Efficient near-ultraviolet (NUV) electroluminescence based on a benzonitrile acceptor HLCT material with balanced carrier mobilities and high color purity.

Balanced carrier injection/transport and high color purity are critical for highly efficient near-ultraviolet (NUV) electroluminescence (EL) emitters. Herein, two novel structurally simple NUV donor-π-acceptor (D-π-A) molecules, namely CZ-PPCN and TPA-PPCN, with a benzene π-bridge containing carbazole/triphenylamine as donors and benzonitrile as the acceptor were designed and synthesized, and they exhibited hybrid local charge transfer (HLCT) characteristics. The introduction of the benzonitrile group of the CZ-PPCN molecule not only enhances charge carrier injection but also promotes hole and electron mobility balance through the formation of supramolecular hydrogen bonds (both up to 10 cm V s).

The impact of postoperative cartoon viewing on emergence delirium in young children: A randomized controlled trial.

Background: Research has revealed non-pharmacological methods mitigate the occurrence of emergence delirium with a lower incidence of negative side effects, but the mechanism remains unclear. This study aimed to investigate whether postoperative cartoon viewing after awakening from sevoflurane anesthesia in the postanesthesia care unit reduces the incidence of emergence delirium in young children, and to examine relevant electroencephalography findings.

Methods: This was a single-center, randomized controlled trial.

Potential Role of CD99 Signaling Pathway in Schwann Cell Dysfunction in Diabetic Foot Ulcers Based on Single-Cell Transcriptome Analysis.

Schwann cell (SC) dysfunction contributes to the delayed healing of diabetic foot ulcers (DFUs). However, the underlying molecular mechanism regarding the unregulated SC function is poorly understood. Thus, we examined the single-cell transcriptome data from different DFU states focusing on SC characteristics.

A retrospective study to predict failure of high-flow oxygen therapy for acute hypoxic respiratory failure.

Objective: This study aimed to analyze the characteristics of patients who fail high-flow nasal cannula(HFNC) therapy for acute hypoxemic respiratory failure(AHRF) and to identify predictors of treatment failure.

Methods: This single-center, retrospective, observational study analyzed clinical data from 388 patients with AHRF. Patients were divided into two groups: the HFNC success group (HFNC-S, n = 256) and the HFNC failure group (HFNC-F, n = 132).

Proliferator-Activated Receptor Alpha Inhibits Abnormal Extracellular Matrix Accumulation and Maintains Energy Metabolism in Late-Onset Fuchs Endothelial Corneal Dystrophy.

Purpose: Fuchs endothelial corneal dystrophy (FECD) is the most common corneal endothelial dystrophy and guttae are crucial in causing progressive loss of corneal endothelium. This study aimed to find a way to inhibit the formation of guttae in FECD.

Methods And Results: Mitochondria fatty acid β-oxidation (FAO) and tricarboxylic acid (TCA) cycle processes were negatively enriched in the FECD group according to gene set enrichment analysis in GSE171830.

Supercritical CO Activation Enables an Exceptional Methanol Synthesis Activity Over the Industrial Cu/ZnO/AlO Catalyst.

The ternary Cu/ZnO/AlO catalyst is widely used in the industry for renewable methanol synthesis. The tenuous trade-off between the strong metal-support interaction (SMSI)-induced Cu-ZnO interface and the accessible Cu surface strongly affects the activity of the final catalyst. Successes in the control of oxide migration on adsorbate-induced SMSI catalysts have motivated this to develop a supercritical CO activation strategy to synchronously perfect the Cu-O-Zn interface and Cu-Cu surface sites through the manipulation of the adsorbate diffusion kinetics, which involves OCH and "side-on" fixed CO species.

Multifunctional oxadiazole-based ultraviolet-emitting materials used as hosts for multicolor phosphorescence.

Highly efficient ultraviolet materials and host materials for organic light-emitting diodes (OLEDs) have been gaining increasing attention in recent years. In this study, three donor-acceptor (D-A) molecules with different HLCT properties were designed and synthesized using oxadiazole as an electron acceptor. Not only does the molecule -PIOXZ exhibit efficient ultraviolet electroluminescence, but it can also serve as the host material for high-efficiency phosphorescent OLEDs (PhOLEDs) with low roll-off.

Food effect trial of the pharmacokinetics and safety of TQ05105 in healthy Chinese subjects.

Purpose: This study aims to investigate the effect of food intake on the pharmacokinetics of TQ05105 tablets in healthy Chinese subjects, and to evaluate the safety in these subjects.

Methods: This Phase I clinical trial involved healthy subjects who received a single oral dose of 15 mg TQ05105, with a 2-day washout period between each period. The plasma concentrations of TQ05105 and its metabolite TQ12550 were quantified using a validated liquid chromatography-tandem mass spectrometry method.

Opposite effects of sevoflurane at high and low concentration on the airway inflammation in juvenile asthma rats: A TMT-based proteomics analysis study.

Background: The incidence of sevoflurane-related adverse respiratory events in children with asthma is notably high. During different phases of sevoflurane anesthesia, asthmatic children's airways are exposed to varying concentrations of the anesthetic. However, the specific effects of different concentrations of sevoflurane on the developing airways with asthmatic hyperreactivity have not been systematically studied.

A single-dose, randomized, crossover bioequivalence study of levamlodipine besilate tablets in healthy subjects.

Levamlodipine, the levorotatory form of amlodipine racemate, has a blood pressure-lowering effect that is twice that of the racemate. The study aims to establish a foundation for the clinical application of the test drug by conducting a phase I clinical bioequivalence trial, comparing its bioequivalence and safety with the reference drug in healthy Chinese subjects. Recruiting 26 healthy subjects for separate bioequivalence trials in both fasting and fed conditions.

fabrication of a plasmonic Bi@BiOCO core-shell heterostructure for photocatalytic CO reduction: structural insights into selectivity modulation.

The precise design of active sites and light absorbers is essential for developing highly efficient photocatalysts for CO reduction. Core-shell heterostructures constructed based on large-sized plasmonic Bi metals are ideal candidates because of the utilization of full-spectrum light and effective charge separation. However, the mechanism of selectivity modulation of large-sized Bi@semiconductor photocatalysts has yet to be explored in depth.

Versatile conductive hydrogel orchestrating neuro-immune microenvironment for rapid diabetic wound healing through peripheral nerve regeneration.

Diabetic wound (DW), notorious for prolonged healing processes due to the unregulated immune response, neuropathy, and persistent infection, poses a significant challenge to clinical management. Current strategies for treating DW primarily focus on alleviating the inflammatory milieu or promoting angiogenesis, while limited attention has been given to modulating the neuro-immune microenvironment. Thus, we present an electrically conductive hydrogel dressing and identify its neurogenesis influence in a nerve injury animal model initially by encouraging the proliferation and migration of Schwann cells.

Improving electron transportation and operational lifetime of full color organic light emitting diodes through a "weak hydrogen bonding cage" structure.

Efficient electron-transporting materials (ETMs) are critical to achieving excellent performance of organic light-emitting diodes (OLEDs), yet developing such materials remains a major long-term challenge, particularly ETMs with high electron mobilities (s). Herein, we report a short conjugated ETM molecule (PICN) with a dipolar phenanthroimidazole group, which exhibits an electron mobility of up to 1.52 × 10 cm (V s).

Efficient near-infrared emission benefits from slowing down the internal conversion process.

Organic deep-red (DR) and near-infrared (NIR) emitters with high photoluminescence quantum yield (PLQY) are rare due to the strong non-radiative () decay. Here, we report two DR/NIR emitters with high PLQY, TPANZPyPI and TPANZ3PI. Interestingly, the TPANZPyPI film exhibits 46.

Derivation of a HEAR Pathway for Emergency Department Chest Pain Patients to Safely Avoid a Second Troponin Test.

The study aims to develop a decision pathway based on HEAR score and 0 h high-sensitivity cardiac troponin T (hs-cTnT) to safely avoid a second troponin test for suspected non-ST elevation myocardial infarction (NSTEMI) in emergency departments. A HEAR score consists of history, electrocardiogram, age, and risk factors. A HEAR pathway is established using a Bayesian approach based on a predefined safety threshold of NSTEMI prevalence in the rule-out group.

Characteristics of the Frustrated Lewis Pairs (FLPs) on the Surface of Albite and the Corresponding Mechanism of H Activation.

The characteristics of frustrated Lewis pairs (FLPs) on albite surfaces were analyzed with density functional theory, and the reaction mechanism for H activation by the FLPs was studied. The results show that albite is an ideal substrate material with FLPs, and its (001) and (010) surfaces have the typical characteristics of FLPs. In the case of H activation, the interaction between the HOMO of H and the SOMO of the Lewis base and the electron acceptance characteristics of the Lewis acid are the key factors.

Changes in global food consumption increase GHG emissions despite efficiency gains along global supply chains.

Greenhouse gas (GHG) emissions related to food consumption complement production-based or territorial accounts by capturing carbon leaked through trade. Here we evaluate global consumption-based food emissions between 2000 and 2019 and underlying drivers using a physical trade flow approach and structural decomposition analysis. In 2019, emissions throughout global food supply chains reached 30 ±9% of anthropogenic GHG emissions, largely triggered by beef and dairy consumption in rapidly developing countries-while per capita emissions in developed countries with a high percentage of animal-based food declined.

Botulinum Toxins for the Treatment of Raynaud Phenomenon: A Systematic Review With Meta-analysis.

Objective: Botulinum toxin (Btx) therapy has emerged as a potential treatment for patients with Raynaud phenomenon (RP) in recent years. This study aimed to investigate the efficacy and safety of Btx treatment for RP.

Methods: Databases of PubMed, EMBASE, Web of Science, and the Cochrane Central Register of Controlled Trials were searched from their inception up to August 2022.

Nonoxidative Coupling of Methane to Produce C Hydrocarbons on FLPs of an Albite Surface.

The characteristics of active sites on the surface of albite were theoretically analyzed by density functional theory, and the activation of the C-H bond of methane using an albite catalyst and the reaction mechanism of preparing C hydrocarbons by nonoxidative coupling were studied. There are two frustrated Lewis pairs (FLPs) on the (001) and (010) surfaces of albite; they can dissociate H under mild conditions and show high activity for the activation of methane C-H bonds. CH molecules can undergo direct dissociative adsorption on the (010) surface, whereas a 50.