Large-Scale Data-Driven Optimization in Deep Modeling With an Intelligent Decision-Making Mechanism.

This study focuses on building an intelligent decision-making attention mechanism in which the channel relationship and conduct feature maps among specific deep Dense ConvNet blocks are connected to each other. Thus, develop a novel freezing network with a pyramid spatial channel attention mechanism (FPSC-Net) in deep modeling. This model studies how specific design choices in the large-scale data-driven optimization and creation process affect the balance between the accuracy and effectiveness of the designed deep intelligent model.

Elevated expression of immune and DNA repair genes in mated queens and kings of the Reticulitermes chinensis termites.

Studies have identified that mating induces a series of physiological changes in animals. In this period, males tending to invest more energy, immune peptides, and other substances to reduce the cost of living for females. This results in lower survival rates in later life than females.

Integration of Encoding and Temporal Forecasting: Toward End-to-End NO Prediction for Industrial Chemical Process.

Forecasting NOx concentration in fluid catalytic cracking (FCC) regeneration flue gas can guide the real-time adjustment of treatment devices, and then furtherly prevent the excessive emission of pollutants. The process monitoring variables, which are usually high-dimensional time series, can provide valuable information for prediction. Although process features and cross-series correlations can be captured through feature extraction techniques, they are commonly linear transformation, and conducted or trained separately from forecasting model.

Integrated Transcriptomic and Metabolomic Analyses Reveal Low-Temperature Tolerance Mechanism in Giant Freshwater Prawn .

Water temperature, as an important environmental factor, affects the growth and metabolism of aquatic animals and even their survival. The giant freshwater prawn (GFP) is a kind of warm-water species, and its survival temperature ranges from 18 °C to 34 °C. In this study, we performed transcriptomic and metabolomic analyses to clarify the potential molecular mechanism of responding to low-temperature stress in adult GFP.

causing infective endocarditis with brain infarction and subarachnoid hemorrhage: a case report.

Introduction: A rare pathogen of Infective Endocarditis (IE), the , has been known to trigger life-threatening complications. The case discussed here is of a teenager with brain infarction and subarachnoid hemorrhage caused by IE due to .

Case Report: A 15-year-old girl with movement disorders involving the left limbs and intermittent fevers was admitted to the hospital.

Extra-articular biceps tendon supplement release in total knee arthroplasty for valgus deformity combined with severe flexion contracture.

To investigate the efficacy of extra-articular biceps tendon supplement (EBS) release in the treatment of valgus knee with severe flexion contracture. We retrospectively studied 27 patients who received EBS release for valgus knee combined with severe flexion contracture from 2018 to 2021. The full-length radiograph of the lower limbs in a standing position was taken before and after the operation, and the tibiofemoral angles before and after the operation were measured on the full-length radiograph of the lower limbs.

A new efficient multi-stage strategy based on the complementarity of ultrafiltration and high resolution biochromatogram for the screening of skin-whitening candidates from the fibrous root of Bletilla striata.

Ultrafiltration-high performance liquid chromatography (UF-HPLC) and high resolution biochromatogram (HR-biochromatogram), have been proven to be effective methods for the rapid discovery of enzyme inhibitors in natural medicines. In attempt to conquer false-positive and false- negative screening results, a new multi-stage strategy based on the complementarity of UF-HPLC and HR-biochromatogram has been proposed for the fast screening of tyrosinase inhibitory components using the fibrous root of Bletilla striata as a case study. For the first two stages, UF- HPLC and HR-biochromatogram, were applied individually for the screening of high-affinity tyrosinase ligands and tyrosinase inhibitors.

MicroRNA in medication related osteonecrosis of the jaw: a review.

Medication related osteonecrosis of the jaw (MRONJ) is a condition caused by inhibition of the osteoclast activity by the anti-resorptive and anti-angiogenic drugs. Clinically, there is an exposure of the necrotic bone or a fistula which fails to heal for more than 8 weeks. The adjacent soft tissue is inflamed and pus may be present as a result of the secondary infection.

Alterations of the Gut Microbiota and Metabolomics Associated with the Different Growth Performances of Families.

To investigate the key gut microbiota and metabolites associated with the growth performance of families, 16S rRNA sequencing and LC-MS metabolomic methods were used. In this study, 90 families were bred to evaluate growth performance. After 92 days of culture, high (H), medium (M), and low (L) experimental groups representing three levels of growth performance, respectively, were collected according to the weight gain and specific growth rate of families.

Environmental regulation and agricultural green productivity growth in China: A retest based on 'Porter Hypothesis'.

Based on the panel data of provincial units in China from 2000 to 2020, this paper uses the entropy method to calculate agricultural environmental regulation level in China from the perspectives of afforestation projects, water conservancy projects and environmental protection projects. Then, this paper calculates agricultural non-point source pollutant emissions in China by using the unit survey and evaluation method, and calculates agricultural green productivity growth in China by using the SBM directional distance function and Luenberger productivity index. On this basis, the influence of environmental regulation on agricultural green productivity growth in China and its mechanism are empirically analysed.

Multifunctional DNA Tetrahedron for Alzheimer's Disease Mitochondria-Targeted Therapy by MicroRNA Regulation.

The principal hallmark of Alzheimer's disease (AD) is neuron mitochondrial dysfunction, whereas mitochondrial miRNAs potentially play important roles. Nevertheless, efficacious mitochondria organelle therapeutic agents for treatment and management of AD are highly advisable. Herein, we report a multifunctional DNA tetrahedron-based mitochondria-targeted therapeutic platform, termed tetrahedral DNA framework-based nanoparticles (TDFNs), which was modified with triphenylphosphine (TPP) for mitochondria-targeting, cholesterol (Chol) for crossing the central nervous system, and functional antisense oligonucleotide (ASO) for both AD diagnosis and gene silencing therapy.

A covalent crosslinking strategy to construct a robust peptide-based artificial esterase.

Peptide-based artificial enzymes derived from the supramolecular assembly of short peptides have attracted growing attention in recent years. However, the stability of these artificial enzymes is still a problem since their noncovalent supramolecular structure is quite sensitive and frail under environmental conditions. In this study, we reported a covalent crosslinking strategy for the fabrication of a robust peptide-based artificial esterase.

Experience of using a virtual reality rehabilitation management platform for breast cancer patients: a qualitative study.

Purposes: Postoperative rehabilitation of upper limb function is crucial for breast cancer. Therefore, we developed a rehabilitation management platform using virtual reality to improve rehabilitation compliance and effect. The purpose of this research was to understand the user usability experience of breast cancer patients about the postoperative rehabilitation management of upper limb function using virtual reality.

Sex differences in patients with heart failure and mildly reduced left ventricular ejection fraction.

Clinical studies on heart failure with mildly reduced left ventricular ejection fraction (HFmrEF) have gradually increased. However, studies on the prognostic differences between men and women among patients with HFmrEF are few, and no evidence on sex differences in such patients exists. Therefore, we retrospectively assessed the data of patients with HFmrEF using propensity score-matched analysis (PSMA).

Deep learning-powered 3D segmentation derives factors associated with lymphovascular invasion and prognosis in clinical T1 stage non-small cell lung cancer.

Background: Lymphovascular invasion (LVI) is an invasive biologic behavior that affects the treatment and prognosis of patients with early-stage lung cancer. This study aimed to identify LVI diagnostic and prognostic biomarkers using deep learning-powered 3D segmentation with artificial intelligence (AI) technology.

Methods: Between January 2016 and October 2021, we enrolled patients with clinical T1 stage non-small cell lung cancer (NSCLC).

AhR Promotes the Development of Non-small cell lung cancer by Inducing SLC7A11-dependent Antioxidant Function.

Aryl hydrocarbon receptor (AhR) is a transcription factor. It is reported that AhR is associated with non-small cell lung cancer (NSCLC), but the mechanisms underlying this relationship remain unclear. Therefore, we investigated the role of AhR in NSCLC to elucidate the underlying mechanisms.

Studies on the inhibition of α-glucosidase by biflavonoids and their interaction mechanisms.

Biflavonoids are a kind of polyphenol compounds with numerous biological functions. However, the potential inhibitory activities of biflavonoids on α-glucosidase are yet unknown. Here, the inhibitory effects of two biflavonoids (amentoflavone and hinokiflavone) on α-glucosidase and their interaction mechanisms were explored using multispectral approaches and molecular docking.

Long-Term Outcomes after Pediatric Mandibular Reconstruction Using Vascularized Free Fibula Flap.

Background: The purpose of this study was to evaluate the long-term outcomes of mandibular reconstruction with vascularized free fibula flap in pediatric patients.

Methods: Consecutive cases of mandibular reconstruction with vascularized free fibula flaps in pediatric patients at Peking University School and Hospital of Stomatology between 1999 and 2019 were reviewed. Postoperative computed tomography (CT) data of all patients were collected at each postoperative follow-up point, and after the age of 18 years.

Heterogeneous pattern of gene expression driven by mutation is involved in the construction of a prognosis model of lung squamous cell carcinoma.

Objective: To investigate the impact that mutation had on the gene heterogeneity expression and prognosis in patients with lung adenocarcinoma.

Methods: In this study, the Cancer Genome Atlas (TCGA) dataset was used to analyze the mutations in lung adenocarcinoma. Lung adenocarcinoma data was collected from the TCGA database, clinical information of patients was analyzed, and bioinformatics statistical methods were applied for mutation analysis and prognosis survival analysis.

Deep Adaptive Fuzzy Clustering for Evolutionary Unsupervised Representation Learning.

Cluster assignment of large and complex datasets is a crucial but challenging task in pattern recognition and computer vision. In this study, we explore the possibility of employing fuzzy clustering in a deep neural network framework. Thus, we present a novel evolutionary unsupervised learning representation model with iterative optimization.

Dual Contrastive Learning Network for Graph Clustering.

Graph representation is an important part of graph clustering. Recently, contrastive learning, which maximizes the mutual information between augmented graph views that share the same semantics, has become a popular and powerful paradigm for graph representation. However, in the process of patch contrasting, existing literature tends to learn all features into similar variables, i.

A cross-sectional study on the need for and utilization of assistive walking devices by people age 55 and older in Shanghai.

We conducted a study to analyze the unmet needs of and risk factors for use of assistive walking devices by the elderly based on sample survey data from Shanghai, China from July to October 2019. Among a total sample size of 11,193 people age 55 and older, 1,947 people (17.39%) needed assistive walking devices, 829 (42.

Long-term outcomes of arthroscopic synovectomy and core decompression through multiple small bone holes for early-stage avascular necrosis of the femoral head.

Objective: This study described a minimally invasive approach for the management of early-stage avascular necrosis of the femoral head, which integrated arthroscopic intra-articular decompression and core decompression by drilling multiple small holes.

Method: A total of 126 patients with 185 hip avascular necrosis were included between March 2005 and January 2008, and the hips were classified, based on the Association Research Circulation Osseous staging system, into stage I (n = 43), stage II (n = 114), and stage III (n = 28). Arthroscopic intra-articular inspection and debridement, along with drilling of multiple small holes for core decompression, were performed.

Perception of and Vaccine Readiness towards Mpox among Men Who Have Sex with Men Living with HIV in China: A Cross-Sectional Study.

Background: Men who have sex with men (MSM) living with HIV make up the majority of cases in the current Mpox outbreak. We aimed to investigate the perception of and vaccine readiness towards Mpox among MSM living with HIV in China.

Methods: This cross-sectional online study was conducted from 10 August to 9 September 2022.