Recent advances in intelligent oxygen delivery systems for tissue regeneration.

Oxygen plays a critical regulatory role in tissue repair and regeneration. However, in the microenvironment of tissues with vascular damage, hypoxia is commonly present. This not only suppresses cell proliferation and differentiation but also delays angiogenesis and extracellular matrix reconstruction, ultimately hindering the tissue regeneration process.

The Effects of Salinity on the Survival, Growth, and Eco-Physiological Parameters of Juvenile Sea Urchin .

is an economically important species in tropical and subtropical waters. To determine the optimal salinity for aquaculture, we examined six salinity levels (20, 24, 28, 32, 36, and 40) during winter and spring, assessing their effects on survival, growth, and eco-physiological parameters of juvenile . Results showed that (1) in winter, the survival rate of juvenile was highest at salinities of 28-36, with 100% survival at salinities of 32-36.

Multimodal data-driven prognostic model for predicting long-term outcomes in older adult patients with sarcopenia: a retrospective cohort study.

Background: Sarcopenia (SP) is a progressive, age-related disease that may result in various adverse health outcomes and even mortality in older adults. Accurately predicting the mortality risk of older adults with SP is essential for informed clinical decision-making. This study aims to utilize machine learning techniques that incorporate sociodemographic factors, health-related metrics, lifestyle variables, and biomarker data to improve risk stratification and management in older adults with SP.

Genome-wide identification, characterization, and expression analysis of scavenger receptor genes in orange-spotted grouper (Epinephelus coioides).

Scavenger receptors (SRs) are a diverse group of pattern recognition receptors that mediate innate immune defenses in teleosts, but their diversity and functional roles in Epinephelus coioides have not been fully characterized. Here, 13 SR genes were identified through genome-wide mining and classified into five subclasses (class A, B, F, H, L). Bioinformatic analysis, including exon-intron organization, motif composition, conserved domains and selection pressure analysis, revealed high intraclass conservation.

Nonreciprocal and enhanced Goos-Hänchen shifts in the cavity-assisted atomic lattice of parity-time antisymmetry.

We propose a scheme for realizing nonreciprocal and largely enhanced Goos-Hänchen (GH) shifts in a lattice of cold atoms exhibiting the parity-time () antisymmetric susceptibility when driven by a probe beam and a coupling beam. This atomic lattice in the free space allows to attain unidirectionally detectable nonreciprocal GH shifts for reflected probe beams provided a Bragg bright resonance is tuned to overlap with an exceptional point. Placing this atomic lattice in an optical cavity, we can further attain bidirectionally detectable nonreciprocal GH shifts for reflected probe beams, benefiting from the interplay between a Bragg bright resonance and a cavity dark resonance.

Investigation of light transmittance and reflectance in the multi-particle sea-fog system.

Studying the transmittance and reflectance of the sea-fog system is of great significance for ocean remote sensing and the accurate detection of targets in sea-fog. To this end, this paper develops a multiple-particle radiative transfer model that can simulate a more realistic ocean environment. We added dynamic wind speed and droplet liquid water contents as influencing factors, simulated the transmittance and reflectance of four sea areas in the Pacific and Atlantic Oceans, and compared them with windless and static wind speed sea areas.

Enhanced microwave electrometry in weakly interacting Rydberg atoms using a modified formula.

This study addresses the restrictions imposed by nonlocal van der Waals (vdW) and dipole-dipole (DD) interactions on the microwave electrometry in cold Rydberg atoms driven into the four-level cascade configuration with relatively high excitation densities. Utilizing the mean-field superatom model, we examine, in particular, the effects of vdW and DD interactions on microwave-controlled transmission spectra of a probe field in the regime of electromagnetically induced transparency (EIT). In response to spectral shifts depending on such Rydberg interactions, we propose a modified formula for correctly describing the nonlinear relationship between the microwave electric field and the splitting of two EIT peaks, which could enhance the measurement accuracy.

Slow-light all-optical transistors based on single-photon-level light storage.

We developed an effective theoretical method to examine the successive propagation dynamics of a gate field and a signal field in an EIT medium of Rydberg atoms exhibiting both self and cross van der Waals () interactions. It is found that the slow-light storage of this gate field can be achieved with an efficiency up to 73.5% and a negligible modification of photon statistics.

Clinical Classification of Adolescent Cervicothoracic Hemivertebra Treated with Surgical Intervention Incorporating Shoulder Balance Considerations.

Objective: Achieving shoulder balance is a critical factor in evaluating the outcomes of cervicothoracic hemivertebra surgery in adolescents. Current classification systems for hemivertebrae fail to adequately consider shoulder balance. This study introduces a novel classification system for adolescent cervicothoracic hemivertebrae, incorporating both the positional characteristics of the hemivertebrae and an assessment of shoulder balance.

Single-cell and spatial transcriptomics reveal mechanisms of radioresistance and immune escape in recurrent nasopharyngeal carcinoma.

Radiotherapy resistance and immune evasion are prominent features of recurrent nasopharyngeal carcinoma (rNPC). However, their mechanisms remain incompletely understood. Here, we conducted single-cell and spatial transcriptomics analysis of 39 tumors from 24 patients to reveal the microenvironmental differences between primary and rNPC.

A telomere-to-telomere gap-free genome assembly of the endangered humphead wrasse (Cheilinus undulatus).

Humphead wrasse, Cheilinus undulatus, is an endangered fish species with high economic and ecological value as well as natural sex change from female to male, while sexual selection occurs in breeding aggregations. In our present study, we constructed the first gap-free telomere-to-telomere (T2T) genome assembly for humphead wrasse, by integration of PacBio HiFi, ONT Ultra-long and Hi-C sequencing techniques. With 99% of the entire sequences anchored into 24 chromosomes, this haplotypic genome assembly spans approximately 1.

Association Between Thymosin β4 and Coronary Arterial Lesions in Children with Kawasaki Disease.

Background: Kawasaki disease (KD) is an acute systemic vasculitis primarily affecting children and is a leading cause of acquired heart disease in developed countries. Recently, an increasing number of studies have demonstrated the close correlations between inflammation and KD. Thymosin β4 (Tβ4) has been reported to play a role in cardiovascular protection and repair by modulating inflammation, angiogenesis, and endothelial function.

Thrombelastogram are associated with coronary artery aneurysm in Kawasaki disease patients.

Background: Kawasaki disease (KD) is a common pediatric disease that readily affects the coronary arteries and can progress to form coronary artery aneurysms (CAA). This study aimed to explore the relationship between thromboelastography MA and CAA and to ascertain whether thromboelastography MA could act as a predictor of CAA in KD patients.

Methods: A total of 243 consecutive KD patients from January 2020 to December 2022 were included in this study.

Senescent macrophages induce ferroptosis in skeletal muscle and accelerate osteoarthritis-related muscle atrophy.

Muscle atrophy around joints is a common issue for people with osteoarthritis (OA), but its causes are poorly understood. Here we demonstrate that chronic inflammation in quadriceps muscle coincides with OA in mice, characterized by an increase in macrophages, activation of inflammatory pathways and tissue vascularization. We show that, during OA progression, macrophages progressively exhibit increasing phenotypes of senescence and promote muscle atrophy through paracrine induction of ferroptosis.

Combretastatin A4-Based Albumin Nanoparticles Remodeling the Tumor Immune Microenvironment to Enhance T Cell Immunotherapy in Colon Cancer.

The immunosuppressive tumor microenvironment formed by many solid tumors, particularly colon cancer, suppresses innate immune molecule expression and consequently limits T cell infiltration. Microtubule inhibitors were originally developed to eliminate tumors by inducing mitotic arrest. However, recent studies have shown that these inhibitors can also disrupt the microtubule dynamics and enhance the efficacy of immunotherapies.

Protein-based embolic agent loaded with ethiodized oil for targeted tumor vascular embolization.

Tumor embolization therapy often involves complex procedures and poses challenges for physicians, especially with radiological imaging guidance. Inspired by physiological processes of misfolded protein aggregation and thrombus formation, we developed a protein-based embolic agent using ethiodized oil and human serum albumin for targeted tumor embolization. By occupying the hydrophobic cavity of albumin and disrupting its refolding process, these ethiodized oil bound human serum albumin nanoparticles (Oil@HSA NPs) achieve spontaneous aggregation and size growth at high concentrations, a unique advantage over conventional phospholipid nanoparticles.

A nomogram for predicting the risk of malnutrition in hospitalized older adults: a retrospective study.

Background: Malnutrition is highly prevalent but under-recognized in hospitalized older adults, which is closely related to increased risk of adverse clinical outcomes and mortality. It is crucial to identify high-risk individuals at an early stage and manage them promptly. This study aimed to explore the predictive factors and develop a nomogram model for predicting the risk of malnutrition in hospitalized elderly patients.

Association of interleukin-35 polymorphisms with Kawasaki disease in Chinese children.

Kawasaki disease is a leading cause of acquired heart disease in children in the developed world, characterised by acute systemic vasculitis, with a complex aetiology that remains poorly understood. Recent studies have highlighted the potential anti-inflammatory effects of Interleukin-35 in various proinflammatory and cardiovascular conditions. However, the relationship between Interleukin-35 gene polymorphisms and Kawasaki disease susceptibility, particularly in Chinese children, has not been well-explored.

Radiation-induced rhinosinusitis in patients with nasopharyngeal carcinoma.

Background: Radiotherapy (RT) is the primary treatment for nasopharyngeal carcinoma (NPC), while its impact on sinonasal mucosa is unclear. We aimed to investigate the progression of sinus mucosal inflammation pre- and post-RT in NPC patients and aid in the prevention and treatment of radiation-induced rhinosinusitis (RiRS).

Methods: This study was based on a prospective cohort with 1410 NPC patients.

Disease trajectories and medical expenditures of older adults with disabilities: insights from China's long-term care insurance program.

Background: In China, long-term care (LTC) system has been implemented in recent years to improve the quality of care for older adults. To address healthcare needs of older adults with disabilities, this study investigated the disease trajectory and medical expenditures.

Methods: This study included older adults aged 65 and above with disabilities, using data from China's Long-Term Care Insurance (LTCI) program since July 2017.

Perfluorocarbon Nanoparticles Loaded with Oxygen Alleviate Acute Kidney Injury via Ameliorating Renal Oxygenation Level.

Renal microcirculatory disturbances and tissue hypoxia play a pivotal role in acute kidney injury (AKI) initiation and progression, and addressing renal hypoxia during the acute phase presents a promising therapeutic strategy for preventing AKI or protecting kidney function. In this study, we explored the renal protective potential of perfluorocarbon nanoparticles (PFPs), engineered for superior oxygen-carrying and delivery capacities, in an AKI mouse. Specifically, PFP-treated mice exhibited significant reductions in tubular dilation, necrosis, and brush border loss in renal tubules.

Etiological Patterns of Protein-Energy Malnutrition in a Pediatric Clinic in China.

BACKGROUND Protein-energy malnutrition (PEM) often occurs within 5 years of age. Untreated PEM in early childhood can affect growth and cognitive function later in life. However, the etiologies of PEM in children are still poorly explored.

Hypertension and burden of myocardial infarction in China: risk factors, gender differences and temporal trends from a National Chronic Disease Surveillance study (2021-2023).

Myocardial infarction (MI) remains a leading global cause of morbidity and mortality, with rising prevalence in China. Hypertension persists as a predominant modifiable risk factor. This study investigates MI prevalence, trends and risk factors using data from China CDC's Chronic Disease Surveillance program.

NO-releasing double-crosslinked responsive hydrogels accelerate the treatment and repair of ischemic stroke.

Stroke is a global disease that seriously threatens human life. The pathological mechanisms of ischemic stroke include neuroinflammation, oxidative stress, and the destruction of blood vessels at the lesion site. Here, a biocompatible hydrogel platform was designed to target multiple pathogenic mechanisms post-stroke, including anti-inflammation, anti-oxidant, and promotion of angiogenesis.

Genomics comparisons provide new insights into the evolution of karyotype and body patterns in Anguilliformes species.

Anguilliformes species not only possess distinctive appearance (such as body elongation and absence of pectoral and/or pelvic fins), but also display diversity in chromosome number, supporting them as a suitable model for studying karyotype evolution and related molecular mechanisms of evolutionary body patterns. However, the ancestral chromosomes and evolutionary chromosomal reorganization in various eels have not been reported yet. The most regulatory or related genes of their distinctive appearance are still unknown.