Single-cell transcriptome sequencing reveals tumor stem cells and their molecular characteristics in intrahepatic cholangiocarcinoma.

Intercellular communication signals in the tumor microenvironment are closely related to behaviors such as cancer cell proliferation and immune evasion. However, the specific roles of intercellular signaling pathways in intrahepatic cholangiocarcinoma (ICC) have not yet been fully characterized. In this study, we analyzed publicly available single-cell RNA sequencing (scRNA-seq) data derived from paired samples of two intrahepatic cholangiocarcinoma (ICC) tissues and two adjacent normal tissues, thoroughly examining their cellular composition.

ESO-Shanghai 20: phase III clinical trial of anti-PD-1 therapy with local intervention for oligometastatic ESCC.

NCT06190782 (ClinicalTrials.gov).

Hydration characteristics and sustainability of calcium carbide slag-activated full solid waste cementitious materials under high temperature curing.

Using calcium carbide slag (CCS) to replace ordinary portland cement (OPC) as an alkali activator for the preparation of full solid waste cementitious material is a green and low carbon method. This study investigates the influence of 80 °C high-temperature curing on ground granulated blast furnace slag - steel slag based supersulfated cement (GS-SSC) incorporating 0 to 20 wt% CCS. The hydration products and microstructure of GS-SSC were analysed using various microscopic techniques, assess the compressive strength and pH value development, exploring the hydration mechanism of CCS activated GS-SSC.

Prefrontal encoding of an internal model for emotional inference.

A key function of brain systems mediating emotion is to learn to anticipate unpleasant experiences. Although organisms readily associate sensory stimuli with aversive outcomes, higher-order forms of emotional learning and memory require inference to extrapolate the circumstances surrounding directly experienced aversive events to other indirectly related sensory patterns that were not part of the original experience. This type of learning requires internal models of emotion, which flexibly track directly experienced and inferred aversive associations.

Differential regulation of fetal bone marrow and liver hematopoiesis by yolk-sac-derived myeloid cells.

Fetal hematopoiesis takes place in the liver before colonizing the bone marrow where it will persist for life. This colonization is thought to be mediated by specification of a microenvironment that selectively recruits hematopoietic cells to the nascent bone marrow. The identity and mechanisms regulating the specification of this colonization niche are unclear.

Sustainable valorization of coal gasification slag through optimized grinding kinetics: Composite cement compressive strength enhancement and environmental assessment.

The utilization of industrial solid wastes for the preparation of supplementary cementitious materials (CGS) has great development potential and helps to solve the problems of resource shortage and environmental pollution. In this paper, the mechanically activated coal gasification slag (CGS) scheme was optimized based on the grinding kinetic model, and the intrinsic connection between particle characteristics, activity index, and CGS-composite cement properties was established. The hydration mechanism of CGS-composite cement was explored by characterization techniques such as XRD, FTIR, TG-DTG, and SEM.

Reutilization of steel slag (SS) in super sulfate cement (SSC): A comparative study of SS dosage and carbonation treatment on strength development, hydration behavior and sustainable development.

The development of low-carbon cementitious materials is one of the important ways to alleviate the problem of large accumulation of industrial by-products and reduce high energy consumption and high carbon emissions in the cement industry. This study investigated the possibility of using steel slag (SS) as an alkaline activator to prepare super sulfate cement (SSC). The hydration reaction test (hydration heat and pH value) and microscopic characterization (XRD, FTIR, TG and SEM) were used to systematically study the influence mechanism of SS dosage and its carbonation treatment on the macroscopic mechanical properties of the samples.

Comprehensive evaluation of low-carbon cementitious materials prepared with industrial by-product calcium carbide residue (CCR) as alkali source.

The preparation of low-carbon cementitious materials through the synergistic coupling of multiple solid wastes has great potential for development, which can improve the problems of resource shortage and environmental pollution. In this paper, a new type of supersulfated cement was developed by using calcium carbide residue (CCR) as an alkaline activator. The effects of CCR content on the mechanical properties and hydration behaviors of the samples under steam curing conditions were discussed.

Study on the mechanical properties of granite responses of cyclic heating and water cooling considering microcosmic and energy.

Investigating the coupling effects of temperature levels and heating-water cooling cycles on the physical and mechanical responses of HDR (hot dry rock) is a vital issue during the exploitation of geothermal energy. In this study, the physical properties of granite specimens were measured first after each heating and water-cooling cycle. Then, uniaxial compressive tests were conducted on those granites to obtain their mechanical properties.

The role of radiomics for predicting of lymph-vascular space invasion in cervical cancer patients based on artificial intelligence: a systematic review and meta-analysis.

The primary aim of this study was to conduct a methodical examination and assessment of the prognostic efficacy exhibited by magnetic resonance imaging (MRI)-derived radiomic models concerning the preoperative prediction of lymph-vascular space infiltration (LVSI) in cervical cancer cases. A comprehensive and thorough exploration of pertinent academic literature was undertaken by two investigators, employing the resources of the Embase, PubMed, Web of Science, and Cochrane Library databases. The scope of this research was bounded by a publication cutoff date of May 15, 2023.

Single-cell transcriptome sequencing reveals SPP1-CD44-mediated macrophage-tumor cell interactions drive chemoresistance in TNBC.

Triple-negative breast cancer (TNBC) is often considered one of the most aggressive subtypes of breast cancer, characterized by a high recurrence rate and low overall survival (OS). It is notorious for posing challenges related to drug resistance. While there has been progress in TNBC research, the mechanisms underlying chemotherapy resistance in TNBC remain largely elusive.

Effect of right internal mammary artery versus radial artery as a second graft vessel in coronary artery bypass grafting on postoperative wound infection in patients: A meta-analysis.

Few studies have shown that radial artery (RA), which is used as a secondary arterial graft, offers superior results compared with right internal thoracic artery (RIMA) in coronary artery bypass grafting (CABG). In a meta-analysis of observational studies starting in 2023, we looked at the effect of re-operation on postoperative infection and haemorrhage in CABG with RA vs. RIMA.

Sustainable assessment and synergism of ceramic powder and steel slag in iron ore tailings-based concrete.

Solid waste management is a critical issue worldwide. Effectively utilizing these solid waste resources presents a viable solution. This study focuses on Iron ore tailings (IOTs), a solid waste generated during iron ore processing, which can be used as supplementary cementitious materials (SCMs) but have low reactivity, hindering their large-scale application in concrete production.

Development and Validation of a Prognosis-Prediction Signature for Patients with Lung Adenocarcinoma Based on 11 Telomere-Related Genes.

Background: The occurrence and progression of lung cancer are correlated with telomeres and telomerase. Telomere length is reduced in the majority of tumors, including lung cancers. Telomere length variations have been associated with lung cancer risk and may serve as therapeutic targets as well as predictive biomarkers for lung cancer.

Effect of Aurora kinase B on polyploidy and decidualization in mouse uterus.

Research Question: Decidualization is critical to the establishment of mouse normal pregnancy. The fibroblast-like stromal cells in the process form polyploid multinucleated cells. Aurora kinase B (Aurora B) has previously been shown to regulate polyploidy in various cells.

Effect of Iron Tailing Powder-Based Ternary Admixture on Acid Corrosion Resistance of Concrete.

Exposure of concrete to acidic environments can cause the degradation of concrete elements and seriously affect the durability of concrete. As solid wastes are produced during industrial activity, ITP (iron tailing powder), FA (fly ash), and LS (lithium slag) can be used as admixtures to produce concrete and improve its workability. This paper focuses on the preparation of concrete using a ternary mineral admixture system consisting of ITP, FA, and LS to investigate the acid erosion resistance of concrete in acetic acid solution at different cement replacement rates and different water-binder ratios.

Adoption of Ultrasound-guided Polymer Nanocarriers in Tumor Chemoradiotherapy and Oxidation Treatment.

The research was aimed at discussing the effectiveness of ultrasound-guided polymer nanocarriers in the clinical treatment of tumors by chemoradiotherapy and oxidation treatment. Twenty female Balb/cAnN (BALB/C) mice were selected as the research objects in the experiment. These mice were set up as tumor-bearing mice, and then ultrasound-guided polymers with different doses, including polyethylene glycol-poly 2-bromoethyl methacrylate (PEG-PBEMA) (Micelle group), free small molecules called l-ascorbyl palmitate (PA) (PA group), PA-micelle micellar particles (PA-Micelle group) prepared in the research, and phosphate buffer solution (PBS) (PBS group) were adopted.

OTX1 silencing suppresses ovarian cancer progression through inhibiting the JAK/STAT signaling.

Background: The aim of our study was to investigate the roles and the underlying mechanisms of orthodenticle homolog 1 (OTX1) in ovarian cancer.

Methods: OTX1 expression was obtained from TCGA database. OTX1 expression in ovarian cancer cells was detected using qRT-PCR and western blot assay.

Testicular macrophages are recruited during a narrow fetal time window and promote organ-specific developmental functions.

A growing body of evidence demonstrates that fetal-derived tissue-resident macrophages have developmental functions. It has been proposed that macrophages promote testicular functions, but which macrophage populations are involved is unclear. Previous studies showed that macrophages play critical roles in fetal testis morphogenesis and described two adult testicular macrophage populations, interstitial and peritubular.