Research progress on the advantages, mechanisms and design strategies of nanomaterials for immunomodulatory angiogenesis.

Owing to the difficulty in achieving effective and timely vascularization, repairing the structure and function of damaged tissues and organs remains a major challenge in clinical practice. The immune microenvironment is a key factor affecting angiogenesis; however, traditional strategies have failed to take full advantage of this property. Recent advances in nanomaterial design have shifted from "immune avoidance" to "immune interaction", representing a breakthrough in promoting angiogenesis.

ShiftKD: Benchmarking knowledge distillation under distribution shift.

Knowledge Distillation (KD) transfers knowledge from large models to small models and has recently achieved remarkable success. However, the reliability of existing KD methods in real-world applications, especially under distribution shift, remains underexplored. Distribution shift refers to the data distribution drifts between the training and testing phases, and this can adversely affect the efficacy of KD.

Effects of microbe-derived antioxidants on growth performance, hepatic oxidative stress, mitochondrial function and cell apoptosis in weaning piglets.

Background: Weaning causes redox dyshomeostasis in piglets, which leads to hepatic oxidative damage. Microbe-derived antioxidants (MA) have great potential for anti-oxidation. This study aimed to investigate changes in hepatic redox system, mitochondrial function and apoptosis after weaning, and effects of MA on growth performance and liver health in weaning piglets.

Facile, green and scalable synthesis of single-layer manganese dioxide nanosheets and its application for GSH and cTnI colorimetric detection.

Manganese dioxide (MnO) nanosheets possess unique physical and chemical properties, making them widely applicable in various fields, such as chemistry and biomedicine. Although MnO nanosheets are produced using bottom-up wet chemistry synthesis methods, their scale is below the gram level and requires a long processing time, restricting their effective scale-up from laboratory to market. We report a facile, green and scalable synthesis of MnO nanosheets by mixing Shiranui mandarin orange juice and KMnO for 30 minutes.

Proangiogenic effect and underlying mechanism of holmium oxide nanoparticles: a new biomaterial for tissue engineering.

Background: Early angiogenesis provides nutrient supply for bone tissue repair, and insufficient angiogenesis will lead tissue engineering failure. Lanthanide metal nanoparticles (LM NPs) are the preferred materials for tissue engineering and can effectively promote angiogenesis. Holmium oxide nanoparticles (HNPs) are LM NPs with the function of bone tissue "tracking" labelling.

Associations between pan-immune-inflammation value and abdominal aortic calcification: a cross-sectional study.

Background: Abdominal aortic calcification (AAC) pathogenesis is intricately linked with inflammation. The pan-immune-inflammation value (PIV) emerges as a potential biomarker, offering reflection into systemic inflammatory states and assisting in the prognosis of diverse diseases. This research aimed to explore the association between PIV and AAC.

Stress Distribution Prediction of Circular Hollow Section Tube in Flexible High-Neck Flange Joints Based on the Hybrid Machine Learning Model.

The flexible high-neck flange is connected to the circular hollow section (CHS) tube through welding, and the placement of the weld seam and corresponding stress concentration factor (SCF) are crucial determinants of the joint's fatigue performance. In this study, three hybrid models combining ant colony optimization (ACO), a genetic algorithm (GA), and grey wolf optimization (GWO) with a random forest (RF) model were developed to predict the stress distribution on the inner and outer walls of the CHS tube under different flange parameter combinations. To achieve this, an automated finite element (FE) analysis program for flexible high-neck flange joints was initially developed based on ABAQUS 2020 software.

Association between the presence and genotype of and periodontitis.

Whether () infection is associated with periodontitis has been contested for decades. The relationship between genotypes and periodontitis has not been clarified either. The present study provides a novel perspective to better understand the role of in the pathogenesis of periodontitis.

Crucial role of the transcription factors family activator protein 2 in cancer: current clue and views.

The transcription factor family activator protein 2 (TFAP2) is vital for regulating both embryonic and oncogenic development. The TFAP2 family consists of five DNA-binding proteins, including TFAP2A, TFAP2B, TFAP2C, TFAP2D and TFAP2E. The importance of TFAP2 in tumor biology is becoming more widely recognized.

RhoA/ROCK1 regulates the mitochondrial dysfunction through Drp1 induced by Porphyromonas gingivalis in endothelial cells.

Porphyromonas gingivalis (P. gingivalis) is a pivotal pathogen of periodontitis. Our previous studies have confirmed that mitochondrial dysfunction in the endothelial cells caused by P.

A Corpus-Driven Study on Three Elements of Third Personal Pronoun Endophora in English Abstracts of Chinese and Foreign Theses.

The corpus is applied to compare and analyze three elements of the third personal pronoun endophora in English abstracts of Chinese and foreign theses. It is discovered that there is no significant difference in the total frequency of third personal pronoun endophora used by Chinese and foreign masters, but there is a significant difference in three elements of third personal pronoun endophora. Native Chinese-speaking masters tend to choose "it" as the anaphor, while native English-speaking masters are inclined to select "them" as the anaphor; antecedents used by native Chinese-speaking masters are mostly consistent with keywords of theses, while antecedents used by native English-speaking masters are rarely consistent with keywords of theses; distances between antecedents and anaphors set by native Chinese-speaking masters are much longer than those set by native English-speaking masters.

Porphyromonas gingivalis infection promotes mitochondrial dysfunction through Drp1-dependent mitochondrial fission in endothelial cells.

Porphyromonas gingivalis (P. gingivalis), a key pathogen in periodontitis, has been shown to accelerate the progression of atherosclerosis (AS). However, the definite mechanisms remain elusive.

Study on Deposition Characteristics of Microparticles in Terminal Pulmonary Acini by IB-LBM.

As an indicator of health risk, the deposition of microparticles in terminal pulmonary acini is of great significance in the medical field. To control particulate pollution and optimize aerosol delivery, it is necessary to perform an in-depth study of the microparticle deposition in terminal pulmonary acini; however, little research has been done on this topic. This paper proposes a respiratory movement model of terminal pulmonary acini using an immersed boundary-lattice Boltzmann method.

Correction: Wang et al. Parametric Formula for Stress Concentration Factor of Fillet Weld Joints with Spline Bead Profile. 2020, , 4639.

The authors wish to revise the following from pages 16-18 in the text of Appendix B [...

Correction: Wang et al. Generalized SCF Formula of Out-Of-Plane Gusset Welded Joints and Assessment of Fatigue Life Extension by Additional Weld. 2021, , 1249.

The authors wish to revise in the text of Appendix A, pages 19-21 [...

A Deep Look into the Program of Rapid Tumor Growth of Hepatocellular Carcinoma.

Background And Aims: Great efforts have been made towards increasing our understanding of the pathogenesis involved in hepatocellular carcinoma (HCC), but the rapid growth inherent to such tumor development remains to be explored.

Methods: We identified distinct gene coexpression modes upon liver tumor growth using weighted gene coexpression network analysis. Modeling of tumor growth as signaling activity was employed to understand the main cascades responsible for the growth.

Parametric Formula for Stress Concentration Factor of Fillet Weld Joints with Spline Bead Profile.

The existing parametric formulae to calculate the notch stress concentration factor of fillet welds often result in reduced accuracy due to an oversimplification of the real weld geometry. The present work proposes a parametric formula for the evaluation of the notch SCF based on the spline weld model that offers a better approximation of the real shape of the fillet weld. The spline model was adopted in FE analyses on T-shape joints and cruciform joints models, under different loading conditions, to propose a parametric formula for the calculation of the SCF by regression analysis.

Periodontal disease and Helicobacter pylori infection in oral cavity: a meta-analysis of 2727 participants mainly based on Asian studies.

Objectives: To assess the association between periodontal disease and Helicobacter pylori (H. pylori) infection in oral cavity.

Materials And Methods: We searched PubMed, Embase, Web of Science, Cochrane library, Gray literature, and clinicaltrials.

Parametric Formulae for Elastic Stress Concentration Factor at the Weld Toe of Distorted Butt-Welded Joints.

The evaluation of the stress concentration factor (SCF) at the notches of welds is of importance, especially for butt-welded joints that are widespread in the industry. Some empirical formulae can be found in the literature to estimate the SCF at the weld toes of butt-welded joints, while few solutions are available for the distorted joints under tensile fatigue test conditions. In the present study, the existing SCF formulae for butt-welded joints loaded in tension are examined and discussed.

Influence of Scanning on Nano Crystalline -Ti Alloys Fabricated by Selective Laser Melting and Their Applications in Biomedical Science.

The present study focuses on the microstructural and bioactive properties evolution in selective laser melting (SLM) titanium alloys. We have applied cross-scan strategy for improving mechanical properties and lower elastic modulus of SLMed Ti-20Mg-5Ta alloys which has been shown to be altering the microstructure and refining the grain size. The cross-scan strategy can refine the microstructure and induce various deformation textures in contrast to the conventional scan strategy.