Demonstration of Monolithic Integration of InAs Quantum Dot Microdisk Light Emitters and Photodetectors Directly Grown on On-Axis Silicon (001).

Silicon-based microcavity quantum dot lasers are attractive candidates for on-chip light sources in photonic integrated circuits due to their small size, low power consumption, and compatibility with silicon photonic platforms. However, integrating components like quantum dot lasers and photodetectors on a single chip remains challenging due to material compatibility issues and mode field mismatch problems. In this work, we have demonstrated monolithic integration of an InAs quantum dot microdisk light emitter, waveguide, and photodetector on a silicon platform using a shared epitaxial structure.

The m6A methyltransferase METTL14 promotes oncogenic Kras induced juvenile myelomonocytic leukemia through dysregulating autophagy.

The N6-methyladenosine (m6A) modification plays an important role in the pathogenesis of various myeloid malignancies. However, its specific role in RAS mutation-induced myeloid malignancy is incompletely understood. In this study, we found that m6A methyltransferase methyltransferase-like 14 (METTL14) was highly expressed and associated with a shorter survival in a RAS-mutation myeloid malignancy, juvenile myelomonocytic leukemia (JMML).

Co-operative epigenetic remodelling by Setd2 deficiency and Kras mutation drives juvenile myelomonocytic leukaemia development and MEK inhibitor sensitivity.

Juvenile myelomonocytic leukaemia (JMML) primarily stems from the Rat Sarcoma (RAS)/Extracellular Signal-Regulated Kinase (ERK) pathway mutations, and currently, there are no effective regimens against JMML, yet various studies have highlighted the importance of deciphering secondary genetic and/or epigenetic alterations in pursuit of treatments. Setd2-mediated-H3K36me3 participates in myriad biological functions and primarily serves as a tumour suppressor gene in carcinogenesis. However, little is known about the synergism between Setd2 deficiency and Kras mutation during JMML onset and progression.

A SNP-based genome-wide association study (GWAS) of seed-yield related traits in using wheat as a reference genome.

Background: is an popular perennial grass for both mowing and grazing when used for pasture establishment in high latitude regions. has the advantages of high yield, high quality, good palatability and high nutritional value. It is widely used in artificial grassland construction and ecological restoration in Inner Mongolia and other regions.

Heat treatment affects gastric digestion kinetics but not amino acid bioavailability of milk proteins: a pig study.

Impact of heat treatment on digestion and absorption of milk proteins in vivo remains unclear. This study used Bama minipigs with duodenum-ileum double cannulas to investigate milk protein digestion and absorption under four heat treatments. During early gastric digestion (20 min), high-temperature treated milk (HTM) and ultra-high-temperature treated milk (UHTM) formed more fragmented protein curds.

Comparative cytotoxicity and toxicological mechanisms of 6:2 Cl-PFAES and PFOS in pancreatic β cells: implications for glucose metabolism disruption.

Previous studies have indicated that 6:2 chlorinated polyfluoroalkyl ether sulfonate (6:2 Cl-PFAES), a substitute for perfluorooctane sulfonate (PFOS), causes disruptions in glucose metabolism, but its toxicological mechanisms remain unclear. Pancreatic β cells are responsible for regulating glucose metabolism. This study used mouse insulinoma β cells (β-TC-6) to study the toxic effects of 6:2 Cl-PFAES and elucidate its potential mechanisms.

The ERF072 Transcription Factor Directly Regulates MtSOC1-Like Expression and Mediates Drought-Accelerated Flowering in Medicago truncatula.

Flowering time is a key agricultural trait that indicates the yield of Medicago truncatula. Although drought stress affects flowering time in this species, the molecular mechanism underlying the enhancement of flowering to facilitate drought tolerance remains unclear. Accelerated flowering at the onset of drought enables drought escape in Medicago truncatula, ethylene-responsive factors are an important class of transcription factors whose members are involved in drought stress processes in numerous plants.

Boosting the activity in the liquid-phase hydrogenation of S-containing nitroarenes by dual-site Pt/CeO catalysts design.

The liquid phase hydrogenation of nitroarenes is an important industrial reaction. The active sites are typically supported metal nanoparticles, which can be easily deactivated when sulfur groups are present in the substrate. Here, we report a new strategy for converting these S-containing nitroarenes by developing a dual-sites Pt/CeO catalyst consisting of highly defective CeO with abundant active oxygen vacancy and Pt sub-nano clusters.

Processing of Dairy Products Can Affect the Digestible Indispensable Amino Acid Score (DIAAS): An In Vivo Study in Bama Minipigs.

Background: During manufacturing, different applied processes can potentially alter macro- and microstructures of milk proteins, which eventually affect the digestibility and the digestible indispensable amino acid score (DIAAS).

Objectives: We aimed to investigate the effects of different processes, including heating and fermentation, on the ileal digestibility of amino acids (AA) and DIAAS in dairy products.

Methods: Six dairy products were produced under different processing conditions.

Activating molecular oxygen by a defect-engineered S-scheme α-FeO/g-CN heterojunction for efficient in-situ photo-Fenton degradation.

Solar-driven molecular oxygen activation provides a sustainable strategy for generating reactive oxygen species, but the crucial step of effective electron transfer from the active sites to activate molecular oxygen remains challenging. Herein, a defect-engineered S-scheme α-FeO/g-CN heterojunction is meticulously constructed to facilitate molecular oxygen activation through the precise orientation of photoelectron transfer channels. Such a special transfer path establishes an effective consecutive photoelectron transfer channel between g-CN and α-FeO.

Arachidonic acid promotes myeloid differentiation of splenic CD45- Ter119+ cells in myeloproliferative neoplasm.

Although splenic CD45Ter119 cells promote cancer progression by secreting artemin, it remains unclear whether these cells play an important role in myeloproliferative neoplasm (MPN). Here, using a Kras-induced mouse model of MPN, we demonstrated that the number and cycling of CD45Ter119 cells increased in the spleens of MPN mice. Moreover, these cells could differentiate into myeloid cells upon stimulation with GM-CSF and mIL-6.

[Exploration of Rational Use of DSA Equipment in IoT and Clinical Service].

Objective: This study aims to address the configuration and efficiency issues in the use of digital subtraction angiography (DSA) equipment through the practical implementation of a rationalization platform based on the Internet of Things (IoT).

Methods: By employing IoT and data integration technologies, the deep integration of DSA equipment operational data with clinical data was achieved to construct a knowledge base for rational use of DSA equipment. Simultaneously, a knowledge base was developed using software engineering techniques to visually display data analysis results.

UV-Vis-NIR Broadband Dual-Mode Photodetector Based on Graphene/InP Van Der Waals Heterostructure.

Dual-mode photodetectors (DmPDs) have attracted considerable interest due to their ability to integrate multiple functionalities into a single device. However, 2D material/InP heterostructures, which exhibit built-in electric fields and rapid response characteristics, have not yet been utilized in DmPDs. In this work, we fabricate a high-performance DmPD based on a graphene/InP Van der Waals heterostructure in a facile way, achieving a broadband response from ultraviolet-visible to near-infrared wavelengths.

The antibacterial efficacy of nitroxoline against multidrug resistant Escherichia coli associated with copper binding.

Nitroxoline (NIT) has been approved for the treatment of uncomplicated urinary tract infections (UTIs) for more than half a century, yet its antimicrobial properties remain incompletely understood. Here, we determined the intricate connections between NIT's metal-chelating capabilities and its antibacterial activity. Metal ion binding characteristics were measured by Ultraviolet-visible (UV-vis) spectroscopy.

Copper(II) enhances the antibacterial activity of nitroxoline against MRSA by promoting aerobic glycolysis.

Nitroxoline (NIT) is an FDA-approved antibiotic with numerous pharmacological properties. However, the intricate connections between its metal-chelating ability and antimicrobial efficacy remain incompletely understood. The specific interactions of NIT with different metal ions were measured via UV-vis absorption spectroscopy.

6:2 fluorotelomer sulfonate as a safer alternative to PFOS: Comparative cytotoxicity and oxidative stress mechanisms in pancreatic β-cells (INS-1 model).

Previous studies suggest that 6:2 fluorotelomer sulfonate (6:2 FTSA) exhibits lower hepatotoxicity and reduced reproductive and developmental toxicity compared to perfluorooctane sulfonate (PFOS), indicating it may offer a safer alternative. This study aimed to investigate whether 6:2 FTSA is safer than PFOS in terms of its cytotoxic effects on pancreatic β-cells. Using rat insulinoma cells (INS-1) as a model of pancreatic β-cells, we compared the effects of 6:2 FTSA and PFOS in both their acid (6:2 FTSA-H, PFOS-H) and potassium salt forms (6:2 FTSA-K, PFOS-K) on cell viability through Cell Counting Kit-8 (CCK-8) assays, Trypan Blue staining, and apoptosis assays.

The ecological security risks of phthalates: A focus on antibiotic resistance gene dissemination in aquatic environments.

Antibiotic resistance genes (ARGs) have become a major focus in environmental safety and human health, with concerns about non-antibiotic substances like microplastics facilitating their horizontal gene transfer. Phthalate esters (PAEs), as ubiquitous plastic additives, are prevalent in aquatic environments, yet there remains a dearth of studies examining their impacts on ARG dissemination. This study focuses on dibutyl phthalate (DBP), a prototypical PAE, to assess its potential influence on the conjugative transfer of ARGs along with the related molecular mechanisms.

Role of organophosphorus pesticides in facilitating plasmid-mediated conjugative transfer: Efficiency and mechanisms.

Non-antibiotic conditions, including organophosphorus pesticides (OPPs), have been implicated in the horizontal gene transfer (HGT) of antibiotic resistance genes (ARGs) to varying degrees. While most studies focus on the toxicity of OPPs to humans and animals, their roles in ARG dissemination remain largely unexplored. In this study, we investigate the effects and involved molecular mechanisms of environmentally relevant concentrations of malathion and dimethoate, two representative OPPs, on plasmid-mediated conjugal transfer.

NtSAP9 confers freezing tolerance in Nicotiana tabacum plants.

Abiotic stresses, such as extreme temperatures, drought, and salinity, significantly affect plant growth and productivity. Among these, cold stress is particularly detrimental, impairing cellular processes and leading to reduced crop yields. In recent years, stress-associated proteins (SAPs) containing A20 and AN1 zinc-finger domains have emerged as crucial regulators in plant stress responses.

Different paths, same destination: Bisphenol A and its substitute induce the conjugative transfer of antibiotic resistance genes.

Antibiotic resistance genes are primarily spread through horizontal gene transfer in aquatic environments. Bisphenols, which are widely used in industry, are pervasive contaminants in such environments. This study investigated how environmentally relevant concentrations of bisphenol A and its substitute (bisphenol S, Bisphenol AP and Bisphenol AF) affect the spread of antibiotic resistance genes among Escherichia coli.

Assessment of the cytotoxicity micro- and nano-plastic on human intestinal Caco-2 cells and the protective effects of catechin.

Micro- and nano-plastics (M/NPs) potentially leach from plastic wrapping into food and beverages. However, the risks of ingested M/NPs to human intestinal health remain unclear. This study aimed to determine the potential risks and mechanisms of PS-M/NPs using a human intestinal epithelial model and to explore protective measures to reduce these risks.

Ultrasensitive Flexible Strain Sensor Made with Carboxymethyl-Cellulose-Anchored Carbon Nanotubes/MXene for Machine-Learning-Assisted Handwriting Recognition.

The combination of wearable sensors with machine learning enables intelligent perception in human-machine interaction and healthcare, but achieving high sensitivity and a wide working range in flexible strain sensors for signal acquisition and accurate recognition remains challenging. Herein, we introduced carboxymethyl cellulose (CMC) into a carbon nanotubes (CNTs)/MXene hybrid network, forming tight anchoring among the conductive materials and, thus, bringing enhanced interaction. The silicone-rubber-encapsulated CMC-anchored CNTs/MXene (CCM) strain sensor exhibits an excellent sensitivity (maximum gauge factor up to 71 294), wide working range (200%), ultralow detection limit (0.

Great truths are always simple: A millimeter-sized macroscopic lanthanum-calcium dual crosslinked carboxymethyl chitosan aerogel bead as a promising adsorbent for scavenging oxytetracycline from wastewater.

Given their increasing environmental and health harms, it is crucial to develop green and sustainable techniques for scavenging antibiotics represented by oxytetracycline (OTC) from wastewater. In the present work, a structurally simple lanthanum-calcium dual crosslinked carboxymethyl chitosan (CMCS-La-Ca) aerogel was innovatively synthesized for adsorptive removal of OTC. It was found that CMCS and La sites collaboratively participated in OTC elimination, and OTC removal peaked over the wide pH range of 4-7.

A photoelectrochemical sensor based on InS/AgInS in situ Z-type heterojunction with "photo-modulated interface charge" for sensitive detection of Programmed Death-Ligand 1.

The construction of heterostructure photoelectrodes can enhance the performance of photoelectrochemical (PEC) sensors. However, it is still a critical challenge to achieve efficient transfer of interface carriers. In this paper, we propose a strategy of "photo-modulated interface charge" to design a PEC sensor based on a hollow hexagonal tubular InS/AgInS in situ Z-type heterojunction for the susceptible detection of Programmed Death-ligand 1 (PD-L1).

The Psathyrostachys juncea DWARF27 gene encodes an all-trans-/9-cis-beta-carotene isomerase in the control of plant branches in Arabidopsis thaliana by strigolactones.

Strigolactones (SLs), carotenoid-derived plant hormones, govern the growth and development of both monocotyledonous and dicotyledonous plants. DWARF27 (D27), a plastid-targeted protein located at the initiation site of the core pathway in SL synthesis, plays a crucial role in regulating plant tillering (branching). In rice (Oryza sativa) and wheat (Triticum aestivum), OsD27 and TaD27-B proteins modulate the number of plant tillers by participating in SL biosynthesis.