Succinate accumulation induces pyroptosis and mitochondrial damage via the inhibition of ATP5F1D in HUVECs.

Atherosclerosis, a chronic inflammatory disorder, is pathophysiologically linked to endothelial cell (EC) pyroptosis. This study aims to elucidate the mechanisms by which succinate exacerbates EC pyroptosis through mitochondrial damage. Serum samples are collected from patients with coronary heart disease (CHD) and healthy controls (HCs), and the levels of succinate, interleukin (IL)-6, and IL-18 are quantified.

Molecular and virulence differences of isolated from blood.

Background: Bloodstream infections (BSIs) accompanied by sepsis with () represents a public health threat being potentially life-threatening. There have been an increasing number of reports on isolates in China. We conducted a case-based genomic and experimental study.

JNK in inflammation and lipid metabolism regulation in atherosclerosis.

Atherosclerosis is a systemic arterial disease characterized by lipid deposition, chronic inflammation, and endothelial dysfunction and is driven by complex, multifactorial regulation. c-Jun N-terminal kinase (JNK), a key member of the stress-activated mitogen-activated protein kinase family, plays a central role in pathogenesis. JNK regulates oxidative stress, lipid metabolism, and inflammation by mediating interactions between cells and organs.

Enhancing spectral estimation accuracy of soil organic carbon by using geographic region and clay content as covariates.

Accurate monitoring of soil organic carbon (SOC) content, a core indicator of soil quality and ecosystem health, is important for sustainable agricultural development. Visible-near infrared (Vis-NIR) spectroscopy has become an important monitoring method owing to its fast, non-destructive, and cost-effective advantages. Regional soil data is difficult to cover soil attribute variations in complex environments.

Multiple Environmental Factors Shaping Hopanoid-Producing Microbes Across Different Ecosystems.

Hopanoids are a series of important lipid biomarkers in the bacterial cellular membranes that are found ubiquitously in different spatial and temporal environments. Squalene-hopane cyclase, a key and prerequisite molecular component of the hopanoid biosynthesis pathway, is encoded by the gene. To investigate the composition, niche, and distribution of microbial -containing communities, we analyzed hopanoid producer data and environmental parameters across different ecosystems on the basis of sequencing reads of peat samples from increasing gradient depths across peatland profile C in the Dajiuhu Peatland, as well as data collected from available published papers.

Efficient and rapid removal of chromium(VI) from water via NH-MIL-101(Fe)/NiAl-LDH composite adsorbent.

Due to the high toxicity and carcinogenicity of Cr(VI), wastewater should be treated to remove Cr(VI) before discharge. In this study, water purification was achieved through the adsorption of Cr(VI) using an Fe-MOF/NiAl-LDH composite (FML), where the Fe-MOF was grown in situ on the NiAl-LDH. This composite used AlOOH, a by-product of the aluminum-water hydrogen production system, as one of its precursors, thereby achieving resource reuse.

Construction of controllable hydrogen production system of aluminum-based gel via solvent exchange strategy and its antioxidant properties.

High-activity aluminum-based composites for hydrogen production have uncontrollable reaction kinetics, releasing large amounts of hydrogen and heat in a short period of time, which severely hinders their application in proton exchange membrane fuel cells (PEMFCs). This study reports a novel method for embedding highly active Al-based composites into PVA/DMSO organogels, where polyvinyl alcohol (PVA) serves as the gel factor and dimethyl sulfoxide (DMSO) acts as the dispersing medium. This method is based on a solvent exchange strategy, which regulates the gradient diffusion of DMSO and HO by adjusting the material network structure, thereby controlling the kinetics of the aluminum-water reaction.

The ZBTB family in cardiac development and diseases.

ZBTB (zinc finger and BTB domain) proteins are a class of evolutionarily conserved transcriptional factors (TFs) with zinc finger (ZF) and BTB (Broad-complex, Tram-track, and Bric-à-brac) domains. The ZBTB protein family has a wide range of functions in numerous biological processes, including cell cycle regulation, DNA repair, organ development, and haematopoietic stem cell fate determination. The ZBTB proteins regulate gene expression through interactions with transcriptional regulators, influencing processes such as myocardial contractility, inflammation, fibrosis, and cellular metabolism.

A systematic review of the current application status of decision-analytical models in the pharmacoeconomic evaluation of targeted therapies for pulmonary arterial hypertension.

Background: The implementation of targeted drug therapy results in a significant improvement in both survival rates and quality of life among patients diagnosed with pulmonary arterial hypertension (PAH), concurrently imposing a greater financial burden on them. The use of pharmacoeconomic evaluation based on decision-analytical models is extensively employed in the rational allocation of healthcare resources.

Objectives: The present study conducted a systematic review of the literature on the pharmacoeconomic evaluation of drugs for treating PAH, with a focus on summarizing the composition and sources of parameters in decision-analytical models.

Distance to the water table shapes the diversity and activity of DNA and RNA viruses in a subalpine peatland.

Peatlands are essential reservoirs of carbon and critical zones for the cycling of greenhouse gases on Earth. Their ecological functions are primarily governed by the microbial communities inhabiting them, which vary with hydrological conditions. However, the roles of viruses in peatland ecosystems remain poorly understood despite their abundance and ubiquity.

Jasmonic Acid (JA) Signaling Pathway in Rice Defense Against Chilo suppressalis Infestation.

Jasmonic acid (JA) signaling plays a crucial role in rice defense against the striped stem borer, Chilo suppressalis, a notorious pest causing significant yield losses. This review explores the current understanding of JA-mediated defense mechanisms in rice, focusing on the molecular basis, regulatory elements, and practical implications for pest management. JA biosynthesis and signaling pathways are induced upon C.

The Role of Genetic Resistance in Rice Disease Management.

Rice () is a crucial staple crop for global food security, particularly in Asia. However, rice production faces significant challenges from various diseases that can cause substantial yield losses. This review explores the role of genetic resistance in rice disease management, focusing on the molecular mechanisms underlying plant-pathogen interactions and strategies for developing resistant varieties.

Weakly supervised deep learning-based classification for histopathology of gliomas: a single center experience.

Multiple artificial intelligence systems have been created to facilitate accurate and prompt histopathological diagnosis of tumors using hematoxylin-eosin-stained slides. We aimed to investigate whether weakly supervised deep learning can aid in glioma diagnosis. We analyzed 472 whole slide images (WSIs) from 226 patients in West China Hospital (WCH) and 1604 WSIs from 880 patients in The Cancer Genome Atlas (TCGA).

Roles of Phyllosphere Microbes in Rice Health and Productivity.

The phyllosphere, comprising the aerial portions of plants, is a vibrant ecosystem teeming with diverse microorganisms crucial for plant health and productivity. This review examines the functional roles of phyllosphere microorganisms in rice (), focusing on their importance in nutrient uptake, disease resistance, and growth promotion. The molecular mechanisms underlying these interactions are explored along with their potential applications in enhancing sustainable rice production.

Investigation on the Distribution of in Yuanshui Unique Fish Species National Aquatic Germplasm Resources Reserve Using Environmental DNA Technology.

Freshwater ecosystems face unprecedented challenges as the cumulative impact of human activities intensifies. While protected areas and species-specific conservation policies are widely implemented, their effectiveness remains difficult to gauge using traditional catch-based surveys. This research employed environmental DNA (eDNA) technology to assess the distribution of the endangered fish, , within the Yuanshui Unique Fish Species National Aquatic Germplasm Resources Reserve (YUFRR) in Hunan, China.

Screening of the highly pathogenic BEdy1 against and exploration of its infection mode.

The white-backed planthopper (WBPH, ) is a notorious pest affecting rice production in many Asian countries. , as the most extensively studied and applied insect pathogenic fungus, is a type of green and safe biological control fungus compared to chemical insecticides, and it does not pose the "3R" problem. In this study, the strain BEdy1, which had better pathogenicity to WBPH, was screened out from eight strains of .

Associations of physical activity, screen time, sleep duration with optimal eating habits among adolescents.

Objective: The aim of this study was to explore the associations of physical activity, screen time and sleep duration with various eating habits among children.

Methods: The data were collected from six surveys of the Youth Risk Behaviour Survey conducted in 2011, 2013, 2015, 2017, 2019, and 2021, with a total of 78, 697 participants with complete information. Information on demographic characteristics (e.

Genome wide association study reveals new genes for resistance to striped stem borer in rice ( L.).

Rice is one of the most important food crops in the world and is important for global food security. However, damage caused by striped stem borer (SSB) seriously threatens rice production and can cause significant yield losses. The development and use of resistant rice varieties or genes is currently the most effective strategy for controlling SSB.

Application of lipopolysaccharide in establishing inflammatory models.

Lipopolysaccharide (LPS), a unique component of the outer membrane of Gram-negative bacteria, possesses immune-activating properties. It induces an immune response by stimulating host cells to produce a lot of inflammatory cytokines with a thermogenic effect, which may cause an inflammatory response. In the past few decades, the structure and function of LPS and its mechanism leading to inflammation have been extensively analyzed.

The expression and clinical significance of UHRF1 in soft tissue sarcomas and its prognostic value.

To explore the expression and prognostic value of UHRF1 gene in soft tissue sarcoma (STS) and its related molecular mechanism. The expression data and clinicopathological parameters of STS were downloaded from the Cancer Genome Atlas (TCGA). The expression level of UHRF1 in STS and adjacent tissues and its relationship with clinicopathological characteristics were analyzed.

Introduction of Cellulolytic Bacterium Z2.6 and Its Cellulase Production Optimization.

Enzyme-production microorganisms typically occupy a dominant position in composting, where cellulolytic microorganisms actively engage in the breakdown of lignocellulose. Exploring strains with high yields of cellulose-degrading enzymes holds substantial significance for the industrial production of related enzymes and the advancement of clean bioenergy. This study was inclined to screen cellulolytic bacteria, conduct genome analysis, mine cellulase-related genes, and optimize cellulase production.

Global hotspots and trends in microbial-mediated grassland carbon cycling: a bibliometric analysis.

Grasslands are among the most widespread environments on Earth, yet we still have poor knowledge of their microbial-mediated carbon cycling in the context of human activity and climate change. We conducted a systematic bibliometric analysis of 1,660 literature focusing on microbial-mediated grassland carbon cycling in the Scopus database from 1990 to 2022. We observed a steep increase in the number of multidisciplinary and interdisciplinary studies since the 2000s, with focus areas on the top 10 subject categories, especially in Agricultural and Biological Sciences.

New mechanisms: From lactate to lactylation to rescue heart failure.

Lactylation of α-myosin heavy chain (α-MHC) has recently been reported to preserve sarcomeric structure and function and attenuate the development of heart failure. Specifically, lactylation enhanced the interaction of α-MHC with the sarcomeric protein Titin, thereby maintaining normal sarcomeric structure and myocardial contractile function. Furthermore, the administration of lactate or inhibition of lactate efflux potentially treats heart failure by restoring lactylation of α-MHC and the interaction of α-MHC with Titin.

Deconstructing the Dimensions of Mycobiome Fingerprints in Luohandu Cave, Guilin, Southern China.

Subterranean karst caves are windows into the terrestrial subsurface to deconstruct the dimensions of mycobiome fingerprints. However, impeded by the constraints of remote locations, the inaccessibility of specimens and technical limitations, the mycobiome of subterranean karst caves has remained largely unknown. Weathered rock and sediment samples were collected from Luohandu cave (Guilin, Southern China) and subjected to Illumina Hiseq sequencing of ITS1 genes.