cohort study to evaluate Pola-R-CHP versus R-CHOP outcomes in routine clinical practice in China.

Magnetic iron oxide nanoparticles: An emerging threat for the environment and human health.

Magnetic iron oxide nanoparticles (FeO NPs, mainly FeO and γ-FeO) are nanomaterials ubiquitously present in aquatic, terrestrial, and atmospheric environments, with a high prevalence and complex sources. Over the past decade, numerous reports have emerged on the presence of exogenous particles in human body, facilitated by the rapid development of separation and detection methods. The health risk associated with magnetic FeO NP have garnered escalating attention due to their presence in human blood and brain tissues, especially for their potential association with neurodegenerative diseases like Alzheimer's disease.

Quantitative Identification of Dopant Occupation in Li-Rich Cathodes.

Elemental doping is widely used to improve the performance of cathode materials in lithium-ion batteries. However, macroscopic/statistical investigation on how doping sites are distributed in the material lattice, despite being a key prerequisite for understanding and manipulating the doping effect, has not been effectively established. Herein, to solve this predicament, a universal strategy is proposed to quantitatively identify the locations of Al and Mg dopants in lithium-rich layered oxides (LLOs).