A cohort of allogeneic hematopoietic stem cell transplantation for pediatric rare diseases (allo-HSCT-PRD): design and preliminary results.

Rare diseases in children have attracted widespread attention worldwide due to their rarity and difficulty in diagnosis and treatment. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is emerging as a promising and curable therapy for multiple rare diseases. However, rare disease research in China is relatively backward, prompting us to construct the first cohort of allo-HSCT for pediatric rare diseases (allo-HSCT-PRD) involving those who underwent allo-HSCT at the Children's Hospital of Fudan University from 1 January 2014 to 31 October 2024.

Organic Carbon Sequestration by Secondary Fe-Mn Complex Minerals via the Anoxic Redox Reaction of Fe(II) and Birnessite.

Organic matter (OM) sequestrated by iron (Fe) and manganese (Mn) complex minerals may be an effective way to achieve organic carbon (OC) persistence in sediments and soils. However, the impact of Fe-Mn complex minerals from a redox reaction of Fe(II) and birnessite on OC dynamics remains unexplored. Herein, the immobilization and molecular transformation of fulvic acid (FA), mediated by a redox reaction of Fe(II) and birnessite, were investigated at pH 4.

In Situ Quantification of Surface pH of Dry Soils and Minerals: An Innovative Approach Combining Indicators and Diffuse Reflectance Spectroscopy.

Most natural soils and minerals are typically dry or semidry, and their surface characteristics and interfacial interactions are distinct from those of slurry systems. The surface acidity of dry soils and minerals cannot be measured by using traditional methods such as potentiometric and temperature-programmed desorption methods. In this article, we describe the development of an analytical method based on a combination of acid-base indicators and diffuse reflectance spectroscopy (DRS).

A Super-Enhancer-Driven Transcriptional Regulatory Circuit Underlying Abiraterone Resistance in Castration-Resistant Prostate Cancer.

Castration-resistant prostate cancer (CRPC) remains the leading cause of mortality among prostate cancer patients. While second-generation androgen receptor (AR) pathway-targeted therapies, such as Abiraterone, have significantly improved survival outcomes, resistance to these treatments ultimately emerges, posing a critical challenge. Understanding the mechanisms underlying Abiraterone resistance is essential for developing strategies to enhance patient outcomes.

Nanoscale and molecular evidences for adsorptive fractionation of dissolved organic matter at the interfaces of Al-bearing ferrihydrite and water.

Ferrihydrite (Fh) usually exists in the form of Al-bearing Fh in soils and sediments, and Al substitution may have a remarkable influence on Fh characteristics, controlling its reaction with dissolved organic matter (DOM). Yet, little is known about the impacts of Al-bearing Fh on the fate of DOM. Here, selective binding and molecular fractionation of DOM was investigated at the interfaces of Al-bearing Fh and water.

Evaluating the influence of alternating flooding and drainage on antimony speciation and translocation in a soil-rice system.

The quantitative evaluation of antimony (Sb) accumulation in rice has garnered significant attention due to the potential risks to human health. A pot experiment was conducted to investigate the essential nodes of Sb transfer in soil-rice system. Seven step extract results showed that during the flooding period, organic matter releasing was the primary factor contributing 14.

Immunological characterization and comparison of children with COVID-19 from their adult counterparts at single-cell resolution.

Introduction: The immunological characteristics that could protect children with coronavirus disease 2019 (COVID-19) from severe or fatal illnesses have not been fully understood yet.

Methods: Here, we performed single-cell RNA sequencing (scRNA-seq) analysis on peripheral blood samples of 15 children (8 with COVID-19) and compared them to 18 adults (13 with COVID-19).

Results: The child-adult integrated single cell data indicated that children with the disease presented a restrained response to type I interferon in most of the major immune cell types, along with suppression of upstream interferon regulatory factor and toll-like receptor expression in monocytes, which was confirmed by interferon stimulation assays.

Hematite enhances microbial autotrophic nitrate removal in carbonate and phosphate-rich environments by increasing Fe(II) activity.

Groundwater contamination by nitrates presents significant risks to both human health and the environment. In groundwater characterized as oligotrophic-low in organic carbon, but abundant in carbonate and phosphate-chemolithoautotrophic bacteria, including nitrate-reducing Fe(II)-oxidizing bacteria (NRFeOB), play a vital role in denitrification. The chemoautotrophic nitrate reduction is sensitive to environmental factors, including widespread iron oxides like hematite in nature.

Idiopathic multicentric Castleman disease and connective tissue disorder successfully treated by siltuximab: a pediatric case report.

Background: Castleman disease (CD) is a rare lymphoproliferative disease. Idiopathic multicentric CD (iMCD), representing a distinct entity in CD, is partly attributed to autoimmune abnormalities and the hyperplastic process in iMCD involving the immune system. Consequently, iMCD presents a range of overlapping manifestations with connective tissue disorder (CTD), resulting in an inability to tell whether they coexist or imitate each other.

Sequestration of Labile Organic Matter by Secondary Fe Minerals from Chemodenitrification: Insight into Mineral Protection Mechanisms.

Labile organic matter (OM) immobilized by secondary iron (Fe) minerals from chemodenitrification may be an effective way to immobilize organic carbon (OC). However, the underlying mechanisms of coupled chemodenitrification and OC sequestration are poorly understood. Here, OM immobilization by secondary Fe minerals from chemodenitrification was investigated at different C/Fe ratios.

Facile low-temperature supercritical carbonization method to prepare high-loading nickel single atom catalysts for efficient photodegradation of tetracycline.

Environmental photocatalysis is a promising technology for treating antibiotics in wastewater. In this study, a supercritical carbonization method was developed to synthesize a single-atom photocatalyst with a high loading of Ni (above 5 wt.%) anchored on a carbon-nitrogen-silicate substrate for the efficient photodegradation of a ubiquitous environmental contaminant of tetracycline (TC).

Effects of zero-valent iron added in the flooding or drainage process on cadmium immobilization in an acid paddy soil.

Zero-valent iron (ZVI) is a promising material for the remediation of Cd-contaminated paddy soils. However, the effects of ZVI added during flooding or drainage processes on cadmium (Cd) retention remain unclear. Herein, Cd-contaminated paddy soil was incubated for 40 days of flooding and then for 15 days of drainage, and the underlying mechanisms of Cd immobilization coupled with Fe/S/N redox processes were investigated.

Biogeochemical cycling in paddy soils controls antimony transformation: Roles of iron (oxyhydr)oxides, organic matter and sulfate.

In paddy fields, periodic flooding and drainage phases can significantly affect the availability of antimony (Sb), but the underlying mechanisms remain unclear. In this study, Sb-contaminated paddy soil was incubated under anaerobic (40 day) and subsequently aerobic (40-55 day) conditions. The Sb fractions was investigated and a kinetic model was established to quantitatively evaluate the main processes controlling Sb transformation.

Protective effect of Dunn extract on oxidative damage of LLC‑PK1 cells induced by HO.

Dunn extract (PPDE) is a well-known treatment used in traditional Chinese medicines, where it is most commonly used to treat coughs and symptoms such as headaches and fever. In the present study, the antioxidant capacity of PPDE was determined by scavenging experiments using DPPH, ABTS·, ·OH, and ·O. The cell survival rate was determined by MTT assay.

Clinical features and treatment outcomes of Castleman disease in children: a retrospective cohort in China.

Unlabelled: Castleman disease (CD) is a rare lymphoproliferative disorder of undetermined etiology. Unicentric CD (UCD) and multicentric CD (MCD) are two phenotypes of CD diagnosed by the histopathology of lymph nodes. We attempted to describe a pediatric CD cohort to optimize the management of this disease.

Novel Insight into Microbially Mediated Nitrate-Reducing Fe(II) Oxidation by sp. Strain BoFeN1 Using Dual N-O Isotope Fractionation.

Microbially mediated nitrate reduction coupled with Fe(II) oxidation (NRFO) plays an important role in the Fe/N interactions in pH-neutral anoxic environments. However, the relative contributions of the chemical and microbial processes to NRFO are still unclear. In this study, N-O isotope fractionation during NRFO was investigated.

Transformation kinetics of exogenous lead in an acidic soil during anoxic-oxic alteration: Important roles of phosphorus and organic matter.

Lead (Pb) can enter soil environment during flooding events such as surface runoff and intensive rainfall. However, the key transformation processes of exogenous Pb during anoxic-oxic alteration remain poorly understood particularly how phosphorus and organic matter contribute to Pb immobilization/release. Here, a kinetic model was established to investigate the Pb transformation in an acidic soil with two levels of Pb contamination under alternating anoxic-oxic conditions, based on the results of seven-step sequential extraction, dissolved organic carbon, sulfate, iron, phosphorus, and surface sites.

A small extent of seawater intrusion significantly enhanced Cd uptake by rice in coastal paddy fields.

Paddy fields located around estuaries suffer from seawater intrusion, and how and to what extent salinity levels influence Cd accumulation in rice grains is still unclear. Pot experiments were carried out by cultivating rice under alternating flooding and drainage conditions with different salinity levels (0.2‰, 0.

The key roles of Fe oxyhydroxides and humic substances during the transformation of exogenous arsenic in a redox-alternating acidic paddy soil.

Arsenic (As) from mine wastewater is a significant source for acidic paddy soil pollution, and its mobility can be influenced by alternating redox conditions. However, mechanistic and quantitative insights into the biogeochemical cycles of exogenous As in paddy soil are still lacking. Herein, the variations of As species in paddy soil spiking with As(III) or As(V) were investigated in the process of 40 d of flooding followed 20 d of drainage.

Reductive Sequestration of Cr(VI) and Immobilization of C during the Microbially Mediated Transformation of Ferrihydrite-Cr(VI)-Fulvic Acid Coprecipitates.

Cr(VI) detoxification and organic matter (OM) stabilization are usually influenced by the biological transformation of iron (Fe) minerals; however, the underlying mechanisms of metal-reducing bacteria on the coupled kinetics of Fe minerals, Cr, and OM remain unclear. Here, the reductive sequestration of Cr(VI) and immobilization of fulvic acid (FA) during the microbially mediated phase transformation of ferrihydrite with varying Cr/Fe ratios were investigated. No phase transformation occurred until Cr(VI) was completely reduced, and the ferrihydrite transformation rate decreased as the Cr/Fe ratio increased.

Dissolved organic matter derived from biodegradable microplastic promotes photo-aging of coexisting microplastics and alters microbial metabolism.

Dissolved organic matter (DOM) leaching from biodegradable microplastics (BMPs) and its characteristics and corresponding environmental implication are rarely investigated. In this study, the main component of DOM leachate from the two BMPs (polyadipate/butylene terephthalate (PBAT)/polycaprolactone (PCL)) was verified by using excitation-emission matrix-parallel factor analysis (EEM-PARAFAC). The PBAT-DOM (PBOM) was aromatized and terrestrial.