AhR Promotes the Development of Non-small cell lung cancer by Inducing SLC7A11-dependent Antioxidant Function.

Aryl hydrocarbon receptor (AhR) is a transcription factor. It is reported that AhR is associated with non-small cell lung cancer (NSCLC), but the mechanisms underlying this relationship remain unclear. Therefore, we investigated the role of AhR in NSCLC to elucidate the underlying mechanisms. We collected clinical lung cancer samples and constructed overexpression and knockdown cell lines to investigate the tumorigenicity of and . Furthermore, we performed a ferroptosis induction experiment and chromatin immunoprecipitation experiment. AhR was highly expressed in NSCLC tissue. AhR knockdown cells showed ferroptosis related phenomenon. Furthermore, Chromatin immunoprecipitation confirmed the correlation between and solute carrier family 7 member 11 () and ferroptosis induction experiment confirmed that AhR affects ferroptosis via . Specifically, AhR regulates ferroptosis-related , which affects ferroptosis and promotes NSCLC progression. AhR promoted NSCLC development and positively correlated with , affecting its actions. bound to the promoter region of promotes NSCLC by activating expression, improving the oxidative sensitivity of cells, and inhibiting ferroptosis. Thus, AhR affects ferroptosis in NSCLC by regulating , providing foundational evidence for novel ferroptosis-related treatments.