An analysis of operational efficiency and its influencing factors in traditional Chinese medicine hospitals in Shaanxi Province, China.

Background: Over the past decade, traditional Chinese medicine (TCM) hospitals in China have experienced significant growth. However, their developmental status remains unclear, posing challenges to the formulation and optimization of relevant healthcare policies. This study aimed to assess the operational efficiency of TCM hospitals in Shaanxi Province and explore its influencing factors, thereby providing empirical evidence to support performance improvement.

Exosomal circ_0093708 as a potential ferroptosis biomarker in cerebral ischemia-reperfusion injury.

Background: Ferroptosis plays a critical role in neuronal injury following cerebral infarction. However, effective therapeutic strategies targeting ferroptosis after cerebral ischemia-reperfusion injury (CI/RI) remain limited. Exosome-based therapy holds significant promise in this context.

Catestatin attenuates cerebral ischemia/reperfusion injury and suppresses endoplasmic reticulum stress.

Ischemic stroke is one of the leading causes of death worldwide. Catestatin (CST), as a pleiotropic hormone, displays an anti-apoptotic effect, in addition to its known roles in cardiovascular regulation. However, the role of CST in ischemic stroke remains unclear.

Age and body mass index are associated with type Ⅲ aortic arch in patients undergoing digital subtraction angiography.

Background And Purpose: Type Ⅲ aortic arch can increase the difficulty of interventional surgery in patients with cerebrovascular diseases. This study was performed to explore the factors associated with type Ⅲ aortic arch.

Materials And Methods: This observational, multicenter, case-control study was performed in Shaanxi Province, China and involved 841 patients who underwent cerebral angiography at 3 stroke centers from April 2019 to August 2020.

IL-8 and IL-1β in the Cerebrospinal Fluid of Patient With Creutzfeldt-Jakob Disease: A Case Report.

Inflammatory cytokines play a crucial role in Creutzfeldt-jakob disease (CJD). We examined inflammatory cytokine levels in both blood and CSF in a CJD patient and an epileptic encephalopathy as a control case. Results showed that IL-6, IL-8, IL-1β, and TNF-α levels were elevated in blood, but only IL-8 and IL-1β levels, especially IL-8, were significantly elevated in Cerebrospinal fluid (CSF).

Shunt Dependency Syndrome Combined with Sinus Stenosis after Cyst-peritoneal Shunting of Arachnoid Cyst: A 20-year Rare Complication.

Shunt dependence syndrome is a serious long-term complication characterized by symptoms and signs of increased intracranial pressure with normal-sized lateral ventricles after several years of arachnoid cyst-peritoneal shunting. It is easy to misdiagnose and overlook when combined with sinus stenosis, thus delaying treatment. Here, we present a 35-year-old man with an unexplained headache and binocular horizontal diplopia with high intracranial pressure.

Correlation between lipoprotein(a) and recurrent ischemic events post-cerebral vascular stent implantation.

Background And Aim: The association of Lipoprotein(a) (Lp[a]) with recurrent ischemic events in stented patients remains uncertain. So, this research aimed to investigate the impact of elevated Lp(a) levels on the occurrence of ischemic events in this specific patient population.

Methods: Totally 553 patients who underwent intracranial or extracranial artery stent implantation were included.

Investigating the Axis as Oxidative Stress-Related Signatures and Immune Infiltration Characteristics in Ischemic Stroke.

Background: Oxidative stress (OS) and immune inflammation play complex intersections in the pathophysiology of ischemic stroke (IS). However, a competing endogenous RNA- (ceRNA-) based mechanism linked to the intersections in IS has not been explored. We aimed to identify potential OS-related signatures and analyze immune infiltration characteristics in IS.

Correlation between microalbuminuria and atherosclerotic intracranial and extracranial arterial stenosis in patients with cerebral infarction.

Background And Aims: Microalbuminuria (MAU) reflects the generalized vascular endothelial dysfunction. Whether MAU has correlation with atherosclerotic intracranial and extracranial arterial stenosis in cerebral infarction patients is not known and is explored in the present investigation.

Methods: We enrolled 255 cerebral infarction patients hospitalized at the department of neurology.

Identification of a ferroptosis-related gene pair biomarker with immune infiltration landscapes in ischemic stroke: a bioinformatics-based comprehensive study.

Background: Ischemic stroke (IS) is a principal contributor to long-term disability in adults. A new cell death mediated by iron is ferroptosis, characterized by lethal aggregation of lipid peroxidation. However, a paucity of ferroptosis-related biomarkers early identify IS until now.

Combination of High-Density Lipoprotein Cholesterol and Lipoprotein(a) as a Predictor of Collateral Circulation in Patients With Severe Unilateral Internal Carotid Artery Stenosis or Occlusion.

Background And Purpose: Collateral circulation is considered an important factor affecting the risk of stroke, but the factors that affect collateral circulation remain unclear. This study was performed to identify the factors associated with collateral circulation, especially blood lipids.

Methods: The study involved patients who had undergone digital subtraction angiography and were confirmed as having severe unilateral stenosis or occlusion of the internal carotid artery (ICA).

Dynorphin A (1-8) inhibits oxidative stress and apoptosis in MCAO rats, affording neuroprotection through NMDA receptor and κ-opioid receptor channels.

The contents of Dynorphin A(1-8) decreased gradually in ischemic cortices in rats and an intracerebroventricular administration of synthetic Dynorphin A(1-8) reduced the volume of cerebral infarction in our previous research. However, the specific protective mechanism is unclear and Dynorphin A(1-8) is unlikely to cross the blood-brain barrier (BBB) by noninvasive oral or intravenous administration as a macromolecule neuropeptide. In this study, intranasal administration was used to middle cerebral artery occlusion(MCAO) rats to assessed the therapeutic effects of Dynorphin A(1-8) by evaluating behavior, volume of cerebral infarct, cerebral edema ratio, histological observation.

The prediction of asymptomatic carotid atherosclerosis with electronic health records: a comparative study of six machine learning models.

Background: Screening carotid B-mode ultrasonography is a frequently used method to detect subjects with carotid atherosclerosis (CAS). Due to the asymptomatic progression of most CAS patients, early identification is challenging for clinicians, and it may trigger ischemic stroke. Recently, machine learning has shown a strong ability to classify data and a potential for prediction in the medical field.