Based on two coconut ( L.) genome-wide investigation of NODULE-INCEPTION-like protein family: evolution and expression profiles during development and stress.

NODULE-INCEPTION-Like Protein (NLP) is a plant-specific transcription factor that plays a crucial role in nitrate uptake and stress responses. However, studies of gene family in coconut are lacking. In this study, 7 genes in the and 6 genes in coconut varities were identified.

TRAF3 is critical for initial T follicular helper cell specification via coordination of the IL-6R/IL-2R-BCL6 signaling nexus.

CD4 T follicular helper (T) cells are essential for orchestrating robust humoral immunity, yet the signals that initiate T cell differentiation are not fully understood. We identified that the adapter protein TRAF3 was required for T cell differentiation and function during systemic inflammatory infections. Loss of CD4 T cell-intrinsic TRAF3 impaired chromatin remodeling and transcriptional programming essential for T cell initiation and instead augmented T1 development and function.

Smartphone-aided fluorescent probe combining lateral flow assay for Cys testing in food and organism.

Combining the fluorescent probe, smartphone and lateral flow assay (LFA) to form a new detecting system, which will meet the requirements of rapid, convenient and on-site analysis of Cys. In this study, BDP-SINO based on BODIPY was developed and displayed high signal-to-noise ratio (363-fold) and fast response speed (1.0 min) for monitoring Cys.

Genome-Wide Identification and Expression Analysis of MYB Transcription Factor Family in Response to Various Abiotic Stresses in Coconut ( L.).

Abiotic stresses such as nitrogen deficiency, drought, and salinity significantly impact coconut production, yet the molecular mechanisms underlying coconut's response to these stresses are poorly understood. MYB proteins, a large and diverse family of transcription factors (TF), play crucial roles in plant responses to various abiotic stresses, but their genome-wide characterization and functional roles in coconut have not been comprehensively explored. This study identified 214 genes (39 1R-MYB, 171 R2R3-MYB, 2 3R-MYB, and 2 4R-MYB) in the coconut genome.

Colorimetric and fluorescent probes for cysteine detection: Applications in food safety and cellular imaging.

In this study, three BODIPY-based fluorescent probes were designed and synthesized. The ultraviolet-visible spectra, fluorescence spectra, smartphone color recognition application and bioimaging were utilized to evaluate the capacity of the probes. By comparing key parameters, BDP-SIN had optimal performances including fastest response (10 min), highest signal-to-noise ratio (815 times) and lowest limit of detection (LOD = 49 nM).

Discovery of the Clinical Candidate Sonrotoclax (BGB-11417), a Highly Potent and Selective Inhibitor for Both WT and G101V Mutant Bcl-2.

The approval of venetoclax, a B-cell lymphoma-2 (Bcl-2) selective inhibitor, for the treatment of chronic lymphocytic leukemia demonstrated that the antiapoptotic protein Bcl-2 is a druggable target for B-cell malignancies. However, venetoclax's limited potency cannot produce a strong, durable clinical benefit in other Bcl-2-mediated malignancies (e.g.

Sonrotoclax overcomes BCL2 G101V mutation-induced venetoclax resistance in preclinical models of hematologic malignancy.

Venetoclax, the first-generation inhibitor of the apoptosis regulator B-cell lymphoma 2 (BCL2), disrupts the interaction between BCL2 and proapoptotic proteins, promoting the apoptosis in malignant cells. Venetoclax is the mainstay of therapy for relapsed chronic lymphocytic leukemia and is under investigation in multiple clinical trials for the treatment of various cancers. Although venetoclax treatment can result in high rates of durable remission, relapse has been widely observed, indicating the emergence of drug resistance.

Train Axlebox Bearing Fault Diagnosis Based on MSC-SGMD.

Train axlebox bearings are subject to harsh service conditions, and the difficulty of diagnosing compound faults has brought greater challenges to the maintenance of high-quality train performance. In this paper, based on the traditional symplectic geometry mode decomposition (SGMD) algorithm, a maximum spectral coherence signal reconstruction algorithm is proposed to extract the intrinsic connection between the SGMD components with the help of the frequency domain coherence idea and reconstruct the key signal components so as to effectively improve the extraction of composite fault features of axlebox bearings under different speed conditions. Firstly, based on the traditional SGMD algorithm, the vibration signal of the axle box is decomposed to extract its symplectic geometry components (SGCs).

Data considerations for predictive modeling applied to the discovery of bioactive natural products.

Natural products (NPs) constitute a large reserve of bioactive compounds useful for drug development. Recent advances in high-throughput technologies facilitate functional analysis of therapeutic effects and NP-based drug discovery. However, the large amount of generated data is complex and difficult to analyze effectively.

Dissociated Deficits between Explicit and Implicit Empathetic Pain Perception in Neurofibromatosis Type 1.

Cognitive impairments and social-function deficits are severe complaints in neurofibromatosis type 1 (NF1) patients. Empathetic pain perception may be disrupted in NF1 patients because of high-level cognitive deficits. This study investigated the empathy profiles of adult patients with NF1, especially concerning whether explicit and implicit empathetic pain perception are abnormal in this population.

Identification of Stabilization of Malvid Anthocyanins and Antioxidant Stress Activation via the AMPK/SIRT1 Signaling Pathway.

Rupr. "Beibinghong" is abundant in anthocyanins, including malvidin (Mv), malvidin-3-glucoside (Mv3G), and malvidin-3,5-diglucoside (Mv35 G). Anthocyanins offer nutritional and pharmacological effects, but their stability is poor.

Research on unknown fault diagnosis of rolling bearings based on parameter-adaptive maximum correlation kurtosis deconvolution.

Maximum correlation kurtosis deconvolution (MCKD) is an effective means of identifying the periodic impulses of fault signals. However, the multiple input parameters required by MCKD complicate the process of fault diagnosis. To overcome this drawback, a new method for identifying fault types based on a parameter-adaptive MCKD method is proposed.

Cerebrospinal fluid dynamics along the optic nerve in patients with spontaneous cerebrospinal fluid rhinorrhea: a retrospective computed tomographic cisternography study.

Purpose: Spontaneous cerebrospinal fluid (CSF) rhinorrhea is related to intracranial pressure (ICP) and dynamic changes. This study investigated CSF dynamics along the optic nerve (ON) in patients with spontaneous CSF rhinorrhea.

Methods: The computed tomographic (CT) cisternographies of 66 patients (132 eyes) with spontaneous CSF rhinorrhea were analysed.

Risk factors and outcomes of cerebrospinal fluid leak related to endoscopic pituitary adenoma surgery.

The incidence of and risk factors for intra- and postoperative cerebrospinal fluid (poCSF) leak in patients who underwent endoscopic surgery for pituitary adenoma were investigated in this retrospective study. A total of 216 consecutive patients operated on by a single neurosurgical team were included. Logistic regression was applied to identify risk factors for intraoperative CSF (ioCSF) and poCSF leaks, and the outcome and management of ioCSF and poCSF leaks were analyzed.

Continuous dural suturing for closure of grade 3 leaks after tumor removal via an endoscopic endonasal approach.

Cerebrospinal fluid (CSF) leakage is a major complication after extended endonasal transsphenoidal surgery (EETSS), which is commonly used in the treatment of anterior skull base tumors. Dural suturing and graded reconstruction are promising techniques to further decrease the incidence of postoperative CSF (poCSF) leakage. The effect of continuous dural suturing in endoscopic surgery was investigated in this retrospective study.

Antioxidant activity of vine tea extract on lipid and protein oxidation in cooked mixed pork patties during refrigerated storage.

To prevent oxidation and maintain the quality of meat products, it is essential to add antioxidants. The aim of this work was to investigate the antioxidant activity of vine tea () extract (VTE) and evaluate the effects of VTE on the quality characteristics and lipid and protein oxidation of cooked mixed pork patties during refrigerated storage. VTE had a significant DPPH radical scavenging activity, and its IC was 15.

Characterization, hypolipidemic and antioxidant activities of degraded polysaccharides from Ganoderma lucidum.

The aim of this work is to characterize the primary structure and physicochemical properties of natural polysaccharides (GLP) and degraded polysaccharides (GLP) from Ganoderma lucidum, and evaluate their hypolipidemic and antioxidant activities. The results of particle size distribution and scanning electron microscopy (SEM) showed that Ganoderma lucidum polysaccharides were effectively degraded by ultrasonic method. GLP was composed of the same monosaccharide units as GLP but with different molar ratios.

Dynamic Load Balancing of Software-Defined Networking Based on Genetic-Ant Colony Optimization.

Load Balancing (LB) is one of the most important tasks required to maximize network performance, scalability and robustness. Nowadays, with the emergence of Software-Defined Networking (SDN), LB for SDN has become a very important issue. SDN decouples the control plane from the data forwarding plane to implement centralized control of the whole network.

Long-term control and predictors of seizures in intracranial meningioma surgery: a population-based study.

Background: The aim of this retrospective study was to investigate the long-term seizure control and antiepileptic drug (AED) prescriptions, as well as identifying predictors of seizure(s) before and after surgery in a population-based cohort of operated intracranial meningioma patients.

Methods: A total of 113 consecutive adult (> 18 years old) patients with newly diagnosed meningioma operated at the Karolinska University Hospital between 2006 and 2008 were included and followed up until the end of 2015. Data on seizure activity and AED prescriptions were obtained through chart review and telephone interview.

Isolation and structural identification of the main anthocyanin monomer in Vitis amurensis Rupr.

Many types of anthocyanins are present in Vitis amurensis Rupr of 'Beibinghong', which is grown in North-east China and has high antioxidant activity. However, the anthocyanin with the highest content in V. amurensis Rupr has not yet been identified.

Neodymium Oxide Induces Cytotoxicity and Activates NF-κB and Caspase-3 in NR8383 Cells.

We investigated whether Nd2O3 treatment results in cytotoxicity and other underlying effects in rat NR8383 alveolar macrophages. Cell viability assessed by the MTT assay revealed that Nd2O3 was toxic in a dose-dependent manner, but not in a time-dependent manner. An ELISA analysis indicated that exposure to Nd2O3 caused cell damage and enhanced synthesis and release of inflammatory chemokines.

Efficacy and safety of olanzapine for treatment of patients with bipolar depression: Chinese subpopulation analysis of a double-blind, randomized, placebo-controlled study.

Background: Depression in bipolar I disorder responds to the atypical antipsychotic olanzapine. This subpopulation analysis assessed whether olanzapine is superior to placebo specifically in the treatment of Chinese patients with bipolar I depression.

Methods: This was a subpopulation analysis of a 6-week, multicenter, double-blind, parallel, randomized, placebo-controlled trial among 12 Chinese study centers.

[HPLC enantioseparation, absolute configuration determination and anti-HIV-1 activity of (±)-F18 enantiomers].

Racemic (±)-F18 (10-chloromethyl-11-demethyl-12-oxo-calanolide A), an analog of nature product (+)-calanolide A, is a new anti-HIV-1 nonnucleoside reverse transcript inhibitor (NNRTI). A successful enantioseparation of (±)-F18 offering (R)-F18 and (S)-F18 was achieved by a chiral stationary phase prepared HPLC. Their absolute configurations were determined by measurement of their electronic circular dichroisms combined with modem quantum-chemical calculations.

Clinical characteristics and post-surgical outcomes of focal cortical dysplasia subtypes.

We retrospectively studied 105 patients with a focal cortical dysplasia (FCD) diagnosed on pathological examination, and investigated the long term postoperative seizure outcomes, different clinical characteristics of the three FCD subtypes, particularly type I and II, and surgical outcomes for each group. FCD is a common cause of drug-resistant epilepsy, which is divided into three different subtypes according to its involvement at different stages of brain development. Each of these groups may have different characteristics and may even have different surgical outcomes.