Assessing the inflammation in pediatric MOGAD: Significance of CSF HMGB1 and related biomarkers.

Background And Purpose: Myelin-oligodendrocyte glycoprotein antibody associated disease (MOGAD) is a common inflammatory disease of the central nervous system (CNS) in children that can lead to demyelination. Evaluation and monitoring of biomarkers associated with its pathogenesis would provide vital information on disease progression and therapeutic assessment.

Methods: We assessed NLRP3, HMGB1, IL-6, and IL-33 levels in the cerebrospinal fluid (CSF) of pediatric patients with MOGAD at different time points and their association with the risk of disease.

Investigation of the soybean infiltration process utilizing low-field nuclear magnetic resonance technology.

This paper employs low-field nuclear magnetic resonance (LF-NMR) technology to meticulously analyze and explore the intricate soybean infiltration process. The methodology involves immersing soybeans in distilled water, with periodic implementation of Carr-Purcell-Meiboom-Gill (CPMG) pulse sequence experiments conducted at intervals of 20 to 30 minutes to determine the relaxation time T2. Currently, magnetic resonance imaging (MRI) is conducted every 30 minutes.

Automated Quality Evaluation of Large-Scale Benchmark Datasets for Vision-Language Tasks.

Large-scale benchmark datasets are crucial in advancing research within the computer science communities. They enable the development of more sophisticated AI models and serve as "golden" benchmarks for evaluating their performance. Thus, ensuring the quality of these datasets is of utmost importance for academic research and the progress of AI systems.

Semantic characteristic grading of pulmonary nodules based on deep neural networks.

Background: Accurate grading of semantic characteristics is helpful for radiologists to determine the probabilities of the likelihood of malignancy of a pulmonary nodule. Nevertheless, because of the complex and varied properties of pulmonary nodules, assessing semantic characteristics (SC) is a difficult task.

Method: In this paper, we first analyze a set of important semantic characteristics of pulmonary nodules and extract the important SCs relating to pulmonary nodule malignancy by Pearson's correlation approach.

Two rare cases of myelin oligodendrocyte glycoprotein antibody-associated disorder in children with leukodystrophy-like imaging findings.

Background: Children with acquired demyelinating syndromes (ADS) whose sera are positive for myelin oligodendrocyte glycoprotein (MOG) immunoglobulin (IgG) can be diagnosed with MOG-IgG associated disorder (MOGAD). Cases with leukodystrophy-like imaging findings with recurrent MOGAD have rarely been reported.

Case Presentation: Two children with MOGAD, whose onset age was 6 months and 3 years, respectively, were admitted to the hospital due to fever and altered consciousness.

Detection of unrecognized spatial disorientation: A theoretical perspective.

Background: Spatial disorientation (SD) is a problem that pilots often encounter during a flight. One reason for this problem is that among the three types of SD, there is no validated method to detect the Type I (unrecognized) SD.

Objective: In this pursuit, initially we reviewed the problems and the evaluation methods of associated with SD.

Design of automatic urine collection system for medical system applications.

Background: The results of urine tests are often affected by improper midstream urine collection time, urine spilling, and urine pollution, all of which can lead to an increase in the test error.

Objective: To solve this problem, aiming at improving the toilet environment at the hospitals and public physical examination centers, this paper designs an automatic urine collection system. It can automatically adjust the position of the urine cup with an infrared remote controller, or manually, adjust the position of the urine cup in special situations according to the needs of the user.

Clinical analysis of myelin oligodendrocyte glycoprotein antibody-associated demyelination in children: A single-center cohort study in China.

Background And Purpose: Myelin oligodendrocyte glycoprotein antibodies (MOG-Abs) are detected at a high rate in childhood of acquired demyelinating syndrome (ADS), but the spectrum and characteristics of MOG-Abs-associated disorders (MOGAD) in children are to be determined. This study aimed to identify clinical features in Chinese children with MOGAD.

Methods: Of 48 children in whom MOGAD were diagnosed in our hospital, we analyzed the manifestations, laboratory test results, imaging characteristics, autoimmune antibodies in cerebrospinal fluid and serum, and response to treatment.

Organophosphorus-based chemical additives induced behavioral changes in zebrafish (Danio rerio): Swimming activity is a sensitive stress indicator.

Organophosphorus flame retardants (OPFRs) have been extensively used as chemical additives in polymer based consumer products. Among them, Isopropylphenyl phosphate (IPPP) and tripropyl phosphate (TPP) are predominant, which have potential to cause neuro-toxic effects on non-target organisms. As behavior (swimming activity) response is the first adjustment due to neurotoxic stress on the fitness of fish.

Pathological lung segmentation based on random forest combined with deep model and multi-scale superpixels.

Accurate segmentation of lungs in pathological thoracic computed tomography (CT) scans plays an important role in pulmonary disease diagnosis. However, it is still a challenging task due to the variability of pathological lung appearances and shapes. In this paper, we proposed a novel segmentation algorithm based on random forest (RF), deep convolutional network, and multi-scale superpixels for segmenting pathological lungs from thoracic CT images accurately.

Silencing of long non‑coding antisense RNA brain‑derived neurotrophic factor attenuates hypoxia/ischemia‑induced neonatal brain injury.

Hypoxic/ischemic (HI) brain damage (HIBD) is a major cause of acute neonatal brain injury, leading to high mortality and serious neurological deficits. The antisense RNA of brain‑derived neurotrophic factor (BDNF‑AS) is transcribed from the opposite strand of the BDNF gene. The aim of the present study was to investigate the role of BDNF‑AS in HI‑induced neuronal cell injury in vivo and in vitro.

Simultaneous eco-toxicity assessment technique using an online monitoring system: effects of different environmental factors on swimming behavior of zebrafish (Danio rerio).

Environmental factors, such as photoperiod and temperature were the main limiting factors for the survival of organisms in the nature environment. Changes in environmental factors are well predicted but determining their effects on organisms are challenging hot topic in the field of eco-toxicology. Thus, technology based eco-toxicity assessment was focused worldwide.

Biochemical and behavior effects induced by diheptyl phthalate (DHpP) and Diisodecyl phthalate (DIDP) exposed to zebrafish.

Both Diheptyl-phthalate (DHpP) and Diisodecyl-phthalate (DIDP) were used extensively as plasticizers. Recently, their occurrence in the environmental matrices and human body fluids have been reported. Unfortunately, these phthalate congeners are without basic toxicity profiles.

A fully automatic segmentation algorithm for CT lung images based on random forest.

Purpose: Several negative factors, such as juxta-pleural nodules, pulmonary vessels, and image noise, make accurately segmenting lungs from computed tomography (CT) images a complex task. We propose a novel hybrid automated algorithm in the paper based on random forest to deal with the issues. Our method aims to eliminate the effect of the factors and generate accurate segmentation of lungs from CT images.

Long non-coding RNA Snhg3 protects against hypoxia/ischemia-induced neonatal brain injury.

Hypoxic-ischemic brain damage (HIBD) is a major cause of morbidity and mortality in the preterm and term infant. However, the precise mechanism of HIBD remains largely elusive. As a newly discovered long non-coding RNA, small nucleolar RNA host gene 3 (Snhg3) has shown its important roles in cell apoptosis, proliferation, and disease development.

Risk factors and outcomes of acute kidney injury in ventilated newborns.

This study aimed to investigate the occurrence and risk factors of acute kidney injury (AKI) in ventilated newborns. In total, 139 newborns receiving mechanical ventilation (MV) were reviewed in this retrospective study. The demographic and clinical data were collected.

Potential effects of internal physio-ecological changes on the online biomonitoring of water quality: The behavior responses with circadian rhythms of zebrafish (Danio rerio) to different chemicals.

The online biomonitoring of aquatic accidental pollution is very important to realize the assessment of complex toxicity. However, the monitoring results would be affected greatly by the internal physio-ecological changes of test organisms, and circadian rhythms might contribute greatly to this kind of effects. In the present study, the behavior responses of zebrafish (Danio rerio) to different concentrations of Deltamethrin, Atrazine, and Thallium (Tl) in 15 days were investigated using an online behavior monitoring system.

A Rapid Terrestrial Laser Scanning Method for Coastal Erosion Studies: A Case Study at Freeport, Texas, USA.

Terrestrial laser scanning (TLS) has become a powerful data acquisition technique for high-resolution high-accuracy topographic and morphological studies. Conventional static TLS surveys require setting up numerous reflectors (tie points) in the field for point clouds registration and georeferencing. To reduce surveying time and simplify field operational tasks, we have developed a rapid TLS surveying method that requires only one reflector in the field.

Role of TGF-Beta1/SMAD2/3 Pathway in Retinal Outer Deep Vascular Plexus and Photoreceptor Damage in Rat 50/10 Oxygen-Induced Retinopathy.

In retinopathy of prematurity (ROP), outer deep vascular plexus (oDVP) was the emerging field, and the mechanisms of photoreceptor dysfunction remained to be explored. ODVP and photoreceptors were related, with oDVP being part of the supplier of oxygen and nutrients to photoreceptors, while their possible relationship in ROP was not clear. TGF-beta1 has been reported indispensable in oDVP development and altered in ROP patients and animal models.

Robust Normal Estimation for 3D LiDAR Point Clouds in Urban Environments.

Normal estimation is a crucial first step for numerous light detection and ranging (LiDAR) data-processing algorithms, from building reconstruction, road extraction, and ground-cover classification to scene rendering. For LiDAR point clouds in urban environments, this paper presents a robust method to estimate normals by constructing an octree-based hierarchical representation for the data and detecting a group of large enough consistent neighborhoods at multiscales. Consistent neighborhoods are mainly determined based on the observation that an urban environment is typically comprised of regular objects, e.

Circular RNA expression profiles in neonatal rats following hypoxic-ischemic brain damage.

Circular RNAs (circRNAs) have been studied in a number of diseases. However, the roles of circRNAs in hypoxic‑ischemic brain damage (HIBD) remains unknown. In the present study, high throughput sequencing was used to profile altered circRNAs in HIBD rats.

High-throughput sequencing analysis of lncRNAs in hippocampus tissues with hypoxic-ischemic brain damage.

LncRNAs abundantly expressed in the brain have vital and wide-ranging functions in different biological processes. However, little is currently known regarding the influence of lncRNAs in developing brains after hypoxic-ischemic brain damage (HIBD). In this study, to investigate the lncRNAs expression signatures and the co-expression network of lncRNAs and mRNAs in the brain after HIBD, we established a and detected the expression profiles of lncRNAs in the HIBD brain and a sham control using high-throughput sequencing.

The online monitoring and assessment of thallium stress using oxygen consumption rate and carbon dioxide excretion rate of zebrafish (Danio rerio).

An online monitoring and assessment system of metabolism to measure oxygen consumption rate (OC) and carbon dioxide (CO) excretion rate (CR) of zebrafish (Danio rerio) was used to illustrate changes in stressful states in 15 days' (360 h) 0.1 μg/L Tl exposure. Tl had a significant inhibition on zebrafish OC and CR (p < 0.