Glycyrrhizic Acid Ameliorates LPS-Induced WI-38 Cell Inflammation, Oxidative Stress, and Ferroptosis via Targeting METTL14 in Infantile Pneumonia.

Background: Infantile pneumonia is a common and significant health concern in the world, with elevated morbidity and mortality rates among affected children. This research is designed to demonstrate the therapeutic action of glycyrrhizic acid (GA) on infantile pneumonia and unravel the underlying mechanisms involved.

Methods: The models in vitro and in vivo were created to analyse the action of GA in infantile pneumonia.

The role of mast cells in allergic rhinitis.

Introduction: In recent decades, mast cells and their mediators have been increasingly recognized as central players in the pathogenesis of allergic rhinitis (AR), a complex chronic nasal disease characterized by pathological changes influenced by genetic factors, various immune cells, and environmental exposures. Mast cells are pivotal in allergic reactions, orchestrating inflammation and airway contraction through the secretion of diverse mediators. Prominent among these mediators are histamine and bioactive lipids, whose physiological effects are prominently observed during the acute phase of allergic reactions.

The association between fecal incontinence and asthma among adult Americans: evidence from NHANES 2005-2010.

Objectives: There is a paucity of research exploring the relationship between fecal incontinence (FI) and asthma. This study seeks to evaluate the potential correlation between FI and asthma among adult Americans.

Methods: Utilizing a cross-sectional design, this study comprised a sample of 11,128 adults aged 20 years and older sourced from the National Health and Nutrition Examination Survey (NHANES) conducted between 2005 and 2010.

The Polymeric Sulfur Hosts From Ferrocene-Based Metal-Organic Framework@TiC Array Structure for Upgrading Energy Density and Longevity of Lithium-Sulfur Batteries.

Polymeric sulfur is emerging as a cathode active material for lithium-sulfur (Li─S) batteries, which can effectively inhibit polysulfide shuttling through the formation of C─S covalent bonds. However, low conductivity and poor electrocatalytic activity of polymeric sulfur severely counteract the electrochemical performance, especially for high-sulfur-loading cathodes. Herein, it is presented one type of new polymeric sulfur host materials composed of ferrocene-based nickel metal-organic framework (NiFc) loaded on the surface of TiC nanosheets (TiC@NiFc), which is prepared through inverse vulcanization reaction between NiFc and sulfur element.

Combined treatment strategy of hydrogel dressing and physiotherapy for rapid wound healing.

Wound care for open wounds is essential for reducing pain, protecting open wounds, speeding up the healing process and avoiding scar formation. Among the various three-dimensional (3D) carrier biomaterials such as films, sponges, and hydrogels, hydrogels are chemically and physically most similar to the natural extracellular matrix (ECM). Meanwhile, hydrogels are also common 3D carriers that can be efficiently loaded with drugs or cells.

A real-world pharmacovigilance study of omalizumab using disproportionality analysis in the FDA adverse drug events reporting system database.

Omalizumab is a biologic agent used in the management of allergic conditions, including asthma and urticaria. Although the efficacy of omalizumab has been well established, its safety profile is primarily derived from clinical trials with limited sample sizes. To conduct a comprehensive evaluation of its safety in larger populations, this study conducted an extensive analysis of data sourced from the America Food and Drug Administration's Adverse Event Reporting System (FAERS), with the aim of elucidating adverse drug events associated with omalizumab in real-world settings.

Klotho improves Der p1-induced bronchial epithelial cell damage by inhibiting endoplasmic reticulum stress to regulate mitochondrial function.

Asthma is a prevalent chronic pediatric lung disease which is commonly perceived as a syndrome of airway inflammation characterized by cough and wheeze in clinic. Klotho is implicated in diverse cellular activities, including inflammation, oxidative stress and apoptosis. This paper aims to explore the role of klotho in asthma and investigate the relevant molecular reaction mechanisms.

NO-N pulse supply caused by biodegradable plastics exacerbates Trifolium repens L. invasion.

The exacerbation of plant invasion by microplastics attracted widespread attention. Pulse resource hypothesis is popular theory to elucidate plant invasion. Our previous work demonstrated biodegradable microplastics (BMPs) could increase the arbuscular mycorrhizal fungi (AMF) colonization rate.

Relationship between lactate levels and 28-day mortality in pediatric sepsis: results from the pediatric intensive care database.

Objective: This study aimed to investigate the relationship between serum lactate levels at admission to the intensive care unit (ICU) and the clinical outcomes of children with sepsis.

Methods: We used the Pediatric Intensive Care (PIC) database to identify 288 pediatric patients with sepsis. We analyzed the relationship between lactate levels and hospital and ICU mortality in sepsis by establishing a segmented multivariable Cox regression model.

Systemic immune-inflammation and prognostic immune nutritional index in oral squamous cell carcinoma patients.

To investigate the systemic immune-inflammation index and prognostic immune nutritional index in the prognostic evaluation of oral squamous cell carcinoma. We analyzed retrospectively the relationship between systemic immune-inflammation index, prognostic immune nutritional index and clinicopathological variables and the overall survival of 262 patients who underwent radical surgery. Multivariate analysis showed high systemic immune-inflammation index (Hazard ratio = 3.

Pseudoaneurysm Following a Puncture of the Distal Radial Artery: A Case Report.

Pseudoaneurysms are not uncommon in the clinic, but they have rarely been reported as a result of distal radial artery puncture. This case report is about an elderly woman who developed a pseudoaneurysm at the distal radial artery puncture site after coronary angiography via the distal radial artery. After timely treatment and long-term follow-up, the patient's hand wound gradually healed.

From surviving to thriving: How preferences shift in helping resource allocation.

The helper's allocation of helping resources to multiple recipients often involves a trade-off between equality and efficiency. This research examines how the condition of potential recipients ("survival" or "development") influences the preferences for helping resources allocation in terms of equality and efficiency. Through seven studies, including a field study (Study 6), we discovered that helpers show a higher preference for equality over efficiency when recipients are in a survival situation (i.

The Prevalence of and -Like Diseases in Patients with Undifferentiated Febrile Illness - Hainan Province, China, 2018-2021.

Introduction: and -like diseases, resulting from obligate intracellular Gram-negative bacteria, pose a growing public health threat in China. To assess the current prevalence of these diseases on Hainan Island, a study was conducted on 9 bacterial pathogens found in patients with undifferentiated febrile illness (UFI) treated in Haikou between 2018 and 2021 using a TaqMan Polymerase Chain Reaction (TaqMan PCR) array.

Methods: Blood samples (=503) were collected from patients with UFI between 2018 and 2021.

Hypoxia-induced Semaphorin 3A promotes the development of endometriosis through regulating macrophage polarization.

Background: Semaphorin 3A (Sema3A) is a member of neural guidance factor family well-known for inducing the collapse of nerve cell growth cone and regulating nerve redistribution. It also has been characterized as an immunoregulatory and tumor promoting factor. Our previous study showed that Sema3A was involved in the regulation of sympathetic innervation and neuropathic pain of endometriosis.

Invasion of Trifolium repens L. aggravated by biodegradable plastics: adjustable strategy for foraging N and P.

The invasion of alien plant and the pollution caused by soil microplastics have emerged as significant ecological threats. Recent studies have demonstrated aggravating effect of non-biodegradable microplastics on plant invasion. However, the impact of biodegradable microplastics (BMPs) on plant invasion remains unclear.

Molecularly imprinted beads based on modified cellulose hydrogel:A novel solid phase extraction filler for specific adsorption of camptothecin.

Traditional solid phase extraction (SPE) suffers from a lack of specific adsorption. To overcome this problem, a combination of adsorption method and molecular imprinting technology by polydopamine modification was proposed to realize specific recognition of target compounds in SPE, which is of great significance to improve the separation efficiency of SPE. Cellulose hydrogel beads were prepared by dual cross-linking curing method and modified with polydopamine to make them hydrophilic and biocompatible.

Different dose aspirin plus immunoglobulin (DAPI) for prevention of coronary artery abnormalities in Kawasaki disease: Study protocol for a multi-center, prospective, randomized, open-label, blinded end-point, non-inferiority trial.

Background: Kawasaki disease is a pediatric acute systemic vasculitis that specifically involves the coronary arteries. Timely initiation of immunoglobulin plus aspirin is necessary for diminishing the incidence of coronary artery abnormalities (CAAs). The optimal dose of aspirin, however, remains controversial.

Silver-Catalyzed Decarboxylative Remote Fluorination via a Zwitterion-Promoted 1,4-Heteroaryl Migration.

A silver-catalyzed decarboxylative remote fluorination via a zwitterion-promoted 1,4-heteroaryl migration has been developed. A variety of heteroaryl-tethered benzyl fluorides have been readily synthesized with good regioselectivity under mild conditions. The zwitterion of the substrate is suggested to accelerate the 1,4-heteroaryl migration, which determines the regioselectivity of this transformation.

Blame others but hurt yourself: blaming or sympathetic attitudes toward victims of COVID-19 and how it alters one's health status.

Objective: This study explored the relationship between blame/sympathy and blamer's/sympathizer's perceived health status.

Design: We recruited participants an online survey platform. Study 1 was a cross-sectional study using data ( = 3304, = 28.

Photoinduced Copper-Catalyzed Enantioconvergent Remote Alkynylation via 1,4-Heteroaryl Migration.

A photoinduced copper-catalyzed enantioconvergent remote alkynylation of -hydroxyphthalimide esters with terminal alkynes via 1,4-heteroaryl migration has been developed. A broad scope of heteroaryl-tethered chiral alkynes has been synthesized with good regio- and enantioselectivities. The chiral-ligand-coordinated copper species plays a dual role as both the photoredox and cross-coupling catalyst.

Corrigendum: Association between precocious puberty and obesity risk in children: a systematic review and meta-analysis.

[This corrects the article DOI: 10.3389/fped.2023.

A seminested recombinase polymerase amplification assay to detect rickettsial pathogens in clinical samples.

Treatment at the early stage of onset is vital for the prognosis of rickettsioses. But the absence of specific clinical symptoms complicates the diagnosis of this condition. Herein we established a seminested recombinase polymerase amplification assay (snRPA-nfo) that enables quick detection and differentiation of rickettsial pathogens in clinical samples with high sensitivity and specificity.