Occurrence and ecological risks of pharmaceuticals along the Yangtze River Basin of China: Insights from target analysis and suspect screening strategy.

Pharmaceuticals have gained global attention in recent decades due to their substantially growing demand and ecological impacts. This study aimed to comprehensively investigate the pollution status of 64 target pharmaceuticals in water (i.e.

Detecting Partial Discharge in Cable Joints Based on Implanting Optical Fiber Using MZ-Sagnac Interferometry.

Detecting partial discharges in cable joints is critical for timely defect identification and reliable transmission system operation. To improve the long-term reliability and sensitivity of the sensing system, a novel method for cable joint monitoring based on implanting optical fibers within the joint structure is proposed. The electric field distribution of the optical fiber-implanted cable joint was simulated, followed by electrical performance tests, demonstrating that optical fiber implantation had a negligible effect on the electrical properties of the cable joint.

Theoretical study of ammonia synthesis catalysed by trimetallic clusters with or without a sumanene support.

DFT calculations were utilized to explore the electrocatalytic nitrogen reduction reaction (NRR) mechanisms catalyzed by trimetallic clusters M (M = Ti, Zr, V, and Nb), both unsupported and supported by bowl-shaped sumanene. The substrate enhanced N adsorption and activation but hindered hydrogenation due to more negative adsorption energies. The substrate promoted hydrogenation of nitrogen, reducing the interference of the hydrogen evolution reaction (HER) and enhancing the NRR selectivity.

Positive impact of the legislation on organotins contamination in the marine environment of Hong Kong.

Since September 2008, the use of organotin compounds (OTs) on antifouling systems on seagoing vessels has been globally banned by the International Maritime Organisation due to their toxic effects to non-target marine organisms. However, the regulation enforcement varies by government, hindering its effectiveness in controlling OTs contamination. For example, the Hong Kong Special Administrative Government enacted related legislation in January 2017.

Rubber-derived chemicals in urban sewer networks and receiving waters: Fingerprints, driving factors and ecological impacts.

Rubber-derived chemicals (RDCs), which include rubber additives (RAs) and their transformation products (TPs), can be released into aquatic environments when rubber products, such as vehicle tires, are in use or discarded. However, RDCs and associated ecological risks have not been thoroughly investigated inside urban sewer networks and their receiving water bodies. To address these issues, we investigated the RDCs in Hong Kong's municipal sewer networks, including sewage and stormwater, as well as their receiving waters, such as rivers and coastal water.

A robust method to quantify pharmaceuticals for the United Nations endorsed Global Estuaries Monitoring (GEM) Programme.

Following human and animal consumption, pharmaceuticals often remain incompletely metabolized, entering aquatic ecosystems via sources like wastewater discharges, landfill leachates, and aquaculture farms, thereby eventually reaching the ocean through estuaries. This influx poses a significant threat to marine ecosystems. The Global Estuaries Monitoring (GEM) Programme, endorsed by the United Nations Decade of Ocean Science for Sustainable Development (2021-2030), aims to establish a standardized method for monitoring pharmaceuticals in the world's estuaries.

Designing Double Perovskites with Organic Dications for Enhancing Stability and Photoelectrical Performance.

Recently, the research on developing lead-free double-B-cation halide perovskites has attracted attention. However, CsInBiCl, the most promising one, was shown to be thermodynamically unstable. To improve the stability, organic dication DiMA (i.

Triglyceride-glucose index and hsCRP-to-albumin ratio as predictors of major adverse cardiovascular events in STEMI patients with hypertension.

This study aimed to evaluate the association between the triglyceride-glucose (TyG) index and high-sensitivity C-reactive protein-to-albumin ratio (hsCAR) and the prognosis of patients with STEMI and hypertension. A total of 699 patients diagnosed with STEMI and hypertension were included in this study database. Compared to the low TyG index group (< 7.

Typical Tire Additives in River Water: Leaching, Transformation, and Environmental Risk Assessment.

Tire wear particles (TWPs) released during vehicle driving can enter water bodies, leading to leaching of tire additives (TAs) in aquatic environments. However, the transformation behavior and related ecological impacts of TAs and their transformation products (TPs) remain unclear. In this study, laboratory-based simulation experiments and field investigations were conducted to explore the transformation mechanisms and ecological risks of TAs.

Occurrence and potential risks of pharmaceutical contamination in global Estuaries: A critical review and analysis.

Input of pollutants to estuaries is one of the major threats to marine biodiversity and fishery resources, and pharmaceuticals are one of the most important contaminants of emerging concern in aquatic ecosystems. To synthesize pharmaceutical pollution levels in estuaries over the past 20 years from a global perspective, this review identified 3229 individual environmental occurrence data for 239 pharmaceuticals across 91 global estuaries distributed in 26 countries. The highest cumulative weighted average concentration level (WACL) of all detected pharmaceuticals in estuarine water was observed in Africa (145,461.

Long-term blood pressure variability and risk of cardiovascular diseases in populations with different blood pressure status: an ambispective cohort study.

Objective: We aimed to investigate the correlation between long-term blood pressure variability (BPV) and the risk of cardiovascular diseases (CVDs) among population with different blood pressure statuses (normotension, well-controlled hypertension, and uncontrolled hypertension).

Methods: In this ambispective cohort study, CVD-free residents aged over 50 years were consecutively enrolled from two community health service centers (CHCs) in Tianjin, China from April 2017 to May 2017. Information on blood pressure was retrospectively extracted from electronic medical records of CHCs between January 2010 and May 2017, and the occurrence of new-onset CVDs was prospectively observed during follow-up until September 2019.

Microplastics in Hong Kong's marine waters: Impact of rainfall and Pearl River discharge.

This study provided a systematic investigation of microplastics in Hong Kong's surface marine waters during the pandemic from 2019 to 2021. Microplastics (2.07 ± 4.

Experimental investigation of influence of amide polymer on loess for subgrade.

The effects of moisture and drying shrinkage can lead to uneven settlement, cracking, and other diseases in loess subgrade. The objective of this study was to investigate the effects of amide polymer (AP) on the permeability, mechanical properties and crack resistance of loess by orthogonal experiments. The basic properties of AP and the permeability, mechanical properties, and dry-wet variation properties of polymer-modified loess were tested, and a scale model verification and simulation analysis were conducted.

Medicating the coast in a metropolitan city: Enantiomeric profiles and joint probabilistic risk assessment of antidepressants and antihistamines.

Pharmaceuticals are receiving increasing attention as emerging contaminants in the aquatic environment. Herein, we investigated the occurrence of 11 antidepressants, 6 antihistamines and 4 metabolites in treated wastewater effluents, rivers, stormwater, and seawater in Hong Kong, with special focus on chirality. The average levels of ∑pharmaceuticals ranged from 0.

Middle mediastinal paraganglioma: A case report and review of the literature.

Rational: Paragangliomas are rare and can occur in many places throughout the body, but mediastinal paragangliomas are even rarer, accounting for less than 0.3% of mediastinal masses. Extremely susceptible to misdiagnosis and mistreatment, which may lead to the death of the patient.

[Research Status and Trend of Devices for Treating Advanced Heart Failure].

Heart failure (HF),a chronic progressive disease,is a global health problem and the leading cause of deaths in the global population.The pathophysiological abnormalities of HF mainly include abnormal cardiac structure (myocardium and valves),disturbance of electrophysiological activities,and weakened myocardial contractility.In addition to drug therapy and heart transplantation,interventional therapies can be employed for advanced-stage HF,including transcatheter interventions and mechanical circulatory assist devices.

New Perspective to Understand and Prioritize the Ecological Impacts of Organophosphate Esters and Transformation Products in Urban Stormwater and Sewage Effluents.

Due to their prevalence in urban contaminated water, the driving factors of organophosphate esters (OPEs) need to be well examined, and their related ecological impacts should include that of their transformation products (TPs). Additionally, a robust framework needs to be developed to integrate multiple variables related to ecological impacts for improving the ecological health assessment. Therefore, OPEs and TPs in urban stormwater and wastewater in Hong Kong were analyzed to fill these gaps.

Microplastic occurrence and ecological risk assessment in the eight outlets of the Pearl River Estuary, a new insight into the riverine microplastic input to the northern South China Sea.

Estuaries are unique transition zones connecting terrestrial and coastal environments and are recognized as primary conveyors for land-derived plastics to open oceans. Riverine microplastics (MPs) have been commonly investigated using sequential sampling which might not effectively reflect the actual load. In this study, sampling at eight outlets was performed during a complete tidal cycle to estimate the MP flux to the Pearl River Estuarine (PRE) using a concurrent sampling strategy.

A systematic study of microplastic occurrence in urban water networks of a metropolis.

The release of microplastics from sewage treatment works (STWs) into the oceans around coastal cities is well documented. However, there are fewer studies on the microplastic abundance in stormwater drains and their emissions into the coastal marine environment via sewage and stormwater drainage networks. Here, we comprehensively investigated microplastic abundance in 66 sewage and 18 sludge samples collected from different process stages at three typical STWs and 36 water samples taken from six major stormwater drains during the dry and wet seasons in Hong Kong, which is a metropolitan city in south China.

Significant riverine inputs of typical plastic additives-phthalate esters from the Pearl River Delta to the northern South China Sea.

Phthalate esters (PAEs) are representative additives used extensively in plastics. In this study, 15 PAEs were investigated at the eight riverine outlets of the Pearl River Delta (PRD). The total concentrations of ΣPAEs, including both the dissolved and particulate phases, ranged from 562 to 1460 ng/L and 679 ng/L-2830 ng/L in the surface and bottom layers, respectively.

Spatiotemporal occurrence of phthalate esters in stormwater drains of Hong Kong, China: Mass loading and source identification.

Urban stormwater is an important pathway for transporting anthropogenic pollutants to water bodies. Phthalate esters (PAEs) are endocrine disruptors owing to their estrogenic activity and potential carcinogenicity and their ubiquitous presence has garnered global interest. However, their transportation by urban stormwater has been largely overlooked.

Association between Early Oral β-Blocker Therapy and Risk for In-Hospital Major Bleeding after Percutaneous Coronary Intervention for Acute Coronary Syndrome: Findings from CCC-ACS Project.

Aims: Information regarding β-blocker use and bleeding risk in patients on antithrombotic therapy in contemporary practice is limited. We examined the association between early (within the first 24 hours) oral β-blocker therapy and major in-hospital bleeds among acute coronary syndrome (ACS) patients treated with percutaneous coronary intervention (PCI).

Methods And Results: In the Improving Care for Cardiovascular Disease in China-ACS project, among patients without contraindications to β-blocker, we examined the association between early oral β-blocker exposure [users/non-users, dosing, and type (metoprolol vs.

The beneficial cutoffs of vitamin D for metabolic syndrome varies by sex among the elderly Chinese population: A cross-sectional study.

Metabolic syndrome (MetS) is a risk factor for various diseases with a high prevalence globally. We aimed to investigate the association of serum vitamin D levels with MetS, and we hypothesized that the beneficial cutoffs of vitamin D for MetS might vary by sex among urban people aged ≥60 years in Tianjin, China. This community-based cross-sectional study was conducted in 2 community health centers.

The Impact of Age on Statin-Related Glycemia: A Propensity Score-Matched Cohort Study in Korea.

The aim of this study was to investigate the influence of statin on glycemic control in different age groups. Patients admitted for suspected or confirmed coronary artery disease between January 2005 and December 2013 in Seoul, Korea were initially enrolled. After propensity score matching, 2654 patients (1:1 statin users and non-users) were selected out of total 5041 patients, including 1477 “young” patients (≤60 y) and 1177 elderly patients (>60 y).