Unraveling Enhanced Superconductivity in Single-Layer FeSe through Substrate Surface Terminations.

Single-layer FeSe on SrTiO(001) substrates shows a superconducting transition temperature much higher than that of bulk FeSe, which has been attributed to factors such as electron doping, interfacial electron-phonon coupling, and electron correlations. To pinpoint the primary driver, we grew single-layer FeSe films on SrTiO(001) substrates with coexisting TiO and SrO surface terminations. Scanning tunneling spectroscopy revealed a larger superconducting gap (17.

An age-related decrease in leptin contributes to CD8 T cell aging in the tumor microenvironment.

T cell dysfunction with age underlies an increased incidence of cancer in elderly individuals; however, how T cell aging is triggered in the tumor microenvironment is unclear. Here, we show that an age-associated reduction in adipocyte-derived leptin contributes to the accumulation of tumor-infiltrating senescent CD8 T cells. Single-cell profiling of human and mouse cancer tissues reveals that the frequency of intratumoral senescent CD8 T cells increases with age, leading to a weak antitumor effect.

High fructose consumption aggravates inflammation by promoting effector T cell generation via inducing metabolic reprogramming.

The intake of sugars, especially glucose and fructose, has significantly increased with the change of lifestyle. Excessive intake of sugar has been proven to be associated with tumors and inflammatory diseases. Fructose directly mediates innate immune responses; however, whether it can directly regulate T-cell immunity remains unknown.

Diet-derived galactose reprograms hepatocytes to prevent T cell exhaustion and elicit antitumour immunity.

Dietary nutrients are inextricably linked to antitumour immune responses. However, the effect of diet-derived galactose on antitumour immunity remains unclear. Here we show that dietary galactose augments CD8 T cell immunity to suppress tumour progression.

Combined High Tibial Osteotomy and Transtibial Drilling of Tibial and Femoral Medial Compartment Cartilage Defect of the Knee.

As the indications for high tibial osteotomy expand, more patients with larger cartilage defects requiring combined microfracture surgery will also be seen. A method was developed to drill through the medial tibia to the medial femur to treat medial compartment cartilage defects in the knee. This method can be combined with high tibial osteotomy without additional incisions.

Effect of Cassia Gum on the Gel Properties of Wheat Flour-Tapioca Starch-Based Batter and the Oil Absorption Capacity of Fried Small Yellow Croaker.

High oil content in breaded fried small yellow croaker (BFYC) was reduced using composite batter gels consisting of tapioca starch, wheat flour, and different concentrations of cassia gum (CG; 0%, 0.2%, 0.4%, 0.

Conversion study of hepatocellular carcinoma using HAIC combined with lenvatinib and PD-1/L1 immunotherapy under the guidance of BCLC staging.

Objective: This study aimed to assess the efficacy and safety of hepatic arterial infusion chemotherapy (HAIC) combined with lenvatinib and immunotherapy and explore its potential as a conversion treatment for unresectable hepatocellular carcinoma (uHCC).

Methods: A retrospective analysis was performed on clinical data from patients with uHCC who underwent HAIC, lenvatinib, and PD-1/PD-L1 immunotherapy. Data were collected from our hospital between November 2018 and December 2022.

Lactate dehydrogenase B facilitates disulfidptosis and exhaustion of tumour-infiltrating CD8 T cells.

The aberrant accumulation of intracellular disulfides promotes cancer cell disulfidptosis; however, how disulfide stress influences tumour-infiltrating CD8 T cell function remains unknown. Here we demonstrate that lactate dehydrogenase B (LDHB) facilitates intratumoural CD8 T cell disulfidptosis and exhaustion, leading to impaired antitumour immunity. SLC7A11-mediated cystine uptake by CD8 T cells induces disulfidptosis, which plays critical roles in the development of exhausted CD8 T cells.

A Bionic Goal-Oriented Path Planning Method Based on an Experience Map.

Brain-inspired bionic navigation is a groundbreaking technological approach that emulates the biological navigation systems found in mammalian brains. This innovative method leverages experiences within cognitive space to plan global paths to targets, showcasing remarkable autonomy and adaptability to various environments. This work introduces a novel bionic, goal-oriented path planning approach for mobile robots.

Ginsenoside Rg1 exerts anti-arrhythmic effect by inhibiting I through cAMP-PKA and PI3K-AKT signaling pathways in rat ventricular myocytes after myocardial ischemia-reperfusion injury.

ObjectiveGinsenoside Rg1 has demonstrated beneficial effects in myocardial ischemia-reperfusion (I/R) injury. However, its potential anti-arrhythmic role in ventricular arrhythmias remains unclear.MethodsIn this study, a whole-cell patch clamp technique was employed to evaluate the effects of Rg1 on L-type calcium current (I) and ventricular arrhythmia.

Mechano-Filtering Encapsulation: A Stitching-Based Packaging Strategy Implementing Active Noise Suppression in Piezoresistive Pressure Sensors.

Flexible pressure sensors face the dual challenges of weak signal extraction and environmental noise suppression in wearable electronics and human-machine interfaces. This research proposes an intelligent pressure sensor utilizing chitosan/carbon nanotube/melamine sponge (CS/CNT/MS) composites, achieving high-performance sensing through a dual-stage noise reduction architecture that combines mechanical pre-filtration and electrical synergistic regulation. An innovative compressed-stitching encapsulation technique creates pressure sensors with equivalent mechanical low-pass filtering characteristics, actively eliminating interference signals below 3 kPa while maintaining linear response within the 3-20 kPa effective loading range (sensitivity: 0.

A Slanted-Finger Interdigitated Transducer Microfluidic Device for Particles Sorting.

Sorting particles or cells of specific sizes in complex systems has long been a focus of many researchers. Acoustic surface waves, which generate acoustic radiation forces on particles or cells and, thus, influence their motion, are commonly used for the non-destructive separation of particles or cells of specific sizes. In previous studies, the frequency of acoustic surface wave generation has been limited by the interdigitated transducer (IDT).

Wide-Range, Washable Piezoresistive Pressure Sensor Based on MCNT-PDMS Dip-Coated PDMS Sponge.

Flexible pressure sensors have great potential for wearable applications such as human health monitoring and human-computer interaction, which require different trade-offs between the sensitivity and operating range. However, preparing washable and wide-range piezoresistive pressure sensors remains a great challenge. Here, we developed a porous flexible elastomer sponge based on a carbon nanotube composite network coating for pressure sensors with extremely high stability and washability over a wide range.

High-Sensitivity and Wide-Range Flexible Pressure Sensor Based on Gradient-Wrinkle Structures and AgNW-Coated PDMS.

Flexible pressure sensors have garnered significant attention due to their wide range of applications in human motion monitoring and smart wearable devices. However, the fabrication of pressure sensors that offer both high sensitivity and a wide detection range remains a challenging task. In this paper, we propose an AgNW-coated PDMS flexible piezoresistive sensor based on a gradient-wrinkle structure.

Flexible Pressure Sensor with Tunable Sensitivity and a Wide Sensing Range, Featuring a Bilayer Porous Structure.

Flexible piezoresistive pressure sensors have great potential in wearable electronics due to their simple structure, low cost, and ease of fabrication. Porous polymer materials, with their highly deformable internal pores, effectively expand the sensing range. However, a single-sized pore structure struggles to achieve both high sensitivity and a broad sensing range simultaneously.

Highly Efficient Spin-Orbit Torque Switching Using Bulk-Insulating Topological Insulator BiSe.

Topological insulators (TIs) are promising for efficient spin-orbit torque (SOT) switching of ferromagnets due to spin-momentum locking of their surface states. However, bulk-conducting channels limit their full potential for low-power operations. Here we synthesize bulk-insulating BiSe on (BiIn)Se/InSe buffer layers by molecular beam epitaxy and compare their SOT efficiency to bulk-conducting BiSe using Kerr rotation and second harmonic Hall measurements.

Diffusion-CAD: Controllable Diffusion Model for Generating Computer-Aided Design Models.

Generative methods for creating computer-aided design (CAD) models have gained significant attention over the past two years. However, existing methods lack fine-grained control over the generated CAD models, making it difficult to manage details such as model dimensions and the relative structure of components. To address these limitations, this study introduces Diffusion-CAD, a diffusion-based generative approach that outputs CAD construction sequences.

Highly Diastereoselective Synthesis of Oxindole-Bearing Pyrroloindoline via Gold Catalyzed Carbophilic Carbene Transfer Reaction.

A new type of gold catalyzed intermolecular dearomative cyclization reaction between diazo oxindole and tryptamine has been developed by utilizing the combination of LAuCl/AgPO (L=hexamethyl phosphane triamine) as the catalyst. This method allows for the facile preparation of a series of C-3-oxindole fused pyrroloindoline products in moderate to good yields with high diastereoselectivities. A plausible reaction mechanism, involving a cascade process of regioselective nucleophilic addition of the carbophilic gold carbenoid intermediate onto tryptamine, followed by an intramolecular cyclization, has been proposed, in which, the high diastereoselectivity is attributed to a preferred transition state.

Isolation and Immunomodulatory Activity of Cyanidin-3-O-(3,6-O-dimalonyl-β-D-glucoside) from the Black Corncob (Zea mays L.) and its Effect on Gut Microbiota in Elderly Feces under Anaerobic Conditions in vitro.

Black corn (Zea mays L.), native to Latin America, has been cultivated for millennia and holds significant cultural and culinary importance. While anthocyanins are well-characterized flavonoids in black corn, acylated derivatives remain insufficiently explored.

Effects of different microfracture drilling parameters on bone quality: a finite element analysis.

Background: Microfracture drilling is a surgical technique that involves creating multiple perforations in areas of cartilage defects to recruit stem cells from the bone marrow, thereby promoting cartilage regeneration in the knee joint. Increasing the exposed bone marrow surface area (more holes in the same area) can enhance stem cell outflow. However, when the exposed area is large, it may affect the mechanical strength of the bone at the site of the cartilage defect.

Antifungal Activity of Rhizosphere Bacillus Isolated from Against .

The serious impact of on jujube black spot disease has seriously affected the quality and yield of jujube, constraining the sustainable development of the jujube industry. The purpose of this study was to isolate and screen highly effective biocontrol strains of jujube black spot disease from jujube rhizosphere soil. Thirty-three soil samples were collected from four regions in southern Xinjiang.

Text-Enhanced Graph Attention Hashing for Cross-Modal Retrieval.

Deep hashing technology, known for its low-cost storage and rapid retrieval, has become a focal point in cross-modal retrieval research as multimodal data continue to grow. However, existing supervised methods often overlook noisy labels and multiscale features in different modal datasets, leading to higher information entropy in the generated hash codes and features, which reduces retrieval performance. The variation in text annotation information across datasets further increases the information entropy during text feature extraction, resulting in suboptimal outcomes.

Human Exposure Levels of Volatile Organic Compounds in E-waste Recycling Area: Get Insight into Impacts of Manipulation Mode and Associations with Oxidative Stress Markers.

There is currently a dearth of evidence regarding the impact of the manipulation mode on human occupational exposure to volatile organic compounds (VOCs) originating from e-waste dismantling. Therefore, 11 VOC metabolites (mVOCs) and four oxidative stress biomarkers (OSBs; i.e.

Changes in Texture and Collagen Properties of Pork Skin during Salt-Enzyme-Alkali Tenderization Treatment.

The effects of salt-enzyme-alkali progressive tenderization treatments on porcine cortical conformation and collagen properties were investigated, and their effectiveness and mechanisms were analyzed. The tenderization treatment comprised three treatment stages: CaCl (25 °C/0-30 min), papain (35 °C/30-78 min), and NaCO (25 °C/78-120 min). The textural, microscopic, and collagenous properties (content, solubility, and structure) of pork skin were determined at the 0th, 30th, 60th, 90th, and 120th min of the treatment process.