Publications by authors named "Yiting Tu"
Objective: Atlantoaxial osteoarthritis (AAOA) cause occipitocervical and retroauricular pain and cervical rotation disorder. Few studies have focused on the relationship between cervical spine structure and the prevalence of AAOA in China. This study aimed to investigate whether the inter-atlanto-occipital ligament ossification, uncovertebral joint degeneration and fat infiltration (FI) in the obliquus capitis inferior (OCI) muscles are associated with atlantoaxial arthritis, and to explore other potential risk factors in a clinical cohort from Eastern China.
View Article and Find Full Text PDFBackground: Previous epidemiological studies have explored the association between obstructive sleep apnea (OSA) and osteoporosis (OP), with inconclusive results due to various biases. Herein, we sought to determine the causal association between OSA and OP through bidirectional two-sample Mendelian randomization analysis.
Methods: Summary-level data for OSA were acquired from the FinnGen consortium, while data for fractures and BMDs (FA-BMD, FN-BMD, LS-BMD and eBMD) were derived from the UKBB and GEFOS.
Daphnetin-mediated mitophagy alleviates intervertebral disc degeneration via the Nrf2/PINK1 pathway.
Acta Biochim Biophys Sin (Shanghai)
January 2025
Intervertebral disc degeneration (IDD) is a major cause of low back pain (LBP), and effective therapies are still lacking. Reactive oxygen species (ROS) stress induces NLRP3 inflammasome activation, and this, along with extracellular matrix metabolism (ECM) degradation in nucleus pulposus cells (NPCs), plays a crucial role in the progression of IDD. Daphnetin (DAP) is a biologically active phytochemical extracted from plants of the , which possesses various bioactivities, including antioxidant properties.
View Article and Find Full Text PDFSystem analysis based on Anoikis-related genes identifies MAPK1 as a novel therapy target for osteosarcoma with neoadjuvant chemotherapy.
BMC Musculoskelet Disord
June 2024
Background: Osteosarcoma (OS) is the most common bone malignant tumor in children, and its prognosis is often poor. Anoikis is a unique mode of cell death.However, the effects of Anoikis in OS remain unexplored.
View Article and Find Full Text PDFSubstrate stiffness is a microenvironment with a certain stiffness constructed by the extracellular matrix and adjacent cells, which plays an important role in the growth and development of cells and tissue formation. Studies have indicated that the stiffness of the brain is about 0.1-1 kPa.
View Article and Find Full Text PDFArticle Synopsis
- - The study explores the genetic links between liver and heart diseases, focusing on a concept called the liver-heart axis (LHA).
- - Researchers used genome-wide association studies to find shared genes and pathways, identifying 53 genetic regions (loci) that influence both liver and heart conditions, with some showing shared causality.
- - Advanced analyses reveal 343 genes related to these diseases, with significant connections to certain tissues like the liver and cardiovascular system, and suggest causal relationships between the traits studied.
Article Synopsis
- * This study found that increasing VSIG4 expression reduces the formation and activity of osteoclasts, which are responsible for bone loss, by affecting various signaling pathways and lowering reactive oxygen species.
- * The research indicates that VSIG4 could be a potential new target for treating postmenopausal osteoporosis by enhancing antioxidant responses and reducing bone loss.
Article Synopsis
- Surgical site infection (SSI) is a common and serious complication arising from posterior cervical surgery, which can have severe consequences if not diagnosed early.
- A study analyzing patients from Wenzhou Medical University utilized various machine learning methods, including gradient boosting and random forests, to develop predictive models for SSI.
- The random forest model showed the best overall performance in predicting SSI, highlighting the potential of these techniques to aid clinicians in assessing and preventing infection risks during surgery.
Delta Cord as a Radiological Localization Sign of Postoperative Adhesive Arachnoiditis: A Case Report and Literature Review.
Diagnostics (Basel)
September 2023
Article Synopsis
- Postoperative adhesive arachnoiditis is an inflammation of the spinal membranes that happens after surgery, leading to scar tissue formation and various symptoms like pain and motor dysfunction.
- A case study of a 37-year-old man who developed this condition after surgeries for Chiari I malformation highlighted the "delta cord sign," where a thick band of arachnoid tissue gives the spinal cord a triangular shape on imaging scans.
- The identification of the delta cord sign during surgery helped the medical team accurately locate the problem area and avoid unnecessary procedures on healthy tissue.
Article Synopsis
- Adolescent idiopathic scoliosis (AIS) leads to high treatment costs and low quality of life, making early screening crucial, yet there are currently no effective serum biomarkers for this purpose.
- A study using an antibody-based protein array identified 29 differentially expressed proteins associated with AIS, with further validation showing that FAP and CD23 levels decrease as scoliosis worsens.
- The findings suggest that FAP and CD23 could serve as potential serum biomarkers, enabling better monitoring of disease progression and personalized treatment approaches.
Corynoline Alleviates Osteoarthritis Development via the Nrf2/NF-B Pathway.
Oxid Med Cell Longev
August 2022
Article Synopsis
- OA is a joint disease largely characterized by inflammation, and Corynoline (COR) shows potential anti-inflammatory effects that may aid in its treatment.
- Research methods included assessing cell viability, examining inflammation markers, and using various imaging techniques to test COR's impacts on OA in models.
- Results indicate that COR protects against ECM degeneration and inflammation by interacting with the Nrf2/NF-κB pathway, suggesting its therapeutic potential for managing OA.*
Persistent Hemodynamic Depression After Carotid Artery Stenting: A Review and Update.
Vasc Endovascular Surg
May 2022
Article Synopsis
- * Carotid endarterectomy (CEA) is the traditional treatment for severe blockages in the internal carotid artery, while carotid artery stenting (CAS) has been proposed as a viable alternative due to advancements in medical technology.
- * This review focuses on the emerging knowledge regarding persistent hemodynamic depression (PHD) after CAS, aiming to enhance understanding and potentially improve prognostic and therapeutic strategies.
Alpk1 Sensitizes Pancreatic Beta Cells to Cytokine-Induced Apoptosis Upregulating TNF-α Signaling Pathway.
Front Immunol
December 2021
Article Synopsis
- Pancreatic beta cell failure is central to type 1 diabetes (T1D), and new research highlights the role of pathogen recognizing receptors (PRRs) in beta cell survival and function.
- The study specifically focuses on alpha-protein kinase 1 (ALPK1) and its effect on MIN6 pancreatic beta cells, finding that ALPK1 expression increases with pro-inflammatory cytokines but does not trigger apoptosis on its own.
- Activation of ALPK1 worsens cytokine-induced apoptosis by enhancing TNF-α signaling, suggesting a potential target for new treatments to protect beta cells in T1D.
Background. Fulminant type 1 diabetes (FT1D) is a novel subtype of type 1 diabetes characterized by extremely rapid onset and complete deficiency of insulin due to the destruction of pancreatic β cells. However, the precise mechanisms underlying the etiology of this disease remain unclear.
View Article and Find Full Text PDFmiR-101a and miR-30b contribute to inflammatory cytokine-mediated β-cell dysfunction.
Lab Invest
December 2015
Inflammatory cytokines have a critical role in the progressive deterioration of pancreatic β-cell function and development of type 1 diabetes. Prolonged exposure of β-cells to inflammatory cytokines results in gene expression modifications, leading to loss of β-cell function. MicroRNAs (miRNAs) are small non-coding RNAs acting as key regulators of gene expression.
View Article and Find Full Text PDFSerum fibroblast growth factor 21 levels are related to subclinical atherosclerosis in patients with type 2 diabetes.
Cardiovasc Diabetol
June 2015
Background: Fibroblast growth factor 21 (FGF21), a glucose and lipid metabolic regulator, has recently been demonstrated to be associated with cardiovascular diseases (CVD) such as carotid atherosclerosis, coronary heart disease and carotid artery plaques. However, the relationship between circulating FGF21 and subclinical atherosclerosis or atherosclerosis of other arteries such as the femoral and iliac artery remains unclear. In this study, we evaluated the association of serum FGF21 with intima-media thickness (IMT) and subclinical atherosclerosis in type 2 diabetic patients.
View Article and Find Full Text PDFArticle Synopsis
- Type 1 diabetes (T1D) is an autoimmune condition caused by the destruction of insulin-producing β-cells, and patients often show reduced neutrophil counts.
- Elevated levels of neutrophil elastase (NE) and proteinase 3 (PR3), both neutrophil enzymes, were found in T1D patients, particularly those recently diagnosed, and these levels increased alongside the presence of autoantibodies against β-cell antigens.
- The study suggests that heightened NE and PR3, along with decreased α1-antitrypsin (a protease inhibitor), indicate increased neutrophil activity, playing a significant role in T1D development, and could potentially serve as biomarkers for diagnosing the disease