Performance comparison of two telescope configurations for backscattered light in space gravitational wave detection.

In space-based gravitational wave detection telescopes, backscattered light generated by the optical elements of the telescope interferes with the received signals, affecting interference measurements. Therefore, the analysis and suppression of backscattered light are crucial issues that must be considered in the telescope. In this paper, the results of a numerical model and simulation analysis are compared to analyze the stray light performance of two existing optical design schemes for telescopes.

Effectiveness of electroacupuncture for the treatment of refractory overactive bladder disease in women: study protocol for a randomised controlled clinical trial.

Introduction: Overactive bladder (OAB) is a common condition, affecting approximately one-fifth to one-sixth of the world's population. The American Urological Association and the Society of Urodynamics, Female Pelvic Medicine and Genitourinary Reconstruction guidelines recommend sacral neuromodulation (SNM) as third-line treatment. Although SNM can relieve the symptoms of refractory OAB, several factors, including high cost and the high incidence of adverse effects, limit its large-scale clinical use.

Spatial differences and formation mechanisms of innovation ecosystem dynamic operational efficiency along the yellow river.

To scientifically evaluate the dynamic operational efficiency, spatial differences, as well as the formation mechanisms of the urban Innovation Ecosystem within the Yellow River Basin is highly important for the high-quality development of China. In the present research, both the economic circulation theory with the Innovation Ecosystem and the Data Envelopment Analysis - Malmquist Productivity Index (DEA-Malmquist) model were adopted to analysis the database from 59 cities along the Yellow River Basin. In parallel, the kernel density estimation, the Gini coefficient, and Panel Vector Autoregression (PVAR) model were applied for further comparison.

PRAP1 regulates colorectal cancer cell proliferation and ferroptosis through the Nrf2 signaling pathway.

Background: Colorectal cancer (CRC) is a common type of cancer that impacts the digestive tract, and current treatment options have limitations. Studies have confirmed that ferroptosis plays a key role in CRC progression. This research sought to clarify how Proline-rich acidic protein 1 (PRAP1) influences CRC advancement and ferroptosis, and to uncover the underlying mechanisms involved.

Study on the evaluation of workface wall stability based on cloud model.

To address the uncertainty and fuzziness during conventional workface rib spalling prediction, a rating system of workface wall stability considering subjective experience factor, mechanical performance of coal mass, workface production condition, and support/surrounding rock coupling was constructed, fuzzy factors such as the number of cracks, crack distribution, and feedback of wall/roof tapping were analyzed systematically and quantitatively based on the long-term inspection experience of coal mine safety inspectors, and rating criteria of workface wall stability were established; the AHP-CRTIC-Game Theory integrated weighting method was used to determine the optimized overall weight. Additionally, the normal cloud model was used to determine the workface wall stability level. The application of this model in the Workface 25,221 of a mine in Xinjiang, China revealed that the workface wall stability was at Level III, suggesting an unstable condition, which was consistent with the on-site observations.

Gold nanoparticles/Cu decorated metal-organic frameworks for synergistic photodynamic/ferroptosis cancer therapy.

Photodynamic therapy (PDT) holds promise for cancer treatment by generating reactive oxygen species via photosensitizers (PSs) activated by specific wavelengths of light. However, the poor water solubility of PSs and the tumor microenvironment, characterized by high glutathione (GSH) levels and hypoxia, limit its efficacy against hypoxic tumors. To overcome these challenges, we developed a novel nano-reactor, Zr(Cu)-MOF@Au@DHA, to augment PDT-ferroptosis therapy.

Influence of interface sawtooth angle on the shear behavior of cement mortar coal composite structure.

The influence of interface morphology is of great importance on the shear behavior of the cement mortar-coal composite structure (CCCS) widely distributed in underground mines. In the present research, both the macroscopic- and microscopic failure characteristics of the CCCS with variable interface sawtooth angles (i.e.

Study on molecular structural heterogeneity of tar-rich coal based on micro-FTIR.

The coal molecular structure in micro-areas plays a critical role in matrix thermal conduction and volatile generation during the pyrolysis of tar-rich coal. However, as a major maceral contributing to hydrocarbon generation, the molecular structures of different micro-areas in vitrinite show heterogeneity, which still lacks research. Micro-FTIR technology was used in this study to characterize the molecular structure in different micro-areas of tar-rich coal with varying tar yields.

Overburden movement law in strip filling mining of upward mining faces.

Strip filling mining significantly improves coal recovery rates and fosters sustainable development in the coal industry. To investigate the overburden movement patterns of strip filling mining, a mine in Tuokexun was selected as the study site. The stability of the composite structure in upward mining faces, as well as the stress distribution and fracture characteristics of the overburden at different stages of strip filling mining, were analyzed using theoretical methods, numerical simulations, and similarity experiments.

Niraparib Enhances and Synergizes with Ganglioside GD2 to Potentiate its Inhibitory Effect on Bladder Cancer Cells.

Purpose: This study aimed to study the inhibitory effect of niraparib alone or in combination with GD2 specific antibody on Bladder Cancer (BCa).

Methods: The migration ability of BCa cells was assessed through a scratch assay. CCK-8 assay was performed to evaluate the viability of BCa cells, and Transwell invasion assays were utilized to examine invasive capacity.

PCB plug-in solder joint defect detection method based on coordinated attention-guided information fusion.

Printed Circuit Boards (PCBs) are the foundational component of electronic devices, and the detection of PCB defects is essential for ensuring the quality control of electronic products. Aiming at the problem that the existing PCB plug-in solder defect detection algorithms cannot meet the requirements of high precision, low false alarm rate, and high speed at the same time, this paper proposes a method based on spatial convolution pooling and information fusion. Firstly, on the basis of YOLOv3, an attention-guided pyramid structure is used to fuse context information, and multiple convolutions of different size are used to explore richer high-level semantic information; Secondly, a coordinated attention network structure is introduced to calibrate the fused pyramidal feature information, highlighting the important feature channels, and reducing the adverse impact of redundant parameters generated by feature fusion; Finally, the ASPP (Atrous Spatial Pyramid Pooling) structure is implemented in the original Darknet53 backbone feature extraction network to acquire multi-scale feature information of the detection targets.

A novel compound heterozygous PCDH15 variants is associated with arRP in a Chinese pedigree.

Background: Retinitis pigmentosa (RP) is a heterogeneous group of inherited retinal diseases. However, it is still not well understand about the relationship between PCDH15 variants and RP.

Methods: In this study, we enrolled a Chinese autosomal recessive retinitis pigmentosa (arRP) pedigree and identified the causative gene in the proband by targeted whole exome sequencing (WES).

Semi-Kinematic Coupling Design and Analysis for Giant Steerable Science Mirror Prototype of Thirty Meter Telescope.

The Giant Steerable Science Mirror prototype is being developed to assess the tertiary mirror system of the Thirty Meter Telescope. In this study, a new semi-kinematic coupling design is proposed for the prototype based on three pairs of V-grooves and canoe-like components to allow for high repeatability accuracy under heavy loads. A mathematical model was constructed to estimate the repeatability accuracy using the corresponding measurement results and machining errors.

Effect of acupuncture on quality of life in patients with chronic prostatitis/chronic pelvic pain syndrome: a randomized controlled trial.

Objectives: To observe the effect and safety of acupuncture on quality of life, pain, and prostate symptoms in patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).

Methods: Seventy patients with CP/CPPS were randomly divided into an acupuncture group (35 cases, 1 case was eliminated) and a sham acupuncture group (35 cases, 3 cases dropped out). The patients in the acupuncture group were treated with routine acupuncture at bilateral Zhongliao (BL 33), Huiyang (BL 35), Shenshu (BL 23) and Sanyinjiao (SP 6), while the patients in the sham acupuncture group were treated with shallow needling at non-meridian and non-acupoint points beside bilateral Zhongliao (BL 33), Huiyang (BL 35), Shenshu (BL 23) and Sanyinjiao (SP 6),without manipulation to induce arrival of ().

Oxygen Vacancy-Rich Bimetallic Au@Pt Core-Shell Nanosphere-Functionalized Electrospun ZnFeO Nanofibers for Chemiresistive Breath Acetone Detection.

Sensitive and selective acetone detection is of great significance in the fields of environmental protection, industrial production, and individual health monitoring from exhaled breath. To achieve this goal, bimetallic Au@Pt core-shell nanospheres (BNSs) functionalized-electrospun ZnFeO nanofibers (ZFO NFs) are prepared in this work. Compared to pure NFs-650 analogue, the ZFO NFs/BNSs-2 sensor exhibits a stronger mean response (3.

Sex-related differences in SIRT3-mediated mitochondrial dynamics in renal ischemia/reperfusion injury.

The prevalence of renal ischemia/reperfusion injury (IRI) in premenopausal women is considerably lower than that in age-matched men. This suggests that sex-related differences in mitochondrial function and homeostasis may contribute to sexual dimorphism in renal injury, though the mechanism remains unclear. Mouse model of unilateral left renal IRI with contralateral kidney enucleation, Ovariectomy in female mice, and a human embryonic kidney (HEK) cell model of hypoxia-reoxygenation were used to study how estrogen affects the sexual dimorphism of renal IRI through SIRT3 in vitro and in vivo, respectively.

Analysis of alignment requirements for off-axis resonant cavity based on coupling efficiency.

The optical path length stability of the off-axis four-reflection telescope is one of the key technical indicators for the TianQin gravitational wave detection system. In the MHz observation band, the telescope must exhibit an optical path length stability of 0.4 / .

Acute renal failure after kidney transplantation due to mizoribine-induced ureteral stones.

Introduction: Mizoribine (MZR) is used to prevent rejection reactions after kidney transplantation and increase the risk of hyperuricemia. There is a lack of reports of MZR-induced ureteral stones after kidney transplantation. The surgery treatment of ureteral stones in transplanted kidney is a challenging clinical issue that should only be performed by experienced urologists at professional centers.

Rapid calculation method for backscattered light of a space gravitational-wave detection telescope.

Stray light is a key issue that must be considered in the TianQin telescope. To solve the problem of a long simulation time and the inability of the simulation results to be fed back to guide the optical design, we propose a fast estimation method for stray light based on the FOV with high accuracy. Compared to other models, the error between our model and the software simulation results is smaller, within one order of magnitude.

Alkalized Cellulose Nanofiber-Interweaved PEDOT:PSS Thin-Film Sensors via Layer-by-Layer Spraying Assembly for Ultrafast Molecular Ammonia Detection.

As a typical representative of conductive polymers (CPs), poly(3,4-ethylenedioxythiophene): polystyrenesulfonate (PEDOT:PSS) is intensively employed for chemiresistive ammonia (NH) sensing on account of its favorable aqueous solubility, benign environmental stability, and outstanding room-temperature conductivity; however, it is severely plagued by low sensitivity and sluggish reaction kinetics. To circumvent these limitations, the guest-alkalized cellulose nanofibers (AC) were introduced into the host PEDOT:PSS matrix by the layer-by-layer spraying assembly method (LBLSA) in this work. The componential proportion-optimized PEDOT:PSS/AC/PEDOT:PSS (P/AC/P) sensor delivered a large sensitivity of 20.

Visual impairment and blindness caused by retinal diseases: A nationwide register-based study.

Background: Retinal disorders cause substantial visual burden globally. Accurate estimates of the vision loss due to retinal diseases are pivotal to inform optimal eye health care planning and allocation of medical resources. The purpose of this study is to describe the proportion of visual impairment and blindness caused by major retinal diseases in China.

Chloroform-infiltrated photonic crystal fiber with high-temperature sensitivity.

The temperature sensor is the core part of the temperature measurement instrument, and its performance directly determines the temperature measurement accuracy. Photonic crystal fiber (PCF) is a new type of temperature sensor with extremely high potential. In this paper, we propose a high-performance, structurally simple, liquid-filled PCF temperature sensor, which is based on a SMF-PCF-SMF (single mode fiber, SMF) sandwich structure.