Association between long-term exposure to low ambient benzene concentrations and mental disorders in the UK: A nested case-control study.

Background: The mental health impacts of long-term ambient benzene exposure remain incompletely understood. We aim to investigate the association between long-term exposure to low-concentration ambient benzene and mental disorders in the general population.

Method: Estimated annual benzene concentrations from UK-wide air pollution maps were linked to health data from 410,605 eligible UK Biobank participants.

Long-term PM2.5 components exposure, genetic susceptibility, and myocardial infarction risk.

Aims: Associations between components of fine particulate matter (PM2.5) exposure and myocardial infarction (MI) risk remain unclear. The aim of this study was to investigate the connection between chronic PM2.

Role of Lung Function, Chronic Obstructive Pulmonary Disease on Hearing Impairment: Evidence for Causal Effects and Clinical Implications.

: Observational studies have shown that chronic obstructive pulmonary disease (COPD) is associated with an increased risk of hearing impairment. However, causality remains unclear, including with respect to lung function. This study aimed to investigate the associations of lung function and COPD with hearing impairment in the UK Biobank and confirm potential causalities using Mendelian randomization (MR).

Association of exposure to ambient Ozone with sleep quality in pregnant women.

No study has investigated the associations between ozone (O) exposure and sleep among pregnant women. This study examined the association of O exposure with sleep quality in Chinese pregnant women. We analyzed data in 7,581 pregnant women.

Exposure to Multiple Metals and Cerebral White Matter Hyperintensity in Chinese Population: A Cross-Sectional Study.

Background: Evidence about the impact of multiple metal exposure on brain neuroimaging metrics remains limited. We aim to investigate the effects of single and mixed metal exposure on white matter hyperintensities (WMHs).

Methods: This cross-sectional study included 1183 subjects without stroke history from the META-KLS (Multi-modality Medical Imaging Study Based on Kailuan Study), which is an existing prospective cohort in Tangshan, China.

Atmospheric Pollutants, Cardiometabolic Disorders, and Dementia in Trajectory Analysis: A 13-Year Longitudinal Cohort Study.

Background: First cardiometabolic disorders (FCMDs) and dementia pose a significant burden on aging populations. Investigating the association between atmospheric pollutants and the progression of FCMDs and dementia is crucial.

Methods: A prospective analysis was conducted on 413 149 participants from the UK Biobank.

Ambient polycyclic aromatic hydrocarbons and cardiovascular disease in China.

Polycyclic aromatic hydrocarbons (PAHs) are a prominent category of ambient air pollutants worldwide, but our understanding of their potential health effects at ambient concentrations is severely limited. Our goal was to investigate the relation between ambient PAHs and daily hospitalizations for cardiovascular disease and explore its potential mechanism. This research included both observational and experimental studies.

Prenatal exposure to ozone and bone mineral density in early childhood: Susceptible window identification.

Background: The effect of prenatal ozone exposure on early childhood bone mineral density (BMD) remains to be explored.

Methods: This study was based on the pediatric subcohort of the Fujian Birth Cohort Study. The mean ozone exposure concentration was calculated for the entire pregnancy, as well as for each trimester (first, second, and third) and for every gestational week.

Independent and combined effects of long-term air pollution exposure and genetic predisposition on COVID-19 severity: A population-based cohort study.

The relationships between air pollution, genetic susceptibility, and COVID-19-related outcomes, as well as the potential interplays between air pollution and genetic susceptibility, remain largely unexplored. The Cox proportional hazards model was used to assess associations between long-term exposure to air pollutants and the risk of COVID-19 outcomes (infection, hospitalization, and death) in a COVID-19-naive cohort (n = 458,396). Additionally, associations between air pollutants and the risk of COVID-19 severity (hospitalization and death) were evaluated in a COVID-19 infection cohort (n = 110,216).

Long-Term Exposure to PM Constituents, Genetic Susceptibility, and Incident Dementia: A Prospective Cohort Study among 0.2 Million Older Adults.

Fine particulate matter, known as PM, is recognized as a risk factor for dementia. However, the specific linkage between PM constituents and dementia is not well understood. We conducted a cohort of 217,336 participants of the UK Biobank to explore the association of long-term exposure to PM constituents with all-cause dementia, Alzheimer's disease (AD), and vascular dementia.

Ambient air pollution exposure in relation to cerebral small vessel disease in Chinese population: A cranial magnetic resonance imaging-based study.

Cerebral small vessel disease (CSVD), a chronic and progressive vascular disorder closely associated with stroke and dementia, is primarily identified and diagnosed in cranial magnetic resonance imaging (MRI). Given the limited evidence on the relationship between air pollution and CSVD, this study aimed to investigate the links between multiple air pollutants exposure and CSVD risk. Eligible subjects and their cranial MRI data were obtained from the Multi-modality Medical Imaging Study Based on Kailuan Study, totaling 1216 participants.

Differential Risk Profiles of Incident Abdominal Aortic Aneurysms in Specific Subgroups: A Large Cohort-based Study.

Objective: The aim of this study is to explore the risk profiles associated with Abdominal aortic aneurysm (AAA) incidence in both the general population and diverse subpopulations.

Summary Background Data: AAA is a life-threatening arterial disease, and there is limited understanding of its etiological spectrum across the age, sex, and genetic risk subgroups, making early prevention efforts more complicated.

Methods: This study encompassed a sample size of 364399 participants from the UK.

Landscape fire PM and hospital admissions for cause-specific cardiovascular disease in urban China.

There is a growing interest in the health impacts of PM originating from landscape fires. We conducted a time-series study to investigate the association between daily exposure to landscape fire PM and hospital admissions for cardiovascular events in 184 major Chinese cities. We developed a machine learning model combining outputs from chemical transport models, meteorological information and observed air pollution data to determine daily concentrations of landscape fire PM.

Exposure to PM and its constituents in relation to thyroid function of pregnant women: Separate and mixture analyses.

The relationships between exposure to PM and its constituents and thyroid hormone (TH) levels in pregnant women are still uncertain, particularly regarding the impact of mixed exposure to PM constituents on thyroid function during pregnancy. This study aimed to investigate the individual and mixed effect of PM and its constituents on TH levels during pregnancy. Fluorescence and chemiluminescence immunoassays were utilized to measure serum concentrations of free thyroxine (FT4) and thyroid-stimulating hormone (TSH) in pregnant women participating in the Fujian Birth Cohort Study (FJBCS).

Long-term exposure to fine particulate matter constituents, genetic susceptibility, and incident heart failure among 411 807 adults.

Aims: Long-term fine particulate matter (PM) exposure has been linked to incident heart failure (HF), but the impacts of its constituents remain unknown. We aimed to investigate the associations of PM constituents with incident HF, and further evaluate the modification effects of genetic susceptibility.

Methods And Results: PM and its constituents, including elemental carbon (EC), organic matter (OM), ammonium (NH ), nitrate (NO ), and sulfate (SO ), were estimated using the European Monitoring and Evaluation Programme model applied to the UK (EMEP4UK) driven by Weather and Research Forecast model meteorology.

Ambient PM Chemical Composition and Cardiovascular Disease Hospitalizations in China.

Little is known about the impacts of specific chemical components on cardiovascular hospitalizations. We examined the relationships of PM chemical composition and daily hospitalizations for cardiovascular disease in 184 Chinese cities. Acute PM chemical composition exposures were linked to higher cardiovascular disease hospitalizations on the same day and the percentage change of cardiovascular admission was the highest at 1.

Air pollutants, genetic susceptibility and the risk of schizophrenia: large prospective study.

Background: Evidence linking air pollutants and the risk of schizophrenia remains limited and inconsistent, and no studies have investigated the joint effect of air pollutant exposure and genetic factors on schizophrenia risk.

Aims: To investigate how exposure to air pollution affects schizophrenia risk and the potential effect modification of genetic susceptibility.

Method: Our study was conducted using data on 485 288 participants from the UK Biobank.

Modifiable lifestyle factors and the risk of post-COVID-19 multisystem sequelae, hospitalization, and death.

Effective prevention strategies for post-COVID complications are crucial for patients, clinicians, and policy makers to mitigate their cumulative burden. This study evaluated the association of modifiable lifestyle factors (smoking, alcohol intake, BMI, physical activity, sedentary time, sleep duration, and dietary habits) with COVID-19 multisystem sequelae, death, and hospitalization in the UK Biobank cohort (n = 68,896). A favorable lifestyle (6-10 healthy factors; 46.

Exposure to Air Pollution, Genetic Susceptibility, and Psoriasis Risk in the UK.

Importance: Psoriasis is a common autoinflammatory disease influenced by complex interactions between environmental and genetic factors. The influence of long-term air pollution exposure on psoriasis remains underexplored.

Objective: To examine the association between long-term exposure to air pollution and psoriasis and the interaction between air pollution and genetic susceptibility for incident psoriasis.

Air Pollution, Genetic Susceptibility, and Risk of Incident Systemic Lupus Erythematosus: A Prospective Cohort Study.

Objective: There are few existing studies that investigate the risk of systemic lupus erythematosus (SLE) associated with long-term exposure to air pollutants. This study aimed to explore associations between long-term exposure to air pollutants and incident SLE and further evaluate interactions and joint effects of genetic risk and air pollutants.

Methods: A total of 459,815 participants were included from UK Biobank.

Association of residential greenness with incident pneumonia: A prospective cohort study.

Residential greenness is considered beneficial to human health, and its association with respiratory function has been found in previous studies. However, its link with pneumonia remains unclear. To explore the association of residential greenness with incident pneumonia, we conducted a prospective cohort study based on participants of the UK Biobank, followed from 2006 to 2010 to the end of 2019.

Early-life exposure to tobacco, genetic susceptibility, and accelerated biological aging in adulthood.

Early-life tobacco exposure serves as a non-negligible risk factor for aging-related diseases. To understand the underlying mechanisms, we explored the associations of early-life tobacco exposure with accelerated biological aging and further assessed the joint effects of tobacco exposure and genetic susceptibility. Compared with those without in utero exposure, participants with in utero tobacco exposure had an increase in Klemera-Doubal biological age (KDM-BA) and PhenoAge acceleration of 0.

Greenness, Genetic Predisposition, and Tinnitus.

This study aimed to investigate the association between residential greenness and tinnitus and the potential interaction between greenness and genetic predisposition to tinnitus. The normalized difference vegetation index (NDVI) is used to measure residential greenness. The tinnitus is defined based on self-reported.