Catechol-polysaccharide complex enhancing the detachment and blood coagulation of polyvinyl alcohol/chitosan cryogel for non-compressible bleeding.

As an efficient hemostatic material for non-compressible bleeding, the abilities of forming strong physical barrier and effectively activating coagulation system is essential. In this study, an expandable polyvinyl alcohol/chitosan (PVA/CS) cryogel with good mechanical properties was prepared with green phase separation method. To enhance the blood cells adhesion and accelerate the production of blood coagulation factor, the quaternized chitosan-polydopamine (QCS-PDA) complex crosslinked with PVA/CS on the surface to obtain PVA/CS/QCS-PDA composite cryogel.

Green and Efficient Preparation of Chitosan-Based Sponge with Synthesized ZnO for Deep Trauma Bleeding and Wound Healing.

Deep trauma often leads to acute bleeding and infections, which are major causes of death. It is worth exploring the preparation of hemostatic materials and improving their hemostatic and antibacterial properties applied to deep trauma by green and efficient methods. In this study, porous chitosan/zinc oxide/alkylated chitosan (CS/ZnO/ACS) sponges were prepared by a freezing phase separation method.

Strength enhanced expandable polyvinyl alcohol/chitosan cryogel for non-compressible hemostasis.

For penetrating and deep non-compressible bleeding, hemostatic materials need to meet the demand of easy filling and rapid expansion to close the wound. However, developing an expandable material with sufficient mechanical strength remains a challenge. This study proposed an improved non-solvent induced phase separation (NIPS) method to prepare polyvinyl alcohol/chitosan (PVA/CS) cryogel with large pore structure (70-75 um) and enhanced mechanical properties.

The / Axis Affects Adipogenesis Through Regulating the / Pathway.

Understanding the regulatory mechanisms of adipogenesis is essential for preventing obesity. Interleukin-33 (IL-33) has recently attracted increasing attention for its role in adipogenesis. The purpose of this study was to explore the function and regulatory mechanism of IL-33 and its receptor suppression of tumorigenicity 2 (ST2) on adipogenesis.

Self-assembling chitosan based injectable and expandable sponge with antimicrobial property for hemostasis and wound healing.

Chitosan and chitosan derivative are widely used in hemostasis, antibiosis and wound repair for its good biocompatibility and unique effect. However, the preparation of chitosan based hemostatic materials or wound dressings generally involves chemical crosslinking agent introduction, acid residue or complicated preparation process, which limits its clinical application. In this study, an injectable and expandable chitosan sponge was constructed by chitosan (CS) and quaternized chitosan (QCS) self-assembly without acid retention and chemical crosslinker introduction.

Photoredox/Copper-Cocatalyzed Domino Annulation of Oxime Esters and NHSCN: Access to Fully Substituted 2-Aminothiazoles.

Domino cyclization of oxime esters and NHSCN facilitated by photoredox and copper cocatalysis has been established. Various structurally diverse fully substituted 2-aminothiazoles have been obtained in good yields at room temperature. It is featured by mild conditions, favorable functional group tolerance, and wide substrate scope.

Alternative Polyadenylation of 1 Is Essential for Accelerated Adipogenesis.

Understanding the mechanism of adipogenesis is an important basis for improving meat quality traits of livestock. Alternative polyadenylation (APA) is a vital mechanism to regulate the expression of eukaryotic genes. However, how the individual APA functions in adipogenesis remains elusive.

Bovine C-X-C Motif Chemokine Ligand 14 Expression Is Regulated by Alternative Polyadenylation and MicroRNAs.

Alternative polyadenylation (APA), including APA that occurs only in the 3' UTR (3' UTR-APA), is an important post-transcriptional regulatory mechanism that leads to distinct 3' UTRs for some genes, increasing the complexity of the transcriptome. The post-transcriptional events regulating the expression of bovine, the C-X-C motif chemokine ligand 14 (CXCL14) gene, remains largely unknown. Here, we find that the bovine CXCL14 gene produces two different lengths of mRNA isoforms due to 3' UTR-APA, and the short and long 3' UTR is 126 bp and 1155 bp, respectively.

Injectable and photothermal antibacterial bacterial cellulose cryogel for rapid hemostasis and repair of irregular and deep skin wounds.

For irregular and deep skin wounds, it's difficult for wound dressing to reach the injured site to achieve rapid hemostasis and provide wound protection. Bacterial cellulose (BC) has high strength and natural three-dimensional pore structure, which endows it shape recovery ability after absorbing blood when injected to the wound. Therefore, in the study, an injectable aldehyde bacterial cellulose/polydopamine (DBC/PDA) photothermal cryogel was prepared by oxidation polymerization method for hemostasis and repair of irregular and deep skin wounds.

Shape memory and antibacterial chitosan-based cryogel with hemostasis and skin wound repair.

Massive damage to the skin can lead to heavy bleeding and potential wound infection. Therefore, the preparation of low-cost wound dressings that meet these requirements by simple methods has a good application prospect. In the study, a shape memory cryogel prepared at low temperatures by mixing chitosan (CS) and citric acid (CA).

Merging photoredox with copper catalysis: enantioselective remote cyanation 1,4-heteroaryl migration.

We have developed a photoredox/Cu dual catalyzed enantioselective remote cyanation 1,4-heteroaryl migration. Experimental and computational studies have been carried out to reveal the reaction mechanism and explain the origins of the regio- and enantioselectivities of the remote cyanation process. This methodology exhibits mild conditions, a broad substrate scope and good regio- and enantioselectivities, which provides a unique approach for catalyst-controlled asymmetric backbone recombination of molecules functional group migration.

Preparation of biodegradable carboxymethyl cellulose/dopamine/Ag NPs cryogel for rapid hemostasis and bacteria-infected wound repair.

Massive hemorrhage caused by accident or surgery is a major factor in accidental death. In addition, bacterial infection is also an important threat after bleeding. Cryogels with interpenetrating macroporous structures pose great application prospects in rapid hemostasis and infected wound repair.

Photoredox/copper cocatalyzed domino cyclization of oxime esters with TMSCN: access to antifungal active tetrasubstituted pyrazines.

A photoredox/copper cocatalyzed domino cyclization of oxime esters with TMSCN has been developed. A range of structurally novel tetrasubstituted pyrazines have been obtained. This method features high bond-forming efficiency, high step economy, broad substrate scope, and gram-scale synthesis.

Brønsted acid-promoted hydroamination of unsaturated hydrazones: access to biologically important 5-arylpyrazolines.

A novel and efficient Brønsted acid-promoted hydroamination of hydrazone-tethered olefins has been developed. A variety of pyrazolines have been easily obtained in good to excellent yields with high chemo- and regioselectivity under simple and mild conditions. This method represents a straightforward, facile, and practical approach toward biologically important 5-arylpyrazolines, which are difficult to access by previously reported radical hydroamination of β,γ-unsaturated hydrazones.

Oxidized bacterial cellulose reinforced nanocomposite scaffolds for bone repair.

Bone tissue engineering has been widely used in promoting the repair and regeneration of bone defects. Tissue-engineered bone scaffolds can simulate the extracellular matrix environment and induce the proliferation and differentiation of osteoblasts. The first issues to be considered when constructing bone repair scaffolds include biocompatibility, stress resistance, degradability and stability.

Nano-hybrid gradient scaffold for articular repair.

Osteoarthritis disease can easily lead to articular cartilage degeneration and subchondral bone damage, so the demand for suitable articular substitutes is gradually increasing. In order to simulate the complex environment of different layers in natural joint, we fabricate the continuous one-phase gradient scaffold. In the study, CS (chitosan) was modified with SH (sodium hyaluronate) and GO (graphene oxide) to form the whole scaffold.

Multifunctional dopamine modification of green antibacterial hemostatic sponge.

A novel hemostatic nanocomposite (OBC-PDA/PDA-MMT/Ag NPs) was prepared. As Functional hemostatic particles, hydrochloric acid modified montmorillonite coated with dopamine (PDA-MMT) doped into oxidized bacterial cellulose (OBC). In the presence of carboxyl and dopamine, silver ions (Ag) were reduced into Ag nanoparticles (Ag NPs) distributed homogeneously on the matrix of PDA-MMT and OBC.

miR-362-3p acts as a tumor suppressor by targeting SERBP1 in ovarian cancer.

Background: Ovarian cancer is the leading lethal gynecological cancer and is generally diagnosed during late-stage presentation. In addition, patients with ovarian cancer still face a low 5-year survival rate. Thus, innovative molecular targeting agents are required to overcome this disease.

Association of the Genetic Polymorphisms rs6259 and rs727428 of the Gene with Polycystic Ovary Syndrome Risk: A Meta-Analysis.

Studies investigating the relationship between polymorphisms of the sex hormone-binding globulin () gene and polycystic ovary syndrome (PCOS) have reported differing results. Therefore, the present meta-analysis was performed to clarify the effects of the and polymorphisms on PCOS risk. Published English language studies were selected through an extensive search of the Web of Science, PubMed, and EMBASE databases.

Nanoparticles: Oral Delivery for Protein and Peptide Drugs.

Protein and peptide drugs have many advantages, such as high bioactivity and specificity, strong solubility, and low toxicity. Therefore, the strategies for improving the bioavailability of protein peptides are reviewed, including chemical modification of nanocarriers, absorption enhancers, and mucous adhesion systems. The status, advantages, and disadvantages of various strategies are systematically analyzed.

Correction: Identification of potential serum biomarkers of acute paraquat poisoning in humans using an iTRAQ quantitative proteomic.

[This corrects the article DOI: 10.1039/C7RA12956D.].

FGF21 protects myocardial ischemia-reperfusion injury through reduction of miR-145-mediated autophagy.

Aims: Fibroblast growth factor 21 (FGF21) plays a critical role in protecting against myocardial ischemia/reperfusion (I/R) injury. However, the molecular mechanism is not completely understood. Here, we aimed to examine whether miRNA-145 (miR-145) is involved in FGF21 protection against myocardial I/R injury through angiopoietin-2 (Angpt2) and autophagy.