Preventive effect of platelet-rich plasma/Bio-Oss granules composite on medication-related osteonecrosis of the jaw in a rat model.

Objective: This study aimed to investigate the preventive effects of the platelet-rich plasma (PRP)/Bio-Oss granules composite on medication-related osteonecrosis of the jaw (MRONJ).

Material And Methods: An MRONJ rat model was established by intraperitoneal injections of zoledronic acid (0.1 mg/kg/dose) thrice a week for 12 weeks.

Free fatty acids induce bile acids overproduction and oxidative damage of bovine hepatocytes via inhibiting FXR/SHP signaling.

Hepatic oxidative injury induced by free fatty acids (FFA) and metabolic disorders of bile acids (BA) increase the risk of metabolic diseases in dairy cows during perinatal period. However, the effects of FFA on BA metabolism remained poorly understood. In present study, high concentrations of FFA caused cell impairment, oxidative stress and BA overproduction.

Metabolic syndrome's new therapy: Supplement the gut microbiome.

This letter to the editor discusses the publication on gut microbiome supplementation as therapy for metabolic syndrome. Gut microbiome dysbiosis disrupts intestinal bacterial homeostasis and is related to chronic inflammation, insulin resistance, cardiovascular diseases, type 2 diabetes mellitus, and obesity. Previous research has found that increasing the abundance of beneficial microbiota in the gut modulates metabolic syndrome by reducing chronic inflammation and insulin resistance.

Clinical pathological characteristics of "crawling-type" gastric adenocarcinoma cancer: A case report.

Background: Gastric cancer (GC) is a significant health problem worldwide, and early detection and accurate diagnosis are crucial for improving patient outcomes. Crawling-type gastric adenocarcinoma is a rare subtype of GC that has unique histopathological and clinical characteristics, and its diagnosis and management can be challenging. This pathological type of GC is also rare.

Sustainable preparation of high-calorific value and low-N and S energy products through the low-temperature alkali fusion of coal gasification fine ash.

Coal gasification fine ash (CGFA) is characterized by high yield, high carbon content, and difficult recovery. This results in waste of coal resources and serious environmental pollution. To address this issue, a novel green deashing process is proposed in this study to modify CGFA into deashed carbon (DAC) with a high calorific value and an ash content of less than 5% through a low-temperature alkaline fusion process.

Gastrointestinal Stromal Tumour with Liver Metastasis Presenting as Gastric Cancer.

Gastrointestinal stromal tumour (GIST) is a malignant tumour of the gastrointestinal lobe tissue, which mostly occurs in the gastrointestinal tract. Clinical manifestations can range from being benign to malignant. It mainly occurs in the gastric and small intestine.

Aorticoesophagal Fistula Combined with Upper Gastrointestinal Bleeding after Endovascular Dissection of Thoracic Aortic Aneurysm.

Aortoesophageal fistula (AEF) is a relatively rare and potentially fatal disease. Secondary AEF is rare but is associated with serious complications and high mortality. There are rare cases of esophageal mediastinal fistula after descending aortic aneurysm stent implantation.

Accuracy of a 3D printed sleeveless guide system used for fiber post removal: An in vitro study.

Objectives: The removal of fiber post is often a challenging task. A 3D printed assembled sleeveless system that guides the head of the handpiece instead of the drill was developed to address this issue. This study aimed to evaluate the accuracy of this novel guide system using an in vitro approach.

Rarely fast progressive memory loss diagnosed as Creutzfeldt-Jakob disease: A case report.

Background: Creutzfeldt-Jakob disease (CJD) is a rare degenerative disease of the central nervous system that can be contagious or hereditary and is a rare cause of rapidly progressive dementia. It almost always results in death within 1-2 years from symptom onset.

Case Summary: Here, we report the case of a 57-year-old male who initially experienced dizziness followed by a 1-mo fast decline in memory function.

Primary nephrotic syndrome complicated by chylothorax: a case report.

Chylothorax is an uncommon and serious clinical condition, typically induced by trauma, either postsurgical or accidental injury, but the mechanism of chylothorax caused by nephrotic syndrome is still unclear. Here, we report a case of primary nephrotic syndrome with membranous nephropathy (MN) in a 66-year-old man who presented with severe chylothorax. The chylothorax was managed by intercostal chest tube drainage, subcutaneous injection of enoxaparin, and treatment with anti-inflammatory agents and diuretics.

Deep Structural Annotation of Glycerolipids by the Charge-Tagging Paterno-Büchi Reaction and Supercritical Fluid Chromatography-Ion Mobility Mass Spectrometry.

Glycerolipids (GLs) are essential for cellular lipid homeostasis, while dysregulation in GL metabolism is often associated with the onset or progression of human-related metabolic diseases. The profile of GLs is thus frequently used as a molecular readout for disease phenotyping. Although mass spectrometry (MS) is the method of choice for GL profiling, the current MS methods are unable to differentiate two major types of structural isomers due to the fact that fatty acyls can be linked to different positions on the glycerol backbone (-positions) and the site(s) of unsaturation in acyl chains.

Plasmapheresis in the treatment of multi-drug intoxication involving levothyroxine sodium and calcium channel blockers: a case report.

Plasmapheresis, a procedure used to remove large molecular weight, protein-bound molecules from a patient's blood, has been shown to be useful in some cases of drug overdose. Levothyroxine sodium intoxication may result from the intentional or accidental ingestion of excessive amounts of the hormone, which can trigger a thyroid storm. However, case reports about the extremely large dose of 15,000 µg of thyroxine intoxication are extremely rare, and even combined with calcium channel blockers (CCBs) poisonings.

Hypothyroidism with elevated pancreatic amylase and lipase without clinical symptoms: A case report.

Background: Hypothyroidism is an endocrine disorder that has worldwide prevalence and can affect multiple organ systems. We report a case of hypothyroidism with elevated pancreatic amylase and trypsin without acute pancreatitis. No such case has been previously reported.

ROP16 ameliorated inflammatory bowel diseases inducing M2 phenotype of macrophages.

Background: Inflammatory bowel disease (IBD) is characterized by chronic and non-specific inflammation of the intestinal mucosa and mainly includes ulcerative colitis and Crohn's disease.

Aim: To explore the beneficial effect of ToxoROP16-induced M2 phynotype macrophages in homeostasis of IBDs through downregulation of M1 inflammatory cells.

Methods: RAW264.

An analytical strategy for accurate, rapid and sensitive quantitative analysis of isoflavones in traditional Chinese medicines using ultra-high performance supercritical fluid chromatography: Take Radix Puerariae as an example.

Isoflavones are phenolic phytoestrogens due to their structural similarity to estradiol, so they usually serve as active component for quality control of traditional Chinese medicines (TCMs) rich in isoflavones. However, TCMs contains various kinds of similar isoflavones, especially isomers, which to a significant extent hinders accurate analysis of isoflavones in TCMs. Here, we present a novel analytical strategy for quality control of TCMs rich in isoflavones using ultra-high performance supercritical fluid chromatography coupled to photodiode array detection (UHPSFC-PDA) and tandem mass spectrometry (UHPSFC-MS/MS).

Investigation of zero TE MR in preoperative planning in dentistry.

Preoperative planning in dentistry relies on imaging to assess the separation between the teeth and mandibular canal. Cone beam CT(CBCT) shows inferior contrast of the mandible canal and features radiation. In this work, the use of zero TE (zTE) imaging as an alternative to CBCT imaging for preoperative planning in dentistry is investigated.

Exploring lipid markers of the quality of coix seeds with different geographical origins using supercritical fluid chromatography mass spectrometry and chemometrics.

Background: Lipids, a group of primary metabolites, could be used as quality markers of Traditional Chinese medicine.

Purpose: The present study was designed to develop a research method to explore lipid markers of the quality of coix seeds with different geographical origins.

Study Design: The geographical origins of coix seeds were divided into three regions based on the latitude.

Village Building Identification Based on Ensemble Convolutional Neural Networks.

In this study, we present the Ensemble Convolutional Neural Network (ECNN), an elaborate CNN frame formulated based on ensembling state-of-the-art CNN models, to identify village buildings from open high-resolution remote sensing (HRRS) images. First, to optimize and mine the capability of CNN for village mapping and to ensure compatibility with our classification targets, a few state-of-the-art models were carefully optimized and enhanced based on a series of rigorous analyses and evaluations. Second, rather than directly implementing building identification by using these models, we exploited most of their advantages by ensembling their feature extractor parts into a stronger model called ECNN based on the multiscale feature learning method.

Separation of furostanol saponins by supercritical fluid chromatography.

Supercritical fluid chromatography (SFC) has good separation efficiency and is suitable for separating weakly polar compounds. Furostanol saponins, as an important kind of steroidal saponins, generally have two sugar chains, which are polar and hydrophilic. The hydroxyl group at the C-22 position of furostanol saponins is active and easily reacts with lower alcohols under appropriate conditions.

Simultaneous quantification of 11 active constituents in Shexiang Baoxin Pill by ultraperformance convergence chromatography combined with tandem mass spectrometry.

On account of the complexity of chemical constituents of Shexiang Baoxin Pill (SBP), a famous traditional Chinese medicine (TCM) formula, a novel and effective UPC-MS/MS method was developed to simultaneously determine the content of 11 active compounds of SBP with outstanding separation ability. Eleven components in SBP, including 2 ginsenosides, 2 bile acids, 3 bufadienolides and 4 volatiles were detected by electrospray ionization tandem mass spectrometry in positive and negative ion modes with multiple reaction monitor (MRM). The analysis was performed at 30°C using an Acquity UPC Diol (3.

Simultaneous quantitation of the diastereoisomers of scholarisine and 19-epischolarisine, vallesamine, and picrinine in rat plasma by supercritical fluid chromatography with tandem mass spectrometry and its application to a pharmacokinetic study.

Dengtaiye tablet has been used to treat chronic bronchitis cough. Scholarisine, 19-epischolarisine, vallesamine, and picrinine are the representative constituents of Dengtaiye. A rapid and sensitive assay based on supercritical fluid chromatography with tandem mass spectrometry has been developed and validated for the determination of the diastereoisomers of scholarisine and 19-epischolarisine, vallesamine, and picrinine in rat plasma using lamotrigine as internal standard.

Simultaneous analysis of eight vitamin E isomers in Moringa oleifera Lam. leaves by ultra performance convergence chromatography.

A new method for simultaneous determination of eight vitamin E isomers including α-, β-, γ-, and δ-tocopherol and α-, β-, γ-, and δ-tocotrienol by ultra-performance convergence chromatography (UPC(2)) equipped with a diode array detector was reported. They were separated on a BEH 2-EP column (3.0 mm × 100 mm, 1.