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Renal leiomyoma is a rare benign mesenchymal tumor of the kidney, which mainly originates from the renal capsule or pelvis. We described 18 F-FDG and 68 Ga-FAPI PET/CT findings in a case of renal leiomyoma. The PET/CT findings showed that the left renal leiomyoma demonstrated intensively increased 68 Ga-FAPI uptake, whereas only inhomogeneously slightly increased 18 F-FDG uptake. This case illustrates that 68 Ga-FAPI PET/CT may be an effective tool for detecting renal leiomyoma.
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http://dx.doi.org/10.1097/RLU.0000000000004791 | DOI Listing |
Diagn Pathol
August 2025
Division of Hematology, Oncology, Blood and Marrow Transplant, Nationwide Children's Hospital, 700 Children's Dr, Columbus, OH, 43205, USA.
Background: Hereditary leiomyomatosis and renal cell carcinoma syndrome (HLRCC) is an autosomal dominant tumor predisposition syndrome with germline fumarate hydratase (FH) pathogenic variants. We describe the unusual clinical presentation, morphologic, and immunohistochemical features of bilateral renal cell carcinoma (RCC) occurring in polycystic kidneys in a 15-year-old male with HLRCC.
Case Presentation: The patient was diagnosed with bilateral polycystic kidneys at 1-year old.
Int J Surg Case Rep
September 2025
Surgical Oncology Department, Salah Azaiez Institute of oncology, Tunis, Tunisia; Faculty of Medicine of Tunis, University Tunis El Manar, Tunis, Tunisia.
Introduction: Intravascular leiomyomatosis (IVL) is a rare, histologically benign condition characterized by the growth of smooth muscle tumors within vascular channels, often mimicking malignant behavior due to intravascular and potential cardiac extension. Despite its benign nature, IVL poses diagnostic and therapeutic challenges due to nonspecific symptoms and understudied malignant potential.
Case Presentation: A 47-year-old woman presented with a significant uterine mass and suspected sarcoma, accompanied by tumoral thrombosis extending from the left ovarian to the renal vein.
Diffuse adult-type gliomas are delineated based on their molecular composition including the presence or absence of mutations in isocitrate dehydrogenase 1 or 2 (IDH1/2), a key enzyme in the citric acid cycle. IDH-mutant tumors are associated with better survival than IDH-wildtype counterparts and can be further subdivided into astrocytoma or oligodendroglioma. Rare gliomas with fumarate hydratase (FH) deficiency have been reported.
View Article and Find Full Text PDFIndian J Urol
July 2025
Department of Urology, University of Southern California, Los Angeles, California, USA.
Benign metastasizing leiomyoma (BML) is thought to arise from either coelomic metaplasia of mesenchymal tissue or peritoneal seeding of uterine fibroid tissue, though its exact etiology is unknown. Herein, we present a 44-year-old Hispanic female with BML identified in the retroperitoneum in the setting of clear cell renal carcinoma. Routine follow-up computed tomography scan, 18 months after a robotic left partial nephrectomy for stage 1 renal tumor, revealed retroperitoneal (para-aortic) adenopathy.
View Article and Find Full Text PDFCureus
June 2025
General Medicine, King's Mill Hospital, Nottinghamshire, GBR.
Leiomyomas, benign tumors derived from smooth muscle, are typically found in the uterus. Urethral involvement is an exceptionally rare occurrence, particularly in the context of a pre-fashioned thigh flap. Our case, therefore, presents a unique and intriguing instance, with only a few similar cases reported.
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