Oral Pathobionts Aggravate Myocardial Infarction Through Mobilization of B2 Cells.

Background: Myocardial infarction (MI) is a high-prevalence disease that threatens human survival and quality of life worldwide. Considerable evidence has suggested that periodontitis (PD) is detrimental to MI. However, the direct impact of PD on MI is unclear; which oral pathobionts contribute to and how microbial signals regulate the pathogenesis of MI remain obscure.

Ionic Hydrogen-Bonded Organic Frameworks: A New Type of Porous Organic Solid Base.

Solid base offers advantages in terms of the ease of handling, environmentally sustainable processes, and tunable interfacial properties. Despite of these benefits, the exploration of new solid bases remains challenging and is an underdeveloped area of research. In this work, we report the discovery of the inherent basicity of hydrogen-bonded organic frameworks (HOFs).

[Effects of acupotomy therapy on macrophage polarization and inhibition of synovial inflammation in rabbits with knee osteoarthritis based on the Notch1/Jagged1/Hes1 signaling pathway].

Objectives: To observe the effects of acupotomy therapy on synovial inflammation, macrophage polarization, and protein expressions of drosophila double-wing edge notch homologous gene 1 (Notch1)/Jagged typical Notch ligand 1 (Jagged1)/Hes family BHLH transcription factor 1 (Hes1) signaling pathway, so as to explore its mechanisms underlying improvement of knee osteoarthritis (KOA).

Methods: Male New Zealand rabbits were randomly divided into the blank, model and acupotomy groups (8 rabbits in each group). The KOA model was established by immobilizing the left hind limb in an extended position using a modified Videman method with a plaster cast for 6 weeks.

Automatic detection of optic canal fractures and recognition and segmentation of anatomical structures in the orbital apex based on artificial intelligence.

Background And Objectives: Traumatic optic neuropathy (TON) caused by optic canal fractures (OCF) can result in severe visual impairment, even blindness. Timely and accurate diagnosis and treatment are crucial for preserving visual function. However, diagnosing OCF can be challenging for inexperienced clinicians due to atypical OCF changes in imaging studies and variability in optic canal anatomy.

Periodontitis aggravates pulmonary fibrosis by -promoted infiltration of neutrophils and Th17 cells.

Introduction: Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease. However, the pathogeny of IPF is poorly understood, and therapeutic options are very limited. Periodontitis (PD) is a chronic inflammatory disease that leads to dysbiosis of both the oral microbiome and host immune responses.

Linking oral microbiota to periodontitis and hypertension unveils that aggravates hypertension via infiltration of interferon-γ T cells.

Unlabelled: Periodontal disease (PD), an inflammatory disease initiated by oral microbiota, may aggravate hypertension (HTN). Few studies were employed to characterize the oral microbiota in hypertensive patients with periodontitis. To investigate the interplay between oral microbiota and hypertension in individuals with periodontitis, we initiated a metagenomic sequencing study on subgingival plaque and saliva samples sourced from HTN patients and those with hypertension and periodontitis (PDHTN).

Corymbinols A and B: Bis-β-triketone Conjugates of Sesquiterpene and Chalcone from the Fruit of .

Corymbinols A () and B (/), unprecedented bis-β-triketone-sesquiterpene and -chalcone hybrids, together with their biogenic precursors corymbinol C () and rhodomyrtosone E () were isolated from the untapped fruit of . The absolute configurations of these compounds were determined by NMR spectroscopy, electronic circular dichroism (ECD) calculations, and X-ray crystallography. Compound exhibited moderate inhibitory activity against cuproptosis in HepG2 cells by 31% at a nontoxic concentration of 20 μM.

Comparison Between Dichoptic and Monocular Training Protocols for Treating Monocular Amblyopia: A Meta-Analysis and Systematic Review.

Purpose: To review the efficacy of dichoptic and monocular strategies for treating monocular amblyopia, and to examine the factors that determine the degree of recovery from amblyopia.

Methods: Mean and individual participant data (IPD) from studies that used either monocular or dichoptic training methods to treat monocular amblyopic patients were analyzed. A mixed-effects model was used to analyze influential factors.

Constructing Biomimetic Channels in Hydrogen-Bonded Organic Framework via Post-Synthesis for Enhanced Proton Conductivity.

Proton transport channels in biological systems are constructed by the specific amino acid residues with hanging carboxylic acid groups acting as proton donors and acceptors, enabling rapid proton conduction via the Grotthuss mechanism. Hydrogen-bonded organic frameworks (HOFs) are promising candidates for artificially simulating proton channels due to their designable structure and abundant proton sources in the network. However, these protons were usually immobilized within hydrogen bonds between two building blocks, which require a high energy barrier for initiating proton transport.

Enhanced diplopia detection and binocular single vision assessment through virtual reality: A comprehensive study.

This study aimed to develop a novel virtual reality (VR)-based binocular single vision (BSV) testing system for the quantitative assessment of diplopia and to evaluate its diagnostic accuracy and stability through clinical research. We first developed a VR-based BSV testing apparatus (VR-BSVT) using Oculus Quest 2 VR glasses and Unity software. The system provides three parameters for assessing subjects' binocular single vision function, and hence their diplopia: VR-BSVF (Virtual Reality-Based Binocular Single Vision Field area), VR-BSVD (Virtual Reality-Based Binocular Single Vision Distance), and VR-BAR (Virtual Reality-Based Binocular Single Vision Field area ratio).

Roles of oral and gut microbiota in acute myocardial infarction.

Introduction: The significance of oral/gut microbiota in acute myocardial infarction (AMI) has been increasingly appreciated. However, correlations between oral/gut microbiota and AMI parameter, as well as the key microbiota that may have a crucial function in this process, remain unclear.

Objectives: To investigate the composition and structure of oral and gut microbiota associated with AMI and explore the roles of specific bacterial species in the progression of AMI.

The Gut Microbiota Mediates the Protective Effects of Spironolactone on Myocardial Infarction.

Myocardial infarction (MI) is a type of cardiovascular disease that influences millions of human beings worldwide and has a great rate of mortality and morbidity. Spironolactone has been used as a critical drug for the treatment of cardiac failure and it ameliorates cardiac dysfunction post-MI. Despite these findings, whether there is a relationship between the therapeutic effects of spironolactone and the gut microorganism after MI has not been determined.

Innovation and challenges of artificial intelligence technology in personalized healthcare.

As the burgeoning field of Artificial Intelligence (AI) continues to permeate the fabric of healthcare, particularly in the realms of patient surveillance and telemedicine, a transformative era beckons. This manuscript endeavors to unravel the intricacies of recent AI advancements and their profound implications for reconceptualizing the delivery of medical care. Through the introduction of innovative instruments such as virtual assistant chatbots, wearable monitoring devices, predictive analytic models, personalized treatment regimens, and automated appointment systems, AI is not only amplifying the quality of care but also empowering patients and fostering a more interactive dynamic between the patient and the healthcare provider.

The relationship between cardiometabolic index and pulmonary function among U.S. adults: insights from the National Health and Nutrition Examination Survey (2007-2012).

Background: Previous findings have revealed that disorders of lipid metabolism may be a risk factor for pulmonary function damage; however, the combined effect of dyslipidemia and central obesity on pulmonary function is unclear. The cardiometabolic index (CMI) is a composite of serum lipids (triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C)) and visceral fat parameters (waist-to-height ratio (WHtR)). This research aimed to investigate the link between CMI and pulmonary function, employing large-scale demographic data sourced from the National Health and Nutrition Examination Survey (NHANES) database.

[Research progress on cambium activity and radial growth dynamics monitoring of coniferous species].

The radial growth of trees plays a crucial role in determining forest carbon sequestration capacity. Understanding the growth dynamics of trees and their response to environmental factors is essential for predicting forest's carbon sink potential under future climate change. Coniferous forest trees are particularly sensitive to climate change, with growth dynamics responding rapidly to environmental shifts.

Differences between long- and short-wavelength light-induced retinal damage and the role of PARP-1 in retinal injury induced by blue light.

Photobiomodulation (PBM) therapy uses light of different wavelengths to treat various retinal degeneration diseases, but the potential damage to the retina caused by long-term light irradiation is still unclear. This study were designed to detect the difference between long- and short-wavelength light (650-nm red light and 450-nm blue light, 2.55 mW/cm, reference intensity in PBM)-induced injury.

Deficiency of ADAR2 ameliorates metabolic-associated fatty liver disease via AMPK signaling pathways in obese mice.

Non-alcoholic fatty liver disease (NAFLD) is a chronic disease caused by hepatic steatosis. Adenosine deaminases acting on RNA (ADARs) catalyze adenosine to inosine RNA editing. However, the functional role of ADAR2 in NAFLD is unclear.

Xanthine oxidase inhibitory constituents from the roots of .

Bioassay-guided purification of the xanthine oxidase (XOD) inhibitory extract of the roots of resulted in the isolation of two new triterpenoids (), designated Ampejaponoside A and B, along with sixteen known compounds (). The structures of Ampejaposide A and B were elucidated by comprehensive analysis of spectroscopic data with the structures of the known compounds confirmed by comparison the spectral data with corresponding values reported in literatures. All the isolates were evaluated for their XOD inhibitory activity .

Removal of diclofenac sodium from water using a polyacrylonitrile mixed-matrix membrane embedded with MOF-808.

MOF-808, owing to the synergistic effect of its large surface area and surface charge matching, showed a diclofenac sodium (DCF) removal capacity as high as 630 mg g, and the ability to adsorb 436 mg g DCF in two hours, outperforming many common Zr-MOFs under the same conditions. Importantly, a series of free-standing mixed-matrix membranes made by combining polyacrylonitrile with MOF-808 were fabricated and exhibited high efficiency of removing DCF from water an easily accessible filtration method.

The promotion-like effect of the M1-STN hyperdirect pathway induced by ccPAS enhanced balance performances: From the perspective of brain connectivity.

Aims: The present study aimed to explore the effect of cortico-cortical paired-associative stimulation (ccPAS) in modulating hyperdirect pathway and its influence on balance performance.

Methods: Forty healthy participants were randomly allocated to the active ccPAS group (n = 20) or the sham ccPAS group (n = 20). The primary motor cortex and subthalamic nucleus were stimulated sequentially with ccPAS.

Clinical effect of laparoscopic radical resection of colorectal cancer based on propensity score matching.

Background: The incidence of colorectal cancer (CRC) is increasing annually. Laparoscopic radical resection of CRC is a minimally invasive procedure preferred in clinical practice.

Aim: To investigate the clinical effect of laparoscopic radical resection of CRC on the basis of propensity score matching (PSM).

Altered salivary microbiota profile in patients with abdominal aortic aneurysm.

Unlabelled: Evidence suggests that the DNA of oral pathogens is detectable in the dilated aortic tissue of abdominal aortic aneurysm (AAA), one of the most fatal cardiovascular diseases. However, the association between oral microbial homeostasis and aneurysm formation remains largely unknown. In this study, a cohort of individuals, including 53 AAA patients and 30 control participants (CTL), was recruited for salivary microbiota investigation by 16S rRNA gene sequencing and bioinformatics analysis.