CMD-OPT model enables the discovery of a potent and selective RIPK2 inhibitor as preclinical candidate for the treatment of acute liver injury.

Acute liver injury (ALI) serves as a critical precursor and major etiological factor in the progression and ultimate manifestation of various hepatic disorders. The prevention and treatment of ALI is still a serious global challenge. Given the limited therapeutic options for ALI, exploring novel targeted therapeutic agents becomes imperative.

Multi-cohort validation of a lipid metabolism and ferroptosis-associated index for prognosis and immunotherapy response prediction in hormone receptor-positive breast cancer.

Hormone receptor-positive (HR+) breast cancer exhibits significant heterogeneity influenced by lipid metabolism and ferroptosis (LMF). While immune checkpoint inhibitors have shown promise in neoadjuvant therapy, as evidenced by the KEYNOTE-756 and CheckMate 7FL trials, identifying the optimal patient population remains challenging. This study aims to classify molecular clusters based on LMF-related genes and develop the LMF_index to predict prognosis and immunotherapy response in HR+ breast cancer.

Perceived stress, risk factors and prognostic monitoring loci for the development of depression.

This article examines stress and its potential role in the development of depression. By reviewing existing literature, the article explores the possible role of stress in diagnosing and monitoring depression and highlights the importance of managing personal stress in the treatment of depression. The article also discusses the many ways that stress and depression are connected, and suggests ideas for subsequent investigations.

Relationship between 21 Medications and Negative Emotions: A Mendelian Randomization Analysis in Asian Populations.

Objective: Negative emotional states, such as nervousness, anxiety, depression, and tension, exert profound detrimental effects on an individual's quality of life and overall health. Although certain widely prescribed medications have been observed to modulate these emotional states, the existing body of research in this domain remains insufficient. To address this gap, Mendelian randomization (MR) methodologies, leveraging large-scale datasets, were employed to investigate the causal relationships between 21 commonly utilized medications and the manifestation of negative emotions.

Efficacy of Virtual Reality-Based Interventions on Cognitive Function in Patients With Neuropsychiatric Disorders: Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Background: Virtual reality (VR) technology has emerged as a promising tool for cognitive rehabilitation in patients with neuropsychiatric disorders. These patients often endure significant cognitive impairments, which are associated with decreased quality of life and increased disease burden. Traditional treatments are limited in improving cognitive functions, making VR-based interventions an area of growing interest.

Characterization of a tagatose 4-epimerase and optimizing its expression for efficient D-tagatose bioconversion from fructose.

D-Tagatose is a promising functional sweetener due to its safety profile and versatile physiological effects. Recently, the bioconversion of D-tagatose from cost-effective natural resources has gained increasing attention. In this study, the hypothetical protein DRJ43_04605 from Thermoprotei archaeon, abbreviated as DRJ43-T4Ease, was identified as a tagatose 4-epimerase capable of efficiently converting d-fructose into D-tagatose.

Mining and identifying a D-mannose isomerase with high fructose isomerization activity and its expression in Bacillus subtilis for D-mannose production.

D-mannose is a functional monosaccharide with numerous positive physiological effects and holds significant commercial potential in the pharmaceutical, nutraceutical, and food industries. In this study, a hypothetical AGE family epimerase/isomerase from Stenotrophomonas maltophilia was identified and characterized as a D-mannose isomerase, named Stma-MIase, capable of efficiently converting d-fructose into D-mannose. Stma-MIase exhibited optimal activity at pH 8.

Predicting early recurrence in hepatocellular carcinoma after hepatectomy using GD-EOB-DTPA enhanced MRI-based model.

Purpose: To develop and validate a comprehensive model for predicting postoperative early recurrence of hepatocellular carcinoma (HCC) based on gadoxetate disodium (Gd-EOB-DTPA)-enhanced MRI.

Methods: 239 patients with HCC who underwent curative surgical resection were recruited from two centers between April 2017 and December 2022. Radiomics features were extracted from the region of interest (ROI) on preoperative Gd-EOB-DTPA-enhanced MR images, and consistency analysis was performed to select stable radiomics features.

Systemic immune characteristics predicting toxicity to immune checkpoint inhibitors in patients with advanced breast cancer.

Background: Immune checkpoint inhibitors (ICIs) are among the most promising treatment options for cancer. However, frequent and sometimes life-threatening immune-related adverse events (irAEs) are associated with ICI treatment. Therefore, it is imperative to establish a model for predicting the risk of irAEs to identify high-risk groups, enable more accurate clinical risk‒benefit analysis for ICI treatment and decrease the incidence of irAEs.

Integrated bulk and single-cell transcriptomic analysis unveiled a novel cuproptosis-related lipid metabolism gene molecular pattern and a risk index for predicting prognosis and antitumor drug sensitivity in breast cancer.

Breast cancer is the second most prevalent malignant tumor worldwide and is highly heterogeneous. Cuproptosis, a newly identified form of cell death, is intimately connected to lipid metabolism. This study investigated breast cancer heterogeneity through the lens of cuproptosis-related lipid metabolism genes (CLMGs), with the goal of predicting patient prognosis, immunotherapy efficacy, and sensitivity to anticancer drugs.

Predictive circulating biomarkers of the response to anti-PD-1 immunotherapy in advanced HER2 negative breast cancer.

Background: Immunotherapy shows promise for treating advanced breast cancer, but only a few patients could respond. Predictive biomarkers from peripheral blood are urgently needed.

Methods: We designed a comprehensive 42-marker mass cytometry panel to profile the peripheral blood samples from 57 patients diagnosed with advanced HER2-negative breast cancer receiving anti-PD-1 combination therapy.

Biochemical characterization and biocatalytic application of a hyperthermostable tagatose 4-epimerase from Infirmifilum uzonense.

D-Tagatose is a representative rare sugar with the physiochemical properties of low energy and high sweetness, as well as excellent physiological functions such as blood sugar regulation, enhancement of intestinal flora, and prevention of dental caries. At present, D-tagatose production involves lactose hydrolysis and D-galactose isomerization processes, resulting in high production costs that hinder its industrial advancement. Tagatose 4-epimerase (T4Ease) has the capability to directly convert d-fructose into D-tagatose through C-4 epimerization, providing a new approach for D-tagatose production.

Training and experimental validation a novel anoikis- and epithelial‒mesenchymal transition-related signature for evaluating prognosis and predicting immunotherapy efficacy in gastric cancer.

Anoikis resistance and improper activation of epithelial‒mesenchymal transition (EMT) are critical factors in tumor metastasis and progression. Despite their interaction, the combined impact of anoikis and EMT on prognosis and immunotherapy in gastric cancer remains underexplored. In this study, we identified 354 anoikis- and EMT-related genes (AERGs) through Venn analysis and performed unsupervised clustering to classify gastric cancer patients into two molecular clusters: A and B.

Comparative efficacy of anthracycline-free and anthracycline-containing neoadjuvant chemoimmunotherapy regimens for triple-negative breast cancer.

Background: The selection of appropriate chemotherapy backbone agents in combination with neoadjuvant immunotherapy for triple-negative breast cancer (TNBC) remains unclear. Herein, we aimed to evaluate the efficacy and safety of anthracycline-free and anthracycline-containing regimens coupled with neoadjuvant immunotherapy.

Method: This retrospective study included 87 patients with TBNC who received neoadjuvant immunotherapy combined with various chemotherapy regimens at three research centers from November 2020 to November 2023.

Optimization of and experimentation with a bifurcated swing tube strip fertilizer spreading device based on MBD-DEM coupling.

Introduction: To improve the utilization rate of fertilizers, realize the precise spreading of fertilizers in controllable strips, and ensure the uniformity of fertilizer spreading in both longitudinal and transversal directions, a bifurcated swing tube fertilizer spreading device driven by a spatial hammer pendulum crank mechanism was designed.

Methods: First, the drive mechanism was designed based on the cylindrical pair of the mechanism. A mathematical model pendulum equation was used to design the swing tube, and the equation of motion of fertilizer particles was established by analyzing the motion and force of fertilizer particles in fertilizer spreading.

Characterization of Runella zeae D-mannose 2-epimerase and its expression in Bacillus subtilis for D-mannose production from D-glucose.

D-Mannose 2-epimerase (MEase) catalyzes the bioconversion between D-glucose and D-mannose. It is an important potential biocatalyst for large-scale production of D-mannose, a functional monosaccharide used in pharmaceutical and food industries. In this study, a new microbial MEase was characterized from Runella zeae DSM 19591.

ER-associated degradation ligase HRD1 links ER stress to DNA damage repair by modulating the activity of DNA-PKcs.

Proteostasis and genomic integrity are respectively regulated by the endoplasmic reticulum-associated protein degradation (ERAD) and DNA damage repair signaling pathways, with both pathways essential for carcinogenesis and drug resistance. How these signaling pathways coordinate with each other remains unexplored. We found that ER stress specifically induces the DNA-PKcs-regulated nonhomologous end joining (NHEJ) pathway to amend DNA damage and impede cell death.

[Application Progress of Wearable Devices in the Field of Depression Monitoring and Intervention].

Depression's high recurrence rate and severe consequences pose significant challenges to public health. To address this issue effectively, this review explores the innovative application of wearable devices in monitoring and intervening in depression, surpassing the limitations of traditional subjective assessments and patient self-reports. The paper systematically analyzes recent studies utilizing wearable devices to monitor physiological and behavioral indicators of depression, categorizing them by different technological types and evaluating their practical effectiveness in early diagnosis and intervention.

Genetic factors in the pathogenesis of cardio-oncology.

In recent years, with advancements in medicine, the survival period of patients with tumours has significantly increased. The adverse effects of tumour treatment on patients, especially cardiac toxicity, have become increasingly prominent. In elderly patients with breast cancer, treatment-related cardiovascular toxicity has surpassed cancer itself as the leading cause of death.

Emotional differences based on comments on doctor-patient disputes with varying levels of severity.

Background: The risks associated with negative doctor-patient relationships have seriously hindered the healthy development of medical and healthcare and aroused widespread concern in society. The number of public comments on doctor-patient relationship risk events reflects the degree to which the public pays attention to such events.

Aim: To explore public emotional differences, the intensity of comments, and the positions represented at different levels of doctor-patient disputes.

Enhancing visual communication through representation learning.

Introduction: This research aims to address the challenges in model construction for the Extended Mind for the Design of the Human Environment. Specifically, we employ the ResNet-50, LSTM, and Object Tracking Algorithms approaches to achieve collaborative construction of high-quality virtual assets, image optimization, and intelligent agents, providing users with a virtual universe experience in the context of visual communication.

Methods: Firstly, we utilize ResNet-50 as a convolutional neural network model for generating virtual assets, including objects, characters, and environments.