Shen Ling Bai Zhu San promotes gut IgA plasma cells to alleviate chronic diarrhea in mice via increasing systematic glutamine.

Ethnopharmacological Relevance: Shen Ling Bai Zhu San (SLBZS) is a classical Chinese herbal formula and has been used for treating chronic diarrhea (CD) for several centuries. However, there is a lack of robust evidence on how SLBZS regulates immune function to improve CD.

Aim Of The Study: To reveal the spleen-invigorating and antidiarrheal effects of SLBZS in chronic diarrhea mice induced by spleen-deficiency, as well as to explore the underlying mechanism.

Licorice Total Flavonoids and Its Gut-Enriched Synergistically Activate the Nrf2 Pathway to Alleviate Liver Injury.

Licorice ( Fisch.), a medicinal and food homologous herb, contains licorice total flavonoids (LTF) as key bioactive components with unresolved hepatoprotective mechanisms. In this study, we focused on the mechanism by which LTF improved antioxidant capacity and regulated the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway according to network pharmacology.

Evaluation of Anti-Inflammatory Effects of Six Ginsenosides and Rg1 Regulation of Macrophage Polarization and Metabolites to Alleviate Colitis.

In ginseng, several ginsenosides have been demonstrated to alleviate dextran sulfate sodium (DSS)-induced colitis, especially the six ginsenosides in this study. However, which ginsenoside has the most potent anti-inflammatory effect and may be selected as a promising candidate for the treatment of colitis remains unclear. A cell inflammation model was induced by lipopolysaccharide (LPS) for 12 h and mouse colitis was induced by sterile water containing DSS lasting seven days.

Electrocapillary Plating-An Innovative Method of Creating Nanostructures Enhances the Working Performance of Implantable Bioelectrodes.

The current optimization of implantable electrodes focuses on reducing impedance and improving anti-inflammatory properties. The fabrication of nanostructures on electrode surfaces is a promising strategy for reducing impedance while also minimizing interference from the array of immune cells that cause foreign body reactions. Electrochemical deposition is a common method for creating nanostructures.

Open-label, phase II study of talimogene laherparepvec plus pembrolizumab for the treatment of advanced melanoma that progressed on prior anti-PD-1 therapy: MASTERKEY-115.

Background: Treatment options for immunotherapy-refractory melanoma are an unmet need. The MASTERKEY-115 phase II, open-label, multicenter trial evaluated talimogene laherparepvec (T-VEC) plus pembrolizumab in advanced melanoma that progressed on prior programmed cell death protein-1 (PD-1) inhibitors.

Methods: Cohorts 1 and 2 comprised patients (unresectable/metastatic melanoma) who had primary or acquired resistance, respectively, and disease progression within 12 weeks of their last anti-PD-1 dose.

Lizhong decoction inhibits porcine epidemic diarrhea virus in vitro and in vivo.

Ethnopharmacological Relevance: Lizhong decoction (LZD) is a frequently utilized traditional Chinese remedy for diarrhea. It is unknown how effective it is as an antiviral against PEDV infection.

Aim Of The Study: In vitro and in vivo PEDV infection models were used to evaluate the anti-PEDV potential of LZD extract.

Effects of Dietary Aqueous Extract Supplementation on Growth Performance, Growth Hormone, Antioxidant and Immune Function, and Intestinal Health of Broilers.

is notably rich in flavonoids and phenylethanoid glycosides, making it a significant natural source of antioxidants. We examined the effects of aqueous extract (CNE) on growth performance, antioxidant function, immunity, intestinal barrier function, nutrient transporters, and microbiota of broilers. A total of 360 one-day-old broilers were randomly assigned to four treatment groups: a basal diet with 0 (control, CON), 300 mg/kg (CNEL), 500 mg/kg (CNEM), and 700 mg/kg (CNEH) CNE for 42 days.

Comparative genomics and phylogenomics of the genus (Fabaceae) based on chloroplast genomes.

(Fabaceae) species are rich in metabolites and widely used in medicine. Research on the chloroplast genome of is important for understanding its phylogenetics, biogeography, genetic diversity, species identification, and medicinal properties. In this study, comparative genomics and phylogenomics of were analyzed based on the chloroplast genome.

A nomogram prediction model of pseudomyxoma peritonei established based on new prognostic factors of HE stained pathological images analysis.

Background: Pseudomyxoma peritonei (PMP) is a rare clinical malignant syndrome, and its rarity causes a lack of pathology research. This study aims to quantitatively analyze HE-stained pathological images (PIs), and develop a new predictive model integrating digital pathological parameters with clinical information.

Methods: Ninety-two PMP patients with complete clinic-pathological information, were included.

Establishment of a cobia (Rachycentron canadum) gill cell line: A valuable tool for immune response studies.

Cobia (Rachycentron canadum), a commercially important marine fish, has been used to develop a novel gill cell line, designated CG, for the first time. The CG cell line was cultured in Leibovitz's-15 medium with 5% fetal bovine serum (FBS) and successfully sub-cultured more than 110 passages. It underwent verification through sequencing of the mitochondrial cytochrome C oxidase subunit I (COI) gene.

Disulfiram ameliorates STING/MITA-dependent inflammation and autoimmunity by targeting RNF115.

STING (also known as MITA) is an adaptor protein that mediates cytoplasmic DNA-triggered signaling, and aberrant activation of STING/MITA by cytosolic self-DNA or gain-of-function mutations causes severe inflammation. Here, we show that STING-mediated inflammation and autoimmunity are promoted by RNF115 and alleviated by the RNF115 inhibitor disulfiram (DSF). Knockout of RNF115 or treatment with DSF significantly inhibit systemic inflammation and autoimmune lethality and restore immune cell development in Trex1 mice and STING bone marrow chimeric mice.

Surface premelting of ice far below the triple point.

Premelting of ice, a quasi-liquid layer (QLL) at the surface below the melting temperature, was first postulated by Michael Faraday 160 y ago. Since then, it has been extensively studied theoretically and experimentally through many techniques. Existing work has been performed predominantly on hexagonal ice, at conditions close to the triple point.

[Prediction of global potential growth areas for Panax ginseng based on GMPGIS system and MaxEnt model].

The suitable habitat for the endangered and valuable medicinal herb Panax ginseng is gradually decreasing. It is crucial to investigate its suitable growing areas in China for global protection and sustainable utilization of P. ginseng.

Etiological analysis of infection after CRS + HIPEC in patients with PMP.

Background: Cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) is the standard treatment for pseudomyxoma peritonei (PMP). It can significantly prolong the survival of patients, but at the same time may increase the risk of postoperative infection.

Method: Patients with PMP who underwent CRS + HIPEC at our center were retrospectively analyzed.

Gene Losses and Homology of the Chloroplast Genomes of and Species.

Research on the chloroplast genome of parasitic plants is limited. In particular, the homology between the chloroplast genomes of parasitic and hyperparasitic plants has not been reported yet. In this study, three chloroplast genomes of (, , and ) and one chloroplast genome of () were sequenced and analyzed, among which is the host of .

Application of conventional IVF during preimplantation genetic testing for aneuploidies: a feasibility study.

Research Question: Is it feasible to apply conventional IVF to couples undergoing preimplantation genetic testing for aneuploidies (PGT-A) with non-severe male infertility?

Design: The last wash fluid of biopsied trophectoderm (TE) cells was collected for whole genome amplification (WGA). A method was developed to determine parental contamination. Using single-nucleotide polymorphism (SNP) analysis, two standard curves were established; further mixtures were used for verification.

Phylogenomic analyses based on the plastid genome and concatenated nrDNA sequence data reveal cytonuclear discordance in genus (Asteraceae: Carduoideae).

species are widely distributed across East Asia and are cultivated as medicinal herbs in China, Japan, and Korea. Their unclear morphological characteristics and low levels of genetic divergence obscure the taxonomic relationships among these species. In this study, 24 plant samples were collected representing five species of located in China; of these, 23 belonged to members of the complex.

Survival prediction by Bayesian network modeling for pseudomyxoma peritonei after cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy.

Objectives: To establish a survival prognostic model for pseudomyxoma peritonei (PMP) treated with cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) based on Bayesian network (BN).

Methods: 453 PMP patients were included from the database at our center. The dataset was divided into a training set to establish BN model and a testing set to perform internal validation at a ratio of 8:2.

Application of DNA barcoding to the entire traditional Chinese medicine industrial chain: A case study of Rhei Radix et Rhizoma.

Background: Safety concerns, caused by complex and unpredictable adulterants, run through the entire industrial chain of traditional Chinese medicines (TCMs). However, the conventional circulation traceability system only focuses on a certain end or link at the back end of the TCM industrial chain, ignoring the integrity of the links cross the entire industrial chain and lacking traceability. In consequence, a strict and rational supervision system is urgently required for the entire industrial chain.

Purcell Enhancement of Erbium Ions in TiO on Silicon Nanocavities.

Isolated solid-state atomic defects with telecom optical transitions are ideal quantum photon emitters and spin qubits for applications in long-distance quantum communication networks. Prototypical telecom defects, such as erbium, suffer from poor photon emission rates, requiring photonic enhancement using resonant optical cavities. Moreover, many of the traditional hosts for erbium ions are not amenable to direct incorporation with existing integrated photonics platforms, limiting scalable fabrication of qubit-based devices.