A new species of (Cypriniformes, Cyprinidae) from the Beipan-Jiang in Guizhou, China.

from the Dabang-He of the Beipan-Jiang Basin in Zhenning County, Guizhou Province, China, is described based on morphological and molecular evidence. The new species can be distinguished morphologically from all congeners in this genus by: (1) normal eyes (5.8%-8.

Genetic Structure of the Cave-Dwelling Catfish (Siluriformes: Siluridae) in Southwest China.

The mountainous regions of Southwest China are biodiversity hotspots where geographical isolation promotes genetic differentiation and species diversification. For cave-dwelling species like the , how geographical isolation, historical climate, and riverscapes have influenced their evolution remains largely unexplored. Based on 255 samples from the Pearl River and the Yangtze River, this study integrated two mitochondrial genes and two nuclear genes to analyze the genetic diversity and structure of the population.

Anthropogenic Extremely Low Volatility Organics (ELVOCs) Govern the Growth of Molecular Clusters Over the Southern Great Plains During the Springtime.

New particle formation (NPF) often drives cloud condensation nuclei concentrations and the processes governing nucleation of molecular clusters vary substantially in different regions. The growth of these clusters from ∼2 to >10 nm diameters is often driven by the availability of extremely low volatility organic vapors (ELVOCs). Although the pathways to ELVOC formation from the oxidation of biogenic terpenes are better understood, the mechanistic pathways for ELVOC formation from oxidation of anthropogenic organics are less well understood.

Mitochondrial Genomes of Six Species (Teleostei, Cyprinidae) and Their Phylogenetic Analysis.

is an important small freshwater economic fish in Southwestern China. In this study, we determined the complete mitochondrial genome (mitogenome) sequences of six species by conventional overlapping PCR and Sanger sequencing. The mitogenomes were 16,591-16,605 bp in length and contained 13 protein-coding genes, 22 transfer RNA genes, two ribosomal RNA genes, and a noncoding region, which was consistent with previously studied Labeoninae mitogenomes.

MicroRNA-24-3p targeting Top1 in perirenal fat is involved in circulating inflammation and high cardiovascular disease risk in patients with primary aldosteronism.

Context: Patients with primary aldosteronism (PA) are at a high risk of cardiovascular diseases (CVD) and metabolic syndrome. Notable inflammatory and fibrotic changes and differential microRNA (miRNA) expression profiles in the perirenal fat observed in PA may contribute to this increased risk, however, which has not been fully elucidated.

Objective: This study aimed to explore the role of high expression of miR-24-3p in perirenal fat in circulating inflammation and its correlation with a high risk of CVD in patients with PA.

IKZF1 promotes pyroptosis and prevents M2 macrophage polarization by inhibiting JAK2/STAT5 pathway in colon cancer.

Pyroptosis and macrophage pro-inflammatory activation play an important role in hepatocellular carcinoma (HCC) progression. However, the specific regulatory mechanisms remain unclear. We identified pyroptosis-related differentially expressed genes (DEGs) based on the GSE4183 and GSE44861 datasets as well as EVenn database.

RiceSNP-ABST: a deep learning approach to identify abiotic stress-associated single nucleotide polymorphisms in rice.

Given the adverse effects faced by rice due to abiotic stresses, the precise and rapid identification of single nucleotide polymorphisms (SNPs) associated with abiotic stress traits (ABST-SNPs) in rice is crucial for developing resistant rice varieties. The scarcity of high-quality data related to abiotic stress in rice has hindered the development of computational models and constrained research efforts aimed at rice improvement and breeding. Genome-wide association studies provide a better statistical power to consider ABST-SNPs in rice.

RiceSNP-BST: a deep learning framework for predicting biotic stress-associated SNPs in rice.

Rice consistently faces significant threats from biotic stresses, such as fungi, bacteria, pests, and viruses. Consequently, accurately and rapidly identifying previously unknown single-nucleotide polymorphisms (SNPs) in the rice genome is a critical challenge for rice research and the development of resistant varieties. However, the limited availability of high-quality rice genotype data has hindered this research.

Comprehensive Analysis of Genes Across the Genome Uncovers Potential Functions in Sexual Reproduction and Abiotic Stress Tolerance.

The Domain of Unknown Function 506 () belongs to the PD-(D/E) XK nuclease superfamily and has been reported to play critical roles in growth and development as well as responses to abiotic stresses. However, the function of genes in () remains unclear. In this study, a total of 18 genes were identified and randomly distributed across eight chromosomes, categorized into four subfamilies.

Predictive models for cholesterol crystals and plaque vulnerability in acute myocardial infarction: Insights from an optical coherence tomography study.

Background: Cholesterol crystals (CCs) are recognized as a risk factor for vulnerable atherosclerotic plaque rupture (PR) and major adverse cardiovascular events. However, their predictive factors and association with plaque vulnerability in patients with acute myocardial infarction (AMI) remain insufficiently explored. Therefore, This study aims to investigate the association between CCs and plaque vulnerability in culprit lesions of AMI patients, identify the factors influencing CCs formation, and develop a predictive model for CCs.

Sex differences in colorectal cancer: with a focus on sex hormone-gut microbiome axis.

Sexual dimorphism has been observed in the incidence and prognosis of colorectal cancer (CRC), with men generally exhibiting a slightly higher incidence than women. Research suggests that this difference may be attributed to variations in sex steroid hormone levels and the gut microbiome. The gut microbiome in CRC shows variations in composition and function between the sexes, leading to the concept of 'microgenderome' and 'sex hormone-gut microbiome axis.

The New Mitochondrial Genome of (Cypriniformes, Xenocyprididae): Sequence, Structure, and Phylogenetic Analyses.

is an endemic small freshwater fish, distributed in the Pearl River system and Qiantang River, China. In this study, we identified and annotated the complete mitochondrial genome sequence of . The mitochondrial genome was 16,619 bp in length and contained 13 protein coding genes (PCGs), two rRNA genes, 22 tRNA genes, and one control region.

PacBio Full-Length Transcriptome of a Tetraploid Provides Insights into the Evolution of Cavefish.

is a second-class nationally protected wild animal in China. As one of the cavefish, has strong adaptability to harsh subterranean environments. In this study, we used PacBio SMRT sequencing technology to generate a first representative full-length transcriptome for .

The Mitochondrial Genome of (Cypriniformes: Cyprinidae): Characterization and Phylogeny.

Mitochondrial genomes (mitogenomes) have been widely used in phylogenetic analysis and evolutionary biology. The Labeoninae is the largest subfamily of Cypriniformes and has great economic importance and ecological value. In this study, we sequenced, annotated, and characterized the complete mitogenome of and then constructed the phylogenetic tree with previously published Labeoninae mitogenomes.

Comprehensive transcripts analysis based on single-molecule real-time sequencing and Illumina sequencing provides insights into the mining of Toll-like receptor family in Schizothorax lissolabiatus.

Schizothorax lissolabiatus is an economically important cold-water fish species in southwestern China. Because of water pollution and habitat destruction, the number of wild populations has dramatically decreased. In this study, we used PacBio single-molecule real-time (SMRT) sequencing and Illumina sequencing to generate the first full-length transcriptome and transcriptome, respectively.

Enhancing acid-base-water ternary aerosol nucleation with organic acid: a case of tartaric acid.

The new particle formation (NPF) process has been observed globally in clean and polluted environments, where the fundamental mechanisms leading to multicomponent aerosol formation remain elusive. Dicarboxylic acids play an important role in atmospheric NPF. In this study, theoretical calculations are performed to assess the effect of tartaric acid (TA) on the formation of clusters consisting of sulfuric acid (SA), ammonia (AM) or amines (methylamine or dimethylamine, MA/DMA) in the presence of water.

The Complete Mitochondrial Genome of the Freshwater Fish (Cypriniformes, Cyprinidae): Genome Characterization and Phylogenetic Analysis.

In this study, we sequenced and characterized the complete mitochondrial genome (mitogenome) of . The mitogenome of was 16,602 bp in length with 13 protein-coding genes (PCGs), 22 transfer RNA (tRNA) genes, 2 ribosomal RNA (rRNA) genes, and a control region. The nucleotide composition of the mitogenome was 31.

A new cavefish of Sinocyclocheilus (Teleostei: Cypriniformes: Cyprinidae) from the Nanpanjiang River in Guizhou, China.

A new species, Sinocyclocheilus xingyiensis, is described based on specimens collected from a karst cave in Guizhou Province, China. The authors used an integrated taxonomic approach, including morphological and molecular data, to identify the new species as a member of the Sinocyclocheilu angularis group, and it can be distinguished from all other members of this group by a combination of the following features: two pairs of long barbels and long pectoral fins, 42-46 lateral-line scales, 7 (13-14) on outer (inner) side of the first gill arch and 35 (14-15 + 4 + 16 - 17) vertebrae. Phylogenetic analyses based on the cytochrome b (cyt b) gene fragment suggest that S.

Comparison of the Efficacy of Endoscopic Radial Incision and Cutting Procedure and Endoscopic Balloon Dilation for Benign Anastomotic Stricture After Low Anterior Resection Combined With Preventive Loop Ileostomy in Rectal Cancer.

Background: Endoscopic radial incision and cutting procedure is a notable technique in the treatment of benign anastomotic strictures after low anterior resection in rectal cancer. However, the efficacy and safety of the endoscopic radial incision and cutting procedure and traditional endoscopic balloon dilation remain unknown.

Objective: To compare the efficacy and safety of the endoscopic radial incision and cutting procedure and endoscopic balloon dilation in patients with anastomotic stricture after low anterior resection.

Maternal exposure to ultrafine particles enhances influenza infection during pregnancy.

Background: Interactions between air pollution and infectious agents are increasingly recognized and critical to identify, especially to protect vulnerable populations. Pregnancy represents a vulnerable period for influenza infection and air pollution exposure, yet interactions during pregnancy remain unclear. Maternal exposure to ultrafine particles (UFPs, [Formula: see text] 100 nm diameter), a class of particulate matter ubiquitous in urban environments, elicits unique pulmonary immune responses.

Bortezomib, Melphalan, and Prednisone With or Without Daratumumab in Transplant-ineligible Asian Patients With Newly Diagnosed Multiple Myeloma: The Phase 3 OCTANS Study.

Introduction: In the global phase 3 ALCYONE trial, daratumumab plus bortezomib/melphalan/prednisone (D-VMP) improved outcomes versus VMP in transplant-ineligible newly diagnosed multiple myeloma (NDMM) patients. Here, we report the primary analysis of the phase 3 OCTANS trial of D-VMP versus VMP in transplant-ineligible Asian NDMM patients.

Patients And Methods: In total, 220 patients were randomized (2:1) to receive 9 cycles of VMP (bortezomib 1.

Complete mitochondrial genomes of two catfishes (Siluriformes, Bagridae) and their phylogenetic implications.

The mitochondrial genome (mitogenome) has been widely used as a molecular marker to investigate phylogenetic analysis and evolutionary history in fish. However, the study of mitogenomes is still scarce in the family Bagridae. In this study, the mitogenomes of and were sequenced, annotated, and analyzed.