The Clinical Utility of Real-Time Patient Reported Outcomes in Cell Therapy Recipients.

Background: The use of patient-reported outcome measures (PROMs) can improve a patient's clinical course by decreasing the incidence and severity of both physical and emotional treatment-related toxicities, uncover unmet patient needs and assist in patients' shared decision-making.

Objectives: The objective of this study was to examine the feasibility and utility of using electronically captured "real time" agenda-setting questions and PROMs at the time of the patient's clinic visit.

Study Design: We designed a prospective observational study that employed a pre-visit questionnaire (PVQ) that included agenda-setting questions and the PROMIS-29 survey, with results incorporated into a clinical decision support dashboard embedded within the patients' electronic medical record (EMR).

Targeting the interplay of cGAS-STING and ferroptosis by nanomedicine in the treatment of cancer.

The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway senses cytosolic DNA and triggers innate immune responses. Pharmacological activation of the cGAS-STING pathway by cGAS-STING agonists to overcome cancer drug resistance offers substantial potential to promote antitumor immunity. However, small-molecule STING agonists show rapid excretion, low bioavailability, non-specificity, and adverse effects, which limit their therapeutic efficacy and in vivo applications.

Serum 25(OH)D levels and mortality risk among middle-aged and elderly populations in the U.S.: A prospective cohort study.

Objective: To investigate the prevalence of vitamin D deficiency and its relationship with all-cause and cause-specific mortality among middle-aged and elderly populations in the U.S.

Methods: Data were sourced from the National Health and Nutrition Examination Survey (NHANES) 2001-2018.

Dual-Functional Ammonium Acetate as a Bilateral Buried Interface Passivator Enabling Efficient and Stable Carbon-Based Hole-Transport-Layer-Free Perovskite Solar Cells.

Planar hole-transport-layer (HTL)-free carbon-based perovskite solar cells (C-PSCs) exhibit notable advantages such as low cost and improved environmental compatibility. However, their practical applications are hindered by a relatively low efficiency and poor stability. The establishment of a buried interface architecture can effectively enhance the long-term stability of the C-PSC devices.

Augmented methanogenic performance in straw-manure co-digestion via micro/nano bubble-enhanced syntrophic metabolism.

This study aimed to investigate the enhancement of methane production by comparing air-nanobubble water (air-NBW) and conventional micro-bubble aeration during the anaerobic co-digestion (AcoD) of rice straw and pig manure. Remarkably, the addition of air-NBW (T3-NBW), as the most effective gas supplementation strategy, resulted in the highest cumulative methane yield of 489.49 mL/g·VS with a minimal lag phase of 0.

Pharmacokinetics, pharmacodynamics, and safety interaction study of tunodafil hydrochloride and alcohol: A randomized, blinded, placebo-controlled, three-cycle crossover study in Chinese healthy men.

Objectives: This study aimed to evaluate the pharmacodynamic effects of administering tunodafil hydrochloride with alcohol on blood pressure and heart rate in healthy Chinese males, and to investigate the mutual pharmacokinetic interactions and safety of the combination.

Methods: The trial was a randomized, blinded, placebo-controlled, three-cycle crossover design, with one administration in each cycle and a 7-day washout interval between cycles. Eighteen healthy men were randomized to receive tunodafil hydrochloride with an alcoholic beverage, placebo with an alcoholic beverage, or tunodafil hydrochloride with a placebo beverage in each cycle.

Super-large record-breaking mitochondrial genome of in Pinaceae.

Introduction: Mitochondrial genomes (mitogenomes) in Pinaceae are notable for their large size and complexity. This study investigates the mitogenome of the critically endangered to understand the drivers of its exceptional genome expansion.

Methods: We sequenced, assembled, and annotated the mitogenome.

Comparison of Transoral Endoscopic Thyroidectomy via the Vestibular Approach and Conventional Open Thyroidectomy for Papillary Thyroid Carcinoma: A Propensity Score-Matched Analysis.

Background: Transoral endoscopic thyroidectomy via the vestibular approach (TOETVA) has gained popularity for treating papillary thyroid cancer (PTC). This study aimed to evaluate the oncologic and surgical outcomes of TOETVA with open thyroidectomy (OT) for PTC.

Patients And Methods: We retrospectively enrolled patients with PTC with preoperative assessment of tumor diameters ≤ 2 cm who underwent TOETVA (n = 59) or OT (n = 324).

Extracellular vesicle heterogeneity through the lens of multiomics.

Extracellular vesicles (EVs) are heterogeneous in size, biogenesis, content, and function. Aggressive cancer cells release a distinct, poorly characterized, and particularly large EV subtype, namely large oncosomes (LOs). This study employs an optimized method to improve LO yields and integrates mass spectrometry and RNA sequencing (RNA-seq) to profile their molecular cargo.

Mesenchymal Stem Cell-Derived Mitochondrial Transfer Promotes Tip Cell Phenotype via Glutathione Metabolic Reprogramming in Stroke Mice.

Angiogenesis is crucial to improving neurovascular remodeling poststroke. Therein, the transformation of endothelial cells (ECs) to tip cells is essential in initiating angiogenesis. Mitochondrial damage in ECs poststroke and associated metabolic disorder are key factors repressing angiogenesis, but the mechanisms are unknown.

The Impact of Omicron-related Stress on Mental Health in the General Population of China.

Background: Outbreaks of infectious disease represent unique stressors for the general population. In this study, we investigated the prevalence of mental health symptoms and associated risk factors in the general population of China during the Omicron wave.

Methods: We conducted a cross-sectional and large sample online survey during the surge of Omicron cases between 17 December 2022 and 8 January 2023 among Chinese citizens.

Denitrative Iodination of Nitroarenes via Light-Promoted Reduction.

Aryl iodides are essential synthons in organic synthesis, whose conventional preparations often suffer from poor selectivity or necessitate multistep procedures. Herein, we present a light-driven denitrative iodination as a one-step approach that directly converts nitroarenes to iodoarenes under mild and transition-metal-free conditions. This streamlined method operates in the absence of strong Brønsted acids, ensuring broad functional group tolerance, including esters, cyano groups, halides, and heterocycles, while also offering operational simplicity and scalability.

The Reliability of CBCT to Assess Quality of Augmented Bone After Lateral Sinus Floor Elevation With Xenografts: A Retrospective Analysis.

Objetives: This study aimed to explore the reliability of cone beam computed tomography (CBCT) in evaluating the quality of augmented bone after lateral sinus floor elevation (LSFE) with xenografts.

Materials And Methods: Thirty-six patients with lost maxillary molars were included, with half of whom received LSFE with xenografts and staged implant placement, and the other half showed no vertical bone defects and underwent implant placement directly. A total of 36 implants were included, with 18 implants in each group.

The investigation of resting-state functional connectivity in male sprinters and endurance runners brains based on fNIRS.

Objective To investigate the impact of extended aerobic and anaerobic exercise on cerebral activity by analyzing the functional connectivity strength attributes of the cerebral cortex in endurance runners (aerobic) and sprint athletes (anaerobic) during the resting state with fNIRS. Method Thirteen sprinters and twelve endurance runners were assessed using a functional near-infrared spectroscopic imaging system to quantify resting-state functional connection strengths for HbO2, HbR, and HbT across the brain, namely in the prefrontal and primary motor cortex. Results (1) In the examination of functional connectivity of HbO2, the overall functional connection strength of the anaerobic group exceeded that of the aerobic group.

Safflower injection against obesity-induced mice podocyte injury by improving insulin resistance through increasing renal INSR and eNOS expression.

Background: Podocyte injury is a common pathologic mechanism in obesity-related glomerulopathy (ORG). Safflower injection (SFI), scientifically extracted and refined from safflower, is used to treat diabetic kidney disease according to clinical guideline. Our previous study confirmed that the main active compounds of SFI ameliorated high glucose-induced podocyte injury.

AdipoRon attenuates depression-like behavior in T2DM mice via inhibiting inflammation and regulating autophagy.

Adiponectin, an adipocyte-derived adipokine, exerts anti-inflammatory effects in the brain, but its specific function in type 2 diabetes mellitus(T2DM) has not been elucidated. Based on the common physiological and pathological mechanisms of T2DM and depression, this study revealed the protective effect of AdipoRon on T2DM-related depressive behavior and its molecular biological mechanism in vivo. Our results showed that AdipoRon treatment enhanced the sucrose consumption of T2DM mice in sucrose preference experiment, reduced the immobility time in the forced swimming experiment, and increased the total movement distance and cross times in the open field experiment.

Molecular dynamics study on the mitigation of radiation damage caused by electron pulses.

The reduction of radiation damage represents a long-term objective for electron microscopists, particularly those engaged in the study of biological and organic matter. Recently, electron pulses in ultrafast transmission electron microscopy have been demonstrated to serve as a damage mitigation technique for radiation-sensitive materials. Nevertheless, the underlying mechanism of the mitigation effects remains unclear.

Carbon-Based Hole Transport Layer-Free Perovskite Solar Cells with an Efficiency beyond 18% Boosted by a Methylammonium Chloride Additive.

Carbon-based perovskite solar cells (C-PSCs) hold great prospects for commercialization due to their lower manufacturing cost and better stability when compared with metal electrode perovskite. Nevertheless, their power conversion efficiency (PCE) is lower than those of metal-based perovskite solar cells because of the inadequate interface contact between the carbon electrode and the perovskite layer. In this study, the hole transport layer (HTL)-free carbon-based perovskite configuration is utilized to further reduce the cost, and the methylammonium chloride (MACl) additive is introduced to passivate the defects of the perovskite and enhance the interface contact performance.

The relationship between hypomagnesemia and ICU mortality in severe hemorrhagic stroke patients: an observational multicentre study on eICU database.

Background: Hemorrhagic stroke is a potentially fatal condition with high mortality and morbidity. However, there is a lack of evidence for this relationship in critically ill patients with hemorrhagic stroke. This study aims to explore the relationship between hypomagnesemia and ICU mortality in severe hemorrhagic stroke patients.

Light-promoted aromatic denitrative chlorination.

Nitroarenes are readily accessible bulk chemicals and can serve as versatile starting materials for a series of synthetic reactions. However, due to the inertness of the C-NO bond, the direct denitrative substitution reaction with unactivated nitroarenes remains challenging. Chemists rely on sequential reduction and diazotization followed by the Sandmeyer reaction or the nucleophilic aromatic substitution of activated nitroarenes to realize nitro group transformations.

The role of lymph node level ratio in predicting prognosis and the benefits of postoperative radiotherapy in patients with pathological N1 stage head and neck squamous cell carcinoma.

Objective: To analyze the role of lymph node level ratio (LNLR) in predicting prognosis and the benefits of postoperative radiotherapy (PORT) in patients with pathological N1 (pN1) head and neck squamous cell carcinoma (HNSCC).

Methods: Patients with pN1 HNSCC from January 2011 to February 2021 were included. Patients were grouped by the LNLR, lymph node yield (LNY), and lymph node ratio (LNR) and were analyzed with the Kaplan-Meier method and multivariate Cox model.

Artificial biomarker-based feedback-regulated personalized and precise thrombolysis with lower hemorrhagic risk.

The body weight-based thrombolytic medication strategy in clinical trials shows critical defects in recanalization rate and post-thrombolysis hemorrhage. Methods for perceiving thrombi heterogeneity of thrombolysis resistance is urgently needed for precise thrombolysis. Here, we revealed the relationship between the thrombin heterogeneity and the thrombolysis resistance in thrombi and created an artificial biomarker-based nano-patrol system with robotic functional logic to perceive and report the thrombolysis resistance of thrombi.

Targeting gut microbiota and metabolism profiles with coated sodium butyrate to ameliorate high-energy and low-protein diet-induced intestinal barrier dysfunction in laying hens.

High energy diets are a risk factor for intestinal barrier damage. Butyrate, a major energy source for intestinal epithelial cells, has been shown to improve barrier dysfunction and modulate the gut microbiota. In this trial, we examined the preventative effect of coated sodium butyrate (CSB) on high-energy and low-protein (HELP)-induced intestinal barrier injury in laying hens, and also worked to determine the underlying mechanisms by an integrative analysis of gut microbiota and the metabolome.