[Correction of progressive hemifacial atrophy by orthognathic surgical procedures combined distraction osteogenesis and scapular flap transplantation: 5 cases report].

Objective: To evaluate the feasibility and the therapeutic effect of orthognathic surgical procedures combined distraction osteogenesis and scapular flap for correction of progressive hemifacial atrophy.

Methods: 5 cases with progressive hemifacial atrophy were treated. 1 mild case was treated with microsurgical de-epithelia scapular flap (MDSF) and genioplasty in one stage.

[Evaluation of patients' temporomandibular joint function after mandible reconstruction with free fibula flap].

Objective: To evaluate the temporomandibular joint (TMJ) function after mandible reconstruction with free fibula flap and with different condyle treatment.

Methods: Forty-one cases of mandible and condyle defects following benign tumor resection were reconstructed with fibula free flap, with the condyle being reconstructed by three methods: placement of the distal end of the fibula flap into the glenoid fossa, the fibula serving as the condyle (24 cases); attachment of the resected condyle as a nonvascularized transplant to the end of the fibula flap (5 cases); condyle preservation plus vascularized fibular reconstruction (12 cases). The postoperative TMJ function was evaluated by Fricton function index.

[Application of fourier transform infrared spectroscopy to non-invasive detection of pleomorphic adenoma of salivary gland in vivo].

In the present work, 20 patients with salivary pleomorphic adenoma were recruited for FTIR spectroscopic measurement. These obtained FTIR spectra were analyzed and compared. It was found that there were significant differences in the spectral features of the skin covering normal salivary gland, pleomorphic adenoma, and carcinoma change of pleomorphic adenoma, such as the changes in peak position, band shape and relative intensity of the bands in the ranges of 1000-1800 cm(-1) and 2800-3000 cm(-1).

[Donor side selection in mandibular reconstruction using the free fibular osteocutaneous flap].

Objective: To form algorithm to select the correct donor side in mandibular reconstruction using free fibular flap.

Methods: Six hundred and two consecutive cases of mandibular reconstruction using free fibular flap from May of 1999 to April of 2007 were reviewed.

Results: There were 424 cases in type I, 71 cases in type II, 63 cases in type III, and 44 cases in type IV.

[Free composite flap transfers in the head and neck region: an 8-year experience].

Objective: To analyze the feasibility and reliability of free tissue flap transfers in the head and neck region.

Methods: One thousand five hundred and eighty-four consecutive free flap transfers performed in 1,501 patients from May 1999 to September 2007 were reviewed. Among the 1,501 patients, 918 were male and 583 were female.

Non-microcystin producing Microcystis wesenbergii (Komárek) Komárek (Cyanobacteria) representing a main waterbloom-forming species in Chinese waters.

It is well known that several morphospecies of Microcystis, such as Microcystis aeruginosa (Kützing) Lemmermann and Microcystis viridis (A. Brown) Lemmermann can produce hepatotoxic microcystins. However, previous studies gave contradictory conclusions about microcystin production of Microcystis wesenbergii (Komárek) Komárek.

[Relationship between extracapsular spread of cervical metastatic lymph node and cervical recurrence in oral cancer patients].

Objective: To investigate the relationship between extracapsular spread (ECS) of cervical metastatic lymph node and the recurrence in patients with oral squamous cell carcinoma (OSCC).

Methods: The medical records of 74 OSCC patients with histologically confirmed cervical lymph node metastasis were reviewed. They were divided into 2 groups, ECS positive (ECS+) and ECS negative (ECS-).

[Reliability of residual internal jugular vein as the receipt vein in free flap transfer in head and neck region].

Objective: To analyze the reliability of residual internal jugular vein as the receipt vein in free flap transfer in head and neck region.

Methods: Sixteen cases of head and neck reconstruction using the end-to-side anastomosis to the residual internal jugular vein were reviewed.

Results: There were 11 radial forearm flaps, 3 fibular flaps, one jejunal flap, and one abdominis myocutaneous flap.

Mat formation in Saccharomyces cerevisiae requires nutrient and pH gradients.

The ability of Saccharomyces cerevisiae to form morphologically complex colony-like structures called mats requires expression of the cell surface glycoprotein Flo11p and growth on a semisolid surface. As the mat grows, it forms two visually distinct populations called the rim (edge of the mat) and the hub (interior of the mat), which can be physically separated from one another based on their agar adherence properties. Here, we show that growth of the mat on a semisolid agar surface creates concentric glucose and pH gradients in the medium that are required for the differentiation of the hub and rim.

Application of 99mTc-pertechnetate scintigraphy to microvascular autologous transplantation of the submandibular gland in patients with severe keratoconjunctivitis sicca.

Unlabelled: Our objective was to evaluate the role of (99m)Tc-pertechnetate scintigraphy on microvascular autologous transplantation of the submandibular gland in patients with severe keratoconjunctivitis sicca (KCS).

Methods: (99m)Tc-Pertechnetate scintigraphy was performed on 106 patients with severe KCS. The patients were examined before surgery and at 1 wk and 3 mo afterward using a standardized protocol that included static scintigrams, time-activity curves, and delayed scintigrams to check the function and secretion of the major salivary glands.

[Influence of prior radiotherapy on free tissue transfer in head and neck region].

Objective: To analyze the influence of prior radiotherapy on free tissue transfer in head and neck region.

Methods: One thousand and sixty-six consecutive free flap transfers performed in 1007 patients in head and neck region from May 1999 to March 2005 were reviewed. Among the 1007 cases, 146 had a history of prior radiotherapy (radiation group), and the other 896 without prior radiotherapy (non-radiation group).

[168 cases of free flap transplantation with double vein anastomoses for reconstruction of head and neck defects].

Objective: To evaluate the reliability and effectiveness of free flap transfer with double vein anastomosis for reconstruction of head and neck defects.

Methods: One hundred and sixty-eight cases of free flap transfers with double vein anastomosis for head and neck reconstruction from September 1999 to April 2003 were reviewed. There were 92 males and 76 females.

[A preliminary study of head and neck reconstruction using free anterolateral thigh flap].

Objective: To analyze the feasibility and reliability of free anterolateral thigh flap transfers in head and neck reconstruction.

Methods: Twenty-two consecutive free anterolateral thigh flap transfers from January 2002 to January 2006 were reviewed. Data concerning the operation included date of surgery, defect description and site, stage and histology of tumor, design of anterolateral free flap, type of perforators, recipient vessel and type of anastomosis used and complications.

Blockade of vascular endothelial growth factor activity suppresses wear debris-induced inflammatory osteolysis.

Objective: Aseptic loosening is a common complication of total joint replacement in humans. Our study examined the hypothesis that wear debris may influence vascular endothelial grow factor (VEGF) expression, and that blocking VEGF bioactivity might improve wear debris-induced inflammatory osteolysis in a mouse model.

Methods: Ultra high molecular weight polyethylene (UHMWPE) particles were introduced into established air pouches on BALB/c mice, followed by implantation of calvaria bone from syngeneic littermates.

Association between UHMWPE particle-induced inflammatory osteoclastogenesis and expression of RANKL, VEGF, and Flt-1 in vivo.

Wear debris-induced vascularized granulomatous periprosthetic tissue may augment the progress of prosthetic loosening, a major clinical problem after total joint replacement. The purpose of this study is to investigate the association of ultra-high-molecular-weight polyethylene (UHMWPE) particle-induced inflammatory osteoclastogenesis and expression of RANK/RANKL and VEGF/VEGF receptors (Flt-1 and Flk-1) using a mouse osteolysis model. UHMWPE particles were introduced into established air pouches on BALB/c mice, followed by implantation of calvaria bone from syngeneic littermates.

Implant wear induces inflammation, but not osteoclastic bone resorption, in RANK(-/-) mice.

Signaling of RANK (receptor activator of nuclear factor kappa B) through its ligand RANKL appears critical in osteolysis associated with aseptic loosening (AL). The purpose of this study was to investigate the role of RANK in a murine osteolysis model developed in RANK knockout (RANK(-/-)) mice. Ultra high molecular weight polyethylene (UHMWPE) debris was introduced into established air pouches on RANK(-/-) mice, followed by implantation of calvaria bone from syngeneic littermates.

[Combined free flap and pedicled pectoralis major myocutaneous flap in reconstruction of extensive composite defects in head and neck region: a review of 9 consecutive cases].

Objective: To analyze the value and reliability of combined free flap and pedicled pectoralis major myocutaneous flap in the reconstruction of extensive composite head and neck defects.

Methods: Nine consecutive cases of combined free flap and pedicled pectoralis major myocutaneous flap transfers for extensive head and neck defects from March 2002 to April 2005 were reviewed. Data concerning the operation included defect description, type of free flap, recipient vessel and complications.

Erythromycin inhibits wear debris-induced inflammatory osteolysis in a murine model.

Up to 20% of patients with total joint arthroplasty will develop radiographic evidence of aseptic loosening (AL), which most likely results from an inflammatory response to billions of wear debris shed from the implant. Our previous work has demonstrated that erythromycin (EM), a macrolide antibiotic, inhibits wear debris-induced inflammatory osteoclastogenesis through the reduction of cytokine production and osteoclast differentiation, both of which involve the NF-kappaB pathway. The aim of the current study was to determine whether EM inhibits wear debris-induced inflammatory osteolysis in a murine osteolysis model.

Pre-mental foramen mandibulotomy for resecting tumors of tongue base and parapharyngeal space.

Background: Resection of tumors arising from the tongue base and the parapharyngeal space is difficult for exposure and manipulation because of their obscure location. The aim of this study was to evaluate the surgical approach of the pre-mental foramen mandibulotomy for resecting the tumors of tongue base and parapharyngeal space.

Methods: Fifty-one patients with tumors of tongue base and parapharyngeal space were treated using the mandibulotomy approach on the pre-mental foramen.

[Postoperative vessel thrombosis and its management after free flap transfers in head and neck region].

Objective: To analyze the rate of postoperative vessel thrombosis and its management after free tissue transfers in head and neck region.

Methods: Eight hundred and forty-nine consecutive free flap transfers were performed from May 1999 to September 2004. Among them, the flaps with postoperative vessel thrombosis were selected and reviewed.

[Color Doppler ultrasound study on pathological changes of lower extremity arteries in patients with metabolic syndrome].

Objective: To explore the pathological changes of lower extremity arteries of patients with metabolic syndrome.

Methods: Fifty patients with metabolic syndrome (MS) and 30 normal volunteers were included in this study. The inner diameters, peak systolic velocities and intima-media thicknesses of the lower extremity arteries, and the sizes and numbers of the plaques in the lower extremity arteries were obtained with color Doppler ultrasound (CDU).

Maxillary reconstruction with the free fibula flap.

Background: The objective of this study was to evaluate the outcomes of using the free fibula flap in the reconstruction of maxillary defects.

Methods: Thirty-four consecutive cases of maxillary reconstruction with the free fibula flap were reviewed. All clinical data were analyzed, including primary diseases, types of maxillary defect, free fibula flap design, perioperative complications, and follow-up results.

[Reconstruction of accessory nerve defects with sternocleidomastoid muscle-great auricular nerve flap].

Objective: To describe a new method of accessory nerve defect reconstruction with sternocleidomastoid muscle-great auricular flap.

Methods: Thirty-four cases receiving traditional radical neck dissection were divided into two groups: single neck dissection group (n = 19) and accessory nerve reconstruction group (n = 15). Surgical procedure of the reconstruction was described in detail.

[Senile chronic submandibular sialadenitis].

Objective: To evaluate the clinic characteristic and treatment of senile chronic submandibular sialadenitis.

Methods: The clinical records of the patients over 50 years old whose final diagnosis was chronic submandibular sialadenitis were reviewed. The patients were diagnosed as neoplasm of submandibular gland before operation, There was no radiographic sign of sialolithiasis, no clinical and laboratory signs of Sjögren syndrome or related autoimmune disease.

A locus for familial generalized lentiginosis without systemic involvement maps to chromosome 4q21.1-q22.3.

Generalized lentiginosis (GL) is characterized by widespread lentigines without associated noncutaneous abnormalities. In this study we performed a genome-wide linkage search in a Chinese family with GL and localized the familial GL locus to chromosome 4q21.1-q22.