The value of radiomics and deep learning based on PET/CT in predicting perineural nerve invasion in rectal cancer.

Objective: The objective of this study is to investigate the value of radiomics features and deep learning features based on positron emission tomography/computed tomography (PET/CT) in predicting perineural invasion (PNI) in rectal cancer.

Methods: We retrospectively collected 120 rectal cancer (56 PNI-positive patients 64 PNI-negative patients) patients with preoperative F-FDG PET/CT examination and randomly divided them into training and validation sets at a 7:3 ratio. We also collected 31 rectal cancer patients from two other hospitals as an independent external validation set.

Comparison of 18 F-FDG and 68 Ga-FAPI PET/CT in a Rare Renal Leiomyoma.

Renal leiomyoma is a rare benign mesenchymal tumor of the kidney, which mainly originates from the renal capsule or pelvis. We described 18 F-FDG and 68 Ga-FAPI PET/CT findings in a case of renal leiomyoma. The PET/CT findings showed that the left renal leiomyoma demonstrated intensively increased 68 Ga-FAPI uptake, whereas only inhomogeneously slightly increased 18 F-FDG uptake.

Design of OMC-Sagnac Loop Using PDMS and Different Package Structures to Improve Sensing Performance and Optimize the Ill-Conditioned Matrix.

In the process of ocean exploration, highly accurate and sensitive measurements of seawater temperature and pressure significantly impact the study of seawater's physical, chemical, and biological processes. In this paper, three different package structures, V-shape, square-shape, and semicircle-shape, are designed and fabricated, and an optical microfiber coupler combined Sagnac loop (OMCSL) is encapsulated in these structures with polydimethylsiloxane (PDMS). Then, the temperature and pressure response characteristics of the OMCSL, under different package structures, are analyzed by simulation and experiment.

Prospective Comparison of the Imaging Value of 99m Tc-MDP Bone Scan and 68 Ga-FAPI-04 PET/CT in Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis Syndrome.

Purpose: This study aimed to explore the imaging value of 68 Ga-FAPI-04 PET/CT in synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome and compare it with that of 99m Tc-MDP bone scan.

Methods: Nineteen participants with SAPHO syndrome underwent 68 Ga-FAPI-04 PET/CT and 99m Tc-MDP bone scan. Demographic data and clinical features were recorded, SAPHO imaging features were analyzed, and the osteoarticular lesion detection rate in both methods was calculated.

Metal-coated high-temperature strain optical fiber sensor based on cascaded air-bubble FPI-FBG structure.

Metal coatings can protect the fragile optical fiber sensors and extend their life in harsh environments. However, simultaneous high-temperature strain sensing in a metal-coated optical fiber remains relatively unexplored. In this study, a nickel-coated fiber Bragg grating (FBG) cascaded with an air bubble cavity Fabry-Perot interferometer (FPI) fiber optic sensor was developed for simultaneous high temperature and strain sensing.

Research Progress on Magneto-Refractive Magnetic Field Fiber Sensors.

The magnetic field is a vital physical quantity in nature that is closely related to human production life. Magnetic field sensors (namely magnetometers) have significant application value in scientific research, engineering applications, industrial productions, and so forth. Accompanied by the continuous development of magnetic materials and fiber-sensing technology, fiber sensors based on the Magneto-Refractive Effect (MRE) not only take advantage in compact structure, superior performance, and strong environmental adaptability but also further meet the requirement of the quasi-distributed/distributed magnetic field sensing; they manifest potential and great application value in space detection, marine environmental monitoring, etc.

Efficacy and safety of Xinmai'an tablet in treatment of premature ventricular contractions due to coronary heart disease: A protocol for systematic review and meta-analysis.

Background: Coronary heart disease (CHD) is the leading cause of human death in the world and a public health problem of global concern. As a common arrhythmia in CHD, premature ventricular contractions are very likely to progress to fatal arrhythmias, resulting in serious adverse consequences. At present, the treatment of premature ventricular contractions due to CHD mainly focuses on catheter ablation, beta-blockers and antiarrhythmics.

Prospective Comparison of Ga-FAPI versus F-FDG PET/CT for Tumor Staging in Biliary Tract Cancers.

Background Gallium 68-labeled fibroblast-activation protein inhibitor (Ga-FAPI), an imaging agent for detecting tumors, represents a promising alternative to fluorine 18 fluorodeoxyglucose (F-FDG). Purpose To compare the potential efficacy of Ga-FAPI PET/CT with that of F-FDG PET/CT for detecting primary tumor and nodal and distant metastases in biliary tract cancer (BTC) and to explore the impact (tumor staging) of Ga-FAPI compared with F-FDG on clinical management of BTC. Materials and Methods This single-center prospective clinical study was performed at the Affiliated Hospital of Southwest Medical University between June 2020 and June 2021.

Comparison of 68Ga-FAPI and 18F-FDG PET/CT in Dermatofibrosarcoma Protuberans.

Dermatofibrosarcoma protuberans is a rare soft tissue sarcoma with a high recurrence rate. Herein, we present 68Ga-FAPI and 18F-FDG PET/CT findings of dermatofibrosarcoma protuberans in a 45-year-old man. Dermatofibrosarcoma protuberans only shows limited FDG uptakes on 18F-FDG PET/CT, but demonstrated intense tracer uptakes on 68Ga-FAPI PET/CT.

The Impact of Total Variation Regularized Expectation Maximization Reconstruction on Ga-DOTA-TATE PET/CT Images in Patients With Neuroendocrine Tumor.

Objective: The aim of this study was to investigate the effects of the total variation regularized expectation maximization (TVREM) reconstruction on improving Ga-DOTA-TATE PET/CT images compared to the ordered subset expectation maximization (OSEM) reconstruction.

Method: A total of 17 patients with neuroendocrine tumors who underwent clinical Ga-DOTA-TATE PET/CT were involved in this study retrospectively. The PET images were acquired with either 3 min-per-bed (min/bed) acquisition time and reconstructed with OSEM (2 iterations, 20 subsets, and a 3.

The Value of Diffuse Splenic and Hepatic F-FDG Uptake on PET/CT in Diagnosing Patients with Anemia.

Objective: Anemia is a disease with a negative impact on the progression and prognosis of tumor diseases and usually diagnosed by blood tests. Imaging examination has been used as an alternative method to diagnose anemia in addition to blood tests for patients who cannot tolerate blood draw (such as those with severe coagulopathy). The purpose of this study was to investigate the role of diffuse splenic and hepatic F-FDG uptake on PET/CT in anemia, by analyzing the correlation between the hemoglobin level and diffuse splenic and hepatic as well as marrow F-FDG uptakes in patients who underwent PET/CT.

Efficacy and safety of Guhong injection for coronary heart disease: A protocol for systematic review and meta-analysis.

Background: Coronary heart disease (CHD) is considered one of the major causes of morbidity and mortality worldwide, posing a serious threat to public health. Current therapeutic approaches for CHD mainly focus on drug therapy, coronary artery bypass grafting, and percutaneous coronary intervention. However, there still exist some problems including drug side effects, adverse cardiac events after percutaneous coronary intervention.

Vitamin D receptor gene polymorphisms and its interactions with environmental factors on renal cell carcinoma risk.

Aims: We designed a case-control study to investigate the effect of vitamin D receptor gene (VDR) gene single nucleotide polymorphisms (SNPs) and possible gene- environment interaction on the susceptibility of renal cell carcinoma (RCC).

Methods: Generalized multifactor dimensionality reduction (GMDR) was used to find out the interaction combinations between SNPs and environmental factors, including gene- gene synergy and gene environment synergy effect. Logistic regression was used to analyze the correlation between the four SNPs in VDR gene and RCC, and the significant interaction combinations found by GMDR model were analyzed by hierarchical analysis.

Three-dimensional versus two-dimensional video-assisted hepatectomy for liver disease: a meta-analysis of clinical data.

Introduction: The benefit of three-dimensional (3D) visualization for liver disease is uncertain.

Aim: To evaluate the effectiveness and safety of 3D versus two-dimensional (2D) video-assisted hepatectomy for LD.

Material And Methods: We searched PubMed, Embase, Cochrane Library, Medline, and Web of Science for studies addressing 3D versus 2D for 2D until 30 February 2020.

Imaging features and prognostic value of F-FDG PET/CT detection of soft-tissue metastasis from lung cancer: a retrospective study.

Background: Soft-tissue metastasis (STM) is a relatively rare, but not exceptional, manifestation of lung cancer. The purpose of this study was to evaluate the imaging features of STM from lung cancer using fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT), and assess the impact of STM detected at baseline PET/CT on patient survival.

Methods: Out of 4543 patients with lung cancer who underwent F-FDG PET/CT in our hospital between January 2013 and September 2018, 85 were diagnosed with STM (78 at baseline PET/CT and 7 at restaging PET/CT) and included in the imaging study.

miR-16-5p modulates the radiosensitivity of cervical cancer cells via regulating coactivator-associated arginine methyltransferase 1.

This study was to investigate the expression of coactivator-associated arginine methyltransferase 1 (CARM1) and miR-16-5p in cervical cancer (CC), and explore their roles in radioresistance. Western blot and immunohistochemistry were used to detect the expression of CARM1 in tissues and cells. Reverse transcription-polymerase chain reaction (RT-PCR) was used to detect the expression of miR-16-5p.

miR-122-5p modulates the radiosensitivity of cervical cancer cells by regulating cell division cycle 25A (CDC25A).

Cervical cancer is one of the most common gynecological malignancies globally, Unfortunately, radiotherapy and chemotherapy are not effective at treating some cases of this disease, and the 5-year survival rate is only 40-50%. Cell division cycle 25A (CDC25A) has been shown to induce radioresistance in a variety of tumor cells, but the role of CDC25A in the radioresistance of cervical cancer has not been fully elucidated. Here, we report that CDC25A is highly expressed and miR-122-5p lowly expressed in cervical cancer tissues and cells.

Gastric Ulcer Mimicking Malignancy on FDG PET/CT.

A 52-year-old woman with newly diagnosed cervical carcinoma was referred an F-FDG PET/CT for staging. The PET/CT images demonstrated the known carcinoma and multiple enlarged lymph nodes with increased FDG activity. In addition, there was a focus of intense FDG activity characteristic of hypermetabolic malignancy in the region of gastric antrum.

Radiolabeling, quality control, biodistribution, and imaging studies of Lu-ibandronate.

The purposes of this study were as follows: (1) to radiolabel ibandronic acid (IBA, a third-generation bisphosphonate) with Lu, investigating optimal labeling conditions, and (2) to analyze biodistribution and imaging properties of intravenous Lu-ibandronate ( Lu-IBA) administered in animals. Lu-labeled methylene diphosphonate ( Lu-MDP) served as a comparator agent. Differing proportions of IBA solution and LuCl solution were combined to determine an optimal ratio for radiolabeling purposes, varying pH, temperature, and time to establish ideal reactivity conditions.

Elevated 18F-NaF uptake in cricoid cartilage in a patient with laryngeal carcinoma: A case report and literature review.

Rationale: Laryngeal cancer is aggressive tumor that arises from the tissues of the larynx. Although any bone can be affected, involvement of cricoid cartilage was reported very rarely, and there has been no report of 18F-sodium fluoride positron emission tomography-computed tomography (F-NaF PET-CT) and 3D PET-CT for the evaluation of cricoid cartilage invasion.

Patient Concerns: A 54-year-old male discovered a protruding mass in the right anterior neck, which had rapidly increased in size over a period of 2 months.

Unexpected Detection of Urethral Stone on 18F-NaF PET/CT.

A 48-year-old man was referred for an F-NaF PET/CT to examine his lower back pain. The images did not identify any osseous lesion. Unexpectedly, the images showed elevated activity in a urethral stone.

Diffuse Increased Sodium Fluoride Gastric Activity in a Patient With Hypercalcemia.

Increased extraosseous uptake of sodium fluoride can be visualized because of many different etiologies. A 62-year-old man with a history of osteoporosis had an F-sodium fluoride PET/CT scan for accessing chest pain caused by an accident. The images showed multiple fractures.

Significant 99mTc-MDP but Unimpressive 18F-NaF Gastric Activity in a Patient With Multiple Myeloma.

A 69-year-old man with a history of low back pain for more than 4 months underwent Tc-MDP bone scan to determine the cause of the symptoms. In addition to the osseous lesions, significant activity in the stomach wall was noted. However, a subsequent F-NaF PET/CT only revealed bone lesion without increased activity in the stomach wall.