Unveiling the polarization switching pathway through tetragonal phase as a metastable intermediate state in ferroelectric HfZrO thin film.

The polarization switching pathway in HfZrO-based ferroelectric thin film is still not well clarified and agreed, limiting the fundamental physical understanding and performance engineering. The key question lies in clarifying the transient intermediate state during the polarization switching of orthorhombic phase. In this work, by designing the ferroelectric and dielectric stacks, we theoretically and experimentally demonstrate a polarization switching pathway through an orthorhombic-tetragonal-orthorhombic phase transition in ferroelectric HfZrO where the non-polar tetragonal phase is metastable.

: A Novel Target in Intrahepatic Cholangiocarcinoma and its Role in Modulating Tumor Behavior.

Background: Intrahepatic cholangiocarcinoma (ICC) is a primary liver cancer typically diagnosed at advanced stages, limiting treatment options and reducing survival rates. Targeted therapy presents a promising strategy to improve outcomes. This study aims to identify novel molecular biomarkers influencing ICC development and explore their roles in tumor progression.

Magnetic Bioadhesive for Tumor Therapy: Synergistic Magnetothermal and Chemodynamic Effects.

Therapeutic bioadhesives with injectability, strong adhesion, magnetothermal responsiveness, sustained efficacy, and biosafety are desired for in situ deep-tumor eradication but remain underexplored. Here, injectable magnetic bioadhesives are developed via physical condensation of zein, poly-lysine (PLL), and FeO nanoparticles. Pre-encapsulated genipin within the resulting zein/PLL/FeO adhesives regulates covalent cross-linking both at the tissue-adhesive interface and within the matrix, enabling the adhesives to achieve self-reinforced tissue adhesion (111.

Sustainable Protein to Generate High-Strength and Durable All-Underwater Adhesive via Physical Condensation Boosting Chemical Cross-linking.

Designing high-performance protein adhesives for hard tissue applications remains challenging. Here, we present a physical condensation boosting chemical cross-linking strategy to produce a high-performance all-underwater adhesive composed of corn-derived zein, genipin, and poly(l-lysine). Physical condensation between anionic zein colloids and cationic poly(l-lysine) generates a soft adhesive.

Hidden structural phase transition assisted ferroelectric domain orientation engineering in HfZrO films.

The polarization of HfO-based ferroelectrics originates from the metastable orthorhombic phase formed during the tetragonal to monoclinic phase transition and is typically controlled by tuning the phase content. However, another way to control polarization via modulating ferroelectric domain orientations remains underexplored. This work uncovers a hidden tetragonal-orthorhombic phase transition pathway to engineer domain orientations and further polarization in polycrystalline HfZrO using single-crystalline TiN substrates.

Are There High-Density Deep States in an Atomic-Layer-Deposited Indium-Gallium-Zinc Oxide Thin Film?

It has been well recognized that high-density deep states exist in indium-gallium-zinc oxide (IGZO) thin films. Many of the device characteristics of IGZO transistors, such as negative bias illumination stability (NBIS), are understood to be related to these deep states. However, in this work, it was found that the deep-state density () of atomic-layer-deposited (ALD) IGZO transistors can be an ultralow value (<2.

A Dynamic Covalent Organic Framework with Entangled 2D Layers.

Dynamic covalent organic frameworks (COFs) represent an emerging class of porous materials with an inherent structural flexibility. However, due to the challenges in their synthesis and structural characterization, research on dynamic COFs remains at an early stage and requires further exploration. Herein, we report the designed synthesis of a novel COF with entangled 2D layers that exhibits interesting dynamic behavior in response to organic vapor exposure.

Optimal low-depth quantum signal-processing phase estimation.

Quantum effects like entanglement and coherent amplification can be used to drastically enhance the accuracy of quantum parameter estimation beyond classical limits. However, challenges such as decoherence and time-dependent errors hinder Heisenberg-limited amplification. We introduce Quantum Signal-Processing Phase Estimation algorithms that are robust against these challenges and achieve optimal performance as dictated by the Cramér-Rao bound.

Predicting very early recurrence in intrahepatic cholangiocarcinoma after curative hepatectomy using machine learning radiomics based on CECT: A multi-institutional study.

Background: Even after curative resection, the prognosis for patients with intrahepatic cholangiocarcinoma (iCCA) remains disappointing due to the extremely high incidence of postoperative recurrence.

Methods: A total of 280 iCCA patients following curative hepatectomy from three independent institutions were recruited to establish the retrospective multicenter cohort study. The very early recurrence (VER) of iCCA was defined as the appearance of recurrence within 6 months.

Advanced renal pelvis carcinoma patient with an ERBB2 insertion mutation: a case report.

The prognosis of renal pelvis cancer is poor and therapeutic options are limited, especially for patients with advanced disease. In this report, we present a case of advanced renal pelvis carcinoma in a male patient in his 60s, characterized by an activating mutation in . Clinical evaluation resulted in a pathological diagnosis of renal pelvis carcinoma with liver metastasis.

Impact of sarcopenia on postoperative outcomes after hepatectomy in older patients with intrahepatic cholangiocarcinoma: A multicentre cohort study.

Background And Aims: Sarcopenia is associated with poor prognosis, but its role in older patients with intrahepatic cholangiocarcinoma (ICC) is unclear. We aimed to evaluate the impact of sarcopenia on the prognosis of older patients with ICC undergoing hepatectomy.

Methods: A total of 363 patients with ICC following hepatectomy from 2015 to 2021 were retrospectively reviewed at five institutions.

Clinical and biomarker analyses of sintilimab plus gemcitabine and cisplatin as first-line treatment for patients with advanced biliary tract cancer.

The prognosis of biliary tract cancer (BTC) remains unsatisfactory. This single-arm, phase II clinical trial (ChiCTR2000036652) investigated the efficacy, safety, and predictive biomarkers of sintilimab plus gemcitabine and cisplatin as the first-line treatment for patients with advanced BTCs. The primary endpoint was overall survival (OS).

Prediction of Response to Lenvatinib Monotherapy for Unresectable Hepatocellular Carcinoma by Machine Learning Radiomics: A Multicenter Cohort Study.

Purpose: We aimed to construct machine learning (ML) radiomics models to predict response to lenvatinib monotherapy for unresectable hepatocellular carcinoma (HCC).

Experimental Design: Patients with HCC receiving lenvatinib monotherapy at three institutions were retrospectively identified and assigned to training and external validation cohorts. Tumor response after initiation of lenvatinib was evaluated.

A multi-omic approach reveals utility of CD45 expression in prognosis and novel target discovery.

CD45, the leukocyte common antigen, is expressed on almost all cells of the immunological and hematological systems. CD45 expression is related to a variety of diseases, including leukemia and lymphoma. In this study, we analyzed the expression level of CD45 across cancers and evaluated the relationship between its expression and patient prognosis.

Use of miRNA Sequencing to Reveal Hub miRNAs and the Effect of miR-582-3p/SMAD2 in the Progression of Hepatocellular Carcinoma.

Hepatocellular carcinoma is a common tumor with a high fatality rate worldwide, and exploring its pathogenesis and deterioration mechanism is a focus for many researchers. Increasing evidence has shown that miRNAs are involved in the occurrence and progression of a variety of cancers, including hepatocellular carcinoma. Therefore, this study mainly aimed identify key miRNAs related to hepatocellular carcinoma and explore their potential functions and clinical significance.

In-situ twistable bilayer graphene.

The electrical and optical properties of twisted bilayer graphene (tBLG) depend sensitively on the twist angle. To study the angle dependent properties of the tBLG, currently it is required fabrication of a large number of samples with systematically varied twist angles. Here, we demonstrate the construction of in-situ twistable bilayer graphene, in which the twist angle of the two graphene monolayers can be in-situ tuned continuously in a large range with high precision.

Direct imaging of interlayer-coupled symmetric and antisymmetric plasmon modes in graphene/hBN/graphene heterostructures.

Much of the richness and variety of physics today are based on coupling phenomena where multiple interacting systems hybridize into new ones with completely distinct attributes. Recent development in building van der Waals (vdWs) heterostructures from different 2D materials provides exciting possibilities in realizing novel coupling phenomena in a designable manner. Here, with a graphene/hBN/graphene heterostructure, we report near-field infrared nano-imaging of plasmon-plasmon coupling in two vertically separated graphene layers.

[Source Apportionment and Spatial Distribution Simulation of Heavy Metals in a Typical Petrochemical Industrial City].

Identifying the quantitative source and hazardous areas of heavy metals in soils plays a pivotal role in soil pollution research, and can provide a basis for regional soil risk monitoring and environmental management. For this purpose, a total of 175 samples were collected in topsoils from Linzi, a typical petrochemical industrial city in Shandong Province. Positive matrix factorization (PMF) and factor analysis with non-negative constraints (FA-NNC) receptor models were applied to analyze the sources of the heavy metals.

[Spatial Characteristics and Environmental Risk of Heavy Metals in Typical Gold Mining Area of Shandong Province].

In order to reveal the influence of anthropogenic factors on soil environment quality, a total of seventy-seven samples in topsoils were collected from Jiaojia gold mining area in Shandong province and were determined for Cu, Pb, Zn, Cr contents. Spatial structure, spatial distributions of concentrations and risk probability of heavy metals were analyzed using spatial statistic analysis. The average concentrations of Cu, Pb, Zn and Cr were 19.

The protective or damaging effect of Tumor necrosis factor-α in acute liver injury is concentration-dependent.

Background: Inflammatory cytokine is important in modulating injured diseases. Tumor necrosis factor-α (TNF-α), one of potent inflammatory cytokines, plays a dominant role in host defense reaction. However, the concrete effect of TNF-α on acute liver injury is totally unclear.

A review on hepatocyte nuclear factor-1beta and tumor.

Hepatocyte nuclear factor-1beta (HNF1β) was initially identified as a liver-specific transcription factor. It is a homeobox transcription factor that functions as a homodimer or heterodimer with HNF1α. HNF1β plays an important role in organogenesis during embryonic stage, especially of the liver, kidney, and pancreas.

Overexpression Of Hepatocyte Nuclear Factor-1beta Predicting Poor Prognosis Is Associated With Biliary Phenotype In Patients With Hepatocellular Carcinoma.

Hepatocyte nuclear factor-1beta (HNF-1B) is involved in the hepatobiliary specification of hepatoblasts to cholangiocytes during liver development, and is strongly expressed throughout adult biliary epithelium. The aim of this study was to examine the expression of HNF-1B in different pathologic subtypes of primary liver cancer, including hepatocellular carcinoma (HCC) and cholangiocarcinoma (ICC), and the relationship between HNF-1B expression, clinicopathological features and prognosis. We retrospectively investigated 2 cohorts of patients, including 183 HCCs and 69 ICCs.

[Effect of the Runoff-sediment Control of the Xiaolangdi Reservoir on DOC Transport].

The sampling was carried out in Sanmenxia hydrological station, Xiaolangdi hydrological station and Huayuankou hydrological station from November 2011 to October 2012. The impact of the runoff-sediment control of the Xiaolangdi reservoir on DOC transport,was analyzed. The results were as follows.

The complete mitochondrial genome of Rhodeus lighti (Cypriniformes: Cyprinidae): sequencing and analysis.

Phylogenetic placement of Rhodeus lighti (R. lighti) remains unresolved. We determined the first complete mitochondrial genome of R.