HISTONE LACTYLATION IN IMMUNE CELLS AND ITS PREDICTIVE ROLE IN SEPSIS PROGRESSION: A PROSPECTIVE OBSERVATIONAL STUDY.

Background: Sepsis, a life-threatening condition caused by infection, induces dysregulated immune responses. Lactylation is a lactate-derived post-translational modification with roles in various cellular processes. We investigated lactylation levels in the immune cells of patients with sepsis and evaluated their association with disease progression.

Diabetes and periodontitis: the role of a high-glucose microenvironment in periodontal tissue cells and corresponding therapeutic strategies.

Background: Periodontitis is a chronic inflammatory disease that leads to the destruction of periodontal tissues and diabetes is a metabolic disease characterized by hyperglycemia. Both of these diseases affect many people worldwide. Epidemiological data have revealed a close relationship between periodontitis and diabetes.

Treadmill Exercise-Induced RNA m6A Methylation Modification in the Prevention of High-Fat Diet-Induced MASLD in Mice.

Exercise is a well-recognized non-pharmacological strategy for preventing and managing metabolic dysfunction-associated steatotic liver disease (MASLD, formerly known as NAFLD). While the benefits of exercise are thought to involve epigenetic mechanisms, the precise role of RNA m6A methylation remains unclear. This study investigates how treadmill exercise modulates RNA m6A methylation to prevent MASLD in a high-fat diet (HFD)-induced mouse model.

Distributed formation control for port-Hamiltonian multi-agent systems by average state estimation.

In recent years, propelled by the rapid development of information technology and the Internet, the formation control of multi-agent systems has gradually emerged as a research hotspot. This paper focuses on the formation control problem of multi-agent mechanical systems with port-Hamiltonian (PH) dynamics. Firstly, the formation problem is converted into an optimization problem whose solution meets the formation requirements.

Quantitative evaluation of cellulose swelling and dissolution behavior by monitoring the retention of NMMO solvent in cellulose fiber structure.

The swelling performance of the biological macromolecules of cellulose in aqueous N-methyl-morpholine-N-oxide (NMMO) solution is a critical factor in improving cellulose dissolution efficiency during lyocell process. We focused on the diffusion behavior of NMMO solvent during cellulose swelling and dissolution process using a novel centrifugation method, clarifying the relationship between NMMO retention value, fiber structural properties, and dissolution efficiency. An effective quantitative index for evaluating the swelling performances of cellulose is NMMO-retention, which was defined by investigating the removal of aqueous NMMO solution from swollen cellulose fibers using centrifugal method.

Insight on dissolution performance of high purity cellulose in N-methyl morpholine-N-oxide aqueous solution with assistance of ultrasonication treatment.

Cellulose dissolution is a critical parameter in cellulose-derived material production. N-methyl morpholine-N-oxide (NMMO) aqueous solution is a green solvent used to dissolve cellulose, while ultrasonication treatment is one of potential ways to enhance cellulose dissolution in it. In this work, with acetic acid/diethylenetriaminepentaacetic acid-purified dissolving pulp, one kind of high purity cellulose as raw material, pore-expanding effect of different ultrasonication treatment conditions was explored, and their influences on uniform penetration and diffusion of NMMO were investigated from both macroscopic and microscopic perspectives.

Enhancing antioxidant and barrier properties of collagen-based films via cellulose microfibrils modification with tannic acid-Fe complex.

Herein, we present a novel collagen-based packaging film that exhibits remarkable antioxidant activity, outstanding oxygen barrier properties, and exceptional mechanical strength. This film was developed by incorporating a combination of cellulose microfibrils (CMF) with modification of the metal-polyphenol network (MPN). The novelty lies in the application of CF with natural, layered, biodegradable, and renewable properties as a substrate and in situ loading of CMF-MPN complex to solve the problems of poor barrier and mechanical properties of CF, meeting the requirements of high antioxidant capacity, mechanical strength, and barrier properties in the food packaging field.

Physical exercise and epigenetic modifications in skeletal muscle, brain, and heart.

The origins of many diseases can be traced to the dynamic interplay of genetic predispositions and environmental exposures post-birth. Epigenetic modifications have recently gained prominence as a significant mediator between genetic information and environmental factors, influencing the occurrence and progression of disease. There is a burgeoning body of evidence supports that physical exercise, acting as an external environmental stimulus, exerts a discernible impact on major epigenetic modifications, including histone modifications, DNA methylation, RNA methylation, and non-coding RNA.

Elevated levels of S100A8 and S100A9 exacerbate muscle mitochondrial fragmentation in sepsis-induced muscle atrophy.

Sepsis-induced skeletal muscle atrophy is common in septic patients with the increases risk of mortality and is associated with myocellular mitochondrial dysfunction. Nevertheless, the specific mechanism of sepsis muscle atrophy remains unclear. Here we conducted a clinical retrospective analysis and observed the elevation of skeletal muscle index (ΔSMI) was an independent risk factor for 60-day mortality in septic patients.

Tear glucose is associated with the presence and severity of diabetic retinopathy.

Purpose: To examine the association between tear glucose (TG) and the presence and severity of diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM).

Methods: A cross-sectional study. TG was examined by rapid qualitative test strip in 160 patients.

Impact of digital device utilization on public health surveillance to enhance city resilience during the public health emergency response: A case study of SARS-CoV-2 response in Thailand (2020-2023).

Objective: This study aims to examine the impact of digital devices on public health surveillance, the impact of public health surveillance on resilient cities, and the impact of digital devices on resilient cities.

Methods: Questionnaires were issued to residents of Thailand during the severe acute respiratory syndrome coronavirus 2 response (2020-2023). In total, 1025 valid responses were recorded from Thai nationals and expatriates.

Ru single-atom nanozymes targeting ROS-ferroptosis pathways for enhanced endometrial regeneration in intrauterine adhesion therapy.

Intrauterine adhesion (IUA) presents a significant challenge in gynecology, characterized by excessive fibrosis and compromised reproductive function, leading to severe infertility. Although biocompatible hydrogels integrated with stem cells offer a promising approach for IUA therapy, clinical applications remain limited. Recent studies have highlighted the role of ferroptosis and reactive oxygen species (ROS) in IUA pathogenesis, yet strategies targeting ferroptosis through antioxidant stress are underexplored.

Giant viruses as reservoirs of antibiotic resistance genes.

Nucleocytoplasmic large DNA viruses (NCLDVs; also called giant viruses), constituting the phylum Nucleocytoviricota, can infect a wide range of eukaryotes and exchange genetic material with not only their hosts but also prokaryotes and phages. A few NCLDVs were reported to encode genes conferring resistance to beta‑lactam, trimethoprim, or pyrimethamine, suggesting that they are potential vehicles for the transmission of antibiotic resistance genes (ARGs) in the biome. However, the incidence of ARGs across the phylum Nucleocytoviricota, their evolutionary characteristics, their dissemination potential, and their association with virulence factors remain unexplored.

Hydrochromic and piezochromic dual-responsive optical film derived from poloxamer and ethyl cellulose for visual fingerprints identification.

Developing new materials that could identify fingerprint using the naked eye and observe the level 3 microscopic details is challenging. Here, we designed a novel hydrochromic and piezochromic dual-responsive optical film, which achieved the visual transparency transition. The performances of hydrochromic and piezochromic responses from high transparency to opaque whiteness were attributed to the introduction of poloxamer.

A Ligand-Directed Spatial Regulation to Structural and Functional Tunability in Aggregation-Induced Emission Luminogen-Functionalized Organic-Inorganic Nanoassemblies.

Aggregation-induced emission luminogen (AIEgen)-functionalized organic-inorganic hybrid nanoparticles (OINPs) are an emerging category of multifunctional nanomaterials with vast potential applications. The spatial arrangement and positioning of AIEgens and inorganic compounds in AIEgen-functionalized OINPs determine the structures, properties, and functionalities of the self-assembled nanomaterials. In this work, a facile and general emulsion self-assembly tactic for synthesizing well-defined AIEgen-functionalized OINPs is proposed by coassembling alkane chain-functionalized inorganic nanoparticles with hydrophobic organic AIEgens.

Hidden diversity and potential ecological function of phosphorus acquisition genes in widespread terrestrial bacteriophages.

Phosphorus (P) limitation of ecosystem processes is widespread in terrestrial habitats. While a few auxiliary metabolic genes (AMGs) in bacteriophages from aquatic habitats are reported to have the potential to enhance P-acquisition ability of their hosts, little is known about the diversity and potential ecological function of P-acquisition genes encoded by terrestrial bacteriophages. Here, we analyze 333 soil metagenomes from five terrestrial habitat types across China and identify 75 viral operational taxonomic units (vOTUs) that encode 105 P-acquisition AMGs.

Incorporation of Decidual Stromal Cells Derived Exosomes in Sodium Alginate Hydrogel as an Innovative Therapeutic Strategy for Advancing Endometrial Regeneration and Reinstating Fertility.

Intrauterine adhesion (IUA) stands as a prevalent medical condition characterized by endometrial fibrosis and scar tissue formation within the uterine cavity, resulting in infertility and, in severe cases, recurrent miscarriages. Cell therapy, especially with stem cells, offers an alternative to surgery, but concerns about uncontrolled differentiation and tumorigenicity limit its use. Exosomes, more stable and immunogenicity-reduced than parent cells, have emerged as a promising avenue for IUA treatment.

Inadvertent perioperative hypothermia and surgical site infections after liver resection.

Background: In the overall surgical population, inadvertent perioperative hypothermia has been associated with an increased incidence of surgical site infection (SSI). However, recent clinical trials did not validate this notion. This study aimed to investigate the potential correlation between inadvertent perioperative hypothermia and SSIs following liver resection.

Melatonin alleviates valproic acid-induced neural tube defects by modulating Src/PI3K/ERK signaling and oxidative stress.

Neural tube defects (NTDs) represent a developmental disorder of the nervous system that can lead to significant disability in children and impose substantial social burdens. Valproic acid (VPA), a widely prescribed first-line antiepileptic drug for epilepsy and various neurological conditions, has been associated with a 4-fold increase in the risk of NTDs when used during pregnancy. Consequently, urgent efforts are required to identify innovative prevention and treatment approaches for VPA-induced NTDs.

Safe control of logical control networks with random impulses.

Under the framework of a hybrid-index model, this paper investigates safe control problems of state-dependent random impulsive logical control networks (RILCNs) on both finite and infinite horizons, respectively. By using the ξ-domain method and the constructed transition probability matrix, the necessary and sufficient conditions for the solvability of safe control problems have been established. Further, based on the technique of state-space partition, two algorithms are proposed to design feedback controllers such that RILCNs can achieve the goal of safe control.

Analysis and validation of diagnostic biomarkers and immune cell infiltration characteristics in pediatric sepsis by integrating bioinformatics and machine learning.

Background: Pediatric sepsis is a complicated condition characterized by life-threatening organ failure resulting from a dysregulated host response to infection in children. It is associated with high rates of morbidity and mortality, and rapid detection and administration of antimicrobials have been emphasized. The objective of this study was to evaluate the diagnostic biomarkers of pediatric sepsis and the function of immune cell infiltration in the development of this illness.

Mechanochromic Self-Healing Materials with Good Stretchability, Shape Memory Behavior, Cyclability, and Reversibility Based on Multiple Hydrogen Bonds.

It is challenging to develop materials with room-temperature self-healing ability and mechanochromic response from mechanical stimuli to optical signals by a facile and simple preparation process. Herein, novel mechanochromic self-healing materials were designed by a simple synthesis procedure, balancing the mechanical properties, self-healing, stretchability, and mechanochromic response. Moreover, we designed and prepared the mechanochromic self-healing materials with different soft and hard segments by introducing multiple hydrogen bonds into the network, improving the mechanical properties and self-healing efficiency.

A signature of immune-related genes correlating with clinical prognosis and immune microenvironment in sepsis.

Background: Immune-related genes (IRGs) remain poorly understood in their function in the onset and progression of sepsis.

Methods: GSE65682 was obtained from the Gene Expression Omnibus database. The IRGs associated with survival were screened for subsequent modeling using univariate Cox regression analysis and least absolute shrinkage and selection operator in the training cohort.